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Homocysteine Modulators
Solgar
4.8
★ ★ ★ ★ ★
(583 ratings)
Vitamin B6 50 mg
Vitamin B12 500 mcg
Score 82.0
An effective formula for homocysteine management, combining TMG with key B vitamins (B6 as P-5-P and Pyridoxine HCl, B12 as Cyanocobalamin, and Folate). Strong for its specific purpose despite non-active B12/folate forms.
Quantity: 120 Capsule(s)Servings size: 2 Vegetarian Capsule(s) (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
Fitness
leaderboard Score 82.0
An effective formula for homocysteine management, combining TMG with key B vitamins (B6 as P-5-P and Pyridoxine HCl, B12 as Cyanocobalamin, and Folate). Strong for its specific purpose despite non-active B12/folate forms.
Solgar Homocysteine Modulators is strategically designed to reduce homocysteine levels, a known risk factor for cardiovascular and cognitive issues. The combination of Trimethylglycine (TMG) with Vitamin B12, Folate, and Vitamin B6 is clinically proven to support healthy homocysteine metabolism by facilitating methylation pathways. The product wisely includes Pyridoxal 5-Phosphate (P-5-P), the active form of B6, which is superior to standard Pyridoxine Hydrochloride for direct bodily utilization. However, it also includes Pyridoxine Hydrochloride, which is less ideal. The Vitamin B12 is in the Cyanocobalamin form, and the Folate form is not specified as active L-methylfolate, which are less preferred than their active counterparts in terms of bioavailability for some individuals, particularly those with MTHFR gene variations. Despite these minor drawbacks, online reviews and nutritionist recommendations often highlight the effectiveness of such combined formulations for homocysteine management, making this a valuable product for its specific purpose. Its competitive price per serving further enhances its appeal.
- Contains Trimethylglycine (TMG) at an effective dose (1000mg) for homocysteine metabolism.
- Includes Pyridoxal 5-Phosphate (P-5-P), the active form of Vitamin B6, for better utilization.
- Provides a comprehensive blend of key B vitamins (B6, B12, Folate) essential for methylation and homocysteine reduction.
- Good value at $0.26 per serving for a specialized formula.
- Uses Cyanocobalamin for Vitamin B12 and a non-active form of Folate (likely folic acid), which are less bioavailable than methylcobalamin and L-methylfolate, respectively.
- Includes both Pyridoxal 5-Phosphate and Pyridoxine Hydrochloride for Vitamin B6, which is redundant and could be simplified to just the active form.
$16.19($0.26 per serving)
 Daily Vita | $ 19.80 | |
 Amazon | $ 17.99 | |
 Pure Formulas | $ 17.99 | |
 iHerb | $ 16.99 | |
 Vitacost | $ 16.19 |
| Ingredient | Amount per serving |
|---|---|
| Calories | 5 Calorie(s) |
| Vitamin B6 (Pyridoxine Hydrochloride) | 50 mg |
| Folate | 666 mcg DFE |
| Vitamin B12 (Cyanocobalamin) | 500 mcg |
| Trimethylglycine | 1000 mg |
| Pyridoxal 5-Phosphate | 6 mg |
Categories
Vitamin B6 85.0
It contains a substantial dose of Vitamin B6 (56mg total), including the active Pyridoxal 5-Phosphate (P-5-P) form, which is superior for direct biological activity. This makes it highly effective for its role in homocysteine metabolism and other B6-dependent functions.
Vitamin B12 70.0
The product provides a good dose of Vitamin B12 (500mcg) which is beneficial for nervous system function and red blood cell formation. However, it uses Cyanocobalamin, which is a common but less bioavailable form compared to methylcobalamin, limiting its overall score in this category.
Goals
Brain Health 85.0
By modulating homocysteine, a neurotoxic compound, this product directly supports brain health. Folate, B12, and B6 are critical for neurotransmitter synthesis and myelin formation, making it highly relevant for cognitive function.
Cognitive Support 85.0
Elevated homocysteine is associated with cognitive decline. This formula's ingredients directly address this by supporting methylation and neuroprotection, thus providing strong cognitive support.
General Health 85.0
Homocysteine modulation is critical for overall health, particularly cardiovascular and neurological well-being. This product addresses a systemic health marker, making it a strong contributor to general health beyond basic B vitamin supplementation.
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