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SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
5.0
★ ★ ★ ★ ★
(11 ratings)
SAMe 200 mg
Score 60.0
High-quality SAMe with excellent B-vitamin cofactors, but significantly overpriced compared to alternatives.
Quantity: 30 Capsule(s)Servings size: 1 Capsule(s) (30 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 60.0
High-quality SAMe with excellent B-vitamin cofactors, but significantly overpriced compared to alternatives.
Designs for Health SAMe with Vitamins B-6 B-12 and 5-MTHF is a thoughtfully formulated supplement that includes critical B vitamins (Methylcobalamin B12, Pyridoxal 5-Phosphate B6, and 5-Methyltetrahydrofolate) alongside SAMe. These cofactors are essential for maximizing the benefits of SAMe, particularly for mood support, as they participate in the methylation cycle. While the quality of ingredients and the brand's reputation are high, the cost per serving is prohibitive, making it difficult to recommend as a primary choice for most consumers when more affordable, albeit sometimes less comprehensive, alternatives exist.
- Includes essential and active B vitamin cofactors (B6, B12, 5-MTHF) that enhance SAMe's efficacy.
- Utilizes a stable form of SAMe (Disulfate P-Toluensulfate) for better absorption.
- Designs for Health is a professional-grade brand known for high-quality supplements.
- Extremely high price per serving, making it a poor value proposition.
- Low review count compared to market leaders, suggesting less widespread consumer adoption.
- Individuals should consult a healthcare professional before combining SAMe with certain medications, especially antidepressants, due to potential interactions.
$58.99($1.96 per serving)
 Pure Formulas | $ 58.99 |
| Ingredient | Amount per serving |
|---|---|
| Vitamin B-6 (Pyridoxal 5-Phosphate) | 5 mg |
| Folate (Glucosamine Salt, [6s]-5-Methyltetrahydrofolate) | 100 mcg |
| Vitamin B12 (Methylcobalamin) | 50 mcg |
| SAMe (S-Adenosyl-L-Methionine Disulfate P-Toluensulfate) | 200 mg |
Categories
SAMe 60.0
This SAMe product is formulated with high-quality, stable SAMe and important cofactors, which is a strong point. However, its premium pricing makes it a less accessible and less competitive option within the broader SAMe market, despite its comprehensive ingredient profile.
Goals
Mood Support 75.0
The inclusion of active B vitamin cofactors is highly beneficial for mood support, as they directly facilitate neurotransmitter synthesis pathways. However, the high cost limits its practicality for consistent long-term use.
Joint Health 60.0
While SAMe is effective for joint health, the 200mg dose is a standard starting point and often requires higher daily intake for therapeutic effects. The B vitamins don't directly impact joint health, and the product's high cost makes it less appealing for managing this condition compared to more affordable plain SAMe options.
Digestive Health 60.0
SAMe supports liver detoxification and general digestive health, and the B vitamins can assist in these metabolic processes. Despite the beneficial cofactors, the very high price makes it less competitive for this goal when compared to alternatives offering similar SAMe doses at a lower cost.
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