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SAMe (S-Adenosylmethionine)

Pure Encapsulations
4.5
(18 ratings)
SAMe 200 mg
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Score 30.0

Premium quality SAMe from a trusted brand, but its high price and lack of cofactors make it a poor value.

Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health

Score 30.0

Premium quality SAMe from a trusted brand, but its high price and lack of cofactors make it a poor value.

Analysis

Pure Encapsulations SAMe is a high-quality product from a brand renowned for its rigorous testing and hypoallergenic formulations, ensuring a clean and reliable supplement. It uses a stable form of SAMe (Disulfate Tosylate) to optimize absorption and effectiveness. However, its primary drawback is its exorbitant price per serving for a basic 200mg SAMe dose without any additional beneficial cofactors, which makes it a very poor value for consumers seeking SAMe supplementation.

Pros
  • Pure Encapsulations is a highly reputable professional-grade brand known for product purity and quality.
  • Uses a stable form of SAMe (Disulfate Tosylate) which is important for efficacy.
Cons
  • Excessively high price per serving compared to all other SAMe products, offering very poor value.
  • Does not include essential B vitamin cofactors that are often recommended for optimal SAMe metabolism.
  • Low review count suggests a smaller market presence or primarily practitioner sales.
Warnings
  • Individuals should consult a healthcare professional before combining SAMe with certain medications, especially antidepressants, due to potential interactions.
$79.00($1.31 per serving)
Pure Formulas
$ 79.00
Vitacost
$ 79.00
Ingredients
IngredientAmount per serving
SAMe (S-Adenosyl-L-Methionine Disulfate Tosylate) 200 mg
Adults 18–50
Categories
SAMe 30.0
This SAMe product's excellent brand reputation for quality is overshadowed by its remarkably high price per serving. As a standalone SAMe, it does not offer competitive value within the SAMe supplement market.
Goals
Mood Support 30.0
While SAMe effectively supports mood, the absence of crucial B vitamin cofactors in this formulation means users might not get optimal methylation support. The very high price also makes it impractical for consistent use required for mood management.
Joint Health 30.0
SAMe is beneficial for joint health, but the 200mg dose often needs to be higher for therapeutic effects. The prohibitive cost per serving makes this product an economically unfeasible option for managing joint discomfort over time.
Digestive Health 30.0
The 200mg SAMe dose can support digestive and liver health, but the extremely high price significantly detracts from its overall value. More cost-effective options are available that provide the same core ingredient without the premium pricing.
90 Value

SAMe 400 mg

NOW
4.6
(1753 ratings)
Offers a robust 400mg SAMe dose from a stable form at an exceptionally attractive price per serving, providing superior overall value for higher potency.
84 Value

SAMe 400 mg

Nutricost
4.7
(728 ratings)
Delivers a potent 400mg dose of SAMe from a stable form at a strong value, making it a cost-effective choice for higher dosing.
80 Value

SAMe 200 mg S-Adenosyl-Methionine

Life Extension
4.8
(1775 ratings)
A highly popular option offering a reliable 200mg SAMe dose at a very competitive price, providing excellent value for a trusted standalone product.
98 Performance

SAMe 200 mg + Cofactors

Metabolic Maintenance
4.6
(30 ratings)
A superior choice due to its inclusion of optimal, bioavailable B vitamin cofactors, providing more comprehensive methylation support alongside SAMe.
95 Performance

SAMe with Vitamins B-6 B-12 and 5-MTHF

Designs for Health
5.0
(11 ratings)
Offers the added benefit of high-quality B vitamin cofactors, enhancing the efficacy of SAMe for mood and methylation pathways, a significant upgrade from a standalone SAMe.
85 Performance

SAMe 400 mg

Life Extension
4.8
(2467 ratings)
Provides a double dose of SAMe (400mg) for increased potency, which can be beneficial for specific needs where a higher concentration is desired.
92 Budget

SAMe 200 mg

NOW
4.5
(1741 ratings)
Offers a stable form of SAMe at a significantly lower price per serving, providing excellent affordability without compromising on core ingredient quality.
88 Budget

SAMe 200

Jarrow Formulas
4.7
(263 ratings)
Provides a very cost-effective 200mg SAMe option from a highly popular and trusted brand, making it much more budget-friendly than the original.
82 Budget

SAMe 200 mg

Natural Factors
4.6
(578 ratings)
A more affordable SAMe option that still offers 200mg per serving, suitable for budget-conscious users who value a pure SAMe product.
90 Value

SAMe 400 mg

NOW
4.6
(1753 ratings)
Offers a robust 400mg SAMe dose from a stable form at an exceptionally attractive price per serving, providing superior overall value for higher potency.
84 Value

SAMe 400 mg

Nutricost
4.7
(728 ratings)
Delivers a potent 400mg dose of SAMe from a stable form at a strong value, making it a cost-effective choice for higher dosing.
80 Value

SAMe 200 mg S-Adenosyl-Methionine

Life Extension
4.8
(1775 ratings)
A highly popular option offering a reliable 200mg SAMe dose at a very competitive price, providing excellent value for a trusted standalone product.
98 Performance

SAMe 200 mg + Cofactors

Metabolic Maintenance
4.6
(30 ratings)
A superior choice due to its inclusion of optimal, bioavailable B vitamin cofactors, providing more comprehensive methylation support alongside SAMe.
95 Performance

SAMe with Vitamins B-6 B-12 and 5-MTHF

Designs for Health
5.0
(11 ratings)
Offers the added benefit of high-quality B vitamin cofactors, enhancing the efficacy of SAMe for mood and methylation pathways, a significant upgrade from a standalone SAMe.
85 Performance

SAMe 400 mg

Life Extension
4.8
(2467 ratings)
Provides a double dose of SAMe (400mg) for increased potency, which can be beneficial for specific needs where a higher concentration is desired.