Product Image

Sustained-Release Niacin with niaXtend 500 mg

Doctor's Best
4.7
(660 ratings)
Niacin 500 mg
Product Image
Score 75.0

A high-dose, sustained-release nicotinic acid supplement that aims to reduce flushing, beneficial for heart health and general metabolism, but carries a potential liver risk for some users.

Quantity: 120 Tablet(s)Servings size: 1 Tablet(s) (120 servings)
Selected goals:
Other goals:
Heart Health
Skin Health
Energy
Metabolism Boost

Score 75.0

A high-dose, sustained-release nicotinic acid supplement that aims to reduce flushing, beneficial for heart health and general metabolism, but carries a potential liver risk for some users.

Analysis

Doctor's Best Sustained-Release Niacin provides 500mg of nicotinic acid, designed to slowly release the nutrient into the bloodstream. This sustained-release mechanism is intended to reduce the severity of the common "niacin flush" and improve tolerance, while still offering the lipid-modulating benefits of nicotinic acid. However, some sustained-release niacin formulations have been historically linked to a higher risk of hepatotoxicity compared to immediate-release forms, making careful monitoring advisable, especially at this higher dose.

Pros
  • High dose of nicotinic acid suitable for cardiovascular benefits
  • Sustained-release aims to reduce flush
Cons
  • Sustained-release forms have been linked to a higher risk of liver enzyme elevation in some studies, potentially leading to hepatotoxicity
  • Still might cause some flush
Warnings
  • Consult a healthcare professional before use, especially if you have liver issues or are taking other medications. Monitor liver function. May still cause flushing in sensitive individuals.
$14.73($0.12 per serving)
Vitacost
$ 15.50
Walmart
$ 20.53
Pure Formulas
$ 15.13
iHerb
$ 14.73
Ingredients
IngredientAmount per serving
Niacin (Nicotinic Acid) 500 mg
Gluten Free Adults 18–50 Vegan Vegetarian
Categories
Niacin 80.0
This is a robust niacin product, offering a high dose of the therapeutic nicotinic acid form. Its sustained-release nature makes it more tolerable for some, positioning it as a strong option within the niacin category despite potential side effects.
Goals
Heart Health 90.0
500mg of nicotinic acid is a strong dose for impacting lipid profiles, including lowering LDL and triglycerides and raising HDL, making it highly effective for heart health support under medical guidance.
Energy 85.0
A substantial 500mg dose effectively contributes to energy metabolism by providing ample substrate for NAD and NADP coenzymes.
Metabolism Boost 85.0
This significant dose of nicotinic acid is highly active in metabolic pathways, supporting the efficient breakdown and utilization of macronutrients for overall metabolic health.
98 Value

Niacinamide 500 mg

NOW
4.7
(8865 ratings)
Provides 500mg of flush-free Niacinamide from a top brand for half the price per serving, making it an outstanding value that offers a safer alternative to sustained-release Niacin.
95 Value

Niacin 500 mg

NOW
4.6
(8550 ratings)
Delivers 500mg of regular Niacin from a highly reputable brand for half the price per serving, offering great value for those prioritizing high-dose Niacin and who can manage the flush.
90 Value

Niacinamide 500 mg

Nature's Way
4.6
(2563 ratings)
Offers 500mg of flush-free Niacinamide from a good brand at a lower price per serving, providing solid value for a high-dose, safer alternative to sustained-release Niacin.
99 Performance

Niacinamide

Thorne
4.7
(1868 ratings)
Thorne is a top-tier brand for purity and quality. This 500mg Niacinamide product is a flush-free alternative generally associated with a lower risk profile compared to sustained-release nicotinic acid.
95 Performance

No-Flush Niacin 500 mg

Source Naturals
4.7
(745 ratings)
This alternative features Inositol Hexanicotinate, a truly flush-free form that is generally considered safer than sustained-release nicotinic acid for long-term high-dose use, from a reputable brand.
98 Performance

Niacinamide 500 mg

NOW
4.7
(8865 ratings)
Offers a safer, flush-free Niacinamide form at the same high dose, from a highly trusted brand, and at a significantly better price. This combines 'better' and 'cheaper' effectively.
98 Budget

Niacinamide 500 mg

NOW
4.7
(8865 ratings)
Offers the same 500mg dose of Niacinamide (flush-free) from a highly reputable brand at half the price per serving, providing a safer and significantly more affordable alternative to sustained-release Niacin.
95 Budget

Niacin 500 mg

NOW
4.6
(8550 ratings)
Provides the same 500mg dose of standard Niacin from a top brand at half the price per serving. While not sustained-release, some prefer immediate release for liver considerations at high doses.
90 Budget

Niacin 500 mg

21st Century
4.5
(1747 ratings)
A very budget-friendly option offering the same 500mg dose of standard Niacin at a lower price per serving. Good for those needing high dose Niacin without the sustained-release form.
98 Value

Niacinamide 500 mg

NOW
4.7
(8865 ratings)
Provides 500mg of flush-free Niacinamide from a top brand for half the price per serving, making it an outstanding value that offers a safer alternative to sustained-release Niacin.
95 Value

Niacin 500 mg

NOW
4.6
(8550 ratings)
Delivers 500mg of regular Niacin from a highly reputable brand for half the price per serving, offering great value for those prioritizing high-dose Niacin and who can manage the flush.
90 Value

Niacinamide 500 mg

Nature's Way
4.6
(2563 ratings)
Offers 500mg of flush-free Niacinamide from a good brand at a lower price per serving, providing solid value for a high-dose, safer alternative to sustained-release Niacin.
99 Performance

Niacinamide

Thorne
4.7
(1868 ratings)
Thorne is a top-tier brand for purity and quality. This 500mg Niacinamide product is a flush-free alternative generally associated with a lower risk profile compared to sustained-release nicotinic acid.
95 Performance

No-Flush Niacin 500 mg

Source Naturals
4.7
(745 ratings)
This alternative features Inositol Hexanicotinate, a truly flush-free form that is generally considered safer than sustained-release nicotinic acid for long-term high-dose use, from a reputable brand.
98 Performance

Niacinamide 500 mg

NOW
4.7
(8865 ratings)
Offers a safer, flush-free Niacinamide form at the same high dose, from a highly trusted brand, and at a significantly better price. This combines 'better' and 'cheaper' effectively.