Zinc plus Selenium

Zinc plus Selenium

Dr. Mercola4.8 (14,473 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 90 servings
Goals
$19.97 $0.22 per serving

Product analysis

77 out of 100

Zinc plus Selenium supports normal immune and antioxidant functions, particularly when dietary intake is low. The selenium contribution also offers favorable value.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality62

Selenium enriched yeast is a favorable selenium source. Zinc and copper identify their forms, but their comparative quality remains uncertain.

Ingredient Transparency100

All three mineral amounts and forms are disclosed, making the serving easy to check. The straightforward label also helps comparisons with similar mineral supplements.

Value For Money58

The selenium contribution offers favorable value. Reliable cost comparisons for zinc and copper are unavailable, leaving the full combination’s value less certain.

Customer Satisfaction94

Customers report very high satisfaction across a large number of ratings. The extensive feedback base makes the satisfaction pattern well established.

Product Focus85

The clearest purpose is filling mineral gaps relevant to normal immune nutrition. Larger selenium intake does not establish added benefit when needs are already met.

Format
Capsule
Container
90 Capsule(s)
Per serving
$0.22
Customer rating
4.8 · 14,473 ratings
Report analysis

Goals

Everyday Health
Impact
Highest effect
B+ Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Selenium · 200 mcgZinc · 15 mg
Study evidence
Selenium Supportive 70 studies
Zinc Supportive 60 studies
Immunity
Impact
Highest effect
B Ingredient FitB- PathwaysA+ EvidenceA+ Formulation Logic
Zinc · 15 mgSelenium · 200 mcg
Study evidence
Selenium Mixed 37 studies
Zinc Supportive 73 studies

Ingredients

IngredientAmount per servingScore
Zinc (Zinc Bisglycinate Chelate)
15 mg
Selenium (Selenium Yeast)
200 mcg 88
Copper (Copper Bisglycinate Chelate)
0.25 mg
Adults 18–50
Report overview
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
A serving provides 200 mcg of selenium, with a moderate product cost per 200 mcg. The amount is below the adult upper intake level. It lists Selenium-enriched Yeast.
How this ingredient is rated

Active Ingredient Quality & Bioavailability81

It lists Selenium-enriched Yeast.
Selenium Chemical Form
It lists Selenium-enriched Yeast.
Form Transparency & Isomer Specificity
The label identifies Selenium-enriched Yeast.

Dose, Safety & Label Transparency100

The serving provides 200 mcg, an amount used in research on antioxidant and thyroid support. The 200 mcg serving is below the 400 mcg adult upper intake level, leaving room for dietary selenium.
Dosage Efficacy Sweet Spot
The serving provides 200 mcg, an amount used in research on antioxidant and thyroid support.
Safety Margin & UL Adherence
The 200 mcg serving is below the 400 mcg adult upper intake level, leaving room for dietary selenium.

Value80

The product cost per 200 mcg of selenium is moderate.
Price per 200 mcg Serving
The product cost per 200 mcg of selenium is moderate.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledEveryday Health forSelenium
  2. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledEveryday Health forSelenium
  3. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledEveryday Health forSelenium
  4. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsEveryday Health forSelenium
  5. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledEveryday Health forSelenium
  6. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsEveryday Health forZinc
  7. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsEveryday Health forZinc
  8. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsEveryday Health forZinc
  9. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsEveryday Health forZinc
  10. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsEveryday Health forZinc
  11. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  12. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  13. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  14. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  15. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  16. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  17. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  18. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  19. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  20. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc