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Methyl-Guard

Thorne
4.9
★ ★ ★ ★ ★
(3266 ratings)
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Score 92

A high-quality, comprehensive blend of active B vitamins (P5P B6, Folate, Methyl B12) and TMG, specifically designed to support methylation and related metabolic functions from a professional brand.

How scoring works
scaleQuantity:180 Capsule(s) • (60 servings)
track_changesGoals:

leaderboard Score 92

A high-quality, comprehensive blend of active B vitamins (P5P B6, Folate, Methyl B12) and TMG, specifically designed to support methylation and related metabolic functions from a professional brand.

How scoring works
$56.00($0.93 per serving)
Vitacost
$ 56.00
Walmart
$ 56.00
Pure Formulas
$ 56.00
iHerb
$ 56.00
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psychologyAnalysis

Thorne's Methyl-Guard is a specialized blend formulated to support methylation processes in the body, which are crucial for numerous biochemical reactions, including neurotransmitter synthesis and homocysteine metabolism. It contains active forms of B vitamins: 20.4 mg of Pyridoxal 5-Phosphate (active B6), 2 mg DFE of Folate, and 1.2 mg of Methylcobalamin (active B12).

The inclusion of 1.8 grams of Betaine Anhydrous (Trimethylglycine or TMG) further supports methylation and homocysteine regulation. This is a premium product designed for comprehensive cellular support, reflected in its ingredient quality and professional-grade brand reputation.

thumb_upPros
  • Contains active forms of B6 (P5P), Folate, and B12 (Methylcobalamin).
  • Includes Betaine Anhydrous (TMG) for enhanced methylation support.
  • Comprehensive blend targets multiple crucial metabolic pathways.
  • From Thorne, a highly respected professional-grade brand.
  • Significant customer satisfaction with over 3200 reviews.
thumb_downCons
  • Very high price per serving, positioning it as a premium product.
  • 60 servings (effectively a 30-day supply if taking 2 caps/day) offers a relatively short duration.
  • May be an overly complex or expensive option for general B6 needs alone.
  • The specific form of Folate is not explicitly provided (e.g., L-5-MTHF).
warningWarnings
  • Individuals on blood-thinning medications should consult a professional due to B vitamins' potential effects on homocysteine.
  • High doses of B vitamins can mask B12 deficiency symptoms; ensure proper diagnosis if supplementing.
  • Consult a healthcare professional if pregnant, nursing, or have a medical condition due to the comprehensive nature of the blend.
scienceNutrient quality
95 Highest impact

The use of active P5P B6, Methylcobalamin B12, and Folate, combined with TMG, represents exceptional nutrient quality and synergistic formulation for comprehensive methylation support.

visibilityIngredient transparency
85 Highest impact

All key active ingredients, including the specific forms (P5P, Methylcobalamin, Trimethylglycine) and their quantities, are clearly listed, though Folate form could be specified for absolute clarity.

workspace_premiumValue for money
65 High impact

While expensive, the comprehensive nature and high quality of the active ingredients offer good value for those specifically needing targeted methylation support, though not for general B6 needs.

thumb_upCustomer satisfaction
85 Highest impact

Over 3200 reviews indicate a very high level of customer satisfaction and trust in this specialized, high-quality product, especially among those seeking methylation support.

storefrontBrand
90 Highest impact

Thorne Research is highly regarded in the professional supplement industry for its commitment to high-quality, pure, and effective formulations, earning strong trust.

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track_changesGoals
flagMood Support
Impact
Highest effect
This powerful blend of active B6, Folate, and B12 directly supports the synthesis of key neurotransmitters, providing exceptional support for mood balance and nervous system health.
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flagBrain Health
Impact
Highest effect
The active B vitamins and TMG are critical for methylation, which is essential for healthy brain function, neurotransmitter production, and sustained mental clarity.
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flagCognitive Support
Impact
Highest effect
The active B vitamins and TMG are critical for methylation, which is essential for healthy brain function, neurotransmitter production, and sustained mental clarity.
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flagMental Focus
Impact
Highest effect
By robustly supporting neurotransmitter synthesis and overall brain metabolism, this blend can significantly enhance mental clarity and focus.
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flagHeart Health
Impact
Highest effect
This product is specifically formulated with nutrients (B6, B12, Folate, TMG) known to support healthy homocysteine levels, which can contribute significantly to cardiovascular wellness.
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flagCardiovascular Support
Impact
Highest effect
This product effectively supports healthy homocysteine levels with a synergistic blend of B vitamins and TMG, making it highly beneficial for cardiovascular function.
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flagMetabolism Boost
Impact
Highest effect
Active B6, Folate, and B12 are fundamental coenzymes in numerous metabolic processes, and TMG further aids energy conversion, offering comprehensive metabolic support.
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flagProductivity Boost
Impact
Highest effect
By optimizing methylation, energy metabolism, and brain function, this blend can strongly contribute to sustained energy, mental clarity, and overall productivity.
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scienceIngredients
IngredientAmount per serving
Vitamin B6
20.4 mg
Folate
2 mg DFE
Vitamin B12
1.2 mg
Betaine Anhydrous
1.8 Gram(s)
grain_off Gluten Free person Adults 18–50
flagReport overview
Vitamin B6 92
This product delivers 20.4mg of Vitamin B6 as Pyridoxal 5-Phosphate (P5P), an active and highly bioavailable form, strategically combined with other methylation cofactors for enhanced utility and superior quality.
scienceView ingredientinventory_2View products
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