Product Image

MediClear Plus

Thorne
4.7
★ ★ ★ ★ ★
(615 ratings)
Betaine Anhydrous 50 mg
Molybdenum 50 mcg
Selenium 70 mcg
Vitamin B5 50 mg
Lysine 500 mg
Calcium 300 mg
Chromium 100 mcg
Product Image
Score55
A high-quality protein and micronutrient base is strengthened by curcumin phytosome and milk thistle. The huge proprietary blend and high cost leave important value and transparency gaps.
How scoring works
Quantity:27 Ounce(s) • (21 servings)
Goals:
General Health
Detoxification
Immunity
Weight Gain
Hair Health
Energy
Heart Health

Score 55

A high-quality protein and micronutrient base is strengthened by curcumin phytosome and milk thistle. The huge proprietary blend and high cost leave important value and transparency gaps.
How scoring works
$75.00($3.57 per serving)
iHerb
$ 75.00
Vitacost
$ 77.73
Pure Formulas
$ 75.00
Report prices

Analysis

Twenty grams of protein, 300 mg calcium, 150 mg magnesium, vitamin C, vitamin D3, zinc, selenium, and active B-vitamin forms provide a useful meal-style nutrition base. The formula can support general nutrition, energy metabolism, and protein intake more credibly than a typical small-dose supplement.

Curcumin phytosome at 400 mg and milk thistle extract at 250 mg are the most meaningful botanical additions. Glycine is substantial, while glutamine, lysine, taurine, betaine, glutathione, green tea, and grape seed range from moderate to token amounts.

A proprietary blend exceeding 26 grams prevents a full assessment of the powder base despite many listed actives. The product may suit someone seeking a broad nutrition shake, but it is expensive and too complex for users who only want protein or a simple multivitamin.

Who is it for
  • Adults seeking a broad nutrition shake
  • Users wanting protein plus vitamins and botanicals
  • People who value active B-vitamin and chelated mineral forms
Best for
  • Meal-style general nutrition
  • Adding protein and micronutrients together
  • Broad liver and antioxidant support

Pros

  • Provides 20 grams of protein
  • Uses methylcobalamin, P-5-P, and riboflavin phosphate
  • Includes chelated zinc, chromium, manganese, and molybdenum
  • Contains curcumin phytosome and milk thistle
  • Glycine amount is meaningful

Cons

  • Very large proprietary blend obscures the powder base
  • High serving cost
  • Many specialty actives are lightly dosed
  • Only 21 servings per container
  • Not calorie-dense enough to replace a full meal

Warnings

  • Vitamin E and curcumin deserve care with anticoagulant or antiplatelet medicines
  • The proprietary blend prevents a complete allergen and interaction assessment from the supplied data
  • Chromium and vanadium may affect blood glucose alongside glucose-lowering medication

Nutrient quality

76 High impact

Protein, active B vitamins, chelated minerals, and absorption-focused botanical complexes create a strong nutritional core. Numerous modest specialty ingredients and a very large hidden blend reduce depth and focus.

Ingredient transparency

42 Lower impact

Many named nutrients and botanicals have specific amounts and forms. A very large proprietary blend, incomplete botanical markers, missing directions, and absent non-active ingredients create major disclosure gaps.

Customer satisfaction

70 High impact

The supplied satisfaction metric is strong and response volume is large. Specific firsthand feedback was not supplied, so recurring complaints and purpose alignment remain uncertain.

Value for money

35 Situational impact

High-quality forms and broad nutrition partly support the cost. The very expensive serving, hidden base, and many modest extras make the formula weakly competitive.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportA CoverageB- Formula Quality
Folate · 500 mcg DFEVitamin B12 · 50 mcgVitamin D · 10 mcgMagnesium · 150 mgBoron · 100 mcgGlycine · 1.65 Gram(s)Selenium · 70 mcgTaurine · 110 mgCurcumin · 400 mgZinc · 10 mgVitamin C · 300 mg

Protein, vitamins, minerals, amino acids, and a bioavailability-enhanced curcumin complex provide unusually broad nutritional coverage. Several active B-vitamin and chelated mineral forms strengthen the formula.

Core nutrients are supplied at useful amounts, but many secondary actives are modest and a very large proprietary blend obscures full assessment. The breadth may suit meal-style nutritional support, though it is more complex than needed for basic daily supplementation.

Study evidence
Curcumin Supportive 64 studies
Detoxification
Detoxification
Impact
Highest effect
A Goal FitB+ Strength of SupportA- CoverageB+ Formula Quality
Folate · 500 mcg DFEVitamin B12 · 50 mcgVitamin B6 · 10 mgMolybdenum · 50 mcgSelenium · 70 mcgMagnesium · 150 mgMilk Thistle · 250 mgBetaine Anhydrous · 50 mgGlutamine · 500 mgVitamin E · 80.6 mgCurcumin · 400 mgZinc · 10 mgVitamin C · 300 mgCholine · 11 mgTaurine · 110 mgRiboflavin · 5 mgGlycine · 1.65 Gram(s)

Glycine, curcumin phytosome, milk thistle, glutamine, taurine, antioxidant vitamins, selenium, and molybdenum create broad support for liver protection and metabolic clearance. Protein and glycine add useful substrate support, while the botanical and mineral components cover complementary pathways.

Several forms are well chosen, including curcumin phytosome, methylcobalamin, selenomethionine, and chelated minerals. Milk thistle is not standardized for silymarin, and taurine, betaine, glutathione, and green tea are relatively modest.

Study evidence
Betaine Anhydrous Mixed 4 studies
Curcumin Supportive 30 studies
Glutamine Supportive 8 studies
Glycine Supportive 5 studies
Green Tea Disputed 16 studies
Milk Thistle Supportive 46 studies
Molybdenum Adverse 1 study
Selenium Supportive 10 studies
Taurine Supportive 2 studies
Immunity
Immunity
Impact
Highest effect
A Goal FitB+ Strength of SupportA- CoverageC+ Formula Quality
Magnesium · 150 mgVitamin C · 300 mgZinc · 10 mgVitamin A · 1.5 mgVitamin D · 10 mcgSelenium · 70 mcg

Vitamins A, C, and D plus zinc and selenium cover barrier integrity, immune-cell function, and antioxidant defenses. Protein, glutamine, lysine, and enhanced curcumin add gut-barrier and inflammatory pathways.

Several core nutrients use favorable forms, but many immune actives are modest and a large proprietary blend limits full assessment. The broad meal-style formula is less focused than a dedicated immune supplement.

Study evidence
Curcumin Supportive 10 studies
Glutamine Supportive 36 studies
Lysine Supportive 2 studies
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Zinc Supportive 73 studies
Weight Gain
Weight Gain
Impact
High effect
B Goal FitB Strength of SupportB- CoverageC+ Formula Quality

Twenty grams of protein provides meaningful material for muscle repair, while 100 calories can contribute to daily energy intake. MCT oil, glycine, glutamine, vitamins, minerals, and enhanced curcumin add recovery and nutritional support.

The serving is not calorie-dense enough to function as a complete mass gainer without additional food. Betaine at 50 mg and taurine at 110 mg are far below performance amounts, so protein carries most of the weight-gain value.

Study evidence
Betaine Anhydrous Disputed 13 studies
Taurine No effect 7 studies
Hair Health
Hair Health
Impact
High effect
B- Goal FitB Strength of SupportB- CoverageC+ Formula Quality
Biotin · 150 mcgVitamin D · 10 mcgZinc · 10 mgIron · 2 mgLysine · 500 mgVitamin C · 300 mg

Twenty grams of protein provides a meaningful structural foundation, supported by lysine, vitamin C, zinc, selenium, biotin, and B vitamins. Chelated zinc and selenomethionine improve the quality of key mineral support.

The formula lacks keratin or a targeted hormonal active and includes many ingredients intended for broader nutrition. Hair support is credible but remains one part of a much wider meal-replacement design.

Study evidence
Biotin Supportive 4 studies
Iron Disputed 25 studies
Lysine Supportive 1 study
Selenium Disputed 7 studies
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Energy
Physical StaminaEssential Energy Nutrients
Energy
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageD+ Formula Quality
Vitamin D · 10 mcgVitamin B5 · 50 mgMagnesium · 150 mgRiboflavin · 5 mgThiamin · 12 mgVitamin B12 · 50 mcgIron · 2 mgPotassium · 100 mg

Protein, B vitamins, magnesium, methylcobalamin, medium-chain fats, and amino acids provide broad metabolic fuel support. Favorable nutrient forms and substantial protein strengthen the nutritional base.

Vitamin B12 and magnesium remain below the rubric’s focused supplemental amounts, and the very large proprietary blend obscures composition. Many botanicals and antioxidants are included at small amounts, creating more breadth than energy depth.

Study evidence
Magnesium Supportive 4 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
High effect
B- Goal FitC Strength of SupportB- CoverageC Formula Quality
Magnesium · 150 mgVitamin B12 · 50 mcgVitamin B6 · 10 mgTaurine · 110 mgGreen Tea · 50 mgCurcumin · 400 mgFolate · 500 mcg DFEVitamin D · 10 mcg

Magnesium, selenium, active B vitamins, and an absorption-enhanced curcumin complex cover several mechanisms relevant to heart health. The formula also includes green tea and grape-seed phytosomes that may add endothelial and antioxidant support.

Several relevant additions are modest, and missing EGCG and curcuminoid yields prevent precise potency assessment. A very broad powder and proprietary blend make the heart-focused contribution harder to separate from its general nutritional role.

Study evidence
Curcumin Supportive 70 studies
Green Tea Supportive 84 studies
Magnesium Supportive 158 studies
Potassium Supportive 182 studies
Selenium Mixed 89 studies

Ingredients

IngredientAmount per serving
Calories
100 Calorie(s)
Total Fat
1.5 Gram(s)
Total Carbohydrates
2 Gram(s)
Dietary Fiber
1 Gram(s)
Protein
20 Gram(s)
Vitamin A
1.5 mg
Vitamin C (Ascorbic Acid)
 300 mg
Vitamin D (Vitamin D3)
 10 mcg
Vitamin E
80.6 mg
Thiamine (Thiamine Hydrochloride)
 12 mg
Riboflavin (Riboflavin 5'-Phosphate Sodium)
 5 mg
Niacin
38 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 10 mg
Folate
500 mcg DFE
Vitamin B12 (Methylcobalamin)
 50 mcg
Biotin
150 mcg
Pantothenic Acid (Calcium Pantothenate)
 50 mg
Choline (Choline Citrate)
 11 mg
Calcium (Calcium Citrate)
 300 mg
Iron
2 mg
Magnesium (Magnesium Citrate)
 150 mg
Zinc (TRAACS Zinc Bisglycinate Chelate)
 10 mg
Selenium (L-Selenomethionine)
 70 mcg
Manganese (TRAACS Manganese Bisglycinate Chelate)
 1.5 mg
Chromium (TRAACS Chromium Nicotinate Glycinate Chelate)
 100 mcg
Molybdenum (TRAACS Molybdenum Glycinate Chelate)
 50 mcg
Sodium
190 mg
Potassium (Potassium Citrate)
 100 mg
Proprietary Blend
26.26 Gram(s)
Glycine
1.65 Gram(s)
Medium Chain Triglyceride
1.5 Gram(s)
L-Glutamine
500 mg
L-Lysine (L-Lysine Monohydrochloride)
 500 mg
Curcumin Phytosome (Curcuma longa extract, Phospholipid complex)
 400 mg
Milk Thistle extract
250 mg
Taurine
110 mg
Methyl Sulfonyl Methane
100 mg
Grape seed phytosome (Phosphatidylcholine Complex, Vitis vinifera extract)
 50 mg
Betaine Anhydrous (Trimethylglycine)
 50 mg
Green Tea Phytosome (Camellia sinensis extract, Phospholipid complex)
 50 mg
Glutathione
30 mg
Boron (Bororganic Boron Glycinate Complex)
 100 mcg
Lutein (Aztec Marigold extract)
 60 mcg
Vanadium (Vanadium Citrate)
 50 mcg
Gluten Free Adults 18–50 Children 4+
Report overview
Betaine Anhydrous (Trimethylglycine) · 50 mg OverallScore82
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value

The formula uses the correct trimethylglycine form and clearly discloses 50 mg per serving. That amount fits modest wellness use but is too low for performance-focused goals. Its high serving cost is partly explained by the broad protein, vitamin, mineral, and phytosome formula rather than betaine alone.

View ingredientView products
Selenium (L-Selenomethionine) · 70 mcg OverallScore76
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

L-selenomethionine provides a well-absorbed organic selenium source with clear isomer labeling. The 70 mcg amount offers modest daily support and leaves a wide safety margin. Its high selenium-specific cost is partly offset by an extensive broader formula.

View ingredientView products
Molybdenum (TRAACS Molybdenum Glycinate Chelate) · 50 mcg OverallScore76
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyD+ Value

A verified glycinate chelate provides excellent expected absorption and stronger quality assurance. The disclosed amount is below the effective collection range, though it remains comfortably within the stated safety limit. The serving cost is moderate or partly justified by useful cofactors in the broader formula.

View ingredientView products

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Selenium supplementation for the primary prevention of cardiovascular disease.
    Rees K; Hartley L; Day C; Flowers N; Clarke A; Stranges S · The Cochrane database of systematic reviews · 2013
    Meta-analysis19,715 participants12 studies pooledGeneral Health forSelenium
  3. Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial.
    Sharifi S; Bagherniya M; Khoram Z; Ebrahimi Varzaneh A; Atkin SL; Jamialahmadi T; Sahebkar A; Askari G · Phytotherapy research : PTR · 2023
    Randomized trial60 participantsDetoxification forCurcumin
  4. Oral Curcumin No More Effective Than Placebo in Preventing Recurrence of Crohn's Disease After Surgery in a Randomized Controlled Trial.
    Bommelaer G; Laharie D; Nancey S; Hebuterne X; Roblin X; Nachury M; Peyrin-Biroulet L; Fumery M; Richard D; Pereira B; Goutte M; Buisson A; POPCUR study group · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
    Randomized trial62 participantsGeneral Health forCurcumin
  5. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forSelenium
  6. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  7. Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease.
    Moradi Kelardeh B; Rahmati-Ahmadabad S; Farzanegi P; Helalizadeh M; Azarbayjani MA · Journal of bodywork and movement therapies · 2021
    Randomized trial45 participantsDetoxification forCurcumin
  8. A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults.
    Schönenberger KA; Laval J; Woods T; Truillet R; Naranjo-Modad S; Mettler S; Fança-Berthon P · Journal of the International Society of Sports Nutrition · 2025
    Randomized trial44 participantsGeneral Health forCurcumin
  9. Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial.
    Rayman MP; Winther KH; Pastor-Barriuso R; Cold F; Thvilum M; Stranges S; Guallar E; Cold S · Free radical biology & medicine · 2019
    Randomized trial491 participantsGeneral Health forSelenium
  10. Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study.
    Goyal S; Beniwal SK; Agarwal P; Brar RK; Jain P; Kumar HS; Das BC · Phytotherapy research : PTR · 2025
    Randomized trial120 participantsGeneral Health forCurcumin
  11. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  12. Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
    Vajdi M; Hassanizadeh S; Hassanizadeh R; Bagherniya M · Nutrition reviews · 2024
    Meta-analysis905 participants15 studies pooledDetoxification forCurcumin
  13. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial.
    Jazayeri-Tehrani SA; Rezayat SM; Mansouri S; Qorbani M; Alavian SM; Daneshi-Maskooni M; Hosseinzadeh-Attar MJ · Nutrition & metabolism · 2024
    Randomized trial84 participantsDetoxification forCurcumin
  14. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  15. The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis.
    Sadeghi N; Mansoori A; Shayesteh A; Hashemi SJ · Phytotherapy research : PTR · 2020
    Randomized trial70 participantsGeneral Health forCurcumin
  16. Circulating Selenium and Cardiovascular or All-Cause Mortality in the General Population: a Meta-Analysis.
    Xiang S; Dai Z; Man C; Fan Y · Biological trace element research · 2021
    Meta-analysis25,667 participants12 studies pooledGeneral Health forSelenium
  17. Therapeutic effects of curcumin supplementation on liver enzymes of nonalcoholic fatty liver disease patients: A systematic review and meta-analysis of randomized clinical trials.
    Ebrahimzadeh A; Ebrahimzadeh A; Fooladshekan S; Mohseni S; Mohtashamian A; Babajafari S; Sohrabi Z · Food science & nutrition · 2025
    Meta-analysis14 studies pooledDetoxification forCurcumin
  18. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial.
    Parohan M; Sarraf P; Javanbakht MH; Foroushani AR; Ranji-Burachaloo S; Djalali M · Nutritional neuroscience · 2021
    Randomized trial100 participantsGeneral Health forCurcumin
  19. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  20. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  21. Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Thanawala S; Shah R; Alluri KV; Bhupathiraju K; Prasad N; Agarwal Y · Journal of pain research · 2025
    Randomized trial139 participantsGeneral Health forCurcumin
  22. Effect of nano-curcumin supplementation on liver fibrosis in patients with NAFLD-associated fibrosis: a double-blind randomized controlled trial.
    Gerami H; Mozaffari-Khosravi H; Mansour A; Sohrabpour AA; Poustchi H; Hashemi Taheri AP; Jaafari MR; Jambarsang S; Khayyatzadeh SS · Scientific reports · 2025
    Randomized trial55 participantsDetoxification forCurcumin
  23. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  24. Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials.
    Jenkins DJA; Kitts D; Giovannucci EL; Sahye-Pudaruth S; Paquette M; Blanco Mejia S; Patel D; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · The American journal of clinical nutrition · 2021
    Meta-analysis43 studies pooledGeneral Health forSelenium
  25. A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study.
    T Krishnareddy N; Thomas JV; Nair SS; N Mulakal J; Maliakel BP; Krishnakumar IM · BioMed research international · 2019
    Randomized trial48 participantsDetoxification forCurcumin
  26. Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials.
    Onakpoya IJ; Spencer EA; Perera R; Heneghan CJ · International journal of rheumatic diseases · 2018
    Meta-analysis797 participants7 studies pooledGeneral Health forCurcumin
  27. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  28. Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses.
    Wang P; Chen B; Huang Y; Li J; Cao D; Chen Z; Li J; Ran B; Yang J; Wang R; Wei Q; Dong Q; Liu L · Frontiers in nutrition · 2024
    Systematic reviewGeneral Health forSelenium
  29. Effects of Curcumin on Postmenopausal Women's Health: A Systematic Review and Meta-Analysis.
    Jin D; Jin S; Sheng G; Cui Z; Gao P; Li G · Phytotherapy research : PTR · 2025
    Meta-analysis982 participants14 studies pooledGeneral Health forCurcumin
  30. Effects of curcumin/turmeric supplementation on liver function in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
    Dehzad MJ; Ghalandari H; Amini MR; Askarpour M · Complementary therapies in medicine · 2023
    Meta-analysisDetoxification forCurcumin
  31. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  32. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  33. Effectiveness and safety of turmeric for the treatment of COVID-19: An updated systematic review and meta-analysis of randomized controlled trials.
    Sawangjit R; Sadoyu S; Manosanthipaibul S; Teerawattanapong N; Puttarak P; Wanaratna K; Charoensup R; Hiransai P; Meetam T; Chaiyakunapruk N · Complementary therapies in medicine · 2025
    Meta-analysis1,407 participants23 studies pooledGeneral Health forCurcumin
  34. Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials.
    Mansour-Ghanaei F; Pourmasoumi M; Hadi A; Joukar F · Integrative medicine research · 2022
    Meta-analysis228 participants4 studies pooledDetoxification forCurcumin
  35. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  36. The association of low selenium and renal insufficiency with coronary heart disease and all-cause mortality: NHANES III follow-up study.
    Eaton CB; Abdul Baki AR; Waring ME; Roberts MB; Lu B · Atherosclerosis · 2011
    Cohort study10,531 participantsGeneral Health forSelenium
  37. Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial.
    Nouri-Vaskeh M; Afshan H; Malek Mahdavi A; Alizadeh L; Fan X; Zarei M · Complementary therapies in medicine · 2020
    Randomized trial70 participantsGeneral Health forCurcumin
  38. Effects of curcumin/turmeric supplementation on the liver enzymes, lipid profiles, glycemic index, and anthropometric indices in non-alcoholic fatty liver patients: An umbrella meta-analysis.
    Molani-Gol R; Dehghani A; Rafraf M · Phytotherapy research : PTR · 2024
    Meta-analysis5,546 participants11 studies pooledDetoxification forCurcumin
  39. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  40. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  41. Betaine consumption as a new clinical approach to treatment and prophylaxis of folate-related pathologies.
    Yeroshkina K; Rossokha Z; Fishchuk L; Gorovenko N · Nutrition reviews · 2023
    Narrative reviewDetoxification forBetaine Anhydrous
  42. Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis.
    Ashtary-Larky D; Bagheri R; Ghanavati M; Asbaghi O; Tinsley GM; Mombaini D; Kooti W; Kashkooli S; Wong A · Critical reviews in food science and nutrition · 2022
    Meta-analysisDetoxification forBetaine Anhydrous
  43. Decoding Betaine: A Critical Analysis of Therapeutic Potential Compared with Marketing Hype-A Narrative Review.
    Nikrandt G; Chmurzynska A · The Journal of nutrition · 2024
    Narrative reviewDetoxification forBetaine Anhydrous
  44. Therapy of NAFLD: antioxidants and cytoprotective agents.
    Chang CY; Argo CK; Al-Osaimi AM; Caldwell SH · Journal of clinical gastroenterology · 2006
    Narrative reviewDetoxification forBetaine Anhydrous
  45. Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.
    Yaikwawong M; Kamdee K; Chuengsamarn S · International journal of molecular sciences · 2025
    Randomized trial227 participantsDetoxification forCurcumin
  46. Efficacy of glutamine supplementation in postoperative patients undergoing hepatic surgery: a systematic review and meta-analysis of randomized controlled trials.
    Meng X; Zhang M; Wang X · Clinics (Sao Paulo, Brazil) · 2026
    Meta-analysis1,198 participants18 studies pooledDetoxification forGlutamine
  47. Glutamine supplementation in preterm infants receiving parenteral nutrition leads to an early improvement in liver function.
    Wang Y; Cai W; Tao YX; Tang QY; Feng Y; Wu J · Asia Pacific journal of clinical nutrition · 2014
    Randomized trial30 participantsDetoxification forGlutamine
  48. Parenteral glutamine protects hepatic function during bone marrow transplantation.
    Brown SA; Goringe A; Fegan C; Davies SV; Giddings J; Whittaker JA; Burnett AK; Poynton CH · Bone marrow transplantation · 1998
    Randomized trial34 participantsDetoxification forGlutamine
  49. Protective effect of parenteral glutamine supplementation on hepatic function in very low birth weight infants.
    Wang Y; Tao YX; Cai W; Tang QY; Feng Y; Wu J · Clinical nutrition (Edinburgh, Scotland) · 2010
    Randomized trial30 participantsDetoxification forGlutamine
  50. A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis.
    Laghi L; Román E; Lan Q; Nieto JC; Canalda-Baltrons A; Poca M; Sánchez-Rodríguez MB; Clària J; Alvarado E; Cuyàs B; Sánchez E; Vidal S; Guarner C; Escorsell À; Manichanh C; Soriano G · Hepatology communications · 2023
    Randomized trial32 participantsDetoxification forGlutamine
  51. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  52. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  53. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  54. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
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  55. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine
  56. Therapeutic benefits of green tea extract on various parameters in non-alcoholic fatty liver disease patients.
    Hussain M; Habib-Ur-Rehman; Akhtar L · Pakistan journal of medical sciences · 2024
    Randomized trial80 participantsDetoxification forGreen Tea
  57. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients with Nonalcoholic Fatty Liver Disease.
    Pezeshki A; Safi S; Feizi A; Askari G; Karami F · International journal of preventive medicine · 2016
    Randomized trial80 participantsDetoxification forGreen Tea
  58. Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study.
    Sakata R; Nakamura T; Torimura T; Ueno T; Sata M · International journal of molecular medicine · 2014
    Randomized trial17 participantsDetoxification forGreen Tea
  59. Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype.
    Hakim IA; Chow HH; Harris RB · The Journal of nutrition · 2008
    Randomized trialDetoxification forGreen Tea
  60. Modulation of human glutathione s-transferases by polyphenon e intervention.
    Chow HH; Hakim IA; Vining DR; Crowell JA; Tome ME; Ranger-Moore J; Cordova CA; Mikhael DM; Briehl MM; Alberts DS · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2007
    Single-arm trial42 participantsDetoxification forGreen Tea
  61. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle
  62. Human molybdenum exposure risk in industrial regions of China: New critical effect indicators and reference dose.
    Kuang HX; Li MY; Zeng XW; Chen D; Zhou Y; Zheng T; Xiang MD; Wu QZ; Chen XC; Dong GH; Yu YJ · Ecotoxicology and environmental safety · 2024
    Cross-sectional study2,267 participantsDetoxification forMolybdenum
  63. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
    Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
    Randomized trialDetoxification forSelenium
  64. [Selenium and oxidative stress in cancer patients].
    Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
    Single-arm trial40 participantsDetoxification forSelenium
  65. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
    Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
    Other40 participantsDetoxification forSelenium
  66. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
    Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
    Cross-sectional study9,445 participantsDetoxification forSelenium
  67. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
    Randomized trial35 participantsDetoxification forSelenium
  68. Dietary amino acid taurine ameliorates liver injury in chronic hepatitis patients.
    Hu YH; Lin CL; Huang YW; Liu PE; Hwang DF · Amino acids · 2008
    Non-randomized trial24 participantsDetoxification forTaurine
  69. Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study.
    Schneider SM; Joly F; Gehrardt MF; Badran AM; Myara A; Thuillier F; Coudray-Lucas C; Cynober L; Trivin F; Messing B · The British journal of nutrition · 2006
    Single-arm trial32 participantsDetoxification forTaurine
  70. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  71. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  72. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  73. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  74. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  75. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  76. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  77. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  78. The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
    Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
    Case-control study100,203 participantsHair Health forIron
  79. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
    Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
    Meta-analysis10,029 participants36 studies pooledHair Health forIron
  80. Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
    Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
    Cohort study261 participantsHair Health forIron
  81. Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
    Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
    Cross-sectional study100 participantsHair Health forIron
  82. Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
    Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
    Cohort study155 participantsHair Health forIron
  83. Causes of hair loss and the developments in hair rejuvenation.
    Rushton DH; Norris MJ; Dover R; Busuttil N · International journal of cosmetic science · 2010
    Narrative reviewHair Health forLysine
  84. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  85. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  86. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
  87. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
    Meta-analysis764 participantsHair Health forSelenium
  88. Scientific opinion on the tolerable upper intake level for selenium.
    EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
    Systematic reviewHair Health forSelenium
  89. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  90. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  91. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  92. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  93. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  94. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  95. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  96. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  97. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  98. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  99. The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Alidadi M; Sahebkar A; Eslami S; Vakilian F; Jarahi L; Alinezhad-Namaghi M; Arabi SM; Vakili S; Tohidinezhad F; Nikooiyan Y; Norouzy A · Advances in experimental medicine and biology · 2021
    Randomized trial66 participantsHeart Health forCurcumin
  100. The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial.
    Shafabakhsh R; Asemi Z; Reiner Z; Soleimani A; Aghadavod E; Bahmani F · Iranian journal of kidney diseases · 2021
    Randomized trial60 participantsHeart Health forCurcumin
  101. Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk.
    El-Rakabawy OM; Elkholy AA; Mahfouz AA; Abdelsalam MM; El Wakeel LM · Scientific reports · 2025
    Randomized trial72 participantsHeart Health forCurcumin
  102. Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial.
    Helli B; Gerami H; Kavianpour M; Heybar H; Hosseini SK; Haghighian HK · Endocrine, metabolic & immune disorders drug targets · 2022
    Randomized trial90 participantsHeart Health forCurcumin
  103. The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.
    Yaikwawong M; Jansarikit L; Jirawatnotai S; Chuengsamarn S · Nutrients · 2024
    Randomized trial227 participantsHeart Health forCurcumin
  104. Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials.
    Khalesi S; Sun J; Buys N; Jamshidi A; Nikbakht-Nasrabadi E; Khosravi-Boroujeni H · European journal of nutrition · 2015
    Meta-analysis13 studies pooledHeart Health forGreen Tea
  105. Effect of Green Tea on Blood Pressure in Healthy Individuals: A Meta-Analysis.
    Yıldırım Ayaz E; Dincer B; Mesci B · Alternative therapies in health and medicine · 2023
    Meta-analysis680 participants9 studies pooledHeart Health forGreen Tea
  106. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.
    Bogdanski P; Suliburska J; Szulinska M; Stepien M; Pupek-Musialik D; Jablecka A · Nutrition research (New York, N.Y.) · 2012
    Randomized trial56 participantsHeart Health forGreen Tea
  107. Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials.
    Zheng XX; Xu YL; Li SH; Liu XX; Hui R; Huang XH · The American journal of clinical nutrition · 2011
    Meta-analysis1,136 participants14 studies pooledHeart Health forGreen Tea
  108. Effects of green tea on lipid profile in overweight and obese women.
    Li A; Wang Q; Li P; Zhao N; Liang Z · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2024
    Meta-analysis1,818 participants15 studies pooledHeart Health forGreen Tea
  109. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledHeart Health forMagnesium
  110. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  111. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  112. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  113. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forMagnesium
  114. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P · Journal of the American College of Cardiology · 2011
    Meta-analysis247,510 participants11 studies pooledHeart Health forPotassium
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    Poorolajal J; Zeraati F; Soltanian AR; Sheikh V; Hooshmand E; Maleki A · PloS one · 2017
    Meta-analysis1,213 participants23 studies pooledHeart Health forPotassium
  116. Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
    O'Donnell M; Mente A; Rangarajan S; McQueen MJ; O'Leary N; Yin L; Liu X; Swaminathan S; Khatib R; Rosengren A; Ferguson J; Smyth A; Lopez-Jaramillo P; Diaz R; Avezum A; Lanas F; Ismail N; Yusoff K; Dans A; Iqbal R; Szuba A; Mohammadifard N; Oguz A; Yusufali AH; Alhabib KF; Kruger IM; Yusuf R; Chifamba J; Yeates K; Dagenais G; Wielgosz A; Lear SA; Teo K; Yusuf S; PURE Investigators · BMJ (Clinical research ed.) · 2019
    Cohort study103,570 participantsHeart Health forPotassium
  117. Effect of Potassium Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Studies.
    D'Elia L; Cappuccio FP; Masulli M; La Fata E; Rendina D; Galletti F · Nutrients · 2023
    Meta-analysis332 participants5 studies pooledHeart Health forPotassium
  118. Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension.
    Kawano Y; Minami J; Takishita S; Omae T · American journal of hypertension · 1999
    Randomized trial55 participantsHeart Health forPotassium
  119. Selenium concentration is associated with occurrence and diagnosis of three cardiovascular diseases: A systematic review and meta-analysis.
    Yang L; Qi M; Du X; Xia Z; Fu G; Chen X; Liu Q; Sun N; Shi C; Zhang R · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022
    Meta-analysis49 studies pooledHeart Health forSelenium
  120. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsHeart Health forSelenium
  121. Exploring the Impact of Selenium Supplementation on Nutritional, Inflammatory, and Cardiac Function in Chronic Heart Failure Patients: A Novel Approach to Managing Deficiency.
    Kou L; Meng F; Fu G; Zhang R · Cardiovascular toxicology · 2025
    Meta-analysis191 participantsHeart Health forSelenium
  122. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsHeart Health forSelenium
  123. Correlation between dietary selenium intake and stroke in the National Health and Nutrition Examination Survey 2003-2018.
    Shi W; Su L; Wang J; Wang F; Liu X; Dou J · Annals of medicine · 2022
    Cross-sectional study39,438 participantsHeart Health forSelenium
  124. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis.
    Wu S; Xiao D · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017
    Randomized trial241 participantsImmunity forCurcumin
  125. Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study.
    Kuwabara Y; Hirose A; Lee H; Kakinuma T; Baba A; Takara T · Journal of dietary supplements · 2023
    Randomized trial99 participantsImmunity forCurcumin
  126. Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial.
    Bahrami A; Mohammadifard M; Rajabi Z; Motahari-Nasab M; Ferns GA · European journal of obstetrics, gynecology, and reproductive biology · 2022
    Randomized trial80 participantsImmunity forCurcumin
  127. The roles of curcumin in regulating the tumor immunosuppressive microenvironment.
    Wang Y; Lu J; Jiang B; Guo J · Oncology letters · 2020
    Narrative reviewImmunity forCurcumin
  128. Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature.
    Nebrisi EE · International journal of molecular sciences · 2021
    Narrative reviewImmunity forCurcumin
  129. Meta-analysis of Glutamine on Immune Function and Post-Operative Complications of Patients With Colorectal Cancer.
    Yang T; Yan X; Cao Y; Bao T; Li G; Gu S; Xiong K; Xiao T · Frontiers in nutrition · 2021
    Meta-analysis2,201 participants31 studies pooledImmunity forGlutamine
  130. Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
    Dong S; Zhao Z; Li X; Chen Z; Jiang W; Zhou W · Frontiers in nutrition · 2023
    Meta-analysis1,201 participants30 studies pooledImmunity forGlutamine
  131. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial.
    Garrel D; Patenaude J; Nedelec B; Samson L; Dorais J; Champoux J; D'Elia M; Bernier J · Critical care medicine · 2003
    Randomized trial45 participantsImmunity forGlutamine
  132. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis.
    Huang Y; Yang XZ; Qin SH; Zhang T; Xie M; Wang JW · World journal of gastrointestinal surgery · 2026
    Meta-analysis1,643 participants27 studies pooledImmunity forGlutamine
  133. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control.
    Wischmeyer PE; Lynch J; Liedel J; Wolfson R; Riehm J; Gottlieb L; Kahana M · Critical care medicine · 2001
    Randomized trial26 participantsImmunity forGlutamine
  134. Lysine-fortified wheat flour improves the nutritional and immunological status of wheat-eating families in northern China.
    Zhao W; Zhai F; Zhang D; An Y; Liu Y; He Y; Ge K; Scrimshaw NS · Food and nutrition bulletin · 2004
    Clinical trial264 participantsImmunity forLysine
  135. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis
    R S Griffith, D E Walsh, K H Myrmel, R W Thompson, A Behforooz · Dermatologica · 1987
    Non-randomized trial52 participantsImmunity forLysine
  136. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  137. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  138. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  139. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  140. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  141. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  142. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  143. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  144. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
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    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  146. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
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    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  148. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
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    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
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    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
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    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
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    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
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    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
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  154. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  155. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  156. Effects of betaine on body composition, performance, and homocysteine thiolactone.
    Cholewa JM; Wyszczelska-Rokiel M; Glowacki R; Jakubowski H; Matthews T; Wood R; Craig SA; Paolone V · Journal of the International Society of Sports Nutrition · 2013
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
  157. Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II.
    Trujillo-González I; Barisione G; Bottiglieri T; Reyes M; Garmendia ML; Mujica-Coopman MF · The Journal of nutrition · 2026
    Cohort study150 participantsWeight Gain forBetaine Anhydrous
  158. Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population.
    Huang BX; Zhu YY; Tan XY; Lan QY; Li CL; Chen YM; Zhu HL · The British journal of nutrition · 2017
    Cohort study1,996 participantsWeight Gain forBetaine Anhydrous
  159. Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study.
    Long JA; Zhong RH; Chen S; Wang F; Luo Y; Lu XT; Yishake D; Chen YM; Fang AP; Zhu HL · The British journal of nutrition · 2021
    Cohort study1,242 participantsWeight Gain forBetaine Anhydrous
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    Waldman HS; Bryant AR; McAllister MJ · Journal of dietary supplements · 2023
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
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    Verner A; Craig S; McGuire W · The Cochrane database of systematic reviews · 2008
    Meta-analysis189 participants9 studies pooledWeight Gain forTaurine
  162. Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis.
    Cao SL; Jiang H; Niu SP; Wang XH; Du S · Indian journal of pediatrics · 2018
    Meta-analysis216 participants9 studies pooledWeight Gain forTaurine
  163. Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study.
    Rosa FT; Freitas EC; Deminice R; Jordão AA; Marchini JS · European journal of nutrition · 2015
    Randomized trial24 participantsWeight Gain forTaurine
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    Rassin DK; Räihä NC; Minoli I; Moro G · JPEN. Journal of parenteral and enteral nutrition · 1990
    Non-randomized trialWeight Gain forTaurine
  165. Taurine supplementation prevents hyperaminoacidemia in growing term infants fed high-protein cow's milk formula.
    Räihä NC; Fazzolari-Nesci A; Boehm G · Acta paediatrica (Oslo, Norway : 1992) · 1997
    Randomized trialWeight Gain forTaurine