SAMe 400 mg
Nutricost
SAMe 400 mg
4.7
★ ★ ★ ★ ★
(728 ratings)
SAMe 400 mg
Score 96.0
The top value 400mg SAMe product, offering high potency in a stable form at an exceptionally low price, ideal for budget-conscious users seeking maximum benefits.
Quantity: 120 Capsule(s)Servings size: 2 Capsule(s) (60 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 96.0
The top value 400mg SAMe product, offering high potency in a stable form at an exceptionally low price, ideal for budget-conscious users seeking maximum benefits.
insights Analysis
Nutricost SAMe 400 mg stands out as a market leader in terms of value, providing a substantial 400mg dose of S-Adenosyl-L-Methionine Disulfate Tosylate, a stable form of SAMe, at an incredibly low price of just $0.59 per serving. This price point makes high-dose SAMe supplementation highly accessible. While Nutricost is generally known as a budget-friendly brand, its solid review count (616) suggests satisfactory user experiences. For SAMe products, enteric coating is critical for bioavailability, and while not explicitly stated, it's generally expected for stable SAMe tablets/capsules. Nutritionists recognize the 400mg dose as effective for a range of benefits. The primary trade-off for this exceptional value is that Nutricost might not have the same level of brand recognition or extensive third-party testing certifications as some premium brands, but for pure cost-effectiveness per milligram of high-quality SAMe, it's difficult to beat.
- Offers a robust 400mg dose of SAMe, highly effective for various health goals.
- Uses the stable S-Adenosyl-L-Methionine Disulfate Tosylate form.
- Exceptionally low price per serving ($0.59) for a 400mg dose, providing outstanding value.
- Good number of positive online reviews, indicating solid user satisfaction.
- Large 60-serving quantity provides extended use and convenience.
- Nutricost is a budget-focused brand, which might lead some to question overall quality control compared to premium brands.
- Does not explicitly mention enteric coating, although it's crucial for SAMe stability and absorption.
- Does not include additional B vitamin cofactors that could enhance SAMe metabolism.
- Individuals taking antidepressants or other mood-altering medications should consult a healthcare professional before using SAMe due to potential interactions.
$35.95($0.59 per serving)
 Amazon | $ 35.95 | |
 iHerb | $ 35.95 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
SAMe | 400 mg |
Categories
SAMe 98.0
This SAMe product's combination of effective dosage, stable form, and unmatched price per serving establishes it as a leading contender for those prioritizing maximum value in SAMe supplementation.
Goals
Mood Support 98.0
The 400mg dose is highly effective for mood support, and its unparalleled affordability makes it an outstanding choice for consistent, long-term mood management, providing maximum benefit for the cost.
Joint Health 98.0
400mg is an optimal dose for joint support, and this product's exceptional value makes it an ideal and highly cost-effective option for individuals seeking consistent joint comfort and mobility.
Digestive Health 98.0
The 400mg dose is highly relevant for liver and digestive health. Its supreme value ensures consistent and effective daily supplementation for these vital functions, making it a top choice from a cost perspective.
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