Joint Guard COX-2 Control
KAL
Joint Guard COX-2 Control
4.7
★ ★ ★ ★ ★
(52 ratings)
N-Acetyl Glucosamine 25 mg
Score 58.0
A multi-ingredient joint support supplement that combines common cartilage builders with herbal anti-inflammatories. It provides good doses of Glucosamine HCl and MSM, but critically underdoses Chondroitin Sulfate and N-Acetyl D-Glucosamine, diminishing its full potential for joint and digestive health compared to stronger alternatives.
Quantity: 60 Tablet(s)Servings size: 2 Tablet(s) (30 servings)
Selected goals:
Other goals:
Joint Health
Digestive Health
leaderboard Score 58.0
A multi-ingredient joint support supplement that combines common cartilage builders with herbal anti-inflammatories. It provides good doses of Glucosamine HCl and MSM, but critically underdoses Chondroitin Sulfate and N-Acetyl D-Glucosamine, diminishing its full potential for joint and digestive health compared to stronger alternatives.
insights Analysis
This product attempts a comprehensive approach to joint health by combining foundational ingredients (Glucosamine HCl, Chondroitin, MSM) with a proprietary blend of botanicals known for their anti-inflammatory and antioxidant properties, such as Clove flower bud extract, Grape skin extract (Resveratrol), Japanese Knotweed root extract, and Devil's Claw. While the 1000mg of D-Glucosamine HCl and 500mg of MSM are reasonable for joint support, the Chondroitin Sulfate Calcium is drastically underdosed at just 100mg, far below the clinically studied 800-1200mg range. The N-Acetyl D-Glucosamine (NAG) at 25mg is also extremely low, rendering it largely ineffective for both joint tissue repair and its secondary goal of digestive health. Online reviews often praise the blend of ingredients, but without specific clinical evidence for this precise combination and dosages, efficacy can be questionable, especially for the lower-dosed components. Nutritionists would likely flag the low doses of Chondroitin and NAG as a significant drawback for a product aiming to address these health areas comprehensively.
- Contains a clinically relevant dose of D-Glucosamine HCl (1000mg) for cartilage support.
- Includes MSM (500mg), which can help reduce joint pain and inflammation.
- Features a blend of herbal extracts (Clove, Grape Skin, Japanese Knotweed, Devil's Claw) known for their anti-inflammatory and antioxidant properties, potentially aiding in COX-2 inhibition.
- Offers a multi-faceted approach to joint health by combining structural components with botanical anti-inflammatories.
- The dose of Chondroitin Sulfate Calcium (100mg) is significantly lower than commonly recommended therapeutic doses (typically 800-1200mg) for effective joint health benefits.
- The N-Acetyl D-Glucosamine (NAG) dose (25mg) is extremely low and likely ineffective for both joint and digestive health, especially when compared to dedicated NAG supplements that offer 500-1000mg per serving.
- Its effectiveness for digestive health is severely limited by the inadequate N-Acetyl D-Glucosamine dosage, making it a poor choice for that specific goal.
- Contains shellfish-derived N-Acetyl D-Glucosamine and D-Glucosamine HCl, which is an allergen for individuals with shellfish allergies.
- Individuals taking blood thinners or with bleeding disorders should consult a healthcare professional due to Devil's Claw, which may have anticoagulant effects.
$19.69($0.65 per serving)
 iHerb | $ 19.69 |
bolt Effectiveness for goals
Some research suggests N-Acetyl Glucosamine may play a role in supporting cartilage health, a key component of joints. It is a precursor to hyaluronic acid, which is important for joint lubrication and shock absorption. However, direct evidence for its effectiveness in improving joint symptoms is still being investigated, with some studies showing mixed results compared to other forms of glucosamine.
Research on N-Acetyl Glucosamine's direct effectiveness for joint health, particularly osteoarthritis, is less extensive and conclusive than for other forms like glucosamine sulfate. Some studies suggest potential benefits for cartilage support. However, more high-quality human trials are needed to confirm these specific effects.
While N-Acetyl Glucosamine is often considered for joint support, its specific effectiveness for relieving osteoarthritis symptoms like pain and stiffness is less established compared to other forms of glucosamine. Some studies suggest it may support cartilage structure, but direct clinical benefits in osteoarthritis patients require further research.
Preliminary studies suggest N-Acetyl Glucosamine may help support the gut lining and reduce inflammation in some individuals with inflammatory bowel disease. It is thought to provide building blocks for glycosaminaminoglycans, which are part of the protective mucus layer of the gut. Further research is ongoing to confirm these effects.
N-Acetyl Glucosamine is a building block for mucin, a protein that forms the protective lining of the gut. Preliminary research, especially in animal models and some small human studies, suggests it may have a role in supporting the integrity of the gut barrier and modulating inflammation. More extensive clinical trials are needed to confirm its widespread effectiveness for inflammatory bowel conditions.
schedule Dosage, timing & forms
Common dosages of N-Acetyl Glucosamine typically range from 500 mg to 1000 mg, often taken one to three times daily. The specific dosage can vary based on individual needs and the product's formulation. Always follow the instructions provided on the supplement label.
Typical dosages for N-Acetyl Glucosamine often range from 500 mg to 1000 mg, taken one to three times daily. Some studies have used higher amounts, such as up to 3000 mg in divided doses, for specific applications. Always follow the product label instructions or consult a healthcare professional for personalized guidance.
N-Acetyl Glucosamine can generally be taken at any time of day. Many people prefer to take it with meals to help minimize any potential mild stomach upset. Some products may suggest taking it in divided doses throughout the day.
While some studies have used up to 3000 mg per day in divided doses, a universal maximum safe daily dose is not firmly established for all individuals. It is crucial to adhere to the dosage recommended on the supplement label or as advised by a healthcare provider. Exceeding recommended doses without professional guidance is generally not advised.
While N-Acetyl Glucosamine can be taken on an empty stomach, consuming it with food may help reduce the likelihood of mild gastrointestinal discomfort. Always check the specific directions on your supplement's packaging. Taking it with food is often a common recommendation for many supplements.
health_and_safety Safety & interactions
N-Acetyl Glucosamine is often derived from the chitin of shellfish. Individuals with shellfish allergies should exercise caution and consult with a healthcare professional before using products sourced from shellfish. Shellfish-free alternatives may be available.
N-Acetyl Glucosamine is generally considered safe for most people when taken orally and appropriately. Mild side effects such as nausea, diarrhea, or constipation may occur in some individuals. Always consult a healthcare professional before starting any new supplement.
N-Acetyl Glucosamine is generally well-tolerated. Some individuals may experience mild gastrointestinal upset, such as nausea, diarrhea, or constipation. These effects are typically transient and resolve with continued use or dosage adjustment.
Due to its structural similarity to heparin, there is a theoretical concern that N-Acetyl Glucosamine could increase the risk of bleeding, especially when taken with anticoagulant or antiplatelet medications. Individuals on such medications should consult a healthcare professional. Blood clotting parameters may need to be monitored.
There is some evidence suggesting that glucosamine products, including N-Acetyl Glucosamine, might potentially increase the risk of bleeding when taken with anticoagulant medications like Warfarin. Individuals on blood thinners should consult their healthcare provider before using NAG. Close monitoring of INR levels may be necessary.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Total Carbohydrates | 2 Gram(s) |
| D-Glucosamine HCl (Shellfish) | 1000 mg |
| MSM | 500 mg |
| Chondroitin Sulfate Calcium (Bovine) | 100 mg |
| N-Acetyl D-Glucosamine (Shellfish) | 25 mg |
| Devil's Claw | 100 mg |
| Japanese Knotweed root extract (total Resveratrol) | 75 mg |
| Grape skin extract | 50 mg |
| Clove flower bud extract (Terpene Hydrocarbons) | 25 mg |
Categories
N-Acetyl Glucosamine 20.0
The product is listed in the 'N-Acetyl Glucosamine' collection, but it contains only 25mg of N-Acetyl D-Glucosamine per serving. This dosage is woefully inadequate compared to dedicated N-Acetyl Glucosamine supplements, which typically provide 500-1000mg per serving, making its inclusion in this collection misleading given its negligible contribution as a primary source of this ingredient.
Goals
Joint Health 65.0
The product provides a substantial dose of D-Glucosamine HCl and a good amount of MSM, which are key ingredients for joint structure and inflammation. The inclusion of various botanical extracts also contributes to anti-inflammatory effects. However, the significantly underdosed Chondroitin Sulfate component prevents it from achieving a higher score for comprehensive joint support, as a full spectrum of these ingredients is typically sought for optimal efficacy.
Digestive Health 15.0
While N-Acetyl D-Glucosamine (NAG) is a relevant ingredient for digestive health, particularly for supporting the gut lining, the dosage of 25mg in this product is extremely low. Therapeutic doses for digestive health typically range from 500mg to 1000mg per day, making this product ineffective for achieving meaningful digestive support through NAG. Other ingredients in the formula do not primarily target digestive health to compensate for this deficiency.