Product Image

Super B-Complex

Pure Synergy
4.6
★ ★ ★ ★ ★
(814 ratings)
Choline 110 mg
Riboflavin 25 mg
Vitamin B6 25 mg
Vitamin B5 25 mg
Thiamin 25 mg
Vitamin B12 200 mcg
Product Image
Score69
Moderate broad coverage is useful, but missing form details and premium cost weaken the value.
How scoring works
Quantity:60 Tablet(s) • (60 servings)
Goals:
Heart Health
General Health
Energy
Metabolism Boost

Score 69

Moderate broad coverage is useful, but missing form details and premium cost weaken the value.
How scoring works
$34.00($0.56 per serving)
Vitacost
$ 39.27
iHerb
$ 35.70
Pure Formulas
$ 34.00
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Analysis

The tablet covers the main B vitamins and provides a useful 110 mg choline amount. Most vitamin amounts are moderate rather than extreme, which is more practical than many B-100 formulas.

The label does not identify the forms of B6, B12, folate, choline, or pantothenic acid. That omission prevents a meaningful assessment of bioavailability and makes the premium serving cost harder to support.

The product may suit someone who wants a general B-complex and values moderate amounts. Active-form products with clearer labeling offer better confidence for methylation, cognitive, or targeted nutrient goals.

Who is it for
  • Adults wanting a moderate-dose B-complex
  • People who value broad coverage over form detail
  • Users seeking some choline alongside B vitamins
Best for
  • General B-vitamin maintenance
  • Energy metabolism support
  • Broad nutrient coverage

Pros

  • Complete B-vitamin profile
  • Includes a meaningful choline amount
  • Avoids extreme B-100 dosing

Cons

  • Most chemical forms are unspecified
  • High serving cost
  • Tablet delivery offers no absorption advantage

Warnings

  • The 25 mg B6 amount should be counted when stacking B-complex products
  • Users with sensitivities should verify the current inactive-ingredient list
  • Unspecified folate and B12 forms may not suit people with known absorption or conversion concerns

Nutrient quality

77 High impact

Several B vitamins do not identify their exact chemical forms. The core B vitamins are supplied at useful amounts for broad nutritional support.

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Ingredient transparency

74 High impact

Every listed active has a specific amount. A complete excipient list is not available in the supplied data.

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Customer satisfaction

73 High impact

The average rating is moderately strong. The large rating volume provides a reliable satisfaction signal.

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Value for money

50 Lower impact

The supply provides weak value per effective serving. Weak or opaque additions reduce practical value.

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Report analysis

Goals

Heart Health
Heart Health
Impact
High effect
B Goal FitC Strength of SupportC+ CoverageA Formula Quality
Vitamin B12 · 200 mcgVitamin B6 · 25 mgFolate · 400 mcg DFE

B vitamins, folate, B12, and choline provide a focused foundation for homocysteine metabolism. The streamlined formula avoids unrelated cardiovascular claims.

The label does not identify active forms for folate, vitamin B6, or vitamin B12, and it does not address lipids, vascular tone, magnesium, or cardiac energy. Its value is narrow and depends mainly on supporting adequate B-vitamin status.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
General Health
General Health
Impact
High effect
B- Goal FitC+ Strength of SupportC CoverageA- Formula Quality
Folate · 400 mcg DFEVitamin B12 · 200 mcg

A focused B-complex can support energy metabolism and help cover a specific group of common nutrients. Most B vitamins are supplied in substantial amounts alongside a useful choline serving.

Chemical forms are often not identified, vitamin B12 quality is unclear, and the formula does not address broader mineral or fat-soluble vitamin needs. It is a coherent option for targeted B-vitamin coverage rather than a complete general-health foundation.

Study evidence
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
High effect
B+ Goal FitD+ Strength of SupportC- CoverageA- Formula Quality
Vitamin B5 · 25 mgRiboflavin · 25 mgThiamin · 25 mgVitamin B12 · 200 mcg

A focused B-complex supplies moderate amounts of the vitamins required for normal cellular energy metabolism. Choline adds a related metabolic nutrient without making the formula overly complex.

Vitamin B12 and several other forms are not identified, which limits confidence in absorption quality. The product supports one metabolic pathway well but offers no mitochondrial, stimulant, or adaptogen support.

Study evidence
Vitamin B12 Disputed 14 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
D- Goal FitD+ Strength of SupportD- CoverageB+ Formula Quality
Biotin · 45 mcgNiacin · 25 mg NEVitamin B12 · 200 mcgRiboflavin · 25 mgThiamin · 25 mgVitamin B5 · 25 mgVitamin B6 · 25 mg

B vitamins support normal cellular energy processing but do not directly stimulate metabolic rate. Several amounts are useful, although important chemical forms are not fully identified.

The streamlined formula provides good depth for one supporting pathway. It lacks thermogenic, thyroid, mitochondrial transport, and glycemic-control actives.

Ingredients

IngredientAmount per serving
Thiamine (Vitamin B1)
 25 mg
Riboflavin (Vitamin B2)
 25 mg
Niacin (Niacinamide)
 25 mg NE
Vitamin B6
25 mg
Folate
400 mcg DFE
Vitamin B12
200 mcg
Biotin
45 mcg
Pantothenic Acid
25 mg
Choline
110 mg
Inositol
5 mg
PABA
5 mg
Gluten Free Adults 18–50 Dairy Free Organic
Report overview
Riboflavin (Vitamin B2) · 25 mg OverallScore55
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

Standard riboflavin provides a moderate 25 mg amount but requires conversion before use. The hard-pressed tablet may release more slowly than capsules or softgels, though the label avoids uncertainty about R5P elemental yield. Value is limited by an above-median serving cost without a premium form or high-potency amount.

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Choline · 110 mg OverallScore55
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD+ Value

The choline amount provides moderate support but remains below a robust standalone dose. The missing choline form leaves ingredient quality uncertain. The serving is practical, while cost per nutrient amount is only average.

View ingredientView products
Vitamin B6 · 25 mg OverallScore54
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value

The 25 mg vitamin B6 dose is well aligned with the intended range, and the one-tablet serving is practical. The label does not disclose the chemical form, so metabolic readiness cannot be assessed. A clean ingredient profile helps, but the serving cost is only moderate for a B-complex.

View ingredientView products
Loading alternative details
85 Performance

BioCoenzymated Active B Complex

Natural Factors
<p>Active forms of thiamine, riboflavin, vitamin B6, folate, and vitamin B12 make this a well-designed B-complex. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although folic acid is less active than methylfolate.</p>
81 Performance

Activated B-Complex High Bioavailability

Swanson
<p>Active B-vitamin forms, benfotiamine, and pantethine create a high-quality, focused formula at a reasonable cost. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although its concentrated doses are more appropriate for deliberate use than casual stacking.</p>
81 Performance

Coenzyme B-Complex Caps

Country Life
<p>Multiple coenzyme vitamin forms create a well-designed B-complex with meaningful nutritional amounts. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although the high pyridoxine amount is less suitable for long-term daily use.</p>
78 Budget

Super Stress B-Complex with Vitamin C

Swanson
<p>Vitamin C and broad B-vitamin coverage provide practical nutritional support at excellent serving value. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
74 Budget

B-Complex '50'

Solgar
<p>Broad B-vitamin coverage fits energy metabolism, but the formula relies on conventional forms and an unnecessarily high vitamin B6 amount. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
63 Budget

Ultra B-100 Complex

Mason Natural
<p>The high-potency B-complex delivers large amounts of several vitamins but relies mostly on conventional forms. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
80 Value

B-Complex '100'

Solgar
<p>A broad high-potency B-vitamin profile supports normal energy metabolism, but most forms are conventional and several amounts greatly exceed routine needs. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
75 Value

Sustained Release B-100

NOW
<p>Broad high-potency B-vitamin coverage supports nutritional energy metabolism, but most forms are conventional. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
80 Value

B-100 Complex with B2 Coenzyme

Nature's Way
<p>Active riboflavin and partial P-5-P improve this otherwise conventional high-potency B-complex. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  2. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  3. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  4. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  5. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  6. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  7. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  8. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  9. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  10. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  11. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  12. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  13. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  14. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  15. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  16. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  17. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsHeart Health forVitamin B12
  18. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  19. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  20. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  21. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsHeart Health forVitamin B6
  22. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  23. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  24. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6