Senolytic Activator
Life Extension
Senolytic Activator
4.6
★ ★ ★ ★ ★
(4126 ratings)
Apigenin 50 mg
Score 72.0
The Senolytic Activator from Life Extension combines Apigenin, highly bioavailable Bio-Quercetin, and Theaflavins, providing a synergistic formula that supports sleep, stress relief, and brain health through its calming and antioxidant properties.
Quantity: 24 Capsule(s)Servings size: 2 Vegetarian Capsule(s) (12 servings)
Selected goals:
Other goals:
Immunity
Heart Health
Anti-Aging
Joint Health
Sleep Support
leaderboard Score 72.0
The Senolytic Activator from Life Extension combines Apigenin, highly bioavailable Bio-Quercetin, and Theaflavins, providing a synergistic formula that supports sleep, stress relief, and brain health through its calming and antioxidant properties.
insights Analysis
Life Extension's Senolytic Activator features a potent combination of 50mg Apigenin, 74mg Bio-Quercetin Phytosome, and 275mg Theaflavins from decaffeinated black tea extract. While the product is named for its senolytic (cellular aging) properties, its ingredient profile directly aligns with the stated goals of Sleep Support, Stress Relief, and Brain Health. Apigenin is a well-researched flavonoid known for its anxiolytic effects and ability to promote relaxation by interacting with GABA receptors, making it beneficial for both sleep and stress. Bio-Quercetin Phytosome ensures superior absorption of quercetin, a powerful antioxidant and anti-inflammatory agent, which supports overall cellular health, including brain function. Theaflavins further contribute with antioxidant properties, potentially aiding cognitive function and reducing oxidative stress.
- Contains Apigenin, a key ingredient for promoting relaxation and aiding sleep, at a clinically relevant dose.
- Includes Bio-Quercetin Phytosome, which significantly enhances the bioavailability of quercetin, maximizing its antioxidant and anti-inflammatory benefits for brain health.
- Features Theaflavins from black tea extract, offering additional antioxidant support that contributes to overall cellular and brain health.
- Formulated by Life Extension, a reputable brand known for its science-backed supplements and quality control.
- High review count indicates general positive user experience and product efficacy for many consumers.
- The price per serving is relatively high compared to single-ingredient Apigenin supplements, which may be a barrier for budget-conscious consumers focused solely on Apigenin's effects.
- The product's primary marketing as a 'Senolytic Activator' might overshadow its direct benefits for sleep, stress, and brain health, potentially confusing consumers seeking specific support in those areas.
- With only 12 servings per bottle, it requires frequent repurchase, which can be less convenient for long-term use.
- Individuals taking blood-thinning medications should consult a healthcare professional before use, as quercetin may have mild anti-platelet effects.
- As with any supplement, it is advisable to consult a healthcare provider before use, especially if you have pre-existing medical conditions or are taking other medications.
$16.49($1.37 per serving)
 Amazon | $ 16.49 | |
 Walmart | $ 16.49 | |
 iHerb | $ 19.50 |
bolt Effectiveness for goals
Apigenin is a flavonoid found in chamomile, which has been traditionally associated with calming properties. Some research suggests that Apigenin may contribute to relaxation and promote sleep by interacting with certain receptors in the brain. However, more extensive human trials are needed to fully establish its efficacy for sleep disorders.
Apigenin is a flavonoid studied for its potential antioxidant, anti-inflammatory, and neuroprotective properties. Research suggests it may support relaxation and promote healthy cellular function. It is commonly found in various fruits, vegetables, and herbs.
Due to its potential calming effects, Apigenin is sometimes investigated for its anxiolytic properties. Preclinical studies and some human trials suggest it may help in reducing mild anxiety symptoms. However, it is not a treatment for clinical anxiety disorders and professional medical advice should be sought for such conditions.
Some research indicates that apigenin may have calming effects that could contribute to improved sleep quality. It has been observed to interact with certain receptors in the brain, potentially promoting relaxation. This effect is often linked to its presence in herbs like chamomile.
Apigenin is thought to possess anxiolytic-like properties, meaning it may help reduce feelings of anxiety. Studies suggest it interacts with central nervous system receptors, which could contribute to a calming effect. This area of research is largely based on pre-clinical findings.
schedule Dosage, timing & forms
Typical supplemental dosages of Apigenin often range from 50 mg to 500 mg per day. Some research studies have explored doses within and beyond this range. It is advisable to consult a healthcare professional for personalized guidance.
Common dosages for Apigenin in dietary supplements often range from 50 mg to 500 mg per day. It is always important to follow the specific instructions provided on the supplement's product label. Individual needs and product formulations can influence the recommended intake.
There isn't a strict, universally established maximum daily dosage for Apigenin across all contexts. It is crucial to strictly adhere to the serving size recommended on the label of your chosen Apigenin supplement. Consulting a healthcare professional is advisable before exceeding suggested doses.
Some sources suggest that taking Apigenin with a meal containing dietary fats may improve its absorption due to its lipophilic nature. However, specific recommendations can vary based on the supplement's formulation. Always refer to the product label for optimal usage instructions.
For individuals new to Apigenin, starting with a lower dose, such as 50 mg or 100 mg per day, can allow the body to adjust. This approach helps assess individual tolerance and response before potentially increasing the dosage. Consultation with a healthcare provider is always recommended.
health_and_safety Safety & interactions
Yes, Apigenin may interact with certain medications. It has been shown to inhibit some cytochrome P450 enzymes (CYPs) in vitro, which could potentially affect how the body processes various drugs. Individuals taking prescription medications, especially anticoagulants or sedatives, should consult their healthcare provider before using Apigenin.
While Apigenin has shown some mild antiplatelet effects in laboratory studies, its clinical significance for interacting with anticoagulant or antiplatelet medications in humans is not well-established. Individuals taking blood thinners should consult a healthcare professional before using Apigenin supplements. This precaution is advised due to the theoretical potential for additive effects.
Apigenin is generally considered well-tolerated in most studies at common dosages. Some individuals might experience mild gastrointestinal discomfort, such as nausea or diarrhea, especially with higher doses. Severe side effects are rare but should be reported to a healthcare professional.
Apigenin is generally well-tolerated when consumed in typical dietary amounts or standard supplement doses. Some individuals might experience mild gastrointestinal upset. Data on adverse effects from high-dose supplementation in humans is limited.
There is limited human research on the safety of Apigenin during pregnancy and breastfeeding. Due to the lack of sufficient data, it is generally recommended to avoid Apigenin supplements during these periods. Always consult a healthcare professional for personalized advice.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Theaflavins | 275 mg |
Bio-Quercetin Phytosome | 74 mg |
Apigenin | 50 mg |
Categories
Apigenin 75.0
The product provides a good 50mg dose of Apigenin, which is consistent with effective dosages found in research and commonly recommended by nutritionists for various benefits, including sleep and relaxation. Its inclusion alongside Bio-Quercetin Phytosome offers a synergistic effect beyond a standalone Apigenin supplement.
Goals
Sleep Support 75.0
Apigenin is the most impactful ingredient for sleep support in this formula, effectively promoting relaxation and reducing the time it takes to fall asleep by interacting with brain receptors. The 50mg dose is well-regarded by nutritionists and online reviews for its calming effects without inducing heavy sedation.
Stress Relief 70.0
Apigenin plays a crucial role in stress reduction due to its anxiolytic properties, helping to calm the nervous system and promote a sense of well-being. While other ingredients offer general health benefits, Apigenin is the direct contributor to immediate stress relief.
Brain Health 70.0
The Bio-Quercetin Phytosome and Theaflavins are powerful antioxidants and anti-inflammatory compounds that support brain health by protecting neurons from oxidative damage and inflammation. Apigenin also contributes through its neuroprotective effects and potential to modulate neural pathways, offering holistic brain support.
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