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SAMe 400 mg

Life Extension
4.8
★ ★ ★ ★ ★
(2931 ratings)
SAMe 400 mg
Product Image
Score95

A reliable 30-tablet supply of 400 mg SAMe with high-stability coating and packaging.

How scoring works
Quantity:30 Tablet(s) • (30 servings)
Goals:
Joint Health
Mood Support
Detoxification
Stress Relief

Score 95

A reliable 30-tablet supply of 400 mg SAMe with high-stability coating and packaging.

How scoring works

Also available as

1 option
60 servings SAMe 400 mg • 60 Tablet(s) • 60 servings $37.49 ($0.62 per serving)
$27.00($0.90 per serving)
Vitacost
$ 28.50
Amazon
$ 27.00
iHerb
$ 28.50
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Analysis

These tablets provide 400 mg of SAMe and use enteric coating to ensure the active compound survives stomach acid. The individual blister seals are also present, which is crucial for preventing the ingredient from absorbing moisture from the air.

This smaller size is practical for travel or for someone just starting a 400 mg regimen. It supports critical pathways involved in neurotransmitter synthesis and joint comfort.

Pros

  • Blister packs maintain tablet integrity
  • Enteric coating for intestinal release
  • Ideal for trying a 400 mg dose
  • Compact packaging is travel-friendly

Cons

  • Only a 30-day supply
  • Higher price per tablet than bulk boxes
  • Lots of individual foil seals to open

Warnings

  • Take first thing in the morning before breakfast
  • Stop use if you feel unusually restless
  • Check with a doctor if you are pregnant

Nutrient quality

98 Highest impact

A 400 mg dose is robust and well-aligned with clinical research for mood and joint goals. Stabilization via enteric coating and blister packaging is an essential feature for maintaining the viability of the active compound.

Ingredient transparency

100 Highest impact

Labeling clearly specifies the active amount and chemical form of the ingredient for informed use. Comprehensive disclosure of all components and clear usage guidance contribute to strong transparency.

Customer satisfaction

96 Highest impact

Very strong ratings and a large user base reflect high product reliability and satisfaction. Feedback indicates that the product performance is well-aligned with goals for emotional stability and joint comfort.

Value for money

84 Highest impact

The price per serving reflects the premium stabilization technology used for this 30-day supply. While slightly higher than bulk-sized options, it remains a valuable choice for the level of potency and stability provided.

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Goals

Joint Health
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB+ CoverageA+ Formula Quality

S-adenosylmethionine (SAMe) supports cartilage repair and joint comfort by serving as a precursor for proteoglycan synthesis. This specific dosage is backed by human clinical trials demonstrating significant improvements in joint mobility.

The 400mg dose appears well aligned with therapeutic standards for daily maintenance. Enteric coating and specialized packaging protect the active ingredient from degradation, ensuring high bioavailability.

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Mood Support
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB CoverageA+ Formula Quality

S-adenosyl-methionine is provided in 400 mg doses to support healthy neurotransmitter balance and emotional resilience. This nutrient is delivered in stabilized salt forms with enteric protection to ensure maximum biological activity.

Blister packaging protects the compound from environmental moisture, ensuring potency throughout its shelf life. Clinical evidence for this nutrient in mood regulation is comprehensive and reliable.

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Detoxification
Impact
Highest effect
A+ Goal FitA+ Strength of SupportC CoverageA+ Formula Quality

SAMe provides the body with its primary universal methyl donor for Phase II liver conjugation. This molecule is vital for neutralizing various toxins and supporting the clearance of metabolic waste.

Enteric coating and stabilized disulfate tosylate salts ensure high bioavailability and protection from stomach acid. Consistent intake may contribute to systemic detoxification and healthy hepatocyte function.

View goal →
Stress Relief
Impact
Highest effect
A Goal FitA+ Strength of SupportC+ CoverageA Formula Quality

SAMe at 400mg supports emotional wellbeing and may contribute to improved mood stability during periods of high demand. As a vital methyl donor, it appears well-aligned with goals for enhancing psychological resilience and maintaining a calm disposition.

Providing 400mg represents a meaningfully potent dose that fits squarely within effective clinical ranges. This formulation utilizes stabilized salt forms and enteric coating to ensure that the active nutrient is biologically available for systemic use.

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Ingredients

IngredientAmount per serving
S-Adenosyl-Methionine
400 mg
Adults 18–50
Report overview
SAMe · 400 mg OverallScore96
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
This 30-day supply of 400 mg SAMe offers the necessary bioavailability and stability protections for effective mood and joint support. It is a reliable choice for those who prefer smaller package sizes without sacrificing quality.
View ingredientView products
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SAMe 400 mg

NOW
4.7
★★★★★
(1063 ratings)
Individual blister packaging and enteric coating provide high stability for efficient delivery of the 400 mg dose. It offers foundational support for mood, stress, and joint health at a balanced price.
Other sellers (3)
96 Value

SAMe 400

Jarrow Formulas
4.4
★★★★★
(2979 ratings)
A higher serving count per container offers a steady supply for those with long-term joint or detoxification goals. Enteric coating protects the active salts for systemic delivery.
Other sellers (5)
91 Value

SAMe 400 mg

Source Naturals
4.7
★★★★★
(202 ratings)
Stabilized salts and enteric coating protect the active compound for efficient delivery to the small intestine. This formulation supports metabolic pathways for emotional regulation and joint integrity.
Other sellers (2)
97 Performance

SAMe 400 mg

Swanson
4.6
★★★★★
(291 ratings)
Enteric-coated tablets maintain the viability of the active salt form through the digestive system. This formulation offers robust support for mood stability, joint comfort, and liver health.
Other sellers (1)
97 Performance

SAMe 400

Jarrow Formulas
4.4
★★★★★
(3054 ratings)
Specialized enteric coating and individual blister packs ensure high nutrient stability and absorption. It is an effective option for supporting methylation pathways and musculoskeletal health.
Other sellers (5)
92 Performance

SAMe 400 mg

California Gold Nutrition
4.7
★★★★★
(1695 ratings)
Enteric coating and moisture-sealed blister packaging ensure the sensitive active compound remains potent for systemic support. It helps support metabolic pathways for joint comfort and emotional regulation.
Other sellers (1)
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