SAMe 400 mg
Life Extension
SAMe 400 mg
4.8
★ ★ ★ ★ ★
(2467 ratings)
SAMe 400 mg
Score 88.0
A high-quality 400mg SAMe from a reputable brand, offering reliable effectiveness but less value than larger pack sizes or more economical brands.
Quantity: 30 Tablet(s)Servings size: 1 Tablet(s) (30 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 88.0
A high-quality 400mg SAMe from a reputable brand, offering reliable effectiveness but less value than larger pack sizes or more economical brands.
insights Analysis
This Life Extension SAMe product delivers a robust 400mg dose, aligning with the dosages often recommended by nutritionists for various health benefits. The brand's strong reputation for scientific rigor and quality control makes it a trusted choice. The substantial number of positive reviews (over 2300) confirms its efficacy and consumer satisfaction. Life Extension SAMe is generally considered to be enteric-coated for optimal absorption and stability, a critical factor for this compound. However, as a 30-serving pack, its price per serving of $0.90 is higher than its 60-count counterpart or more budget-friendly 400mg options. This makes it a less economical choice for long-term, consistent supplementation, although it's convenient for initial trials or shorter-term needs.
- Provides a robust 400mg dose of SAMe, effective for various health goals.
- Life Extension is a highly reputable brand known for science-backed formulations and quality.
- Very high number of positive online reviews, indicating widespread consumer trust and effectiveness.
- Only 30 servings, requiring frequent reordering for consistent, long-term users.
- Higher price per serving ($0.90) compared to larger pack sizes or more value-oriented brands, making it less economical.
- Does not explicitly state the specific form of SAMe (e.g., Disulfate Tosylate), though Life Extension typically uses stable forms.
- Does not include additional B vitamin cofactors that could enhance SAMe metabolism.
- SAMe may interact with certain medications, including antidepressants and blood thinners; consult a healthcare professional before use.
$27.00($0.90 per serving)
 Amazon | $ 27.00 | |
 iHerb | $ 27.00 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| S-Adenosyl-Methionine | 400 mg |
Categories
SAMe 85.0
As a SAMe product, its effective dosage and trusted brand make it a strong option. However, its smaller quantity and resulting higher price per serving compared to similar high-quality options reduce its overall value proposition.
Goals
Mood Support 90.0
The 400mg dose is highly effective for mood support, making this a reliable choice. However, the 30-serving quantity means a quicker repurchase cycle compared to larger, more economical packs.
Joint Health 90.0
This product's 400mg dose is an optimal and highly effective dosage for supporting joint comfort. Its effectiveness is well-supported, but the quantity may not suit long-term joint health regimens.
Digestive Health 90.0
The 400mg dose is highly relevant for liver and digestive health, offering significant support. While effective, more cost-effective larger packs are available for continuous supplementation.
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