SAMe 200 mg S-Adenosyl-Methionine
Life Extension
SAMe 200 mg S-Adenosyl-Methionine
4.8
★ ★ ★ ★ ★
(1775 ratings)
SAMe 200 mg
Score 95.0
Excellent value SAMe from a reputable brand with strong consumer trust.
Quantity: 30 Tablet(s)Servings size: 1 Tablet(s) (30 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 95.0
Excellent value SAMe from a reputable brand with strong consumer trust.
insights Analysis
Life Extension is a highly respected brand in the supplement industry, known for its science-backed formulations and commitment to quality. This 200mg SAMe product delivers a solid dose of the active ingredient at a very attractive price point. The exceptionally high review count indicates widespread consumer satisfaction and trust. While it doesn't include B vitamin cofactors, its affordability allows users to easily supplement those separately if desired, making it a flexible and cost-effective option for addressing mood, joint, and digestive health goals.
- Excellent price per serving, offering great value for a 200mg SAMe product.
- Life Extension is a highly respected brand with a strong reputation for quality and research.
- Very high review count indicates widespread consumer satisfaction and proven efficacy.
- Offers a convenient and effective dose for common SAMe uses.
- Does not include B vitamin cofactors, which may be beneficial for optimal SAMe metabolism, particularly for mood support.
- Individuals should consult a healthcare professional before combining SAMe with certain medications, especially antidepressants, due to potential interactions.
$18.75($0.62 per serving)
 iHerb | $ 18.75 | |
 Amazon | $ 18.75 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| S-Adenosyl-Methionine | 200 mg |
Categories
SAMe 95.0
This SAMe product stands out as an excellent option due to its exceptional value and strong brand backing. It delivers a reliable dose of SAMe without an inflated price, making it a go-to choice in the SAMe market.
Goals
Joint Health 95.0
The 200mg SAMe dose is a good starting point for joint health, and the product's value makes it a sustainable option for long-term use. Its efficacy for joint support is well-regarded by a large user base.
Digestive Health 95.0
This SAMe product is highly effective for supporting digestive and liver health at a very competitive price. The consistent positive reviews reflect its reliability for these benefits.
Mood Support 90.0
This product provides an effective 200mg SAMe dose for mood support at an excellent price. While it lacks B vitamin cofactors, its affordability allows users to easily add them if needed, making it a strong foundational choice.
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