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GI Response

INNATE Response Formulas
4.9
★ ★ ★ ★ ★
(44 ratings)
Glutamine 5000 mg
Aloe 300 mg
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Score71
A substantial glutamine dose and several complementary gut-support ingredients provide meaningful breadth. Premium cost and incomplete aloe purification details are the main concerns.
How scoring works
Quantity:8 Liquid(s) • (30 servings)
Goals:
Digestive Health
Immunity

Score 71

A substantial glutamine dose and several complementary gut-support ingredients provide meaningful breadth. Premium cost and incomplete aloe purification details are the main concerns.
How scoring works
$60.46($2.01 per serving)
Pure Formulas
$ 69.99
Vitacost
$ 69.99
iHerb
$ 60.46
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Analysis

One liquid serving provides 5 g L-glutamine, 400 mg arabinogalactan, 300 mg aloe gel extract, and 200 mg each of marshmallow, slippery elm, MSM, and Sustamine. The glutamine amount is substantial and the soothing botanicals are clearly quantified.

Glutamine and Sustamine support intestinal fuel and recovery pathways, while arabinogalactan and mucilaginous herbs broaden digestive and immune-related support. Aloe inner-leaf sourcing, aloin removal, concentration ratio, and polysaccharide standardization are not confirmed.

Only 30 servings are provided, and the daily cost is very high. It fits users seeking a comprehensive liquid rather than value-focused glutamine alone.

Who is it for
  • Adults seeking a digestive-support liquid
  • Users whose needs match the disclosed ingredient amounts
  • People who can screen ingredient-specific medication and tolerance concerns
Best for
  • Comparing form, dose, and practical value
  • Goal-aligned supplement selection
  • Users who prefer a digestive-support liquid

Pros

  • Provides 5 g L-glutamine
  • Includes arabinogalactan and aloe
  • Adds marshmallow and slippery elm
  • All active amounts are disclosed

Cons

  • Only 30 servings
  • Very high serving cost
  • Aloe aloin removal is not confirmed
  • No aloe polysaccharide standardization

Warnings

  • Aloe purity details are incomplete, so users sensitive to laxative anthraquinones should use caution
  • Marshmallow and slippery elm can slow absorption of oral medicines when taken together
  • People with severe liver or kidney disease should review a 5 g glutamine supplement with their clinician

Nutrient quality

85 Highest impact

Glutamine receives a full supplemental amount and alanyl-glutamine adds a useful complementary form. The soothing botanicals are moderately dosed, while incomplete aloe purification limits safety confidence.

Ingredient transparency

80 High impact

Listed active ingredients have specific weights and no proprietary blend hides their doses. Complete use directions and a full other-ingredients list are not included in the supplied facts.

Customer satisfaction

62 Moderate impact

The supplied average rating is strong, and the small review sample limits confidence. No detailed comments are provided to assess repeated complaints or whether experiences match the intended use.

Value for money

51 Moderate impact

Weak dose efficiency or high recurring cost limits practical value. Incomplete form, activity, or use details remain the main value trade-off.

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Goals

Digestive Health
Impact
Highest effect
A Goal FitA Strength of SupportA- CoverageA+ Formula Quality
Glutamine · 5000 mg

A full L-glutamine amount anchors a focused barrier-support formula with aloe, marshmallow, slippery elm, arabinogalactan, and alanyl-glutamine. The combination provides both epithelial fuel and localized soothing at meaningful amounts.

Aloe sourcing does not confirm inner-leaf purification or aloin removal, so sensitive users cannot rule out a laxative or cramping contribution. The formula is strongest for lining support rather than enzyme replacement or high-fiber regularity.

Study evidence
Aloe Supportive 7 studies
Glutamine Supportive 37 studies
Immunity
Impact
High effect
B- Goal FitA- Strength of SupportC+ CoverageA- Formula Quality

Glutamine, arabinogalactan, and soothing botanicals support the gut barrier, which is an important part of immune defense. Glutamine has useful evidence for barrier support during physiological stress, though direct immune benefits in healthy users are less certain.

L-glutamine at 5000 mg is a full supplemental amount, while the supporting fiber and botanicals are more modest. Every active has an exact amount and Sustamine is identified, although botanical standardization is limited.

Study evidence
Glutamine Supportive 36 studies

Ingredients

IngredientAmount per serving
L-Glutamine
5000 mg
Arabinogalactan
400 mg
Aloe vera gel extract
300 mg
Marshmallow root powder
200 mg
MSM
200 mg
Slippery Elm bark powder
200 mg
Sustamine
200 mg
Adults 18–50
Report overview
Glutamine · 5000 mg OverallScore74
C Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

A full glutamine amount is paired with several ingredients commonly used for digestive support. One scoop is practical, although the label does not claim micronized processing. Cost per gram of glutamine is relatively high, partly reflecting the broader gut-focused formula.

Aloe · 300 mg OverallScore65
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

Aloe gel is disclosed, but the label does not confirm inner-leaf sourcing, purification, or aloin removal; the extract lacks a concentration ratio or defined polysaccharide standardization. The disclosed 300 mg extract serving meets the meaningful-dose threshold for concentrated aloe. Cost per serving is high, but substantial companion ingredients partly improve value; a large glutamine dose plus marshmallow and slippery elm helps justify the premium.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis of Glutamine on Immune Function and Post-Operative Complications of Patients With Colorectal Cancer.
    Yang T; Yan X; Cao Y; Bao T; Li G; Gu S; Xiong K; Xiao T · Frontiers in nutrition · 2021
    Meta-analysis2,201 participants31 studies pooledImmunity forGlutamine
  2. Glutamine granule-supplemented enteral nutrition maintains immunological function in severely burned patients.
    Peng X; Yan H; You Z; Wang P; Wang S · Burns : journal of the International Society for Burn Injuries · 2006
    Randomized trial48 participantsImmunity forGlutamine
  3. A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study.
    Størsrud S; Pontén I; Simrén M · Journal of gastrointestinal and liver diseases : JGLD · 2016
    Randomized trial68 participantsDigestive Health forAloe
  4. A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life.
    Hutchings HA; Wareham K; Baxter JN; Atherton P; Kingham JG; Duane P; Thomas L; Thomas M; Ch'ng CL; Williams JG · ISRN gastroenterology · 2011
    Randomized trial110 participantsDigestive Health forAloe
  5. Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trial.
    Leite RD; Lima NL; Leite CA; Farhat CK; Guerrant RL; Lima AA · Arquivos de gastroenterologia · 2013
    Randomized trial46 participantsDigestive Health forGlutamine
  6. Treatment of acute diarrhea with oral rehydration solutions containing glutamine.
    Ribeiro Júnior H; Ribeiro T; Mattos A; Palmeira C; Fernandez D; Sant'Ana I; Rodrigues I; Bendicho MT; Fontaine O · Journal of the American College of Nutrition · 1994
    Randomized trial120 participantsDigestive Health forGlutamine
  7. Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients.
    Sahebnasagh A; Ghasemi A; Akbari J; Alipour A; Lashkardoost H; Ala S; Hosseinimehr SJ; Salehifar E · BMC complementary medicine and therapies · 2020
    Randomized trial42 participantsDigestive Health forAloe
  8. Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial.
    Sahebnasagh A; Ghasemi A; Akbari J; Alipour A; Lashkardoost H; Ala S; Salehifar E · Journal of alternative and complementary medicine (New York, N.Y.) · 2017
    Randomized trial20 participantsDigestive Health forAloe
  9. Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial.
    Sahebnasagh A; Saghafi F; Ghasemi A; Akbari J; Alipour A; Habtemariam S; Safdari M; Ghaleno HR; Salehifar E · Journal of gastrointestinal cancer · 2022
    Randomized trial20 participantsDigestive Health forAloe
  10. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis.
    Huang Y; Yang XZ; Qin SH; Zhang T; Xie M; Wang JW · World journal of gastrointestinal surgery · 2026
    Meta-analysis1,643 participants27 studies pooledDigestive Health Immunity forGlutamine
  11. Glutamine prevents diarrhea in colorectal cancer patients undergoing chemotherapy or chemoradiotherapy: a meta-analysis.
    Chen L; Wang D; Meng C; Sun H; Li R; Miao G; Liu P · BMC gastroenterology · 2025
    Meta-analysis311 participants5 studies pooledDigestive Health forGlutamine
  12. Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner.
    Pugh JN; Sage S; Hutson M; Doran DA; Fleming SC; Highton J; Morton JP; Close GL · European journal of applied physiology · 2018
    Randomized trial10 participantsDigestive Health forGlutamine
  13. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea.
    Yalçin SS; Yurdakök K; Tezcan I; Oner L · Journal of pediatric gastroenterology and nutrition · 2004
    Randomized trial128 participantsDigestive Health forGlutamine
  14. Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
    Dong S; Zhao Z; Li X; Chen Z; Jiang W; Zhou W · Frontiers in nutrition · 2023
    Meta-analysis1,201 participants30 studies pooledImmunity forGlutamine
  15. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial.
    Garrel D; Patenaude J; Nedelec B; Samson L; Dorais J; Champoux J; D'Elia M; Bernier J · Critical care medicine · 2003
    Randomized trial45 participantsImmunity forGlutamine
  16. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control.
    Wischmeyer PE; Lynch J; Liedel J; Wolfson R; Riehm J; Gottlieb L; Kahana M · Critical care medicine · 2001
    Randomized trial26 participantsImmunity forGlutamine