Co-Enzyme B-Complex
NOW
Co-Enzyme B-Complex
4.8
★ ★ ★ ★ ★
(4189 ratings)
Vitamin B6 50 mg
Vitamin B5 50 mg
PABA 25 mg
Niacin 100 mg
Choline 25 mg
Vitamin B12 250 mcg
Biotin 1000 mcg
Score 97.0
A highly effective B-complex featuring activated forms of B vitamins and additional neuro-supportive compounds, offering premium quality at an accessible price.
Quantity: 60 Capsule(s)Servings size: 2 Veg Capsule(s) (30 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
Skin Health
leaderboard Score 97.0
A highly effective B-complex featuring activated forms of B vitamins and additional neuro-supportive compounds, offering premium quality at an accessible price.
insights Analysis
This NOW B-complex is a top-tier choice due to its exceptionally well-formulated profile, utilizing co-enzymated B vitamins such as Methylcobalamin, Quatrefolic, and P-5-P for optimal absorption and utilization. Beyond the essential B vitamins, it includes valuable "neuro-factors" like Inositol, Alpha Lipoic Acid, CoQ10, and Betaine Anhydrous, enhancing its support for brain health, energy, and overall well-being. Its significant advantage lies in offering this premium, comprehensive formulation at a highly competitive price point, making it an outstanding value in the market. Its high review count indicates broad consumer satisfaction and trust.
- Features active, co-enzymated forms of B vitamins (e.g., Methylcobalamin B12, Quatrefolic Folate, P-5-P B6), ensuring high bioavailability and direct utilization by the body without requiring metabolic conversion.
- Includes a broad spectrum of synergistic nutrients like CoQ10, Alpha Lipoic Acid, Inositol, PABA, and Betaine Anhydrous, providing comprehensive support beyond basic B vitamin functions, particularly for cognitive and cellular health.
- Offers an exceptional quality-to-price ratio, making a premium, comprehensive B-complex formula accessible to a wider consumer base, as evidenced by its high volume of positive reviews.
- The high dosages of certain B vitamins might lead to potential side effects like temporary skin flushing (from Niacin) or vivid dreams for sensitive individuals, although these are generally mild and transient.
- For individuals looking for a minimalist supplement, the extensive list of ingredients might be considered more than necessary if only basic B vitamin supplementation is required, potentially leading to unnecessary intake.
- While excellent for a B-complex, it does not include a full spectrum of vitamins and minerals found in comprehensive multivitamins, so additional supplements may be needed depending on individual nutritional gaps.
- High doses of B vitamins can occasionally cause gastrointestinal upset or skin reactions in sensitive individuals, so starting with a lower dose or consulting a professional may be advisable.
- As with any supplement, individuals with pre-existing medical conditions or those taking prescription medications should consult a healthcare professional due to potential interactions.
- The presence of active forms of B vitamins means they are potent, and users should adhere strictly to recommended dosages to avoid potential imbalances or adverse effects, especially with long-term use.
$15.79($0.52 per serving)
 Vitacost | $ 15.79 | |
 Daily Vita | $ 16.20 | |
 Pure Formulas | $ 16.66 | |
 iHerb | $ 17.13 | |
 Amazon | $ 169.00 |
bolt Effectiveness for goals
Coenzymated B vitamins are in their active forms, meaning the body does not need to convert them before utilization. This can lead to more efficient absorption and immediate availability for metabolic processes. These active forms, like P-5-P for B6 or Methylcobalamin for B12, directly participate in enzyme functions critical for energy production and nervous system health.
Folate, Vitamin B12, and Vitamin B6 work synergistically in the methionine cycle, which is crucial for methylation processes and homocysteine metabolism. This combination helps maintain healthy homocysteine levels, which is important for cardiovascular and neurological health. They also support red blood cell formation and nervous system function.
Alpha Lipoic Acid is a potent antioxidant that also plays a role in mitochondrial energy metabolism, much like B vitamins and CoQ10. It can help regenerate other antioxidants, including CoQ10 and Vitamin C, extending their beneficial effects. Together, these compounds support the efficiency of energy production pathways within cells.
Different forms of Niacin offer distinct benefits or absorption profiles. Inositol Hexanicotinate is often considered a 'flush-free' form of Niacin, reducing the common skin flushing associated with conventional Niacin. NAD Trihydrate is a form of Nicotinamide Adenine Dinucleotide, which is a coenzyme central to energy metabolism and cellular function.
Betaine Anhydrous, or Trimethylglycine (TMG), is a methyl donor that works closely with Folate, Vitamin B12, and Vitamin B6 in methylation pathways. It supports the conversion of homocysteine to methionine, an alternative pathway to the one involving Folate and B12. This helps maintain healthy homocysteine levels and supports liver health.
schedule Dosage, timing & forms
Co-enzyme forms of B vitamins are already in their active state, which means the body does not need to convert them before use. This can make them more readily available for various metabolic processes. For individuals with certain genetic variations that affect nutrient metabolism, these active forms may offer enhanced bioavailability.
A typical recommendation for a comprehensive B-complex supplement is one capsule daily. It is generally advised to take it with a meal. Always follow the specific instructions provided on the product label for the most accurate guidance.
B vitamins are often recommended to be taken in the morning or early afternoon, as they are involved in energy metabolism. Taking them later in the day might interfere with sleep for some sensitive individuals, though this varies. Consuming them with food can also aid in absorption and minimize potential stomach discomfort.
The active forms of folate and Vitamin B12 included are considered highly bioavailable, meaning the body can use them directly without conversion. This can be particularly beneficial for individuals whose bodies may have difficulty converting synthetic or less active forms. These forms are chosen for their enhanced absorption and utilization.
B vitamins are essential cofactors for cellular energy production, a process further supported by CoQ10, which is critical for ATP synthesis. Alpha Lipoic Acid functions as an antioxidant and can regenerate other antioxidants, also playing a role in energy metabolism. Their combined presence can synergistically support energy generation and protect against oxidative stress at a cellular level.
health_and_safety Safety & interactions
The bright yellow color often observed in urine after taking a B-vitamin supplement is typically due to Riboflavin (Vitamin B2). Riboflavin has a natural yellowish color, and any excess not utilized by the body is excreted through the urine, which is a harmless effect. This is a common and expected occurrence.
Some forms of Niacin can cause a temporary skin flush, redness, or itching, especially at higher doses. However, certain forms like Inositol Hexanicotinate, also known as 'no-flush' niacin, are designed to minimize this effect. This product contains multiple forms, including Inositol Hexanicotinate, but individual reactions can vary.
Yes, high doses of Biotin can interfere with certain lab tests, particularly those that use biotin-streptavidin technology. This interference can lead to falsely high or low results for tests measuring hormones, cardiac markers, or others. It is advisable to inform your healthcare provider about any biotin supplementation before laboratory testing.
Coenzyme Q10 (CoQ10) may potentially reduce the effectiveness of blood-thinning medications like warfarin, while Alpha Lipoic Acid could theoretically increase the risk of bleeding. Individuals on anticoagulant therapy should consult their healthcare provider before taking supplements containing these ingredients. Monitoring is often recommended to ensure medication efficacy and safety.
Alpha Lipoic Acid may help lower blood sugar levels, which could potentially enhance the effects of diabetes medications. This interaction could lead to hypoglycemia in some individuals. Those with diabetes or on glucose-lowering drugs should monitor their blood sugar closely and consult their doctor before use.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Vitamin C (Magnesium Ascorbate) | 60 mg |
| Thiamin (Thiamine Hydrochloride, Cocarboxylase) | 50 mg |
| Riboflavin (Riboflavin-5-Phosphate Sodium, Riboflavin) | 50 mg |
| Niacin (Vitamin B3, NAD Trihydrate, Inositol Hexanicotinate) | 100 mg |
| Vitamin B-6 (Pyridoxine Hydrochloride, P-5-P Monohydrate) | 50 mg |
| Folate (Quatrefolic (6S)-5-MTHF, Glucosamine Salt) | 667 mcg DFE |
| Vitamin B12 (Methylcobalamin, Dibencozide) | 250 mcg |
| Biotin | 1000 mcg |
| Pantothenic Acid (Vitamin B5, Pantethine, Calcium Pantothenate) | 50 mg |
| Choline (Choline Bitartrate) | 25 mg |
| Betaine Anhydrous | 50 mg |
| Alpha Lipoic Acid | 50 mg |
| PABA | 25 mg |
| Inositol (Inositol Hexaphosphate, Inositol Hexanicotinate, Inositol) | 30 mg |
| CoQ10 | 10 mg |
Categories
Vitamin B12 95.0
Provides 500mcg of Vitamin B12 in highly bioavailable forms: Methylcobalamin and Dibencozide. These activated forms are superior to Cyanocobalamin, ensuring efficient absorption and utilization, crucial for energy, nerve health, and red blood cell formation.
Vitamin B6 95.0
Offers 100mg of Vitamin B6, split between Pyridoxine Hydrochloride and the highly bioavailable P-5-P Monohydrate. P-5-P is the active form readily used by the body for critical enzymatic reactions, especially in neurotransmitter synthesis.
Biotin 95.0
Provides a substantial 1000mcg of Biotin, a generous and effective dose for supporting metabolic functions, as well as promoting healthy hair, skin, and nails. This is a robust quantity for daily supplementation.
Goals
Metabolism Boost 99.0
As B vitamins are indispensable coenzymes for nearly every metabolic process, the high potency and activated forms in this complex ensure highly efficient conversion of macronutrients into energy. This significantly optimizes metabolic function, making it a top performer.
General Health 99.0
This product stands out as an exceptional choice for general health due to its inclusion of highly bioavailable B vitamin forms, coupled with a spectrum of neuro-supportive and antioxidant compounds. This comprehensive blend offers widespread systemic benefits, from energy to cellular protection.
Energy 98.0
The inclusion of highly active and comprehensive B vitamins like Thiamin, Riboflavin-5-Phosphate, Pantethine, and Methylcobalamin ensures maximal efficiency in cellular energy production. CoQ10 and Alpha Lipoic Acid further boost mitochondrial function, making this an extremely effective energy support.
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