SAMe 200 mg
NOW
SAMe 200 mg
4.5
★ ★ ★ ★ ★
(1741 ratings)
SAMe 200 mg
Score 92.0
An exceptionally high-value 200mg SAMe product from a reputable brand, ideal for long-term, cost-effective supplementation with proven user satisfaction.
Quantity: 120 Capsule(s)Servings size: 1 Veg Capsule(s) (120 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 92.0
An exceptionally high-value 200mg SAMe product from a reputable brand, ideal for long-term, cost-effective supplementation with proven user satisfaction.
insights Analysis
This NOW SAMe product, offering 120 servings of 200mg S-Adenosyl-L-Methionine Disulfate Tosylate, is a cornerstone for budget-conscious consumers seeking long-term SAMe supplementation. At $0.31 per serving, it represents one of the most economical options available for this dosage, allowing users to maintain consistent intake without significant financial strain. The overwhelming number of positive online reviews (over 1600) underscores its proven track record and consumer confidence. While it doesn't include additional B vitamin cofactors, its stability (implied by the Tosylate form and brand reputation for enteric coating) and purity make it a foundational choice. Its main limitation remains the 200mg dose per capsule, meaning higher daily therapeutic doses would require multiple capsules, though its low cost per unit makes this highly feasible.
- Excellent price per serving ($0.31) for a large 120-count quantity, offering superior long-term value.
- Uses the stable S-Adenosyl-L-Methionine Disulfate Tosylate form of SAMe.
- Extremely high number of positive online reviews, demonstrating widespread reliability and effectiveness.
- NOW is a highly reputable brand known for quality and affordability.
- Only 200mg SAMe per serving, requiring multiple capsules for higher therapeutic doses.
- Does not include additional B vitamin cofactors that could support SAMe metabolism.
- Individuals taking antidepressants or other mood-altering medications should consult a healthcare professional before using SAMe due to potential interactions.
$33.93($0.28 per serving)
 Amazon | $ 33.93 | |
 Vitacost | $ 41.09 | |
 Daily Vita | $ 43.40 | |
 iHerb | $ 45.92 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| SAMe (S-Adenosyl-L-Methionine Disulfate Tosylate) | 200 mg |
Categories
SAMe 90.0
This SAMe product's incredible value for a large quantity, coupled with a stable SAMe form and the trusted NOW brand, makes it a benchmark for affordable and effective SAMe supplementation.
Goals
Mood Support 90.0
The 200mg dose is a practical starting point for mood support, and the product's exceptional affordability allows for flexible dosing to achieve desired effects over an extended period without breaking the bank.
Joint Health 85.0
While 200mg is a lower dose for joint support, the product's outstanding value means users can easily take multiple capsules to reach the more commonly recommended 400-800mg daily for joint benefits, making it a very economical choice.
Digestive Health 85.0
For liver and digestive health, 200mg provides a solid base. Its high cost-effectiveness facilitates continuous and flexible dosing to support these goals, allowing for higher total daily intake if beneficial.
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