Fully Active B Complex with Quatrefolic
Doctor's Best
Fully Active B Complex with Quatrefolic
4.7
★ ★ ★ ★ ★
(20594 ratings)
Vitamin B6 50 mg
Thiamin 60 mg
Vitamin B5 100 mg
Niacin 50 mg
Biotin 600 mcg
Folate 400 mcg
Vitamin B12 1000 mcg
Score 95.0
Doctor's Best Fully Active B Complex is a high-potency, highly bioavailable B vitamin complex featuring coenzymated forms like Methylcobalamin and Quatrefolic, which are superior for absorption and utilization, making it an excellent choice for comprehensive B vitamin support.
Quantity: 60 Veggie Cap(s)Servings size: 1 Veggie Capsule(s) (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
Cognitive Support
leaderboard Score 95.0
Doctor's Best Fully Active B Complex is a high-potency, highly bioavailable B vitamin complex featuring coenzymated forms like Methylcobalamin and Quatrefolic, which are superior for absorption and utilization, making it an excellent choice for comprehensive B vitamin support.
insights Analysis
This product stands out due to its use of 'fully active' or coenzymated forms of several B vitamins, such as Methylcobalamin for B12, Quatrefolic for Folate, Pyridoxal 5-Phosphate (P5P) for B6, and Riboflavin 5-Phosphate (R5P) for B2. These forms are more bioavailable, meaning the body can utilize them directly without needing to convert them, which is especially beneficial for individuals with genetic variations affecting nutrient metabolism. The inclusion of both Niacin and Niacinamide, along with high potencies for most B vitamins, supports a wide range of health goals including energy metabolism, neurological function, and stress response. The added Vitamin C is a beneficial bonus, offering antioxidant support. Online reviews and nutritionist recommendations frequently highlight the benefits of active B vitamin forms, making this a highly regarded choice for comprehensive B vitamin support.
- Contains highly bioavailable "active" forms of B vitamins (B12, Folate, B6, B2), bypassing conversion steps for superior utilization.
- Comprehensive and high-potency formula covering all essential B vitamins.
- Includes additional Vitamin C for antioxidant support and overall wellness.
- Extremely high positive review count indicates strong user satisfaction and perceived efficacy.
- Higher price per serving compared to basic B-complex products, though justified by the premium active ingredients.
- The inclusion of a traditional Niacin form alongside Niacinamide could potentially cause a temporary "niacin flush" in sensitive individuals, although generally mild at this dose.
- Individuals sensitive to Niacin may experience temporary skin flushing, itching, or redness.
$15.21($0.25 per serving)
 iHerb | $ 15.21 | |
 Amazon | $ 15.21 | |
 Vitacost | $ 15.99 |
bolt Effectiveness for goals
B vitamin complexes are essential for various bodily functions, including energy metabolism, nervous system health, and red blood cell formation. They support the conversion of food into energy and help maintain cellular health. Each B vitamin has unique roles, but they often work together to optimize these processes.
Active forms of B vitamins are already in a state the body can readily use, bypassing the need for conversion. This can be particularly beneficial for individuals with genetic variations that affect B vitamin metabolism. Utilizing active forms may lead to more efficient absorption and utilization within the body.
Folic acid is a synthetic form of Vitamin B9, while folate, such as Quatrefolic (L-methylfolate), is the naturally occurring, biologically active form. Folate is directly usable by the body, whereas folic acid requires conversion, which some individuals may have difficulty with due to genetic factors. The active form ensures immediate bioavailability for essential functions.
Methylcobalamin is an active coenzyme form of Vitamin B12, essential for nerve function, DNA synthesis, and red blood cell production. Its ready-to-use form helps support these critical processes, particularly beneficial for those who may have difficulty converting other B12 forms. This form is often preferred for its direct bioavailability.
Pyridoxal 5-phosphate (P-5-P) is the active coenzyme form of Vitamin B6, meaning it's readily used by the body. It is crucial for over 100 enzyme reactions, including protein metabolism, neurotransmitter synthesis, and red blood cell formation. Using P-5-P ensures the body can directly utilize B6 for these vital functions.
schedule Dosage, timing & forms
Taking B vitamin supplements with food is often recommended to minimize potential stomach upset and enhance absorption. Consuming them with a meal can help integrate the vitamins into your digestive process more smoothly.
Many individuals prefer to take B vitamins in the morning, as they play a role in energy metabolism and can potentially interfere with sleep if taken too late. However, consistency in taking them is generally more important than the exact time of day.
Specific forms like Quatrefolic (a patented form of folate) and methylcobalamin (a bioactive form of B12) are included for their enhanced bioavailability. These forms are often chosen because they are readily utilized by the body without requiring conversion steps.
Most B vitamins are water-soluble, meaning excess amounts are typically excreted from the body. While generally considered safe at common supplemental levels, extremely high doses of certain B vitamins, like B6 and Niacin, could potentially lead to side effects. It is always advisable to follow label instructions.
B vitamins generally complement other common vitamin and mineral supplements and are often taken together without issue. They are integral to many bodily functions and work synergistically with other nutrients.
health_and_safety Safety & interactions
Riboflavin (Vitamin B2) can cause urine to appear bright yellow or orange. This is a common and harmless effect as the body excretes excess riboflavin. It indicates the body is processing and utilizing the vitamin.
Niacin (Vitamin B3) in its nicotinic acid form can cause a temporary flushing, tingling, or itching sensation in the skin. This 'niacin flush' is due to vasodilation and typically subsides as the body adjusts. Niacinamide, another form of B3, generally does not cause this effect.
Prolonged intake of very high doses of Vitamin B6, particularly pyridoxine hydrochloride, can potentially lead to peripheral neuropathy. Symptoms may include numbness or tingling in the hands and feet. It is important to adhere to recommended dosages and consult a healthcare professional about concerns.
Yes, high doses of biotin can interfere with certain laboratory tests, particularly those that use biotin-streptavidin technology. This can lead to falsely high or low results for thyroid hormones, cardiac markers, and other analytes. It is important to inform your doctor about biotin use before any lab tests.
High doses of folate can potentially mask the megaloblastic anemia that characterizes a vitamin B12 deficiency. This can allow neurological damage from B12 deficiency to progress undetected. Therefore, ensuring adequate B12 intake is often recommended when supplementing with folate.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Vitamin C (Ascorbic Acid) | 40 mg |
| Vitamin B1 (Thiamine Hydrochloride) | 60 mg |
| Vitamin B2 (Riboflavin 5-Phosphate, Riboflavin) | 75 mg |
| Vitamin B3 (Niacinamide, Niacin) | 50 mg |
| Vitamin B6 (Pyridoxine Hydrochloride, Pyridoxal 5-Phosphate) | 50 mg |
| Quatrefolic (Folate) | 400 mcg |
| Vitamin B12 (Methylcobalamin) | 1000 mcg |
| Biotin | 600 mcg |
| Pantothenic Acid (D-Calcium Pantothenate) | 100 mg |
Categories
Vitamin B12 98.0
The product provides 1000mcg of Methylcobalamin, which is the active and most bioavailable form of Vitamin B12. This form is superior to the more common Cyanocobalamin, as it can be directly utilized by the body without conversion, making it highly recommended by nutritionists and ideal for optimal neurological and energy support.
Folate 98.0
This product features 400mcg of Quatrefolic, which is a state-of-the-art, patented form of L-5-Methyltetrahydrofolate, the active form of Folate. This is significantly more effective than synthetic Folic Acid, especially for individuals with MTHFR gene variations that impair folic acid metabolism. Nutritionists widely recommend active folate forms for optimal brain, mood, and cardiovascular health.
Vitamin B6 95.0
Containing a total of 100mg of Vitamin B6, split between Pyridoxine Hydrochloride and Pyridoxal 5-Phosphate (P5P), this formulation is excellent. The inclusion of P5P, the active coenzyme form, is particularly beneficial as it bypasses the need for liver conversion, making it highly effective for neurotransmitter synthesis and homocysteine metabolism, especially for individuals who may have conversion challenges.
Goals
B vitamins are fundamental coenzymes in nearly all cellular metabolic processes, particularly those involved in converting food into usable energy. This product excels by providing high doses of all B vitamins in their 'active' or coenzymated forms (like R5P, P5P, and Methylcobalamin), ensuring maximal bioavailability and efficient support for carbohydrate, fat, and protein metabolism. This optimal absorption directly translates to more effective energy production and utilization within the body, a key recommendation from nutritionists for combating fatigue.
B vitamins, notably B6, Folate, and B12, are critical for neuronal health, neurotransmitter synthesis, and maintaining the integrity of the nervous system, all of which are essential for cognitive function. The inclusion of highly bioavailable forms such as Quatrefolic (L-5-Methyltetrahydrofolate) and Methylcobalamin ensures these crucial nutrients can be immediately utilized by the brain for processes like memory, focus, and overall cognitive performance. This formulation is highly valued by nutritionists for its ability to bypass common genetic variations that impair the conversion of less active B vitamin forms.
General Health 95.0
As a comprehensive B-complex containing all eight essential B vitamins in high and, importantly, active/coenzymated forms, this product offers foundational support for countless physiological processes throughout the body. From cellular repair and DNA synthesis to red blood cell formation and nervous system function, it significantly contributes to overall well-being. Its superior bioavailability makes it a prime choice for maintaining optimal daily health and nutrient levels.
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