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Skin Nails & Hair

Solgar
4.7
★ ★ ★ ★ ★
(83722 ratings)
Copper 2 mg
Zinc 15 mg
Proline 50 mg
Silicon 50 mg
Product Image
Score82
A focused and well-dosed beauty formula with good mineral balance, though silicon disclosure could be clearer.
How scoring works
Quantity:120 Tablet(s) • (60 servings)
Goals:
Skin Health
Hair Health
Nail Health
General Health

Score 82

A focused and well-dosed beauty formula with good mineral balance, though silicon disclosure could be clearer.
How scoring works
$18.92($0.31 per serving)
Vitacost
$ 20.07
iHerb
$ 18.92
Daily Vita
$ 22.27
Amazon
$ 18.92
Pure Formulas
$ 20.24
Report prices

Analysis

One gram of MSM anchors the formula, with vitamin C, proline, and lysine supporting structural protein and collagen-related nutrition. Zinc, copper, and silicon add relevant mineral coverage for skin, hair, and nails.

Zinc citrate and copper glycinate are useful forms, and the zinc-to-copper balance is sensible. Silicon is listed through two sources, but the true elemental contribution from each source is not fully clear.

Two tablets per serving and a long supply make routine use practical. The formula is most relevant to appearance-related goals and less useful as a broad immune, bone, or hormone supplement.

Who is it for
  • Adults seeking skin, hair, and nail nutrition
  • Users wanting MSM with structural amino acids
  • People who value clear active dosing
Best for
  • Hair and nail support
  • Skin structure nutrition
  • MSM-based beauty supplementation

Pros

  • Provides one gram of MSM
  • Pairs zinc with copper
  • Includes vitamin C, proline, and lysine
  • Offers a long supply

Cons

  • Silicon form totals are not fully clear
  • Requires two tablets
  • Does not address broader nutritional gaps

Warnings

  • The 15 mg zinc amount should be counted with other zinc supplements
  • MSM may cause digestive upset in sensitive users
  • Copper-containing supplements may be unsuitable for people advised to restrict copper

Nutrient quality

89 Highest impact

Several well-regarded forms support good ingredient quality. The core doses and intended use remain reasonably coherent.

.

Ingredient transparency

83 Highest impact

Most active amounts are clearly disclosed. Missing directions and inactive ingredients keep disclosure incomplete.

.

Customer satisfaction

71 High impact

The supplied average is strong and rests on a large review count. No review text was provided to assess recurring complaints or firsthand experiences.

.

Value for money

80 Highest impact

Serving efficiency is favorable for the disclosed formula. A focused active profile supports value.

.
Report analysis

Goals

Skin Health
Skin Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportA- CoverageA Formula Quality
Zinc · 15 mgVitamin C · 120 mgCopper · 2 mgProline · 50 mgSilicon · 50 mg

OptiMSM, silicon, vitamin C, zinc, copper, and proline create a clearly skin-focused matrix and repair formula. Vitamin C and copper provide logical cofactors for collagen synthesis, while silicon and MSM support connective-tissue structure.

The ingredient amounts are clearly disclosed and several use well-absorbed forms. Evidence for oral MSM and silicon skin outcomes is less established than for collagen peptides, which are not included.

Study evidence
Copper Supportive 16 studies
Proline Disputed 4 studies
Silicon Supportive 16 studies
Vitamin C Supportive 53 studies
Zinc Supportive 66 studies
Hair Health
Hair Health
Impact
Highest effect
B+ Goal FitB Strength of SupportB CoverageA+ Formula Quality
Zinc · 15 mgLysine · 50 mgVitamin C · 120 mg

One gram of branded MSM, 50 mg silicon, vitamin C, zinc citrate, chelated copper, proline, and lysine create a focused structural and follicle-support formula. Lysine and proline are low for standalone amino-acid support, but the sulfur, mineral, and silicon pathways remain meaningful.

The concise formula avoids broad multivitamin padding and pairs collagen-related cofactors logically. Silicon source ambiguity is the main disclosure weakness, while the high listed amount may exceed what many targeted silicon products provide.

Study evidence
Copper Adverse 4 studies
Lysine Supportive 1 study
Silicon Supportive 2 studies
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Nail Health
Nail Health
Impact
High effect
B Goal FitC Strength of SupportB- CoverageA Formula Quality
Silicon · 50 mg

Silicon, MSM, vitamin C, zinc, proline, and lysine form a focused blend for nail structure and connective tissue support. The formula addresses both mineral cross-linking and amino-acid building blocks.

Exact amounts are disclosed, but the duplicated silicon entries and unusually high listed amount make the active silicon yield uncertain. Lack of biotin or collagen narrows the evidence base, although the streamlined design remains well aligned with brittle-nail support.

Study evidence
Silicon Supportive 2 studies
Vitamin C Supportive 1 study
Zinc No effect 1 study
General Health
General Health
Impact
High effect
C+ Goal FitB Strength of SupportC CoverageB+ Formula Quality
Zinc · 15 mgVitamin C · 120 mg

Zinc citrate, vitamin C, and chelated copper provide useful micronutrient support with clear amounts. A substantial branded MSM dose adds focused structural support, while silicon and amino acids are more modest.

The streamlined formula has good depth for skin, hair, and connective-tissue needs. General-health breadth remains limited because it omits vitamin D, magnesium, essential fatty acids, and a wider vitamin base.

Study evidence
Vitamin C Supportive 56 studies
Zinc Supportive 60 studies
Immunity
Immunity
Impact
Moderate effect
C- Goal FitC Strength of SupportD+ CoverageC+ Formula Quality
Vitamin C · 120 mgZinc · 15 mg

Zinc citrate and vitamin C provide a narrow but credible nutritional link to immune function. The disclosed forms are clear and suitable for routine use.

Most of the formula targets connective tissue, hair, and nails through MSM, silicon, proline, and lysine. Limited immune pathway coverage and a modest vitamin C amount keep it from serving as a well-rounded immunity option.

Study evidence
Lysine Supportive 2 studies
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies
Bone Health
Bone Health
Impact
Moderate effect
D+ Goal FitD+ Strength of SupportD+ CoverageD Formula Quality
Copper · 2 mgLysine · 50 mgZinc · 15 mgProline · 50 mgVitamin C · 120 mg

The formula offers meaningful matrix support but little direct mineralization support. Silicon, vitamin C, zinc, copper, lysine, and proline relate to collagen structure and bone-matrix enzymes.

Calcium, magnesium, vitamin D, and vitamin K are absent. It may complement a complete bone regimen but cannot replace one.

Study evidence
Copper Disputed 20 studies
Lysine Supportive 2 studies
Proline Disputed 2 studies
Silicon Supportive 13 studies
Vitamin C Supportive 46 studies
Zinc Supportive 33 studies

Ingredients

IngredientAmount per serving
Vitamin C (L-Ascorbic Acid)
 120 mg
Zinc (Zinc Citrate)
 15 mg
Copper (Copper Glycinate Amino Acid Chelate)
 2 mg
MSM (OptiMSM)
 1000 mg
Silicon (L. calcareum, Silicon Dioxide)
 50 mg
L-Proline
50 mg
L-Lysine (L-Lysine Hydrochloride)
 50 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Halal Vegetarian
Report overview
Copper (Copper Glycinate Amino Acid Chelate) · 2 mg OverallScore91
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA- Value

The copper glycinate amino acid chelate is a highly absorbable form with clear label disclosure. The copper amount matches the collection target. The zinc-to-copper balance falls outside the preferred range, though both minerals are present. The serving cost is favorable relative to the collection norm.

View ingredientView products
Zinc (Zinc Citrate) · 15 mg OverallScore78
B Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value

Zinc citrate offers solid absorption as an organic salt. The amount is well aligned with daily maintenance and carries a low copper-imbalance risk. The serving cost falls in the middle band and provides reasonable value.

View ingredientView products
Silicon (L. calcareum, Silicon Dioxide) · 50 mg OverallScore60
C Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyB+ Value

The red-algae source offers moderate form quality, but the listed silicon amount is well above the preferred range. Source identity is clearer than standardization, while duplicate form listings create uncertainty. Low cost helps value, though the high dose and label ambiguity limit suitability.

View ingredientView products
Loading alternative details
81 Performance

Hair Skin & Nails Collagen Plus Formula

Life Extension
Substantial collagen peptides and keratin provide more direct structural support for hair, skin, and nails than the original mineral-and-MSM formula. Biotin and supporting nutrients add breadth, although basic mineral forms and a low silicon amount limit refinement.
70 Performance

Ligament Restore

Pure Encapsulations
Glucosamine and structural nutrients including proline, lysine, and silicon closely match the original's connective-tissue theme. Collagen and several secondary actives are modest, and missing excipient details reduce clarity.
65 Performance

Vegan Collagen Builder +

Amen
Vitamin C, biotin, lysine, proline, and silica create a coherent plant-based framework for collagen-related hair and nail support. The amino-acid amounts are modest and numerous small fruit and herb additions offer less functional depth than the original MSM dose.
84 Budget

Zinc-Copper Balance

AOR Advanced Orthomolecular Research Premium
Well-matched zinc and copper in citrate and picolinate forms preserve two of the original formula's stronger minerals at a lower serving cost. MSM, silicon, proline, and lysine are omitted, so the option is better suited to focused mineral support than complete hair, skin, and nail coverage.
83 Budget

Zinc 30 mg

Nature's Life
Zinc picolinate with copper offers an economical mineral-balance alternative with strong hair alignment. The zinc amount is substantial and the repeated copper entries reduce clarity, while the original's MSM, silicon, and structural amino acids are absent.
81 Budget

Zinc Plus 25 mg

Nature's Answer
Favorable zinc forms, active vitamin B6, and added copper provide focused skin and hair support at a lower serving cost. Repeated zinc entries obscure the form split, and the narrower formula does not replace MSM, silicon, proline, or lysine.
82 Value

Thyroid Energy

NOW
Well-specified zinc and copper plus meaningful tyrosine provide strong mineral quality and good hair alignment at a lower serving cost. Iodine, guggul, and ashwagandha can complicate thyroid conditions or thyroid-medicine use, and the formula lacks the original's MSM and silicon.
79 Value

Healthy Eyes Lutein & Zeaxanthin

21st Century
Zinc, copper, antioxidant vitamins, lutein, and zeaxanthin provide broad antioxidant and mineral support at strong serving value. Oxide mineral forms are weaker than the original citrate and glycinate forms, and the eye-focused formula does not supply MSM or structural amino acids.
80 Value

PreserVision AREDS 2 Formula

Bausch & Lomb
Substantial zinc and copper with antioxidant vitamins offer strong disclosed mineral coverage at low serving cost. The amounts are intended for focused vision support rather than casual hair use, and high zinc and vitamin E make the formula a poor substitute for the original structural nutrients without appropriate guidance.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin.
    Barel A; Calomme M; Timchenko A; De Paepe K; Demeester N; Rogiers V; Clarys P; Vanden Berghe D · Archives of dermatological research · 2006
    Randomized trial50 participantsSkin Health Hair Health Nail Health forSilicon
  2. Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence.
    Dhaliwal S; Nguyen M; Vaughn AR; Notay M; Chambers CJ; Sivamani RK · American journal of clinical dermatology · 2020
    Systematic review22 studies pooledSkin Health forZinc
  3. Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
    Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
    Randomized trial57 participantsSkin Health forCopper
  4. Copper hypersensitivity.
    Fage SW; Faurschou A; Thyssen JP · Contact dermatitis · 2015
    Narrative reviewSkin Health forCopper
  5. Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
    Piérard-Franchimont C; Goffin V; Henry F; Uhoda I; Braham C; Piérard GE · International journal of cosmetic science · 2010
    Randomized trial150 participantsHair Health forZinc
  6. Hair Loss and Zinc Deficiency: A Cross-Sectional Study.
    Liran O; Vered S; Cohen B; Shapiro Ben David S; Nakhleh A; Rahamim-Cohen D; Azuri J; Adler L · Healthcare (Basel, Switzerland) · 2025
    Cross-sectional study23,975 participantsHair Health forZinc
  7. Menkes disease and response to copper histidine: An Indian case series.
    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
    Case series4 participantsHair Health forCopper
  8. Trace element levels in alopecia areata.
    Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
    Case-control study100 participantsHair Health forCopper
  9. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forZinc
  10. Nail Supplements: When, How, and Why?
    Zaraa I; Richert B · Skin appendage disorders · 2026
    Narrative reviewNail Health forSilicon
  11. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  12. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  13. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  14. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  15. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  16. Amino Acid Intakes Are Associated With Bone Mineral Density and Prevalence of Low Bone Mass in Women: Evidence From Discordant Monozygotic Twins.
    Jennings A; MacGregor A; Spector T; Cassidy A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study135 participantsBone Health forLysine
  17. Dietary L-lysine and calcium metabolism in humans.
    Civitelli R; Villareal DT; Agnusdei D; Nardi P; Avioli LV; Gennari C · Nutrition (Burbank, Los Angeles County, Calif.) · 1993
    Clinical trial75 participantsBone Health forLysine
  18. Human bone collagen synthesis is a rapid, nutritionally modulated process.
    Babraj JA; Smith K; Cuthbertson DJ; Rickhuss P; Dorling JS; Rennie MJ · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2005
    Methods validation study8 participantsBone Health forProline
  19. Osteogenesis imperfecta: recent findings shed new light on this once well-understood condition.
    Basel D; Steiner RD · Genetics in medicine : official journal of the American College of Medical Genetics · 2009
    Narrative reviewBone Health forProline
  20. The effect of choline-stabilized orthosilicic acid in patients with peri-implantitis: an exploratory randomized, double-blind, placebo controlled study.
    Teughels W; Celik GU; Tarce M; De Cock I; Persyn SM; Haytac MC · BMC oral health · 2021
    Randomized trial21 participantsBone Health forSilicon
  21. Calcium Phosphate Modified with Silicon vs. Bovine Hydroxyapatite for Alveolar Ridge Preservation: Densitometric Evaluation, Morphological Changes and Histomorphometric Study.
    Cadenas-Vacas G; Martínez-Rodríguez N; Barona-Dorado C; Sánchez-Labrador L; Cortés-Bretón Brinkmann J; Meniz-García C; Martínez-González JM · Materials (Basel, Switzerland) · 2021
    Non-randomized trialBone Health forSilicon
  22. Silicon: a review of its potential role in the prevention and treatment of postmenopausal osteoporosis.
    Price CT; Koval KJ; Langford JR · International journal of endocrinology · 2013
    Narrative reviewBone Health forSilicon
  23. Osteogenic Effect of a Bioactive Calcium Alkali Phosphate Bone Substitute in Humans.
    Knabe C; Adel-Khattab D; Rezk M; Cheng J; Berger G; Gildenhaar R; Wilbig J; Günster J; Rack A; Heiland M; Knauf T; Stiller M · Bioengineering (Basel, Switzerland) · 2023
    Clinical trial38 participantsBone Health forSilicon
  24. Silicon and bone health.
    Jugdaohsingh R · The journal of nutrition, health & aging · 2007
    Narrative reviewBone Health forSilicon
  25. Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
    Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
    Meta-analysis19,484 participants17 studies pooledBone Health forVitamin C
  26. Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
    Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Meta-analysis6 studies pooledBone Health forVitamin C
  27. Smoking, antioxidant vitamins, and the risk of hip fracture.
    Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
    Cohort study66,651 participantsBone Health forVitamin C
  28. Micronutrients and the risk of hip fracture: Case-control study.
    Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
    Case-control study189 participantsBone Health forVitamin C
  29. Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
    Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Cross-sectional study1,196 participantsBone Health forVitamin C
  30. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsBone Health forZinc
  31. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsBone Health forZinc
  32. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsBone Health forZinc
  33. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  34. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledBone Health forZinc
  35. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  36. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  37. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  38. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  39. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  40. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  41. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  42. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  43. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  44. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  45. UV damage to hair and the effect of antioxidants and metal chelators.
    Millington KR; Marsh JM · International journal of cosmetic science · 2021
    In vitro / ex vivo studyHair Health forCopper
  46. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
    Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
    In vitro / ex vivo studyHair Health forCopper
  47. Causes of hair loss and the developments in hair rejuvenation.
    Rushton DH; Norris MJ; Dover R; Busuttil N · International journal of cosmetic science · 2010
    Narrative reviewHair Health forLysine
  48. Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair
    R R Wickett, E Kossmann, A Barel, N Demeester, P Clarys, D Vanden Berghe, M Calomme · Archives of Dermatological Research · 2007
    Randomized trial48 participantsHair Health forSilicon
  49. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  50. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  51. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  52. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  53. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  54. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  55. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  56. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  57. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  58. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  59. Lysine-fortified wheat flour improves the nutritional and immunological status of wheat-eating families in northern China.
    Zhao W; Zhai F; Zhang D; An Y; Liu Y; He Y; Ge K; Scrimshaw NS · Food and nutrition bulletin · 2004
    Clinical trial264 participantsImmunity forLysine
  60. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis
    R S Griffith, D E Walsh, K H Myrmel, R W Thompson, A Behforooz · Dermatologica · 1987
    Non-randomized trial52 participantsImmunity forLysine
  61. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  62. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  63. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  64. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  65. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  66. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  67. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  68. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  69. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  70. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  71. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  72. Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
    Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
    Randomized trialSkin Health forCopper
  73. Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
    Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
    Animal experimentSkin Health forCopper
  74. Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
    Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
    Animal experimentSkin Health forCopper
  75. Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
    Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
    Single-arm trialSkin Health forCopper
  76. Improvement of crow's feet lines by topical application of 1-carbamimidoyl-L-proline (CLP).
    Kawashima M; Yokose U; Hachiya A; Fujimura T; Tsukahara K; Kawada H; Kitahara T; Takema Y; Terui T; Nakagawa H · European journal of dermatology : EJD · 2014
    Randomized trial126 participantsSkin Health forProline
  77. Collagen synthesis in human musculoskeletal tissues and skin.
    Babraj JA; Cuthbertson DJ; Smith K; Langberg H; Miller B; Krogsgaard MR; Kjaer M; Rennie MJ · American journal of physiology. Endocrinology and metabolism · 2005
    Methods validation studySkin Health forProline
  78. Genotype-phenotype spectrum of PYCR1-related autosomal recessive cutis laxa.
    Dimopoulou A; Fischer B; Gardeitchik T; Schröter P; Kayserili H; Schlack C; Li Y; Brum JM; Barisic I; Castori M; Spaich C; Fletcher E; Mahayri Z; Bhat M; Girisha KM; Lachlan K; Johnson D; Phadke S; Gupta N; Simandlova M; Kabra M; David A; Nijtmans L; Chitayat D; Tuysuz B; Brancati F; Mundlos S; Van Maldergem L; Morava E; Wollnik B; Kornak U · Molecular genetics and metabolism · 2014
    Case series33 participantsSkin Health forProline
  79. Collagen structure in skin from fibromyalgia patients.
    Ribel-Madsen S; Gronemann ST; Bartels EM; Danneskiold-Samsøe B; Bliddal H · International journal of tissue reactions · 2006
    Case-control study35 participantsSkin Health forProline
  80. The Efficacy of a Silicone Sheet in Postoperative Scar Management.
    Kim JS; Hong JP; Choi JW; Seo DK; Lee ES; Lee HS · Advances in skin & wound care · 2018
    Randomized trialSkin Health forSilicon
  81. A non-inferiority study to compare the effect of silica gel fiber dressing with alginate dressing on healing of venous leg ulcers.
    Zhang L; Yang J; Wang H; Cai Y; Zhao W; Dong R; Liu D; Lu X · Wound management & prevention · 2023
    Randomized trial130 participantsSkin Health forSilicon
  82. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsSkin Health forSilicon
  83. Retrospective Study on the Clinical Superiority of the Vacuum-Assisted Closure System with a Silicon-based Dressing over the Conventional Tie-over Bolster Technique in Skin Graft Fixation.
    Chou PR; Wu SH; Hsieh MC; Huang SH · Medicina (Kaunas, Lithuania) · 2020
    Cohort study26 participantsSkin Health forSilicon
  84. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars.
    O'Brien L; Pandit A · The Cochrane database of systematic reviews · 2006
    Meta-analysis559 participants13 studies pooledSkin Health forSilicon
  85. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  86. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  87. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  88. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  89. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  90. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  91. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  92. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  93. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  94. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc