Product Image

Super Macho

DLC Laboratories Inc.
4.4
★ ★ ★ ★ ★
(77 ratings)
Zinc 15 mg
Vitamin B6 25 mg
Vitamin B5 100 mg
Thiamin 40 mg
Niacin 30 mg
Riboflavin 15 mg
Tyrosine 100 mg
Product Image
Score59
Best suited to energy, with the clearest benefits coming from the disclosed active ingredients. Cyanocobalamin and several conventional vitamin forms are less favorable, while ginseng and tyrosine appear modest for targeted effects.
How scoring works
Quantity:50 Softgel(s) • (25 servings)
Goals:
Energy
General Health

Score 59

Best suited to energy, with the clearest benefits coming from the disclosed active ingredients. Cyanocobalamin and several conventional vitamin forms are less favorable, while ginseng and tyrosine appear modest for targeted effects.
How scoring works
$11.36($0.45 per serving)
Walmart
$ 11.36
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Analysis

A broad B-vitamin panel supports cellular energy, while tyrosine, ginseng, and taurine add possible alertness and stamina pathways. The B12 and pantothenic acid amounts are meaningful, and zinc provides additional metabolic support. Cyanocobalamin and several conventional vitamin forms are less favorable, while ginseng and tyrosine appear modest for targeted effects.

Zinc, vitamin B6, and folate have secondary roles in bone metabolism. The formula lacks calcium, magnesium, vitamin D, vitamin K, and meaningful matrix support. Several relevant nutrients are adequately dosed, but their forms are ordinary and not skeletal-specific.

Zinc citrate provides a well-absorbed organic salt in a swallowed softgel. The clearly disclosed 15 mg amount suits daily maintenance, and copper imbalance risk is low at this level despite no added copper. Value is middling because the per-serving cost sits above the collection median.

Who is it for
  • People seeking energy support
  • People seeking general health support
  • People seeking brain health support
Best for
  • Energy
  • General Health
  • Brain Health

Pros

  • A broad B-vitamin panel supports cellular energy, while tyrosine, ginseng, and taurine add possible alertness and stamina pathways.
  • The B12 and pantothenic acid amounts are meaningful, and zinc provides additional metabolic support.
  • Zinc and a concentrated B-vitamin profile provide relevant support for immune function and energy metabolism.
  • Zinc citrate is a suitable form, while cyanocobalamin and folic acid are less preferred vitamin forms.
  • The glandular ingredient, ginseng, tyrosine, and taurine reflect a narrow male-vitality focus and are modestly dosed.

Cons

  • Cyanocobalamin and several conventional vitamin forms are less favorable, while ginseng and tyrosine appear modest for targeted effects.
  • The formula spans more than one energy mechanism but lacks strong depth outside the B vitamins.
  • The formula offers some general nutritional value but is less coherent than a focused B-complex or mineral product.
  • B vitamins support neurological metabolism, while tyrosine and ginseng add limited focus and stress-resilience potential.
  • Tyrosine and ginseng are far below common targeted cognitive amounts, while B12 uses cyanocobalamin and folate uses folic acid.

Warnings

  • B6, B12, and folic acid support homocysteine metabolism, while taurine has some cardiac relevance.
  • The male-vitality design lacks a strong lipid, vascular, or cardiac-energy active.
  • Daily vitamin B6 at 25 mg may cause nerve symptoms with prolonged use in susceptible people.
  • Less preferred B-vitamin forms and the absence of core lipid, vascular, or cardiac-energy actives limit its usefulness for this goal.

Nutrient quality

47 Lower impact

Zinc citrate is a reasonable form, while folic acid and cyanocobalamin are conventional choices. Core B vitamins are substantial, but tyrosine, ginseng, and taurine are modest.

Ingredient transparency

78 High impact

Specific amounts are supplied for every listed active. Inactive softgel ingredients are not included in the supplied data.

Customer satisfaction

56 Moderate impact

The supplied average indicates weak or mixed aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

49 Lower impact

The low cost helps, but formula quality is reduced by weak specialty doses. Serving cost is accessible for the disclosed nutrient amounts.

Report analysis

Goals

Energy
Essential Energy Nutrients
Energy
Impact
High effect
B+ Goal FitC+ Strength of SupportB- CoverageC+ Formula Quality
Vitamin B5 · 100 mgRiboflavin · 15 mgThiamin · 40 mgVitamin B12 · 500 mcg

A broad B-vitamin panel supports cellular energy, while tyrosine, ginseng, and taurine add possible alertness and stamina pathways. The B12 and pantothenic acid amounts are meaningful, and zinc provides additional metabolic support.

Cyanocobalamin and several conventional vitamin forms are less favorable, while ginseng and tyrosine appear modest for targeted effects. The formula spans more than one energy mechanism but lacks strong depth outside the B vitamins.

Study evidence
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
C Goal FitB- Strength of SupportC+ CoverageD+ Formula Quality
Folate · 400 mcgVitamin B12 · 500 mcgTaurine · 100 mgZinc · 15 mg

Zinc and a concentrated B-vitamin profile provide relevant support for immune function and energy metabolism. Zinc citrate is a suitable form, while cyanocobalamin and folic acid are less preferred vitamin forms.

The glandular ingredient, ginseng, tyrosine, and taurine reflect a narrow male-vitality focus and are modestly dosed. The formula offers some general nutritional value but is less coherent than a focused B-complex or mineral product.

Study evidence
Folate Supportive 80 studies
Taurine No effect 3 studies
Vitamin B12 Adverse 66 studies
Zinc Supportive 60 studies
Brain Health
Essential Brain Nutrition
Brain Health
Impact
Moderate effect
C+ Goal FitC- Strength of SupportC- CoverageC+ Formula Quality
Folate · 400 mcgVitamin B12 · 500 mcgVitamin B6 · 25 mgThiamin · 40 mg

B vitamins support neurological metabolism, while tyrosine and ginseng add limited focus and stress-resilience potential. The main vitamin amounts are transparent and B12 reaches a substantial level.

Tyrosine and ginseng are far below common targeted cognitive amounts, while B12 uses cyanocobalamin and folate uses folic acid. It functions mainly as a metabolic vitamin formula rather than a strong brain-health product.

Study evidence
Folate Supportive 90 studies
Tyrosine Supportive 7 studies
Vitamin B12 Supportive 74 studies
Hair Health
Hair Health
Impact
Moderate effect
C- Goal FitB- Strength of SupportC- CoverageD Formula Quality
Zinc · 15 mg

Zinc, folate, B12, and B vitamins can support hair when dietary deficiency contributes to shedding. The male-vitality design and bovine glandular do not provide a well-supported hair-growth pathway.

Zinc citrate is a useful form, while folic acid and cyanocobalamin are conventional choices. The bovine orchic material is poorly characterized and adds uncertainty without a clear hair benefit.

Study evidence
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies
Zinc Supportive 22 studies
Testosterone Support
Testosterone Support
Impact
Moderate effect
C Goal FitC- Strength of SupportC- CoverageD+ Formula Quality
Zinc · 15 mg

Zinc and vitamin B6 provide credible foundational support for steroid synthesis and hormone regulation. The amounts are useful, while ginseng, tyrosine, taurine, and bovine orchic material are too light or weakly supported for direct testosterone effects.

Zinc citrate is well absorbed, but pyridoxine requires conversion and glandular sourcing details are sparse. The formula offers moderate nutrient depth without vitamin D, magnesium, boron, or a well-studied adaptogen.

Study evidence
Taurine Not classified

No linked studies yet.

Zinc Disputed 7 studies
Immunity
Immunity
Impact
Moderate effect
D Goal FitC Strength of SupportD CoverageD+ Formula Quality
Zinc · 15 mg

Zinc citrate provides a meaningful immune-relevant nutrient, but the product is chiefly positioned around male vitality rather than immunity. B vitamins, glandular material, and small botanical additions do not establish broad immune support.

The zinc amount and form are appropriate for maintenance. The remaining ingredients offer little direct pathway coverage and make the formula less coherent for this goal.

Study evidence
Zinc Supportive 73 studies
Skin Health
Skin Health
Impact
Moderate effect
D Goal FitC Strength of SupportD- CoverageD- Formula Quality
Zinc · 15 mg

Zinc offers a meaningful maintenance contribution to skin repair and normal barrier function. The remaining B vitamins, amino acids, ginseng, and bovine glandular material target male vitality rather than skin.

The zinc amount is clearly disclosed and uses an absorbable citrate form. No collagen, hydration active, or substantial antioxidant system supports a broader skin benefit.

Study evidence
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Calories
10 {Calories}
Total Fat
1 Gram(s)
Vitamin B1 (Thiamine Hydrochloride)
 40 mg
Vitamin B2 (Riboflavin)
 15 mg
Niacin (Niacinamide)
 30 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 25 mg
Folic Acid
400 mcg
Vitamin B12 (Cyanocobalamin)
 500 mcg
Pantothenic Acid (Calcium Pantothenate)
 100 mg
Zinc (Zinc Citrate Dihydrate)
 15 mg
Orchic Substance (Bovine Glandular)
 10000 mcg
L-Tyrosine
100 mg
Panax ginseng
30 mg
Taurine
100 mg
Men 18–50
Report overview
Zinc (Zinc Citrate Dihydrate) · 15 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD Value

Zinc citrate provides a well-absorbed organic salt in a swallowed softgel. The clearly disclosed 15 mg amount suits daily maintenance, and copper imbalance risk is low at this level despite no added copper. Value is middling because the per-serving cost sits above the collection median.

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Vitamin B6 (Pyridoxine Hydrochloride) · 25 mg OverallScore68
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The formula supplies a preferred-range B6 amount in a practical two-softgel serving. Pyridoxine hydrochloride requires conversion, though riboflavin is included as a supporting cofactor. High serving cost for the B6 form limits value despite clear labeling.

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Vitamin B5 (Calcium Pantothenate) · 100 mg OverallScore66
B Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Calcium pantothenate provides a stable, well-absorbed standard form of vitamin B5. The 100 mg serving provides useful general metabolic support but remains below intensive-use amounts. The cost efficiency for vitamin B5 is poor because the broader combination carries much of the product's value, while excipient purity cannot be confirmed from the provided data.

View ingredientView products
Loading alternative details
79 Performance

Coenzyme B-Complex Advanced

Country Life
<p>More focused Vitamin B12, Niacin, Thiamin coverage comes from 50.00mg Vitamin B6 as Pyridoxal 5-Phosphate, 400.00mcg Vitamin B12 as Methylcobalamin, 53.00mg Niacin as Inositol Hexaniacinate, 60.00mg Vitamin C as Ascorbic Acid, 60.00mg Vitamin C as Calcium Ascorbate, 60.00mg Vitamin C as Chromium Ascorbate, 60.00mg Vitamin C as Copper Ascorbate, 60.00mg Vitamin C as Magnesium Ascorbate, 60.00mg Vitamin C as Manganese Ascorbate, 60.00mg Vitamin C as Potassium Ascorbate, 60.00mg Vitamin C as Zinc Ascorbate, 26.00mg Thiamin as Thiamine Cocarboxylase Chloride, 26.00mg Thiamin as Thiamine Hydrochloride, 37.00mg Riboflavin, 37.00mg Riboflavin as Riboflavin 5-Phosphate, 53.00mg Niacin as Nicotinamide Adenine Dinucleotide, 50.00mg Vitamin B6 as Pyridoxine Alpha-Ketoglutarate Hydrochloride, 50.00mg Vitamin B6 as Pyridoxine Hydrochloride, 360.00mcg DFE Folate as (6S)-5-Methyltetrahydrofolate-Glucosamine Salt, 300.00mcg Biotin as D-Biotin, 76.00mg Pantothenic Acid as Calcium D-Pantothenate, 76.00mg Pantothenic Acid as Pantethine, 25.00mg Benfotiamine, 5.00mg LifePQQ as Pyrroloquinoline Quinone Disodium Salt, and 500.00mcg Nicotinamide Adenine Dinucleotide. Compared with Super Macho, the disclosed forms and broader shared-nutrient fit provide a more targeted ingredient profile; however, the substantial vitamin B6 amount may be unsuitable for long-term stacking.</p>
73 Performance

B-50 Gels

Carlson
<p>More focused Niacin, Thiamin, Vitamin B6 coverage comes from 50.00mg Vitamin B6 as Pyridoxine Hydrochloride, 50.00mg Thiamine as Thiamine Mononitrate, and 50.00mg Riboflavin as Vitamin B2. Compared with Super Macho, the disclosed forms and broader shared-nutrient fit provide a more targeted ingredient profile; however, the substantial vitamin B6 amount may be unsuitable for long-term stacking.</p>
79 Performance

CoEnzyme B-Complex

KAL
<p>More focused Vitamin B12, Niacin, Thiamin coverage comes from 400.00mcg Folate as (6S) 5-Methyltetrahydrofolate Glucosamine Salt, 20.00mg Thiamine as Thiamine Mononitrate, and 40.00mg Niacin as Inositol Hexanicotinate. Compared with Super Macho, the disclosed forms and broader shared-nutrient fit provide a more targeted ingredient profile; however, inactive ingredients and complete use directions are not included in the supplied data.</p>
85 Budget

B-Complex Plus

Pure Encapsulations
<p>A lower-cost serving retains useful Vitamin B12, Niacin, Thiamin coverage through 100.00mg Thiamine as Thiamine Hydrochloride, 108.00mg Niacin as Inositol Hexanicotinate, and 16.70mg Vitamin B6 as Pyridoxal 5-Phosphate. Compared with Super Macho, it reduces recurring cost while keeping the formula nutritionally relevant; however, inactive ingredients and complete use directions are not included in the supplied data.</p>
75 Budget

B-Complex

Paradise Earth's Blend
<p>A lower-cost serving retains useful Vitamin B12, Niacin, Thiamin coverage through 400.00mcg Folate as L-Methylfolate, 50.00mg Vitamin B2 as Riboflavin 5-Phosphate, 500.00mcg Vitamin B12 as Methylcobalamin, 10.00mg Vitamin B-1 as Benfotiamine, 10.00mg Vitamin B1 as Thiamine Mononitrate, 50.00mg Vitamin B-3 as Niacin, 50.00mg Vitamin B-3 as Niacinamide, 50.00mg Vitamin B-6 as Pyridoxal 5-Phosphate, 300.00mcg Biotin, 50.00mg Vitamin B5 as Calcium Pantothenate, 50.00mg Choline Bitartrate, 50.00mg Inositol, 75.00mg Nature's C Veggie Berry Blend, 65.00mg Organic Alkalizing Green Juice Powders, 47.00mg Organic Aqua Superfoods, 33.00mg Stress & Energy Adaptogens (Extracts), and 31.00mg Probiotics. Compared with Super Macho, it reduces recurring cost while keeping the formula nutritionally relevant; however, some blended ingredients lack individual amounts, which limits a complete comparison.</p>
73 Budget

B-50 Gels

Carlson
<p>A lower-cost serving retains useful Niacin, Thiamin, Vitamin B6 coverage through 50.00mg Vitamin B6 as Pyridoxine Hydrochloride, 50.00mg Niacin as Niacinamide, 50.00mg Riboflavin as Vitamin B2, 50.00mg Thiamine as Thiamine Mononitrate, 50.00mg Thiamine as Vitamin B1, 680.00mcg DFE Folate, 50.00mcg Vitamin B12 as Cyanocobalamin, 50.00mcg Biotin, 50.00mg Pantothenic Acid as D-Calcium Pantothenate, and 50.00mg Phosphatidyl Choline as Soybeans. Compared with Super Macho, it reduces recurring cost while keeping the formula nutritionally relevant; however, the substantial vitamin B6 amount may be unsuitable for long-term stacking.</p>
80 Value

B-Complex '100'

Solgar
<p>A practical quality-to-cost balance combines Vitamin B12, Niacin, Thiamin coverage with 100.00mg Thiamine as Thiamine Mononitrate, 100.00mg Niacin as Niacinamide, and 100.00mg Riboflavin as Vitamin B2. Compared with Super Macho, the ingredient depth is favorable for the serving cost; however, the substantial vitamin B6 amount may be unsuitable for long-term stacking.</p>
80 Value

B-100 Complex with B2 Coenzyme

Nature's Way
<p>A practical quality-to-cost balance combines Vitamin B12, Niacin, Thiamin coverage with 100.00mg Niacin as Niacinamide, 100.00mg Riboflavin as Riboflavin 5-Phosphate, 50.00mg Vitamin B6 as Pyridoxal 5-Phosphate, 100.00mg Thiamine as Vitamin B1, 100.00mg Riboflavin as Vitamin B2, 50.00mg Vitamin B6 as Pyridoxine Hydrochloride, 666.00mcg DFE Folate, 100.00mcg Vitamin B12 as Cyanocobalamin, 100.00mcg Biotin, 100.00mg Pantothenic Acid as Calcium D-Pantothenate, 25.00mg Choline as Choline Bitartrate, and 100.00mg Inositol. Compared with Super Macho, the ingredient depth is favorable for the serving cost; however, the substantial vitamin B6 amount may be unsuitable for long-term stacking.</p>
71 Value

B 50 Complex

Thompson
<p>A practical quality-to-cost balance combines Niacin, Thiamin, Vitamin B6 coverage with 50.00mg Niacin as Niacinamide, 50.00mg Vitamin B6 as Pyridoxine Hydrochloride, 50.00mg Riboflavin as Vitamin B2, 50.00mg Thiamine as Thiamine Mononitrate, 50.00mg Thiamine as Vitamin B1, 50.00mg Niacin as Vitamin B3, 400.00mcg Folic Acid, 50.00mcg Vitamin B12 as Cyanocobalamin, 50.00mcg Biotin, 50.00mg Pantothenic Acid as Calcium Pantothenate, and 205.00mg Base Complex Blend. Compared with Super Macho, the ingredient depth is favorable for the serving cost; however, some blended ingredients lack individual amounts, which limits a complete comparison.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  2. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  3. Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial.
    Namazzi R; Opoka R; Conroy AL; Datta D; Tagoola A; Bond C; Goings MJ; Ryu MS; Cusick SE; Krebs NF; Jang JH; Tu W; Ware RE; John CC · Blood advances · 2023
    Randomized trial252 participantsImmunity forZinc
  4. Intestinal and systemic immune responses to an oral cholera toxoid B subunit whole-cell vaccine administered during zinc supplementation.
    Karlsen TH; Sommerfelt H; Klomstad S; Andersen PK; Strand TA; Ulvik RJ; Ahrén C; Grewal HM · Infection and immunity · 2003
    Randomized trial30 participantsImmunity forZinc
  5. B Vitamins and Hip Fracture: Secondary Analyses and Extended Follow-Up of Two Large Randomized Controlled Trials.
    Garcia Lopez M; Bønaa KH; Ebbing M; Eriksen EF; Gjesdal CG; Nygård O; Tell GS; Ueland PM; Meyer HE · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Randomized trialBone Health forVitamin B6
  6. The association of homocysteine, folate, vitamin B12, and vitamin B6 with fracture incidence in older adults: a systematic review and meta-analysis.
    He T; Jin X; Koh YS; Zhang Q; Zhang C; Liu F · Annals of translational medicine · 2022
    Meta-analysis28 studies pooledBone Health forFolate Bone Health forVitamin B6
  7. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls.
    Saito M; Fujii K; Marumo K · Calcified tissue international · 2006
    Case-control study50 participantsBone Health forVitamin B6
  8. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate
  9. Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial.
    Oliai Araghi S; Kiefte-de Jong JC; van Dijk SC; Swart KMA; Ploegmakers KJ; Zillikens MC; van Schoor NM; de Groot LCPGM; Lips P; Stricker BH; Uitterlinden AG; van der Velde N · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial2,919 participantsBone Health forFolate
  10. Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status.
    McLean RR; Karasik D; Selhub J; Tucker KL; Ordovas JM; Russo GT; Cupples LA; Jacques PF; Kiel DP · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2004
    Cross-sectional study1,632 participantsBone Health forFolate
  11. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  12. Excess serum zinc concentration is associated with incident fracture in men: Tehran lipid and glucose study.
    Bahadoran Z; Hadaegh F; Azizi F; Ghasemi A · Scientific reports · 2026
    Cohort study1,968 participantsBone Health forZinc
  13. Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study.
    Hyun TH; Barrett-Connor E; Milne DB · The American journal of clinical nutrition · 2004
    Cohort study396 participantsBone Health forZinc
  14. Zinc supplementation and bone growth in pubertal girls.
    Clark PJ; Eastell R; Barker ME · Lancet (London, England) · 1999
    Randomized trial47 participantsBone Health forZinc
  15. The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A phase 2 randomized, placebo-controlled trial with a multi-arm, parallel-group design.
    Karandish M; Mozaffari-Khosravi H; Mohammadi SM; Cheraghian B; Azhdari M · Phytotherapy research : PTR · 2021
    Randomized trial84 participantsMetabolism Boost forZinc
  16. Relationship between zinc and glucose metabolism in Japanese adults.
    Suka M; Tsuruta H; Takao T; Yanagisawa H · Diabetology international · 2026
    Cross-sectional study533 participantsMetabolism Boost forZinc
  17. Antioxidant role of zinc in diabetes mellitus.
    Cruz KJ; de Oliveira AR; Marreiro Ddo N · World journal of diabetes · 2015
    Narrative reviewMetabolism Boost forZinc
  18. Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review.
    Banaszak M; Górna I; Przysławski J · Nutrients · 2021
    Narrative reviewMetabolism Boost forZinc
  19. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledBrain Health forFolate
  20. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
    Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
    Randomized trial136 participantsBrain Health forFolate
  21. Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
    Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
    Randomized trial220 participantsBrain Health forFolate
  22. Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
    Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
    Cohort study3,974 participantsBrain Health forFolate
  23. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
    Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
    Cohort study3,910 participantsBrain Health forFolate
  24. Combined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players.
    Bilgin S; Bozyılan E; Buzdağlı Y; Karaç Öcal Y; Gürkan O; Toktaş S; İnan H; Egil İ; Yarayan YE · Frontiers in nutrition · 2026
    Randomized trial24 participantsBrain Health forTyrosine
  25. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.
    Jongkees BJ; Hommel B; Kühn S; Colzato LS · Journal of psychiatric research · 2016
    Narrative reviewBrain Health forTyrosine
  26. Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans.
    Hensel C; Becker M; Düzel S; Demuth I; Norman K; Steinhagen-Thiessen E; Gallinat J; Lindenberger U; Kühn S · NeuroImage · 2019
    Cross-sectional study286 participantsBrain Health forTyrosine
  27. Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II.
    Plini ERG; Melnychuk MC; Harkin A; Dahl MJ; McAuslan M; Kühn S; Boyle RT; Whelan R; Andrews R; Düzel S; Drewelies J; Wagner GG; Lindenberger U; Norman K; Robertson IH; Dockree PM · The journal of nutrition, health & aging · 2023
    Cross-sectional study398 participantsBrain Health forTyrosine
  28. Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.
    Jongkees BJ · Cognitive, affective & behavioral neuroscience · 2021
    Randomized trial45 participantsBrain Health forTyrosine
  29. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  30. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health forVitamin B12
  31. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  32. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  33. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  34. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  35. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  36. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  37. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  38. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  39. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  40. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  41. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  42. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  43. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  44. Cognitive Effects of Taurine and Related Sulphur-Containing Amino Acids: A Systematic Review of Human Trials and Considerations for Plant-Based Dietary Transitions.
    Moore JA; Cousins AL; Taylor RMJ; Griffiths AR; Young HA · Foods (Basel, Switzerland) · 2026
    Systematic review244 participants8 studies pooledGeneral Health forTaurine
  45. Association between habitual dietary taurine intake and the risk of metabolic dysfunction-associated steatotic liver disease: a prospective cohort study.
    Zhang S; Xu X; Wang D; Gu Y; Wu H; Meng G; Zhang Q; Liu L; Borné Y; Niu K; Bai L · Food & function · 2026
    Cohort study16,699 participantsGeneral Health forTaurine
  46. Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials.
    Nie Z; Liu Y; Zhang M; Wu C; Cao Q; Xu J; Zheng Y; Min Z; Zhang W; Han S · Nutrition reviews · 2025
    Meta-analysis34 studies pooledGeneral Health forTaurine
  47. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  48. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  49. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  50. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  51. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  52. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  53. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  54. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  55. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  56. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  57. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  58. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  59. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  60. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  61. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  62. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  63. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  64. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  65. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  66. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  67. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  68. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  69. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  70. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  71. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  72. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  73. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  74. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  75. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  76. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  77. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  78. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc
  79. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  80. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  81. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  82. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  83. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc