Luteolin

non-nutrient_non-botanical
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Luteolin is a naturally occurring flavonoid, a class of plant-derived compounds known for their health benefits. It functions as a powerful antioxidant, helping to neutralize harmful free radicals and reduce oxidative stress throughout the body. Furthermore, luteolin exhibits strong anti-inflammatory effects by modulating various inflammatory pathways. Research also suggests its potential neuroprotective qualities, which may support cognitive function and overall brain health, making it a valuable compound for enhancing cellular resilience and systemic well-being.

Natural sources
CeleryParsleyBroccoliOnion leavesCarrotsPeppersCabbageApple skinsChamomile teaThymeDandelion

Ingredient forms

No public comparison lists found.

Timing & Intake
AnytimeWith foodTake with Meals to optimize absorption and reduce potential mild gastrointestinal upset.
Luteolin's absorption can be enhanced when taken with food due to the presence of dietary fats, which may improve its bioavailability.
Optimal Dosage
Minimum500 mg
Maximum1500 mg
Safety & Toxicity
Toxicity Threshold3000 mg
Toxicity EffectGastrointestinal distress, fatigue
3 safety notes
  • Pregnant or breastfeeding individuals should consult their healthcare provider before using luteolin.
  • Individuals taking anticoagulant (blood-thinning) medications should exercise caution and consult a doctor, as luteolin may possess mild blood-thinning properties.
  • Always discuss with a healthcare professional before starting any new supplement, especially if you have existing medical conditions or are on other medications.
Goals
Sleep Support
Sleep Support
Impact
Moderate effect
Typical dose:50–200 mg

Laboratory findings about luteolin’s antioxidant or nervous-system activity do not show that taking it improves human sleep. Direct clinical evidence is needed to support claims about falling asleep, fewer awakenings, or deeper sleep. Its value as an addition to a sleep blend remains uncertain.

Focuses on
Nervous system activityAntioxidant supportExperimental sleep research
Most relevant for
Individuals exploring experimental plant-based compounds who understand that sleep benefits are currently unproven in humans.

Potential benefits

  • Nervous System Interaction.Unconfirmed. Laboratory studies suggest potential effects on the nervous system, but these have not been confirmed to aid human sleep.
  • Antioxidant Activity.Unconfirmed. As a flavonoid, it exhibits antioxidant properties in pre-clinical models, though its impact on sleep quality remains theoretical.

Limitations

  • No Clinical Validation.There are currently no human clinical trials demonstrating that luteolin improves sleep onset, duration, or quality.
  • Indirect Evidence.Proposed mechanisms from laboratory findings are not sufficient evidence of effectiveness for human sleep concerns.

Study evidence

No published studies for this goal yet.

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Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Situational effect
Typical dose:50–200 mg

Luteolin is a powerful bioflavonoid that excels at stabilizing mast cells, reducing the release of histamine and other inflammatory mediators. This makes it particularly effective for allergy-related inflammation and neuroinflammation, offering targeted support beyond general antioxidants.

Focuses on
Mast cell stabilizationCytokine regulationNeuroinflammationAllergy-related inflammationHistamine inhibition
Most relevant for
Individuals seeking to support healthy inflammatory responses, particularly those related to mast cell activity or neurological pathways.

Potential benefits

  • Mast Cell Stabilization.Unconfirmed. Luteolin is suggested to help manage the release of histamine, though this effect is unconfirmed for this goal due to a lack of supplied research.
  • Cytokine Regulation.Unconfirmed. May influence the production of inflammatory cytokines; however, its specific impact on anti-inflammatory support remains unproven here.
  • Neurological Support.Unconfirmed. Proposed to assist with neuroinflammation, but clinical evidence in humans for this specific outcome was not provided.

Limitations

  • Unconfirmed Efficacy.The specific benefits for anti-inflammatory support are currently unproven as no direct research was provided in this context.
  • Absorption Constraints.Low bioavailability is a common limitation for flavonoids, which may impact the ingredient's effectiveness in reaching systemic targets.

Study evidence

No published studies for this goal yet.

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Studies

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Interactions

Positive Interactions

Vitamin C
May enhance the overall antioxidant capacity when combined with luteolin, contributing to greater protection against oxidative stress.
Vitamin E
Offers synergistic antioxidant effects with luteolin, leading to enhanced cellular protection from free radicals.
Selenium
Works synergistically with luteolin to bolster the body's antioxidant defense mechanisms.
Curcumin
Both compounds are renowned for their potent anti-inflammatory properties, potentially leading to a more pronounced anti-inflammatory effect when combined.
Green Tea
The catechins in green tea can offer synergistic antioxidant and anti-inflammatory benefits when taken with luteolin.
Coenzyme Q-10
Combined with luteolin, it can provide enhanced antioxidant support crucial for cellular energy production and protection.
Resveratrol
As another powerful polyphenol, resveratrol may synergistically enhance luteolin's antioxidant and anti-inflammatory actions.
Flavonoid
Luteolin itself is a flavonoid, and combining it with other flavonoids can lead to synergistic effects, amplifying overall health benefits.
Astaxanthin
Astaxanthin's powerful antioxidant properties can be complemented by luteolin, resulting in broader spectrum antioxidant protection.
Lycopene
Shows synergistic antioxidant effects with luteolin, particularly in protecting against oxidative stress.
carotenoids
Luteolin can work synergistically with various carotenoids to provide comprehensive antioxidant protection.
Omega-3
Omega-3 fatty acids, known for their anti-inflammatory effects, can synergize with luteolin's anti-inflammatory properties for enhanced benefit.
Fish Oil
The anti-inflammatory effects of fish oil (rich in Omega-3s) can be synergistic with luteolin's inflammatory modulation, offering comprehensive support.

Negative Interactions

Ginkgo
Both Ginkgo and luteolin may possess mild blood-thinning properties. Concurrent use, especially in higher doses or in individuals on anticoagulant medications, could theoretically increase the risk of bleeding. It is advisable to consult a healthcare professional.