GI Response

GI Response

INNATE Response Formulas4.9 (44 ratings)
Format:Powder Quantity: 8 Liquid(s) · 30 servings
Goals
$60.46 $2.01 per serving

Product analysis

47 out of 100

GI Response centers on glutamine for gut support, with possible benefits most relevant to a specific group with bowel symptoms after infection. The unspecified herbal preparations make it harder to compare the added ingredients with those used in research.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

The ingredient preparations and forms are not specified. That limits comparisons of glutamine and the herbal ingredients with more clearly identified alternatives.

Ingredient Transparency63

All listed amounts are stated, allowing serving comparisons. Specific forms and herbal preparations are not identified, making the ingredient details less clear.

Value For Money33

Glutamine offers limited value, while aloe is expensive at the serving price. The remaining ingredients lack a reliable cost comparison.

Customer Satisfaction74

Customer ratings are generally positive. The relatively small review pool limits how confidently satisfaction can be generalized.

Product Focus75

Gut support is the main purpose, with glutamine most relevant to selected bowel-symptom settings. The immune findings concern specific exercise or ingredient preparations and do not establish a routine benefit.

Format
Powder
Container
8 Liquid(s)
Per serving
$2.01
Customer rating
4.9 · 44 ratings
Report analysis

Goals

Gut Health
Impact
High effect
B+ Ingredient FitC- PathwaysB EvidenceA+ Formulation Logic
Glutamine · 5000 mg

Glutamine has a relevant intestinal-barrier role, but the positive symptom trial involved a selected group with post-infectious IBS with diarrhea and increased intestinal permeability. The 5 g per serving matches one dose in that trial, which used three doses daily, so it does not establish the trial's daily exposure or routine gut repair. Aloe received credit in the saved calculation, but its capsule mass cannot establish the standardized syrup exposure used in the supplied reflux study.

How this product is rated for Gut Health

Ingredient fit83

Glutamine and aloe received the saved contributions. Their disclosed amounts do not remove population and preparation limits.
Goal fit
The formula has a digestive focus, while two additional actives broaden its ingredient mix.
Dose adequacy
The saved amount comparison accepts glutamine and aloe; one 5 g glutamine serving is only one dose of the trial's three-dose daily regimen.

Pathways59

The saved findings emphasize intestinal-barrier functions, with a smaller gastric-mucosal contribution.
Depth
Intestinal-barrier functions are the strongest represented area, driven by glutamine's narrow clinical context.
Breadth
Only intestinal-barrier functions reach the breadth threshold; gastric-mucosal support remains below it.

Evidence79

Glutamine leads the saved evidence finding, with support restricted to a selected post-infectious IBS subgroup.
Evidence strength
Glutamine provides the leading saved evidence contribution; its selected patient population limits generalization.
Studied preparation
The saved check accepts both preparations, but aloe milligrams do not establish the standardized syrup exposure in the supplied study.

Formulation logic100

The credited ingredients can contribute independently, and no evaluated conflict was found.
Partner coverage
The credited ingredients retain their contributions without a missing required partner.
Conflicts
No evaluated ingredient conflict was identified.
Effective doses
All credited ingredients reach the saved minimum amount threshold; this is not proof of an effective clinical dose.
Study evidence
Aloe Supportive 7 studies
Glutamine Supportive 37 studies
Immunity
Impact
High effect
C+ Ingredient FitD+ PathwaysB+ EvidenceA+ Formulation Logic

Glutamine has limited evidence involving timed drinks after endurance exercise, which does not establish a routine immune benefit from this serving in general adults. The saved findings recognize glutamine, but its context limits that interpretation. Arabinogalactan evidence is specific to a verified ResistAid preparation in adults with recurrent colds; generic arabinogalactan does not establish the same effect.

How this product is rated for Immunity

Ingredient fit67

The relevant ingredients have a connection to immune support, with the strength of their amount findings varying by nutrient.
Goal fit
The formula includes relevant immune ingredients alongside ingredients aimed at other uses, which makes its immune focus less concentrated.
Dose adequacy
The known amount reaches the saved comparison range; this does not establish an optimal dose or additional benefit at higher exposure.

Pathways52

The strongest saved connection is barrier and antimicrobial defense. The supplied context limits transfer to routine adult benefit.
Depth
The strongest saved connection is barrier and antimicrobial defense. The supplied context limits transfer to routine adult benefit.
Breadth
The saved findings concentrate on one immune area, with limited breadth elsewhere.

Evidence83

The saved evidence finding is favorable, but the supplied scientific context does not establish a routine adult respiratory benefit.
Evidence strength
Glutamine leads the saved evidence finding; the supplied context does not establish a routine adult respiratory benefit.
Studied preparation
The preparation is accepted in the saved findings, but that does not resolve the supplied population, preparation or outcome limitations.

Formulation logic100

The recognized ingredients meet the partner checks, and no configured conflict was found. Amount uncertainties still limit ingredients whose quantities are unresolved.
Partner coverage
The recognized ingredients do not require an additional partner for the roles considered here.
Conflicts
No configured ingredient conflict was identified from the available facts; this does not establish overall safety.
Effective doses
The recognized ingredients reach the saved amount threshold; that threshold is a comparison point, not proof of clinical effectiveness.
Study evidence
Glutamine Supportive 36 studies

Ingredients

IngredientAmount per servingScore
L-Glutamine
5000 mg 70
Arabinogalactan
400 mg
Aloe vera gel extract
300 mg 51
Marshmallow root powder
200 mg
MSM
200 mg
Slippery Elm bark powder
200 mg
Sustamine
200 mg
Adults 18–50
Report overview
Glutamine · 5000 mg OverallScore70
C- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
Aloe · 300 mg OverallScore51
F Composition And Label DisclosureA+ Composition And Label DisclosureF Commercial Price And Usability
Each serving lists 300 mg of aloe vera gel extract. The whole-product price is about $2.02 per serving.
How this ingredient is rated

Composition and Label Disclosure22

Aloe vera gel is identified; the saved facts do not establish a qualifying purification process. An aloe extract is identified; no exact active-marker concentration is established in the saved facts.
Aloe Part and Processing Disclosure
Aloe vera gel is identified; the saved facts do not establish a qualifying purification process.
Marker and Preparation Disclosure
An aloe extract is identified; no exact active-marker concentration is established in the saved facts.

Composition and Label Disclosure100

The stated amount is 300 mg of aloe vera per serving.
Individual Preparation Amount Disclosure
The stated amount is 300 mg of aloe vera per serving.

Commercial Price and Usability10

The whole-product price is about $2.02 per serving.
Commercial Price per Labeled Serving
The whole-product price is about $2.02 per serving.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients.
    Sahebnasagh A; Ghasemi A; Akbari J; Alipour A; Lashkardoost H; Ala S; Hosseinimehr SJ; Salehifar E · BMC complementary medicine and therapies · 2020
    Randomized trial42 participantsGut Health forAloe
  2. Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial.
    Sahebnasagh A; Ghasemi A; Akbari J; Alipour A; Lashkardoost H; Ala S; Salehifar E · Journal of alternative and complementary medicine (New York, N.Y.) · 2017
    Randomized trial20 participantsGut Health forAloe
  3. Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial.
    Sahebnasagh A; Saghafi F; Ghasemi A; Akbari J; Alipour A; Habtemariam S; Safdari M; Ghaleno HR; Salehifar E · Journal of gastrointestinal cancer · 2022
    Randomized trial20 participantsGut Health forAloe
  4. A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study.
    Størsrud S; Pontén I; Simrén M · Journal of gastrointestinal and liver diseases : JGLD · 2016
    Randomized trial68 participantsGut Health forAloe
  5. A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life.
    Hutchings HA; Wareham K; Baxter JN; Atherton P; Kingham JG; Duane P; Thomas L; Thomas M; Ch'ng CL; Williams JG · ISRN gastroenterology · 2011
    Randomized trial110 participantsGut Health forAloe
  6. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis.
    Huang Y; Yang XZ; Qin SH; Zhang T; Xie M; Wang JW · World journal of gastrointestinal surgery · 2026
    Meta-analysis1,643 participants27 studies pooledGut Health Immunity forGlutamine
  7. Glutamine prevents diarrhea in colorectal cancer patients undergoing chemotherapy or chemoradiotherapy: a meta-analysis.
    Chen L; Wang D; Meng C; Sun H; Li R; Miao G; Liu P · BMC gastroenterology · 2025
    Meta-analysis311 participants5 studies pooledGut Health forGlutamine
  8. Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner.
    Pugh JN; Sage S; Hutson M; Doran DA; Fleming SC; Highton J; Morton JP; Close GL · European journal of applied physiology · 2018
    Randomized trial10 participantsGut Health forGlutamine
  9. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea.
    Yalçin SS; Yurdakök K; Tezcan I; Oner L · Journal of pediatric gastroenterology and nutrition · 2004
    Randomized trial128 participantsGut Health forGlutamine
  10. Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trial.
    Leite RD; Lima NL; Leite CA; Farhat CK; Guerrant RL; Lima AA · Arquivos de gastroenterologia · 2013
    Randomized trial46 participantsGut Health forGlutamine
  11. Meta-analysis of Glutamine on Immune Function and Post-Operative Complications of Patients With Colorectal Cancer.
    Yang T; Yan X; Cao Y; Bao T; Li G; Gu S; Xiong K; Xiao T · Frontiers in nutrition · 2021
    Meta-analysis2,201 participants31 studies pooledImmunity forGlutamine
  12. Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
    Dong S; Zhao Z; Li X; Chen Z; Jiang W; Zhou W · Frontiers in nutrition · 2023
    Meta-analysis1,201 participants30 studies pooledImmunity forGlutamine
  13. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial.
    Garrel D; Patenaude J; Nedelec B; Samson L; Dorais J; Champoux J; D'Elia M; Bernier J · Critical care medicine · 2003
    Randomized trial45 participantsImmunity forGlutamine
  14. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control.
    Wischmeyer PE; Lynch J; Liedel J; Wolfson R; Riehm J; Gottlieb L; Kahana M · Critical care medicine · 2001
    Randomized trial26 participantsImmunity forGlutamine