Total Cleanse Liver

Total Cleanse Liver

Solaray4.8 (2,393 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 30 servings
Goals
$23.19 $0.77 per serving

Product analysis

48 out of 100

Total Cleanse Liver supplies selenium for normal immune and antioxidant functions, particularly when intake is low. Its unidentified blend makes the added ingredients’ contribution difficult to judge.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality37

The selenium form is named but has only moderate form quality. Unidentified blend ingredients and unspecified forms leave much of the mixture’s quality uncertain.

Ingredient Transparency62

All listed amounts are disclosed, helping you check the serving. Most forms and the blend contents remain unspecified, leaving important parts of the mixture unclear.

Value For Money27

Selenium is expensive for the amount provided, while glutathione offers limited serving value. Value for the remaining components is uncertain, making the mixture harder to compare.

Customer Satisfaction88

Customer ratings are highly favorable across a substantial review base. That gives a broad satisfaction picture, without establishing cleansing effects.

Product Focus40

The clearest supported roles are selenium’s normal immune and antioxidant functions. Unidentified blend ingredients make the full formula and their added contribution uncertain.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.77
Customer rating
4.8 · 2,393 ratings
Report analysis

Goals

Immunity
Impact
Highest effect
B+ Ingredient FitD+ PathwaysA- EvidenceA+ Formulation Logic
Vitamin C · 120 mgSelenium · 100 mcg

Selenium contributes to normal immune function, without establishing extra protection when intake is adequate. The serving amount is compared with the saved reference, which does not establish an optimal dose or greater benefit at higher exposure.

How this product is rated for Immunity

Ingredient fit83

The counted amounts reach the saved comparison levels, without establishing an optimal intake or additional benefit above them.
Goal fit
The formula includes immunity-related ingredients alongside ingredients directed at other goals.
Dose adequacy
The counted amounts reach the saved comparison levels, without establishing an optimal intake or additional benefit above them.

Pathways53

The strongest saved connection is oxidative and inflammatory balance, rather than a direct measure of infection protection.
Depth
The strongest saved connection is oxidative and inflammatory balance, rather than a direct measure of infection protection.
Breadth
The saved findings cover oxidative and inflammatory balance.

Evidence85

Selenium provides the leading saved contribution; its supported role does not establish infection prevention.
Evidence strength
Selenium provides the leading saved contribution; its supported role does not establish infection prevention.
Studied preparation
The saved findings accept the preparations with sufficient amounts; this does not establish testing of the complete formula.

Formulation logic100

All counted ingredients reach the saved minimum amount threshold, which is not proof of clinical effectiveness.
Partner coverage
The counted ingredients can contribute without an additional partner; this does not establish synergy.
Conflicts
No configured ingredient conflict was identified.
Effective doses
All counted ingredients reach the saved minimum amount threshold, which is not proof of clinical effectiveness.
Study evidence
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
Everyday Health
Impact
High effect
B Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Selenium · 100 mcgVitamin C · 120 mg

Selenium supplies a nutrient involved in normal immune and antioxidant functions. The nutritional contributions are most useful when intake is low; extra benefit with adequate intake is not established.

How this product is rated for Everyday Health

Ingredient fit76

Selenium and the other relevant nutrients provide the main connection to general health. Additional actives make the formula less focused on this goal.
Goal fit
Relevant nutrients contribute to general health, alongside other actives with less direct support for this goal.
Dose adequacy
The relevant amounts reach the saved nutritional comparison endpoints; larger amounts do not establish greater benefit.

Pathways60

The strongest area is antioxidant and immune defence. Contributions also reach the saved coverage level across antioxidant and immune defence.
Depth
The strongest supported area is antioxidant and immune defence, through the relevant nutrient contributions.
Breadth
The supported areas reaching the saved coverage level are antioxidant and immune defence.

Evidence82

Selenium provides the strongest supported contribution. The supplied context limits routine expectations to filling nutritional gaps rather than improving outcomes in adequately nourished adults.
Evidence strength
Selenium provides the strongest supported contribution here; usefulness remains conditional on the relevant nutritional or population context.
Studied preparation
The relevant preparations match those recognized by the saved findings; this does not establish superiority of a form or delivery method.

Formulation logic100

The relevant ingredients can contribute independently, and no configured conflict was found. Their presence together does not establish an added combination benefit.
Partner coverage
The relevant ingredients can contribute independently or have their required partners present; no extra combination benefit is established.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
All ingredients retained for contribution meet the saved amount threshold; that threshold does not prove a clinical benefit.
Study evidence
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid, Natural)
120 mg
Selenium (Selenomethionine)
100 mcg 58
Total Cleanse Liver Blend
635 mg
N-Acetyl Cysteine
200 mg
L-Glutathione
25 mg 24
Adults 18–50
Report overview
D+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
A serving provides 100 mcg of selenium as selenomethionine. The saved information does not specify its L form.
How this ingredient is rated

Active Ingredient Quality & Bioavailability53

Selenomethionine is identified, but the saved information does not specify its L form.
Selenium Chemical Form
The selenium is recorded as selenomethionine, without an identified L form.
Form Transparency & Isomer Specificity
Selenomethionine is named, but the saved facts do not specify its L form.

Dose, Safety & Label Transparency88

The serving provides 100 mcg of selenium. It falls below the upper limit used in the evaluation, though food and other sources also contribute to total intake.
Dosage Efficacy Sweet Spot
A serving supplies 100 mcg of selenium, an amount used for selenium support.
Safety Margin & UL Adherence
The 100 mcg in a serving is below the upper limit used in the evaluation; food and other products also contribute to total selenium intake.

Value10

At the listed price, about $1.55 of the whole product corresponds to 200 mcg of selenium. The cost also covers any other ingredients.
Price per 200 mcg Serving
At the listed price, about $1.55 of the whole product corresponds to 200 mcg of selenium. The cost also covers any other ingredients.
Gluthathione · 25 mg OverallScore24
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyD- Value
The serving lists 25 mg of glutathione, a small amount the evaluation considers unlikely to provide systemic antioxidant support. The saved facts do not specify the form, limiting comparisons of absorption.
How this ingredient is rated

Active Ingredient Quality & Bioavailability14

The saved facts identify glutathione but do not specify its form, so its absorption characteristics cannot be compared from these facts.
Glutathione Form and Delivery System
The saved facts identify glutathione but do not specify its form, so its absorption characteristics cannot be compared from these facts.
Branded Ingredients and Purity Signals
The saved facts do not identify a branded glutathione source or a specific purity claim.

Dose, Safety & Label Transparency26

The listed 25 mg per serving is a small amount that the evaluation considers unlikely to provide systemic antioxidant support. The amount is individually listed as 25 mg per serving. The saved facts also indicate flow agents.
Glutathione Potency per Serving
The listed 25 mg per serving is a small amount that the evaluation considers unlikely to provide systemic antioxidant support.
Label Transparency and Excipient Quality
The amount is individually listed as 25 mg per serving. The saved facts also indicate flow agents.

Value40

The whole-product serving costs about $0.77.
Price per Bioavailable Serving
The whole-product serving costs about $0.77.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: results of a double-blind, randomised trial.
    Smyth JF; Bowman A; Perren T; Wilkinson P; Prescott RJ; Quinn KJ; Tedeschi M · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trial151 participantsEveryday Health forGluthathione
  2. Glutathione and morbidity in a community-based sample of elderly.
    Julius M; Lang CA; Gleiberman L; Harburg E; DiFranceisco W; Schork A · Journal of clinical epidemiology · 1995
    Cross-sectional study33 participantsEveryday Health forGluthathione
  3. The role of zinc, copper, plasma glutathione peroxidase enzyme, and vitamins in the development of allergic diseases in early childhood: The Polish mother and child cohort study.
    Stelmach I; Grzelewski T; Bobrowska-Korzeniowska M; Kopka M; Majak P; Jerzynska J; Stelmach W; Polańska K; Sobala W; Gromadzińska J; Wąsowicz W; Hanke W · Allergy and asthma proceedings · 2014
    Cohort study240 participantsEveryday Health forGluthathione
  4. Status of glutathione and other thiols and disulfides in human plasma.
    Kleinman WA; Richie JP · Biochemical pharmacology · 2000
    Cross-sectional studyEveryday Health forGluthathione
  5. Impact of a tailored exercise regimen on physical capacity and plasma proteome profile in post-COVID-19 condition.
    Chowdhury MMH; Fontaine MN; Lord SE; Quenum AJI; Limoges MA; Rioux-Perreault C; Lucier JF; Cliche DO; Levesque D; Boisvert FM; Cantin AM; Allard-Chamard H; Menendez A; Ilangumaran S; Piché A; Dionne IJ; Ramanathan S · Frontiers in physiology · 2024
    Single-arm trialEveryday Health forGluthathione
  6. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledEveryday Health forSelenium
  7. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledEveryday Health forSelenium
  8. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledEveryday Health forSelenium
  9. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsEveryday Health forSelenium
  10. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledEveryday Health forSelenium
  11. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledEveryday Health forVitamin C
  12. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEveryday Health forVitamin C
  13. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsEveryday Health forVitamin C
  14. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsEveryday Health forVitamin C
  15. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsEveryday Health forVitamin C
  16. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  17. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  18. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  19. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  20. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium