Sinuplex

Sinuplex

Metagenics4.7 (26 ratings)
Format:Tablet Quantity: 120 Tablet(s) · 120 servings
Goals
$49.95 $0.41 per serving

Product analysis

41 out of 100

Sinuplex brings several ingredients together for the convenience of one supplement. Most forms are undisclosed, making the preparations harder to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality24

Ingredient quality remains uncertain because most preparations are not identified. Vitamin C has a named form, but that alone does not establish quality for the mixture.

Ingredient Transparency70

All listed amounts are stated, making servings easier to compare. Only vitamin C has a named form, leaving the remaining preparations unclear.

Value For Money48

The serving price is favorable when considered as a source of nettle but high relative to the bromelain amount. Value for the remaining ingredients is uncertain.

Customer Satisfaction70

Customer ratings are positive. The very small number of responses leaves the wider satisfaction pattern uncertain.

Product Focus0

The combination has a narrow intended purpose, but a clear benefit remains uncertain. Its several ingredients make it more complex than a supplement chosen for one ingredient alone.

Format
Tablet
Container
120 Tablet(s)
Per serving
$0.41
Customer rating
4.7 · 26 ratings
Report analysis

Goals

Inflammation
Impact
Limited evidence
F Ingredient FitF PathwaysF EvidenceF Formulation Logic
Vitamin C · 150 mg
Study evidence
Bromelain Supportive 12 studies
Vitamin C Supportive 50 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
150 mg
Quercetin
200 mg
Stinging Nettle Root Extract
100 mg 92
Bromelain
50 mg 60
N-Acetylcysteine
25 mg
Gluten Free Adults 18–50
Report overview
B+ Composition And Label DisclosureA+ Composition And Label DisclosureA+ Commercial Price And Usability
The serving provides 100 mg of nettle at a low cost per serving. It uses nettle extract, though the available plant-part detail does not specify root or leaf.
How this ingredient is rated

Composition and Label Disclosure80

The nettle extract has a root or leaf disclosure, though the available detail does not say which. A ratio or marker standardization is not specified in the available information.
Root or Leaf Identity Disclosure
A root or leaf disclosure is recorded for the nettle extract, though the available detail does not specify which.
Nettle Preparation and Marker Detail
The nettle is an extract; a ratio or marker standardization is not specified in the available information.

Composition and Label Disclosure100

The selected serving's nettle amount is stated as 100 mg.
Nettle Amount Disclosure
The selected serving's nettle amount is stated as 100 mg.

Commercial Price and Usability100

The cost per selected serving is low.
Selected-Serving Price Comparison
The cost per selected serving is low.
Bromelain · 50 mg OverallScore60
A+ Composition And Label DisclosureD- Composition And Label DisclosureF Commercial Price And Usability
A serving states 50 mg of bromelain. The whole-serving price relative to 500 mg of declared bromelain is high. The stated activity is 2400 GDU per gram. The botanical source is unspecified.
How this ingredient is rated

Composition and Label Disclosure100

The stated activity is 2400 GDU per gram.
Enzyme Activity Disclosure
The stated activity is 2400 GDU per gram.
Declared GDU per Gram
The preparation states 2400 GDU per gram.

Composition and Label Disclosure40

A serving states 50 mg of bromelain. The botanical source is unspecified.
Declared Bromelain Mass
A serving states 50 mg of bromelain.
Botanical Source Disclosure
The botanical source is unspecified.

Commercial Price and Usability20

The whole-serving price relative to 500 mg of declared bromelain is high.
Cost per 500 mg Declared Bromelain
The whole-serving price relative to 500 mg of declared bromelain is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study.
    Ordesi P; Pisoni L; Nannei P; Macchi M; Borloni R; Siervo S · Quintessence international (Berlin, Germany : 1985) · 2016
    Randomized trial80 participantsInflammation forBromelain
  2. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
    Mendes ML; do Nascimento-Júnior EM; Reinheimer DM; Martins-Filho PR · Medicina oral, patologia oral y cirugia bucal · 2019
    Meta-analysis6 studies pooledInflammation forBromelain
  3. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain.
    Müller S; März R; Schmolz M; Drewelow B; Eschmann K; Meiser P · Phytotherapy research : PTR · 2013
    Randomized trial12 participantsInflammation forBromelain
  4. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study.
    Colletti A; Procchio C; Pisano M; Martelli A; Pellizzato M; Cravotto G · Nutrients · 2024
    Randomized trial42 participantsInflammation forBromelain
  5. Therapeutic uses of pineapple-extracted bromelain in surgical care - A review.
    Muhammad ZA; Ahmad T · JPMA. The Journal of the Pakistan Medical Association · 2019
    Narrative reviewInflammation forBromelain
  6. The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trial.
    Namazi N; Esfanjani AT; Heshmati J; Bahrami A · Pakistan journal of biological sciences : PJBS · 2012
    Randomized trial50 participantsInflammation forStinging Nettle
  7. Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial.
    Akbar Karami A; Sheikhsoleimani M; Reza Memarzadeh M; Haddadi E; Bakhshpour M; Mohammadi N; Mehdi Mirhashemi S · Pakistan journal of biological sciences : PJBS · 2021
    Randomized trial60 participantsInflammation forStinging Nettle
  8. Safety, Tolerability, and Efficacy of Hox Alpha, a Dry Extract from Stinging Nettle Leaves versus OTC NSAIDs in Osteoarthritis: A Retrospective, Propensity-Matched 12-Week Analysis from the German Pain e-Registry (SIPHARO Study).
    Überall MA; Küster MA; Müller-Schwefe PCG; Müller-Schwefe GHH · Journal of pain research · 2026
    Cohort study2,146 participantsInflammation forStinging Nettle
  9. [Recommendations of the DGRh Committee on Complementary Medicine and Nutrition on the application of selected phytotherapeutic drugs and herbal medicines in rheumatology].
    Keyßer G; Seifert O; Frohne I; Michalsen A; Pfeil A; Reuß-Borst M; Sander O · Zeitschrift fur Rheumatologie · 2025
    Guideline / consensusInflammation forStinging Nettle
  10. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain
    C Randall, H Randall, F Dobbs, C Hutton, H Sanders · Journal of the Royal Society of Medicine · 2000
    Randomized trial27 participantsInflammation forStinging Nettle
  11. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsInflammation forVitamin C
  12. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledInflammation forVitamin C
  13. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledInflammation forVitamin C
  14. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledInflammation forVitamin C
  15. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsInflammation forVitamin C