E-400 D-Alpha with Mixed Tocopherols

E-400 D-Alpha with Mixed Tocopherols

NOW4.8 (674 ratings)
Format:Softgel Quantity: 100 Softgel(s) · 100 servings
Goals

Product analysis

72 out of 100

E-400 D-Alpha with Mixed Tocopherols pairs vitamin E with selenium for nutritional support of normal antioxidant and immune functions when intake is low. Missing proportions within the vitamin E mixture limit close comparison with other products.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality70

Selenium-enriched yeast is a favorable selenium form. Vitamin E quality remains uncertain, and its different declarations do not establish one reliable combined total.

Ingredient Transparency80

The listed amounts and forms are disclosed. Missing proportions within the vitamin E mixture still prevent a complete composition comparison.

Value For Money52

Selenium offers moderate value at the whole-product cost. Value for the vitamin E contribution cannot be judged confidently.

Customer Satisfaction81

Customer feedback is very positive across several hundred ratings. The review base describes satisfaction without establishing immune benefits.

Product Focus84

The small ingredient list keeps the purpose centered on nutritional antioxidant and immune support. Extra benefit is uncertain when selenium and vitamin E needs are already met.

Format
Softgel
Container
100 Softgel(s)
Per serving
$0.15
Customer rating
4.8 · 674 ratings
Report analysis

Goals

Immunity
Impact
Highest effect
A Ingredient FitC PathwaysA- EvidenceA+ Formulation Logic
Selenium · 100 mcg
Study evidence
Selenium Mixed 37 studies
Vitamin E Supportive 21 studies
Everyday Health
Impact
Highest effect
A Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Selenium · 100 mcg
Study evidence
Selenium Supportive 70 studies

Ingredients

IngredientAmount per servingScore
Vitamin E (D-Alpha-Tocopherol)
268 mg
Selenium (Selenium Yeast)
100 mcg 80
Mixed Tocopherols (D-Beta Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol)
48 mg
Gluten Free Adults 18–50 Kosher Dairy Free
Report overview
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value
100 mcg of selenium per serving supports daily maintenance. The cost is moderate relative to the selenium supplied. The selenium comes from Selenium-enriched Yeast.
How this ingredient is rated

Active Ingredient Quality & Bioavailability81

The selenium comes from Selenium-enriched Yeast.
Selenium Chemical Form
The selenium comes from Selenium-enriched Yeast.
Form Transparency & Isomer Specificity
The label names Selenium-enriched Yeast, without a specific branded source.

Dose, Safety & Label Transparency88

100 mcg of selenium per serving supports daily maintenance. The 100 mcg serving is below the 400 mcg adult upper limit, leaving room for selenium from food.
Dosage Efficacy Sweet Spot
100 mcg of selenium per serving supports daily maintenance.
Safety Margin & UL Adherence
The 100 mcg serving is below the 400 mcg adult upper limit, leaving room for selenium from food.

Value60

The cost is moderate relative to the selenium supplied.
Price per 200 mcg Serving
The cost is moderate relative to the selenium supplied.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledEveryday Health forSelenium
  2. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledEveryday Health forSelenium
  3. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledEveryday Health forSelenium
  4. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsEveryday Health forSelenium
  5. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledEveryday Health forSelenium
  6. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  7. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  8. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  9. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  10. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  11. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects.
    Meydani SN; Barklund MP; Liu S; Meydani M; Miller RA; Cannon JG; Morrow FD; Rocklin R; Blumberg JB · The American journal of clinical nutrition · 1990
    Randomized trial32 participantsImmunity forVitamin E
  12. Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
    Chen S; Ahmad B; Palanisamy UD; Hafid SRA; Selvaduray KR; Radhakrishnan AK · Nutrition research (New York, N.Y.) · 2026
    Randomized trial150 participantsImmunity forVitamin E
  13. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.
    Mahalingam D; Radhakrishnan AK; Amom Z; Ibrahim N; Nesaretnam K · European journal of clinical nutrition · 2011
    Randomized trialImmunity forVitamin E
  14. Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
    Hemilä H; Virtamo J; Albanes D; Kaprio J · Chest · 2004
    Randomized trial29,133 participantsImmunity forVitamin E
  15. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial.
    Meydani SN; Meydani M; Blumberg JB; Leka LS; Siber G; Loszewski R; Thompson C; Pedrosa MC; Diamond RD; Stollar BD · JAMA · 1997
    Randomized trial88 participantsImmunity forVitamin E