Advanced UC-II Joint Relief

Advanced UC-II Joint Relief

NOW4.8 (5,801 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals

Product analysis

59 out of 100

Advanced UC-II Joint Relief combines cartilage, hyaluronic acid and nutrients, with vitamin D able to help cover a dietary shortfall. The blend contents are not fully identified, making the complete formula harder to assess.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality58

The boron form is a strength, while the quality of several other forms remains uncertain. Unspecified cartilage details and unidentified blend components limit a closer comparison.

Ingredient Transparency75

Ingredient amounts and most forms are listed, which helps you compare servings. The cartilage form and the blend composition remain unspecified.

Value For Money37

The cost is relatively high if boron is your main reason for buying the formula. Value for vitamin D, calcium and hyaluronic acid remains uncertain.

Customer Satisfaction91

Customer feedback is very positive across thousands of ratings. That gives a substantial view of satisfaction without showing whether the formula produces a particular health benefit.

Product Focus40

Vitamin D can support nutritional adequacy, but that does not establish a general testosterone increase. The small calcium contribution and unresolved collagen amount also limit what can be concluded about broader benefits.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.38
Customer rating
4.8 · 5,801 ratings
Report analysis

Goals

Everyday Health
Impact
High effect
C- Ingredient FitD PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 25 mcgBoron · 3 mg
Study evidence
Boron Supportive 6 studies
Vitamin D Supportive 115 studies
Impact
Moderate effect
D+ Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 25 mcgBoron · 3 mg
Study evidence
Boron Disputed 3 studies
Vitamin D Supportive 56 studies

Ingredients

IngredientAmount per servingScore
Vitamin D3 (Cholecalciferol)
25 mcg
Calcium (Aquamin TG)
15 mg
UC-II Standardized Chicken Cartilage
40 mg
Aquamin TG (Lithothamnium spp.)
50 mg
Hyaluronic Acid (Sodium Hyaluronate)
25 mg
Boron (Bororganic Glycine)
3 mg 86
Gluten Free Adults 18–50 Dairy Free
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
A serving provides 3 mg of boron, and the cost for that amount is high when the full serving price is used. It uses Bororganic Glycine.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The source is Bororganic Glycine. Bororganic Glycine is a trademarked source.
Boron Form & Bioavailability
The source is Bororganic Glycine.
Trademarked & High-Purity Sources
Bororganic Glycine is a trademarked source.

Dose, Safety & Label Transparency100

The serving provides 3 mg of elemental boron. The amount and source are stated.
Elemental Dose Transparency
The elemental boron amount and source are stated.
Dosage Efficacy & Safety Margin
The serving provides 3 mg of elemental boron.

Value30

The cost is high for the amount of boron, based on the full serving price.
Price per 3mg Elemental Boron
The cost is high for the amount of boron, based on the full serving price.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM · Complementary therapies in clinical practice · 2015
    Randomized trial113 participantsEveryday Health forBoron
  2. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; González Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R · Journal of the American Academy of Dermatology · 2015
    Randomized trialEveryday Health forBoron
  3. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT · Journal of drugs in dermatology : JDD · 2015
    Clinical trial336 participantsEveryday Health forBoron
  4. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; Franzén L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2009
    Single-arm trial30 participantsEveryday Health forBoron
  5. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei · Biological Trace Element Research · 2015
    Randomized trial78 participantsEveryday Health forBoron
  6. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledEveryday Health forVitamin D
  7. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsEveryday Health forVitamin D
  8. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledEveryday Health forVitamin D
  9. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledEveryday Health forVitamin D
  10. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledEveryday Health forVitamin D
  11. Biochemical and physiologic consequences of boron deprivation in humans.
    Nielsen FH · Environmental health perspectives · 1995
    Single-arm trial12 participantsTestosterone Support forBoron
  12. Plasma boron and the effects of boron supplementation in males.
    Green NR; Ferrando AA · Environmental health perspectives · 1995
    Randomized trial19 participantsTestosterone Support forBoron
  13. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
    Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour · Journal of Trace Elements in Medicine and Biology · 2011
    Non-randomized trial8 participantsTestosterone Support forBoron
  14. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  15. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  16. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  17. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  18. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D