Highest effect
Magnesium
Mineral
Impact
Highest effect
Typical dose:200–400 mg / day
While essential for hundreds of enzymatic reactions, magnesium's key role here is its ability to inhibit SHBG from binding to testosterone. This action increases the amount of 'free' testosterone circulating in the body, which is the form that is biologically active and can exert its effects on tissues.
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Vitamin D
Vitamin
Impact
Highest effect
Typical dose:1000–4000 IU / day
Vitamin D receptors are present in the testes, and as a secosteroid hormone, it plays a direct role in the synthesis of testosterone. Numerous studies have shown a significant positive association between blood Vitamin D levels and total testosterone, making the correction of any deficiency a foundational step.
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Zinc
Mineral
Impact
Highest effect
Typical dose:15–30 mg / day
Zinc is a critical cofactor for enzymes involved in testosterone production. It also plays a role in inhibiting aromatase, the enzyme that converts testosterone to estrogen. Deficiency, which can be common in athletes, is directly linked to hypogonadism and low testosterone.
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High effect
Ashwagandha
Botanical
Impact
High effect
Typical dose:300–600 mg / day
Ashwagandha's primary mechanism is the significant reduction of cortisol levels. Chronically elevated cortisol can suppress the hypothalamic-pituitary-gonadal (HPG) axis, leading to lower testosterone. By mitigating this stress response, Ashwagandha creates a more favorable anabolic environment, with multiple clinical trials showing direct increases in testosterone levels.
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Boron
Mineral
Impact
High effect
Typical dose:3–10 mg / day
The evidence for Boron's ability to significantly decrease Sex Hormone-Binding Globulin (SHBG) and thereby increase free testosterone is quite robust, especially in the short term. This places its efficacy above other situational botanicals. The current classification undervalues its direct and measurable impact on key hormonal markers.
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Creatine
Other
Impact
High effect
Creatine's ability to increase DHT, a powerful testosterone metabolite, is well-documented. This hormonal shift, combined with its primary effect of improving strength and work capacity, creates a highly anabolic environment. A priority of 0 is a significant error for a supplement with such relevant and proven effects.
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Fish Oil
Fatty Acid
Impact
High effect
Typical dose:1000–3000 mg / day
The health of cell membranes in the Leydig cells of the testes is critical for proper hormone production. Omega-3s improve membrane fluidity and function. Studies suggest that higher omega-3 intake is associated with improved testicular function and higher levels of Luteinizing Hormone (LH), a precursor signal for testosterone production.
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Melatonin
Other
Impact
High effect
The majority of daily testosterone release occurs during sleep. Melatonin supplementation can normalize circadian rhythms and improve sleep architecture, directly addressing a common and potent cause of suppressed testosterone levels. Quality sleep is essential for a healthy hormonal profile.
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Moderate effect
Selenium
Mineral
Impact
Moderate effect
Selenium is vital for creating antioxidant enzymes that preserve the health of Leydig cells, where testosterone is synthesized. Protecting these cells from oxidative stress is crucial for maintaining optimal hormone production. A priority of 0 overlooks its important role in testicular health.
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Vitamin E
Vitamin
Impact
Moderate effect
The testes are highly susceptible to oxidative damage, which can disrupt the sensitive process of steroidogenesis. As a primary fat-soluble antioxidant, Vitamin E neutralizes free radicals within the lipid membranes of testicular cells, ensuring the integrity and efficiency of testosterone production.
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Situational effect
Aspartic Acid
Amino Acid
Impact
Situational effect
D-Aspartic Acid (DAA) acts as a signaling molecule to stimulate LH release, which signals testosterone production. While effective, the impact is often transient and most significant in untrained or sub-fertile men. A priority of 0 is too low; it should be classified as a low-tier situational supplement.
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Cordyceps
Botanical
Impact
Situational effect
Animal studies show Cordyceps can stimulate testosterone production, possibly by mimicking the action of Luteinizing Hormone (LH) on Leydig cells. As an adaptogen, it may also help modulate the body's stress response, creating a more favorable environment for hormone production.
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Fenugreek
Botanical
Impact
Situational effect
Typical dose:500–600 mg / day
Fenugreek is rich in furostanolic saponins, which are believed to inhibit the enzymes aromatase and 5-alpha-reductase. By reducing the conversion of testosterone to estrogen and DHT, it may help support higher levels of free testosterone, with studies showing positive effects on libido and body composition.
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Ginger
Botanical
Impact
Situational effect
Typical dose:1000–2000 mg / day
Emerging research, particularly in men with oxidative stress-related infertility, indicates that ginger can increase testosterone levels. Its proposed mechanisms include stimulating LH production, increasing cholesterol levels within the testes for hormone synthesis, and reducing oxidative damage to Leydig cells.
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Stinging Nettle
Botanical
Impact
Situational effect
Typical dose:300–600 mg / day
Stinging Nettle root contains compounds called lignans that have a high affinity for Sex Hormone-Binding Globulin (SHBG). By occupying binding sites on SHBG, it leaves less of the protein available to bind and inactivate testosterone, thereby increasing the amount of free, bioavailable testosterone.
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Taurine
Amino Acid
Impact
Situational effect
Research suggests taurine can act at the level of the hypothalamus to increase Luteinizing Hormone (LH) release, a direct precursor signal for testosterone production. It also functions as an antioxidant within the testes, preserving the health of testosterone-producing Leydig cells.
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Vitamin B6
Vitamin
Impact
Situational effect
Vitamin B6 is a crucial cofactor for steroid hormone synthesis and helps regulate prolactin levels, which can be antagonistic to testosterone. A priority of 0 undervalues its essential supportive role in maintaining hormonal equilibrium.
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