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NAC 500 mg with Milk Thistle

4.8
★ ★ ★ ★ ★
(2727 ratings)
Milk Thistle 300 mg
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Score79
A sensible NAC and milk thistle pairing is held back by unclear silymarin potency and a token broccoli addition.
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Capsule
Quantity:60 Capsule(s) • (30 servings)
Goals:
Detoxification

Score 79

A sensible NAC and milk thistle pairing is held back by unclear silymarin potency and a token broccoli addition.
How scoring works
$19.97($0.66 per serving)
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$ 24.99
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$ 21.99
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$ 19.97
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Analysis

NAC supplies 500 mg per capsule serving and supports glutathione production. Milk thistle seed extract adds a complementary botanical component, while broccoli powder offers a small food-based addition.

The milk thistle entry does not identify silymarin percentage or active yield. Fifty milligrams of broccoli powder is modest and no glucoraphanin or sulforaphane content is stated.

Adults seeking NAC with basic milk thistle in one product are the best fit. Anyone wanting a precise milk thistle dose should choose a standardized extract alongside NAC.

Who is it for
  • Adults seeking NAC with milk thistle
  • People wanting combined glutathione and botanical support
  • Users who prefer a compact two-capsule serving
Best for
  • NAC supplementation
  • Combined antioxidant support
  • Basic milk thistle use

Pros

  • Provides 500 mg of NAC
  • Pairs NAC with milk thistle
  • Discloses all ingredient weights

Cons

  • Silymarin potency is unknown
  • Broccoli powder amount is small
  • Requires two capsules per serving

Warnings

  • NAC may cause nausea or reflux and can intensify headache or low blood pressure in people using nitroglycerin.
  • Milk thistle can cause allergic reactions in people sensitive to ragweed-family plants.
  • NAC may add to glucose-lowering effects in people taking insulin or diabetes medicines.

Nutrient quality

85 Highest impact

N-acetyl-cysteine is a useful glutathione precursor, while the milk thistle extract lacks silymarin standardization. The N-acetyl-cysteine amount is useful and the milk thistle extract weight is substantial, though active yield is uncertain.

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Ingredient transparency

79 High impact

Active ingredients generally have stated amounts and no proprietary blend hides a dose. Serving counts are available, while full directions and the other-ingredients list are missing.

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Customer satisfaction

70 High impact

The supplied aggregate rating is strong and the rating volume provides some confidence in that metric. No comment-level evidence is available to assess recurring complaints or confirm how experience matches the intended purpose.

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Value for money

82 Highest impact

Useful multi-pathway dosing supports reasonable value despite incomplete milk thistle specification. The focused three-active formula compares well with broader blends that dilute the core ingredients.

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Goals

Detoxification
Impact
Highest effect
A Goal FitB- Strength of SupportB CoverageA Formula Quality
Milk Thistle · 300 mg

NAC provides a strong glutathione precursor, while milk thistle adds complementary liver-cell protection. Broccoli powder offers a smaller secondary link to Phase II enzyme activity.

The NAC amount is useful, but the milk thistle extract lacks silymarin standardization and the broccoli amount is modest. The formula still provides a clear, well-balanced liver-support strategy across more than one pathway.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
N-Acetyl-Cysteine
500 mg
Milk Thistle seed extract
300 mg
organic Broccoli powder
50 mg
Adults 18–50
Report overview
Milk Thistle · 300 mg OverallScore20
D- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

A 300 mg seed extract is disclosed, but no silymarin standardization or active yield is given. The dry capsule lacks absorption-enhancing technology. The serving cost is above the collection norm for a non-standardized extract.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  3. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  4. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  5. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  6. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  7. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  8. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  9. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle