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Liver 21 Day Cleanse

4.3
★ ★ ★ ★ ★
(5024 ratings)
Milk Thistle 150 mg
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Score48
A recognizable botanical blend is undermined by unclear extract potency and enzymes without activity units. The short, three-capsule course also offers weak value.
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Capsule
Quantity:63 Capsule(s) • (21 servings)
Goals:

Score 48

A recognizable botanical blend is undermined by unclear extract potency and enzymes without activity units. The short, three-capsule course also offers weak value.
How scoring works
$27.02($1.28 per serving)
iHerb
$ 27.02
Amazon
$ 47.99
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Analysis

Artichoke at 225 mg, dandelion at 150 mg, and milk thistle at 150 mg provide the botanical core. A 300 mg chloroplast ingredient broadens the blend but has no clear active markers.

Milk thistle and artichoke are unstandardized in the supplied facts. Lipase and protease entries lack activity units, so their digestive contribution cannot be assessed.

The product provides only twenty-one three-capsule servings. It is difficult to justify against simpler formulas with verified silymarin and meaningful enzyme activity disclosure.

Who is it for
  • Adults specifically seeking a short-course botanical blend
  • People who can tolerate artichoke and dandelion
  • Users not requiring verified enzyme activity
Best for
  • Short-term multi-herb use
  • Artichoke and dandelion combination
  • Users comfortable with three capsules

Pros

  • Botanical amounts are listed
  • Includes milk thistle, artichoke, and dandelion
  • Twenty-one measured servings
  • No hidden botanical blend

Cons

  • No silymarin standardization
  • Enzymes lack activity units
  • Only twenty-one servings
  • Three capsules per serving
  • Weak value

Warnings

  • Artichoke and dandelion may be unsuitable with bile-duct obstruction or symptomatic gallstones.
  • Milk thistle and dandelion may trigger reactions in people sensitive to ragweed-family plants.
  • Fungal-derived enzymes may be unsuitable for users sensitive to their source organisms.

Nutrient quality

43 Lower impact

Recognizable liver-support botanicals provide a basic thematic foundation. Modest doses, vague additions, and unusable enzyme activity detail sharply reduce formula quality.

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Ingredient transparency

64 Moderate impact

Most listed ingredients have visible amounts and no proprietary blend is used. Unusable enzyme activity, vague naming, incomplete directions, and absent excipients weaken clarity.

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Customer satisfaction

64 Moderate impact

The aggregate satisfaction signal is favorable and has some support from the supplied volume. Specific experience details are absent, so complaint patterns and purpose fit cannot be confirmed.

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Value for money

19 Limited impact

Recognizable botanicals provide limited baseline value. Weak dose depth, vague extras, and high serving positioning make the formula uncompetitive.

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Ingredients

IngredientAmount per serving
Solarplast (Chloroplast)
300 mg
Artichoke leaf extract
225 mg
Dandelion Leaf Extract
150 mg
Milk Thistle Seed Extract
150 mg
Protease SP (Aspergillus oryzae, Bacillus subtilis)
0 NP
Lipase (Candida rugosa)
0 NP
Adults 18–50
Report overview
Milk Thistle · 150 mg OverallScore13
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Milk thistle seed is the appropriate source plant part, but the extract has no stated standardization or absorption technology. Without a silymarin percentage, the active dose cannot be determined. Its high serving cost and three-capsule serving offer poor value for the disclosed quality.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  3. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  4. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  5. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  6. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  7. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  8. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  9. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle