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Milk Thistle

Paradise
4.7
★ ★ ★ ★ ★
(2728 ratings)
Milk Thistle 250 mg
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Score79
A focused seed extract offers very good everyday value, though the actual silymarin yield is not shown.
How scoring works
Quantity:120 Capsule(s) • (120 servings)
Goals:
Detoxification

Score 79

A focused seed extract offers very good everyday value, though the actual silymarin yield is not shown.
How scoring works
$21.85($0.18 per serving)
Vitacost
$ 21.85
Pure Formulas
$ 22.99
iHerb
$ 22.99
Vitacost
$ 21.85
Amazon
$ 22.99
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Analysis

Milk thistle seed extract supplies a focused ingredient that supports normal liver-cell antioxidant defenses. Naming both the seed source and silymarin class gives the label more useful context than a generic whole-herb entry.

The serving still lacks a silymarin percentage or calculated active yield. A conventional dry capsule provides no stated phytosome, phospholipid, or other absorption-focused delivery.

The clean formula and low serving cost suit long-term users who do not need a multi-herb blend. Buyers who require an exact active dose should choose a more fully standardized label.

Who is it for
  • Adults seeking a focused milk thistle seed extract
  • Value-conscious regular users
  • People who prefer single-ingredient capsules
Best for
  • Long-term liver antioxidant support
  • Simple daily use
  • Avoiding proprietary or multi-herb blends

Pros

  • Seed source is disclosed
  • Silymarin is identified
  • Low serving cost

Cons

  • No active concentration
  • No absorption-enhancing format
  • Narrow single-pathway coverage

Warnings

  • Milk thistle may cause nausea, gas, or loose stools in sensitive users.
  • People allergic to ragweed, daisies, or related plants may also react to milk thistle.
  • Milk thistle may affect blood-sugar control; people using insulin or glucose-lowering medicine should check with their prescriber.

Nutrient quality

77 High impact

Seed sourcing and a focused single-active design fit the intended use well. Unknown active yield and basic delivery limit dose confidence.

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Ingredient transparency

79 High impact

The plant part, active class, and total amount are clearly identified. Concentration, usage, and excipient details remain missing.

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Customer satisfaction

72 High impact

The average rating is positive, and the available feedback volume provides useful confidence. No specific experience details are supplied to assess recurring complaints or purpose fit.

.

Value for money

88 Highest impact

Economical use and a filler-free seed extract support strong value. Unverified active concentration prevents a top category comparison.

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Report analysis

Goals

Detoxification
Impact
High effect
B+ Goal FitC Strength of SupportD CoverageA+ Formula Quality
Milk Thistle · 250 mg

Milk thistle seed extract directly supports hepatocyte protection, and silymarin is identified as the relevant active class. The missing silymarin percentage prevents confirmation of the actual active dose.

The streamlined formula offers good depth for one liver-protective pathway but no conjugation or antioxidant-recycling cofactors. Its single-active design is clean and coherent.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Milk Thistle seed extract (Silymarin)
250 mg
Gluten Free Adults 18–50 Vegan Vegetarian
Report overview
D- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC Value

The seed extract uses an appropriate plant part and identifies silymarin, but no concentration or active yield is shown. The dry capsule offers no special absorption support. Its very low serving cost is attractive, though confirmed potency remains unavailable.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  3. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  4. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  5. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  6. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  7. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  8. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  9. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle