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Milk Thistle 250 mg

4.7
★ ★ ★ ★ ★
(6921 ratings)
Milk Thistle 250 mg
Product Image
Score79
Seed sourcing and a named silymarin form are positives, but the label still does not quantify active silymarin.
How scoring works
Capsule
Quantity:200 Capsule(s) • (200 servings)
Goals:
Detoxification

Score 79

Seed sourcing and a named silymarin form are positives, but the label still does not quantify active silymarin.
How scoring works
$22.24($0.11 per serving)
iHerb
$ 28.02
Vitacost
$ 28.02
Amazon
$ 22.24
Walmart
$ 32.16
Vitacost
$ 28.02
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Analysis

Seed-derived milk thistle with silymarin named on the label is a more informative starting point than an unspecified whole-herb product. The focused capsule is well aligned with antioxidant and liver-cell support.

A 250 mg extract amount is disclosed, but the label does not state what percentage is silymarin. A plain dry capsule also provides no identified phospholipid or other delivery feature for absorption.

The large supply and simple formula suit regular users who value convenience and economical use. It remains a better match for general support than for someone comparing products by a confirmed active dose.

Who is it for
  • Regular milk-thistle users
  • Adults who prefer a simple capsule
Best for
  • Long-term supply convenience
  • Focused botanical support

Pros

  • Uses milk thistle seed extract
  • Silymarin is identified
  • Single-active formula

Cons

  • Silymarin percentage is missing
  • No stated absorption support
  • Active dose cannot be calculated

Warnings

  • Milk thistle can cause digestive upset in some users; stop or reduce use if symptoms persist.
  • People allergic to ragweed-family plants may also react to milk thistle.
  • Milk thistle may affect blood sugar, so people using glucose-lowering medicine should discuss it with their clinician.

Nutrient quality

81 Highest impact

The preferred seed source and named silymarin form support basic quality. The extract amount is relevant, but missing standardization limits confidence in an effective active dose.

Ingredient transparency

77 High impact

The active ingredient has a stated amount without a hidden proprietary blend. Standardization or source details, daily-use directions, and non-active ingredients remain incomplete.

Customer satisfaction

71 High impact

The supplied average rating is strong and is supported by very large review count. No detailed feedback is available to assess repeated complaints or purpose-specific experiences.

Value for money

87 Highest impact

A very low qualitative serving cost and focused seed extract provide good practical value. Missing active-marker yield prevents a reliable potency comparison.

Report analysis

Goals

Detoxification
Impact
High effect
B+ Goal FitC- Strength of SupportD- CoverageA+ Formula Quality
Milk Thistle · 250 mg

Milk thistle is directly aligned with liver protection and has relevant human evidence, although results vary by condition. Its role is mainly antioxidant and hepatocyte support rather than comprehensive metabolic clearance.

The extract amount is clearly disclosed, but the label names silymarin without stating a standardized percentage. Potency therefore cannot be compared reliably with standardized milk thistle extracts.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Milk Thistle seed extract (Silymarin)
250 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The extract comes from milk thistle seed, but the silymarin percentage is not disclosed. A plain capsule provides no identified absorption support. The very low cost still cannot be linked to a verified effective dose.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  3. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  4. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  5. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  6. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  7. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  8. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  9. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle