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Milk Thistle 1000 mg

4.7
★ ★ ★ ★ ★
(12131 ratings)
Milk Thistle 250 mg
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Score75
The focused softgel is easy to use and offers good value, though its active silymarin potency cannot be verified.
How scoring works
Softgel
Quantity:50 Softgel(s) • (50 servings)
Goals:
Detoxification

Score 75

The focused softgel is easy to use and offers good value, though its active silymarin potency cannot be verified.
How scoring works
$9.50($0.19 per serving)
iHerb
$ 11.91
Vitacost
$ 13.09
Amazon
$ 9.50
Walmart
$ 9.50
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Analysis

A simple milk thistle softgel is directly relevant to liver-cell and antioxidant support without unrelated active ingredients. Softgel delivery may offer a practical advantage over an ordinary dry capsule for a poorly soluble botanical.

The label lists 250 mg of extract but does not show the amount represented by the product name or the actual silymarin yield. Without standardization or plant-part information, the functional dose remains uncertain.

Easy once-daily-style serving size and accessible value make it suitable for basic use. Shoppers who want tightly defined potency should choose an extract that states its silymarin percentage and active amount.

Who is it for
  • Adults wanting an uncomplicated softgel
  • Budget-conscious milk-thistle users
Best for
  • Simple daily supplementation
  • Capsule alternatives with a softgel format

Pros

  • Focused single-active formula
  • Softgel delivery
  • Clearly listed extract weight

Cons

  • No standardized silymarin yield
  • Plant part is unspecified
  • Product-name equivalency is unclear

Warnings

  • Milk thistle can cause digestive upset in some users; stop or reduce use if symptoms persist.
  • People allergic to ragweed-family plants may also react to milk thistle.
  • Milk thistle may affect blood sugar, so people using glucose-lowering medicine should discuss it with their clinician.

Nutrient quality

77 High impact

A softgel may aid dispersion compared with plain powder, but the extract lacks active-marker details. The extract amount is relevant, yet the actual silymarin dose cannot be calculated.

Ingredient transparency

73 High impact

The active ingredient has a stated amount without a hidden proprietary blend. Standardization or source details, daily-use directions, and non-active ingredients remain incomplete.

Customer satisfaction

71 High impact

The supplied average rating is strong and is supported by exceptionally large review count. No detailed feedback is available to assess repeated complaints or purpose-specific experiences.

Value for money

80 High impact

A focused formula and low qualitative serving cost provide practical value. The absence of a verified active dose keeps value from being dependable.

Report analysis

Goals

Detoxification
Impact
High effect
B+ Goal FitD+ Strength of SupportD- CoverageA+ Formula Quality
Milk Thistle · 250 mg

Milk thistle is directly aligned with liver protection and has relevant human evidence, although results vary by condition. Its role is mainly antioxidant and hepatocyte support rather than comprehensive metabolic clearance.

The extract amount is clearly disclosed, but no silymarin standardization is provided. Potency therefore cannot be compared reliably with standardized milk thistle extracts.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Milk Thistle extract
250 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Milk Thistle · 250 mg OverallScore17
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The extract amount is listed, but no silymarin percentage or active-marker yield is provided. The softgel format may support solubility, while the source plant part remains unspecified. Its low per-serving cost is offset by the inability to verify an effective silymarin dose.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  3. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  4. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  5. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  6. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  7. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  8. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  9. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle