5-Methyl Folate 1000 mcg

5-Methyl Folate 1000 mcg

Protocol For Life Balance4.9 (234 ratings)
Format:Tablet Quantity: 90 Tablet(s) · 90 servings
Goals
$24.00 $0.26 per serving

Product analysis

89 out of 100

5-Methyl Folate 1000 mcg supplies folate in an active form to support normal blood formation and cell division.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality100

The folate is supplied in an active form that the body can use. That supports its form quality without establishing extra benefits from a larger serving.

Ingredient Transparency80

The folate amount and named forms are disclosed. Their individual proportions are not stated, limiting a complete breakdown of the folate sources.

Value For Money100

The folate provides favorable value in an active form. The practical benefit still depends on whether additional folate is needed.

Customer Satisfaction78

Customer ratings are highly positive. The modest number of ratings makes this a less established picture than a larger review history would provide.

Product Focus75

The clearest role is supporting normal blood formation and cell division, with no established hair-growth benefit when intake is adequate. The high folate serving without vitamin B12 also deserves attention when considering the rest of your nutrient intake.

Format
Tablet
Container
90 Tablet(s)
Per serving
$0.26
Customer rating
4.9 · 234 ratings
Report analysis

Goals

Everyday Health
Impact
Highest effect
A+ Ingredient FitC PathwaysB+ EvidenceA Formulation Logic
Folate · 1667 mcg

Folate provides essential nutritional support for blood formation and one-carbon metabolism. Larger amounts do not establish greater health benefits once intake is adequate. The saved findings flag high folate without vitamin B12.

How this product is rated for Everyday Health

Ingredient fit97

The formula supplies counted nutrients with differing amounts. Their usefulness is primarily in filling dietary gaps.
Goal fit
The formula concentrates on the counted nutrients, while its links span several health purposes.
Dose adequacy
The counted nutrients reach their saved amount references; that does not establish additional benefits from higher intake.

Pathways60

The strongest saved coverage concerns one-carbon metabolism and blood formation. These nutritional roles do not establish broad preventive benefits.
Depth
The strongest saved coverage concerns one-carbon metabolism and blood formation, reflecting nutritional roles rather than proven disease prevention.
Breadth
The saved coverage reaches one-carbon metabolism and blood formation.

Evidence82

Vitamin B9 (Folate) leads the saved evidence finding through nutritional relevance; this does not establish extra benefit when intake is already adequate.
Evidence strength
Vitamin B9 (Folate) leads the saved evidence finding through nutritional relevance; this does not establish extra benefit when intake is already adequate.
Studied preparation
The saved preparation check is satisfied for the counted nutrients. No chemical-form or delivery advantage is established.

Formulation logic93

The saved findings flag high folate without vitamin B12. The saved partner requirements are satisfied.
Partner coverage
The counted nutrients work independently or meet their partner requirements under the saved findings; no additional combination benefit is established.
Conflicts
The saved findings flag high folate without vitamin B12.
Effective doses
All counted nutrients pass the saved minimum amount threshold; this describes eligibility rather than a proven dose that improves health.
Study evidence
Folate Supportive 80 studies
Hair Health
Impact
High effect
A+ Ingredient FitF PathwaysC+ EvidenceA+ Formulation Logic

Folate supports normal cell division and nutrient adequacy. Those functions do not establish an independent hair-growth effect in adults with adequate intake. The declared methylfolate form and substantial serving amount do not by themselves demonstrate better hair outcomes.

How this product is rated for Hair Health

Ingredient fit97

The declared actives are focused on the ingredients linked to hair health. The recognized ingredient amounts reach the supplied comparison anchors; this does not establish a proven hair-treatment dose.
Goal fit
The declared actives are focused on the ingredients linked to hair health.
Dose adequacy
The recognized ingredient amounts reach the supplied comparison anchors; this does not establish a proven hair-treatment dose.

Pathways0

No direct coverage was assigned to the evaluated hair mechanisms.
Depth
No direct coverage was assigned to the evaluated hair mechanisms.
Breadth
The formula does not reach the comparison’s meaningful-coverage level for any evaluated hair mechanism.

Evidence68

Vitamin B9 (Folate) supplies the strongest recognized evidence contribution, with the ingredient-specific limitations described above.
Evidence strength
Vitamin B9 (Folate) supplies the strongest recognized evidence contribution, with the ingredient-specific limitations described above.
Studied preparation
The recognized forms match the supplied preparation criteria, which does not by itself prove routine hair-growth benefit.

Formulation logic100

The recognized ingredients have no missing required partners or configured conflicts. Amount-based qualifications remain relevant.
Partner coverage
No missing required partner was identified among the recognized ingredients.
Conflicts
No configured ingredient conflict was identified; this is not a general safety finding.
Effective doses
The recognized ingredients meet the comparison’s minimum amount criterion, without establishing clinically effective hair-treatment doses.
Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per servingScore
Folate (Glucosamine Salt, Quatrefolic (6S)-5-MTHF)
1667 mcg 80
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyA+ Value
The serving declares 1667 mcg DFE of folate. The cost per serving is low. It uses L-5-Methyltetrahydrofolate Glucosamine Salt, an active form that bypasses the MTHFR conversion step.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses L-5-Methyltetrahydrofolate Glucosamine Salt, an active form that bypasses the MTHFR conversion step. A branded folate source is indicated, though its name is not specified here.
Folate Form Hierarchy
It uses L-5-Methyltetrahydrofolate Glucosamine Salt, an active form that bypasses the MTHFR conversion step.
Patented Sources & Isomeric Purity
A branded folate source is indicated, though its name is not specified here.

Dose, Safety & Label Transparency50

The serving declares 1667 mcg DFE of folate.
Folate Dosage by Declared Basis
The serving declares 1667 mcg DFE of folate.

Value100

The cost per serving is low.
Price per Bioavailable Serving
The cost per serving is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsEveryday Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsEveryday Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsEveryday Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewEveryday Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledEveryday Health forFolate
  6. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  7. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  8. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  9. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  10. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate