Vitamin D3 125 mcg (5000 IU) with Sea-Iodine

Vitamin D3 125 mcg (5000 IU) with Sea-Iodine

Life Extension4.9 (3,866 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals

Product analysis

64 out of 100

Vitamin D3 125 mcg (5000 IU) with Sea-Iodine combines vitamin D and affordable iodine for nutritional support, with iodine helping normal thyroid hormone production when intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality32

Vitamin D3 is named, but its relative form quality cannot be firmly compared. The iodine form is unspecified, limiting a complete quality comparison.

Ingredient Transparency81

Both nutrient amounts are stated. Vitamin D3 is clearly named, while the iodine form is unspecified.

Value For Money63

The low serving cost offers favorable value for iodine. The value contributed by vitamin D remains uncertain.

Customer Satisfaction92

Customer ratings are very positive. Thousands of ratings give an established picture of satisfaction, without establishing effectiveness.

Product Focus76

The clearest role is supplying iodine for normal thyroid function when intake is low. The high nutrient amounts do not establish extra energy or a faster metabolism when nutritional needs are met.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.17
Customer rating
4.9 · 3,866 ratings
Report analysis

Goals

Energy
Impact
High effect
A Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
Iodine · 1000 mcgVitamin D · 125 mcg
Study evidence
Iodine Adverse 3 studies
Vitamin D Supportive 32 studies
Metabolism Support
Impact
High effect
A Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 125 mcg
Study evidence
Iodine Mixed 17 studies
Vitamin D Supportive 65 studies

Ingredients

IngredientAmount per servingScore
Vitamin D (Cholecalciferol)
125 mcg
Iodine
1000 mcg 82
Gluten Free Adults 18–50
Report overview
Iodine · 1000 mcg OverallScore82
C+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value
Each serving provides 1,000 mcg of iodine at a low cost per serving. The amount is higher than needed for basic daily maintenance. The blend includes potassium iodide, but its other iodine forms and their proportions are unclear.
How this ingredient is rated

Active Ingredient Quality & Bioavailability69

The blend includes potassium iodide, but its other iodine forms and their proportions are unclear. A marine sourcing marker is recorded, though its specific details are unclear.
Iodine Form & Bioavailability
The blend includes potassium iodide, but its other iodine forms and their proportions are unclear.
Marine Source Purity & Sourcing
A marine sourcing marker is recorded, though its specific details are unclear.

Dose, Safety & Label Transparency85

1,000 mcg of iodine per serving is higher than needed for basic daily maintenance. The stated amount is below the adult upper intake level.
Dosage Efficacy for Daily Support
1,000 mcg of iodine per serving is higher than needed for basic daily maintenance.
Dosage Safety & Upper Limits
1,000 mcg is below the 1,100 mcg adult upper intake level.
Elemental Iodine Transparency
The iodine amount is stated as 1,000 mcg per serving.

Value100

The cost per labeled serving is low.
Price Per Effective Serving
The cost per labeled serving is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
  2. Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  3. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  4. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  5. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  6. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  7. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  8. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  9. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.
    Herter-Aeberli I; Cherkaoui M; El Ansari N; Rohner R; Stinca S; Chabaa L; von Eckardstein A; Aboussad A; Zimmermann MB · The Journal of nutrition · 2015
    Randomized trial163 participantsMetabolism Support forIodine
  10. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency.
    Zimmermann MB; Adou P; Torresani T; Zeder C; Hurrell RF · European journal of clinical nutrition · 2000
    Single-arm trial51 participantsMetabolism Support forIodine
  11. Serum Iodine Concentration as a Biomarker for Individual Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study in Hubei Province.
    Xu M; Dai X; Wang Z; Guo C; Zhang B; Guo H · Public health nutrition · 2026
    Cross-sectional study1,197 participantsMetabolism Support forIodine
  12. Iron status influences the efficacy of iodine prophylaxis in goitrous children in Côte d'Ivoire.
    Zimmermann MB · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2002
    OtherMetabolism Support forIodine
  13. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Côte d'Ivoire.
    Zimmermann M; Adou P; Torresani T; Zeder C; Hurrell R · The American journal of clinical nutrition · 2000
    Non-randomized trial109 participantsMetabolism Support forIodine
  14. Effects of vitamin D supplementation on insulin resistance and lipid metabolic profiles in women with gestational diabetes mellitus: A randomized controlled trial.
    Duan Y; Zhang S; Ma X; Li L; Jia K · African journal of reproductive health · 2026
    Randomized trial120 participantsMetabolism Support forVitamin D
  15. Vitamin D3 improves glucose metabolism and attenuates inflammation in prediabetic human and mice.
    Zhang Y; Ni P; Miao Y; Chen H; Tang L; Song H; Li W; Li X · The Journal of nutritional biochemistry · 2024
    Randomized trialMetabolism Support forVitamin D
  16. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial.
    Mitri J; Dawson-Hughes B; Hu FB; Pittas AG · The American journal of clinical nutrition · 2011
    Randomized trial92 participantsMetabolism Support forVitamin D
  17. The Effects of Vitamin D Supplementation on Glycemic Control, Lipid Profiles and C-Reactive Protein Among Patients with Cardiovascular Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Ostadmohammadi V; Milajerdi A; Ghayour-Mobarhan M; Ferns G; Taghizadeh M; Badehnoosh B; Mirzaei H; Asemi Z · Current pharmaceutical design · 2020
    Meta-analysis630 participants8 studies pooledMetabolism Support forVitamin D
  18. The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis.
    Mirhosseini N; Vatanparast H; Mazidi M; Kimball SM · The Journal of clinical endocrinology and metabolism · 2017
    Meta-analysis1,528 participants24 studies pooledMetabolism Support forVitamin D