Detox & Liver Health

Detox & Liver Health

Reg'Activ4.7 (176 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 30 servings
Goals
$39.96 $1.33 per serving

Product analysis

63 out of 100

Detox & Liver Health may help fill low selenium intake and support normal immune and antioxidant functions. Several key ingredients compare poorly with the serving cost, limiting value.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality84

Selenium uses a favorable, clearly identified form. Most other forms are unspecified, so the wider formula's quality remains uncertain.

Ingredient Transparency70

All listed amounts are disclosed, making serving contents easy to check. Only the selenium form is named, leaving most ingredients less clearly described.

Value For Money13

Value is poor for the ingredients that can be compared, including selenium and milk thistle. Value for some other ingredients remains uncertain, without resolving the less favorable picture.

Customer Satisfaction73

Customer feedback is very positive, though the review base is modest. The reviews describe satisfaction without establishing detoxification or liver benefits.

Product Focus71

The clearest contribution is selenium nutrition when intake is low. The other ingredient roles do not establish routine toxin removal or improved liver health.

Format
Capsule
Container
60 Capsule(s)
Per serving
$1.33
Customer rating
4.7 · 176 ratings
Report analysis

Goals

Impact
Moderate effect
B Ingredient FitF PathwaysB+ EvidenceA- Formulation Logic
Selenium · 100 mcgMilk Thistle · 250 mg
Study evidence
Selenium Supportive 10 studies
Everyday Health
Impact
High effect
C+ Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Selenium · 100 mcg
Study evidence
Selenium Supportive 70 studies
Immunity
Impact
High effect
B- Ingredient FitD+ PathwaysA- EvidenceA+ Formulation Logic
Selenium · 100 mcg
Study evidence
Selenium Mixed 37 studies

Ingredients

IngredientAmount per servingScore
Selenium (Selenomethionine)
100 mcg 77
Lactobacillus fermentum ME-3
60 mg
Milk Thistle fruit extract
250 mg 44
N-Acetyl-Cysteine
200 mg
L-Methionine
50 mg 49
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
A serving provides 100 mcg of selenium, with a very high product cost per 200 mcg. The amount is below the adult upper intake level. It lists L-Selenomethionine.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It lists L-Selenomethionine.
Selenium Chemical Form
It lists L-Selenomethionine.
Form Transparency & Isomer Specificity
The label identifies L-Selenomethionine.

Dose, Safety & Label Transparency88

The 100 mcg serving is within the range described for daily maintenance. The 100 mcg serving is below the 400 mcg adult upper intake level, leaving room for dietary selenium.
Dosage Efficacy Sweet Spot
The 100 mcg serving is within the range described for daily maintenance.
Safety Margin & UL Adherence
The 100 mcg serving is below the 400 mcg adult upper intake level, leaving room for dietary selenium.

Value10

The product cost per 200 mcg of selenium is very high.
Price per 200 mcg Serving
The product cost per 200 mcg of selenium is very high.
Methionine · 50 mg OverallScore49
C Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value
Each serving provides 50 mg of L-Methionine at a high cost per serving. The available information does not specify a purity grade or testing standard for the methionine.
How this ingredient is rated

Active Ingredient Quality & Bioavailability60

The form is L-Methionine. The available information does not specify a purity grade or testing standard for the methionine.
Methionine Isomer Form
The form is L-Methionine.
Purity and Source Standards
The available information does not specify a purity grade or testing standard for the methionine.

Dose, Safety & Label Transparency58

Each serving provides 50 mg of L-Methionine.
Methionine Dosage Potency
Each serving provides 50 mg of L-Methionine.
Transparency of Disclosure
The label states 50 mg of methionine per serving.

Value10

The cost per serving is high.
Price per Methionine Serving
The cost per serving is high.
F Composition And Label DisclosureA+ Composition And Label DisclosureF Commercial Price And Usability
The serving provides 250 mg milk thistle fruit extract at a relatively high cost per serving. It lists 250 mg silymarin, though the concentration is not stated.
How this ingredient is rated

Composition and Label Disclosure10

The milk thistle fruit extract has no stated silymarin concentration or extract ratio.
Declared Silymarin Concentration
Neither a silymarin concentration nor an extract ratio is available.

Composition and Label Disclosure100

The serving lists 250 mg milk thistle fruit extract and 250 mg silymarin.
Extract and Marker Amount Disclosure
Both extract weight and 250 mg silymarin are stated.

Commercial Price and Usability0

The selected serving is costly.
Selected-Serving Price Comparison
The serving price is relatively high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledEveryday Health forSelenium
  2. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledEveryday Health forSelenium
  3. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledEveryday Health forSelenium
  4. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsEveryday Health forSelenium
  5. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledEveryday Health forSelenium
  6. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  7. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  8. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  9. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  10. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  11. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsLiver & Detox forMilk Thistle
  12. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsLiver & Detox forMilk Thistle
  13. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsLiver & Detox forMilk Thistle
  14. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsLiver & Detox forMilk Thistle
  15. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledLiver & Detox forMilk Thistle
  16. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
    Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
    Randomized trialLiver & Detox forSelenium
  17. [Selenium and oxidative stress in cancer patients].
    Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
    Single-arm trial40 participantsLiver & Detox forSelenium
  18. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
    Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
    Other40 participantsLiver & Detox forSelenium
  19. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
    Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
    Cross-sectional study9,445 participantsLiver & Detox forSelenium
  20. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
    Randomized trial35 participantsLiver & Detox forSelenium