BioActive Folate & Vitamin B12

BioActive Folate & Vitamin B12

Life Extension4.8 (12,245 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 90 servings
Goals

Product analysis

65 out of 100

BioActive Folate & Vitamin B12 supports normal blood formation and may help fatigue related to low folate or B12 intake. The clearly stated amounts and forms make the pair straightforward to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

Both vitamin forms are identified, but preparation quality remains uncertain. The methylfolate and methylcobalamin names do not establish superior benefits.

Ingredient Transparency100

Both vitamin amounts and forms are clearly stated. That makes the pair easy to compare with similar supplements.

Value For Money40

Value for money remains uncertain. There is not enough information for a reliable cost comparison of either vitamin.

Customer Satisfaction92

Customer ratings are very positive. The large number of ratings gives the feedback a substantial base.

Product Focus74

The pair stays focused on related nutritional functions, especially normal blood formation. Fatigue benefits depend on low nutrient intake, and a separate hair-regrowth benefit is not established.

Format
Capsule
Container
90 Capsule(s)
Per serving
$0.10
Customer rating
4.8 · 12,245 ratings
Report analysis

Goals

Impact
Highest effect
A Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Folate · 680 mcg DFEVitamin B12 · 300 mcg

Folate and vitamin B12 contribute nutrients used in blood formation and one-carbon metabolism. They can help fill a dietary gap, but these normal functions do not establish extra benefit when intake is adequate. The methylfolate and methylcobalamin forms do not establish superiority, and the product’s contribution is concentrated in these related functions.

How this product is rated for Everyday Health

Ingredient fit92

The contributing ingredients receive a partial amount allowance in the saved comparison; this is not a clinical benefit threshold.
Goal fit
The ingredients with a supported contribution are focused on this goal, although the product is also linked to other goals.
Dose adequacy
The contributing ingredients receive a partial amount allowance in the saved comparison; this is not a clinical benefit threshold.

Pathways60

The strongest contribution is in one-carbon metabolism and blood formation, reaching the saved comparison’s full coverage. The meaningful contribution is concentrated in one area rather than spread across the broader goal.
Depth
The strongest contribution is in one-carbon metabolism and blood formation, reaching the saved comparison’s full coverage.
Breadth
The meaningful contribution is concentrated in one area rather than spread across the broader goal.

Evidence82

Vitamin B9 (Folate) leads the saved evidence comparison; its nutritional role does not establish additional benefit when intake is adequate.
Evidence strength
Vitamin B9 (Folate) leads the saved evidence comparison; its nutritional role does not establish additional benefit when intake is adequate.
Studied preparation
The contributing ingredients with qualifying amounts match preparations accepted in the saved comparison; this does not establish superiority of their forms.

Formulation logic100

All ingredients retained as contributors reach the saved minimum amount threshold; that threshold is not a proven effective clinical dose.
Partner coverage
The contributing ingredients can act independently or have their required partners; no additional combination benefit is established.
Conflicts
No configured ingredient conflict was identified in the supplied facts; this is not a comprehensive safety assessment.
Effective doses
All ingredients retained as contributors reach the saved minimum amount threshold; that threshold is not a proven effective clinical dose.
Study evidence
Folate Supportive 80 studies
Hair Health
Impact
High effect
A Ingredient FitF PathwaysB EvidenceA+ Formulation Logic

Folate supports normal cell division, while vitamin B12 contributes to general nutrient adequacy. These roles and the saved amount findings do not establish independent hair regrowth. Higher amounts do not demonstrate stronger hair outcomes.

How this product is rated for Hair Health

Ingredient fit90

The relevant nutrient ingredients connect with hair mainly through nutritional sufficiency, with the selected serving determining the amount finding.
Goal fit
The included active ingredients are focused on the recognized hair-related nutrient contribution.
Dose adequacy
The selected serving provides partial or uneven amounts across the recognized ingredients, limiting the saved amount finding.

Pathways0

The saved result does not cover the specified hair mechanisms; nutritional relevance can still exist.
Depth
The saved findings identify nutrient support without coverage of the four specified hair mechanisms.
Breadth
None of the specified mechanisms reaches the saved coverage threshold.

Evidence78

The saved evidence finding recognizes individual ingredients and preparations, subject to their specific hair-outcome limitations.
Evidence strength
Vitamin B12 leads the saved evidence finding, although the supplied context limits how confidently routine hair benefits can be expected.
Studied preparation
The recognized preparations meet the saved preparation criteria; this does not mean the finished product has demonstrated regrowth.

Formulation logic100

The saved findings show no unmet partner requirement or configured conflict; amount recognition does not prove extra benefit from the combination.
Partner coverage
The recognized ingredients have no unmet partner requirement in the saved findings; this does not establish synergy.
Conflicts
No configured ingredient conflict was identified; this finding does not establish overall safety.
Effective doses
All ingredients counted here pass the saved minimum amount threshold, which is a comparison criterion rather than a proven treatment dose.
Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per servingScore
Folate (L-5-Methyltetrahydrofolate)
680 mcg DFE
Vitamin B12 (Methylcobalamin)
300 mcg 73
Gluten Free Adults 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyD+ Value
A serving provides 300 mcg of B12 as methylcobalamin. The whole-product price works out to about $0.33 per 1,000 mcg of B12.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The B12 is methylcobalamin, a bioactive form.
Bioactive B12 Form Selection
The listed B12 form is methylcobalamin.

Dose, Safety & Label Transparency58

The label identifies the form and lists 300 mcg of B12 per serving.
Therapeutic Dosage Level
A serving contains 300 mcg of vitamin B12.
Label and Form Transparency
The label identifies methylcobalamin and specifies the B12 amount per serving.

Value50

The whole-product price works out to about $0.33 per 1,000 mcg of B12.
Price per 1,000 mcg B12
The whole-product price works out to about $0.33 per 1,000 mcg of B12.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsEveryday Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsEveryday Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsEveryday Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewEveryday Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledEveryday Health forFolate
  6. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsEveryday Health forVitamin B12
  7. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsEveryday Health forVitamin B12
  8. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsEveryday Health forVitamin B12
  9. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsEveryday Health forVitamin B12
  10. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsEveryday Health forVitamin B12
  11. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  12. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  13. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  14. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  15. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  16. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  17. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  18. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  19. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12