L-Glutathione 100 mg
Metabolic Maintenance
L-Glutathione 100 mg
4.6
★ ★ ★ ★ ★
(164 ratings)
Glutathione 100 mg
Score 58.0
A Setria Glutathione supplement with added Vitamin C, but its high price for a modest dose significantly reduces its value.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Anti-Aging
Detoxification
Skin Health
Anti-Inflammatory Support
leaderboard Score 58.0
A Setria Glutathione supplement with added Vitamin C, but its high price for a modest dose significantly reduces its value.
insights Analysis
Metabolic Maintenance offers 100 mg of Setria Glutathione alongside 120 mg of Vitamin C. The inclusion of Setria is a strong positive for bioavailability, and Vitamin C is beneficial as it helps regenerate glutathione in the body. However, the product's major drawback is its very high price per serving, making it significantly more expensive than other Setria options or higher-dose reduced glutathione products, especially considering the relatively low 100mg glutathione dosage. While the added Vitamin C is a plus, it doesn't justify the disproportionate cost for the glutathione content.
- Contains premium Setria Glutathione for enhanced absorption.
- Includes Vitamin C which synergistically supports glutathione levels.
- Extremely high price per serving for only 100mg of glutathione.
- Low glutathione dose for comprehensive effects despite Setria form.
$32.00($0.53 per serving)
 iHerb | $ 32.00 | |
 Amazon | $ 32.00 |
bolt Effectiveness for goals
The effectiveness of oral glutathione supplementation for directly increasing intracellular glutathione levels is a subject of ongoing research. While some studies suggest that specific forms, like liposomal or S-acetyl-glutathione, may help raise plasma glutathione, traditional forms face challenges with absorption. The body's natural synthesis of glutathione is a primary regulator of its levels.
The effectiveness of oral glutathione can vary due to challenges with absorption and degradation in the digestive system. Some forms, like liposomal or S-acetyl glutathione, are designed to improve bioavailability. Research on the systemic impact of various oral forms is ongoing.
Traditional reduced glutathione supplements have historically faced challenges with absorption due to degradation in the digestive tract. Newer forms, such as liposomal or S-acetyl-glutathione, are specifically designed to improve bioavailability and are generally considered more effectively absorbed. Research continues to evaluate the optimal delivery methods for glutathione.
Glutathione is a primary antioxidant in the body, crucial for neutralizing free radicals and combating oxidative stress. Supplementation is hypothesized to support the body's natural antioxidant defenses. The extent of this effect can depend on the supplement form and individual physiological factors.
Some research suggests that high doses of oral glutathione might have skin-lightening effects by inhibiting melanin production, but the evidence is not conclusive and often involves specific populations. These studies often require high dosages and more robust, larger-scale research is needed to confirm efficacy for this purpose. It is not approved for this use by major health authorities.
schedule Dosage, timing & forms
Liposomal glutathione encapsulates glutathione in tiny lipid bubbles (liposomes), which are designed to protect it from degradation in the digestive tract. This delivery method aims to enhance its absorption and bioavailability compared to standard oral reduced glutathione. The liposomal structure helps transport the glutathione more efficiently into the bloodstream.
N-acetylcysteine (NAC) is a precursor that the body uses to synthesize its own glutathione. While not glutathione itself, supplementing with NAC is a common strategy to support the body's endogenous glutathione production. It provides cysteine, a crucial amino acid needed for glutathione synthesis.
Oral glutathione dosages can vary widely depending on the specific form and individual needs, often ranging from 250 mg to 1000 mg per day. It's best to follow the manufacturer's recommendations on the product label. Consulting with a healthcare professional can provide personalized guidance.
Typical oral glutathione dosages can range from 250 mg to 1000 mg per day. The specific amount may vary depending on the product formulation and individual needs. It is advisable to follow the manufacturer's recommendations.
Reduced glutathione (GSH) is the active form naturally found in the body, but it can be prone to degradation during digestion when taken orally. S-acetyl glutathione is a modified form designed for improved stability and bioavailability. The acetyl group is intended to protect it until absorption, allowing it to be cleaved off inside cells to release active glutathione.
health_and_safety Safety & interactions
Oral glutathione is generally considered safe for most adults when taken in appropriate doses. Some individuals have reported mild side effects such as abdominal cramps, bloating, or allergic reactions like rash. Inhaled glutathione might cause asthma exacerbation in sensitive individuals.
Oral glutathione supplements are generally well-tolerated by most individuals. Some people might experience mild gastrointestinal discomfort, such as abdominal cramps or bloating. Rarely, allergic reactions like rash have been reported, and inhaled forms might trigger asthma in susceptible individuals.
There is limited information on significant drug interactions with glutathione supplements. However, it is always advisable to consult a healthcare professional, especially when taking prescription medications. They can assess potential interactions based on your specific health profile.
The maximum safe dosage for glutathione can vary depending on the form, individual health, and specific application. While studies have used oral doses up to 1000 mg/day, it is crucial to follow product label instructions and consult a healthcare provider for personalized guidance. Excessive doses may not provide additional benefits and could lead to unknown effects.
Insufficient research is available regarding the safety of glutathione supplementation during pregnancy and breastfeeding. For this reason, it is generally recommended to avoid use or consult a healthcare provider before considering supplementation. A healthcare professional can weigh the potential benefits against any unknown risks.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin C | 120 mg |
Setria Glutathione | 100 mg |
Categories
Glutathione 58.0
Although it uses Setria and includes Vitamin C, the prohibitive price for a 100mg dose places it among the least cost-effective options within the glutathione supplement category, reducing its appeal.
Goals
Anti-Aging 58.0
While Setria and Vitamin C are beneficial for antioxidant support, the high cost for a modest 100mg of glutathione makes it less competitive for long-term anti-aging supplementation compared to more affordable higher-dose options.
Detoxification 58.0
The low glutathione dosage, even with Vitamin C, may not be potent enough for significant detoxification support, and the prohibitive cost makes higher consistent intake impractical for most users.
Skin Health 58.0
The dose is too low for impactful skin health benefits often associated with glutathione, and the high price deters consistent usage, making it an inefficient choice for this goal.
Recommended Alternatives
85 Value 
L-Glutathione 100 mg
Swanson
4.6
★★★★★
(1271 ratings)
Provides the same dose of Setria Glutathione at a significantly lower price per serving, making it a much more cost-effective choice if 100mg is sufficient and additional Vitamin C isn't a primary requirement.
95 Value 
Glutathione 500 mg
NOW
4.6
★★★★★
(50447 ratings)
Offers five times the glutathione dose with added synergistic ingredients for a far more competitive price per serving, delivering exceptional overall value compared to the original.
80 Value 
Liver Refresh
NOW
4.8
★★★★★
(19787 ratings)
Includes 100mg of L-Glutathione alongside a comprehensive blend of other liver-supporting nutrients at a significantly lower price per serving, offering a holistic approach to detoxification at better value.
95 Performance 
Glutathione 500 mg
NOW
4.6
★★★★★
(50021 ratings)
Offers a much higher dose (500mg) of reduced glutathione, along with Alpha-Lipoic Acid and Milk Thistle, providing a more comprehensive and potent approach to detoxification beyond just glutathione and Vitamin C.
92 Performance 
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Provides a much higher dose (500mg) of reduced glutathione from a very reputable brand, offering stronger foundational support compared to a 100mg dose.
70 Performance 
Glutathione Booster
Carlson
4.7
★★★★★
(1106 ratings)
While its glutathione dose is lower (20mg), it includes a robust blend of glutathione-supporting nutrients like 200mg NAC, 50mg ALA, Milk Thistle, Selenium, and Vitamin C, offering a broad-spectrum approach to boosting glutathione levels.
85 Budget
L-Glutathione 100 mg
Swanson
4.6
★★★★★
(1271 ratings)
Offers the same 100mg dose of Setria Glutathione, but at a significantly lower price per serving, making it a much more budget-friendly option.
75 Budget 
High Potency L-Glutathione 200 mg
Swanson Ultra
4.6
★★★★★
(498 ratings)
Provides double the Setria Glutathione dose (200mg) for a considerably lower price per serving, offering much greater potency for the cost.
90 Budget 
Glutathione 250 mg
NOW
4.6
★★★★★
(11303 ratings)
Delivers 2.5 times the glutathione dose (250mg) at a significantly lower price per serving, offering a substantially more economical option for higher potency.
85 Value
L-Glutathione 100 mg
Swanson
4.6
★★★★★
(1271 ratings)
Provides the same dose of Setria Glutathione at a significantly lower price per serving, making it a much more cost-effective choice if 100mg is sufficient and additional Vitamin C isn't a primary requirement.
95 Value
Glutathione 500 mg
NOW
4.6
★★★★★
(50447 ratings)
Offers five times the glutathione dose with added synergistic ingredients for a far more competitive price per serving, delivering exceptional overall value compared to the original.
80 Value
Liver Refresh
NOW
4.8
★★★★★
(19787 ratings)
Includes 100mg of L-Glutathione alongside a comprehensive blend of other liver-supporting nutrients at a significantly lower price per serving, offering a holistic approach to detoxification at better value.
95 Performance
Glutathione 500 mg
NOW
4.6
★★★★★
(50021 ratings)
Offers a much higher dose (500mg) of reduced glutathione, along with Alpha-Lipoic Acid and Milk Thistle, providing a more comprehensive and potent approach to detoxification beyond just glutathione and Vitamin C.
92 Performance
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Provides a much higher dose (500mg) of reduced glutathione from a very reputable brand, offering stronger foundational support compared to a 100mg dose.
70 Performance
Glutathione Booster
Carlson
4.7
★★★★★
(1106 ratings)
While its glutathione dose is lower (20mg), it includes a robust blend of glutathione-supporting nutrients like 200mg NAC, 50mg ALA, Milk Thistle, Selenium, and Vitamin C, offering a broad-spectrum approach to boosting glutathione levels.