Glutathione 500 mg
NOW
Glutathione 500 mg
4.6
★ ★ ★ ★ ★
(50021 ratings)
Milk Thistle 100 mg
Glutathione 500 mg
Score 80.0
A high-value glutathione complex with reduced glutathione for better absorption, complemented by Alpha Lipoic Acid and Milk Thistle for comprehensive detoxification and antioxidant benefits.
Quantity: 120 Capsule(s)Servings size: 1 Veg Capsule(s) (120 servings)
Selected goals:
Other goals:
Anti-Aging
Detoxification
Heart Health
Skin Health
Anti-Inflammatory Support
leaderboard Score 80.0
A high-value glutathione complex with reduced glutathione for better absorption, complemented by Alpha Lipoic Acid and Milk Thistle for comprehensive detoxification and antioxidant benefits.
insights Analysis
This NOW Glutathione supplement is formulated with 500mg of Reduced Glutathione, 50mg of Alpha-Lipoic Acid, and 100mg of Milk Thistle Fruit/Seed Extract, standardized to Silymarin Flavonoids. The 'Reduced' form of glutathione is particularly noteworthy as it is the active, stable form that is more readily absorbed and utilized by the body, addressing a common concern with oral glutathione. The synergistic blend of ALA and Milk Thistle further enhances the product's effectiveness by supporting glutathione regeneration and comprehensive liver detoxification. With 120 servings, it offers the lowest price per serving among its NOW counterparts, providing excellent long-term value for consistent use in promoting detoxification, skin health, and anti-aging benefits. Online reviews are highly favorable, attesting to its popularity and perceived efficacy.
- Contains 500mg of 'Reduced' Glutathione, which is the active and more bioavailable form compared to non-reduced.
- Includes synergistic ingredients like Alpha Lipoic Acid and Milk Thistle for enhanced detoxification and antioxidant support.
- Excellent price per serving due to the large quantity (120 capsules), offering great long-term value.
- From a highly reputable brand (NOW) with widespread positive reviews, indicating reliability.
- While 'reduced' form is superior, oral glutathione absorption can still be a limiting factor for some individuals compared to more advanced delivery methods like liposomal or intravenous forms.
- The Alpha Lipoic Acid dose at 50mg is effective for support, but might be considered low for specific therapeutic interventions where higher doses are often used.
- As with any supplement impacting detoxification pathways, individuals with chronic health conditions or those on prescription medications should consult a healthcare provider prior to use.
- Minor digestive issues are possible, such as bloating or mild upset, although the combination of ingredients is generally well-tolerated by most users.
$30.45($0.25 per serving)
 iHerb | $ 30.45 | |
 Amazon | $ 30.45 | |
 Vitacost | $ 39.59 | |
 Daily Vita | $ 45.10 |
bolt Effectiveness for goals
Glutathione is a powerful antioxidant naturally produced in the body, crucial for detoxification and immune function. Supplementation is explored for its potential to reduce oxidative stress and support overall cellular health. Some studies indicate benefits for skin health and mitigating age-related oxidative damage.
Yes, Glutathione is considered the body's 'master antioxidant,' playing a central role in combating oxidative stress. It directly neutralizes free radicals and helps to regenerate other antioxidants, such as Vitamin C and E. Maintaining optimal glutathione levels is critical for cellular protection against oxidative damage.
Milk Thistle, particularly its active compound silymarin, is widely studied for its potential hepatoprotective effects. It may help protect liver cells from damage and support their regeneration. Research suggests benefits for various liver conditions, though more human trials are continuously being conducted.
Milk Thistle's active ingredient, silymarin, is believed to exert a protective effect on liver cells. It may help by stabilizing cell membranes and acting as an antioxidant to neutralize harmful free radicals. This protective action is relevant for various toxins that can impact liver health.
Yes, Milk Thistle is often associated with detoxification due to its liver-supportive properties. The liver is a primary organ for detoxifying harmful substances from the body. By supporting liver health, Milk Thistle may indirectly contribute to the body's natural detoxification pathways.
schedule Dosage, timing & forms
Standardized Milk Thistle extracts typically recommend dosages ranging from 200 mg to 400 mg, usually taken two or three times daily. These dosages are often standardized to contain 70-80% silymarin, the active compound. Always follow the specific instructions on the product label.
Look for supplements standardized to contain 70-80% silymarin, as this indicates a consistent level of the active compound. Choose reputable brands that provide third-party testing or quality assurance. Check the total silymarin content per serving, not just the raw extract amount.
Milk Thistle supplements can generally be taken with or without food. Some individuals may prefer taking it with a meal to minimize any potential mild digestive upset. Refer to the product-specific instructions for optimal use.
Common dosages for Milk Thistle extracts, standardized to contain 70-80% silymarin, generally range from 200 mg to 400 mg. This is often taken two to three times daily. The specific dosage can depend on the product's concentration and the intended use, so following label instructions is advisable.
Milk Thistle is generally considered safe for long-term use, with studies often extending up to several years. However, it's advisable to consult a healthcare professional for guidance on prolonged use. Adhere to label instructions or professional advice.
health_and_safety Safety & interactions
Yes, milk thistle can interact with certain medications. It may affect how the liver processes some drugs, potentially reducing their effectiveness or increasing side effects. Specific interactions include blood thinners (anticoagulants), diabetes medications, anti-anxiety drugs (benzodiazepines), and some statins. Always consult a healthcare professional before combining milk thistle with prescription drugs.
Individuals with allergies to ragweed, marigolds, daisies, or chrysanthemums should use caution due to potential cross-reactivity. Pregnant or breastfeeding individuals should avoid milk thistle due to insufficient safety data. People with hormone-sensitive conditions like breast, uterine, or ovarian cancer should also consult a doctor before use, as milk thistle may have estrogenic effects.
Generally, there are no known adverse interactions reported when milk thistle and glutathione are taken together. In fact, some research suggests they may complement each other's liver-supportive effects. However, individual responses can vary.
Milk thistle is generally well-tolerated, but some individuals may experience mild gastrointestinal issues such as nausea, diarrhea, or bloating. Allergic reactions, though rare, can also occur, especially in those allergic to plants in the Asteraceae family. It is advisable to consult a healthcare professional if you experience persistent or severe side effects.
Milk thistle has been observed in some studies to potentially lower blood sugar levels, which could be relevant for individuals with diabetes or those on diabetes medication. Glutathione's direct effect on blood sugar is not as clearly established, though it plays a role in metabolic processes. Diabetics should monitor blood glucose closely and consult their doctor before using either supplement.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Glutathione, Reduced | 500 mg |
Milk Thistle Fruit, Seed Extract | 100 mg |
Alpha-Lipoic Acid | 50 mg |
Categories
Glutathione 80.0
Featuring 500mg of 'Reduced' Glutathione is a significant advantage, as this form is more stable and readily absorbed than non-reduced variants. The presence of Alpha Lipoic Acid further optimizes the body's utilization and regeneration of glutathione for maximum impact.
Milk Thistle 70.0
The inclusion of 100mg of Milk Thistle extract (standardized to Silymarin) provides valuable liver support, enhancing the overall detoxification profile of the product. While not a primary Milk Thistle supplement, its presence is a significant benefit within this comprehensive blend.
Goals
Detoxification 90.0
The combination of reduced Glutathione, Milk Thistle, and Alpha Lipoic Acid forms a powerful trio for detoxification. Reduced glutathione is highly effective in neutralizing toxins, and the supporting ingredients further enhance liver function and antioxidant recycling for comprehensive detox support.
Anti-Aging 88.0
By directly boosting cellular glutathione levels and supporting the antioxidant network, this product directly addresses oxidative damage, a primary driver of aging. The reduced form of glutathione is critical for combating cellular senescence and maintaining youthful cellular function.
Reduced glutathione is a key regulator of the immune system and powerful anti-inflammatory agent. Combined with the anti-inflammatory properties of Alpha Lipoic Acid and Milk Thistle, this supplement effectively helps to reduce systemic inflammation and oxidative stress.
Recommended Alternatives
80 Value 
Silymarin Complex
California Gold Nutrition
4.8
★★★★★
(70682 ratings)
This complex provides 300mg of Milk Thistle extract along with Dandelion, Artichoke, and Turmeric, offering comprehensive liver and antioxidant support at a highly competitive price per serving ($0.12), delivering excellent value for its multi-ingredient profile.
78 Value 
High Potency L-Glutathione 200 mg
Swanson Ultra
4.6
★★★★★
(498 ratings)
Utilizes Setria Glutathione, a patented and highly regarded form known for better bioavailability, offering a quality glutathione option at a reasonable price per serving ($0.23), focusing on the core ingredient's efficacy.
77 Value 
Double Strength Silymarin 300 mg
NOW
4.8
★★★★★
(59188 ratings)
From the same reputable brand, this provides a stronger dose of Milk Thistle (300mg) plus Artichoke and Dandelion at a very good price per serving ($0.14), offering enhanced liver and detoxification support as a primary benefit.
88 Performance 
Anti-Alcohol HepatoProtection Complex
Life Extension
4.5
★★★★★
(3351 ratings)
Features a very high dose of N-Acetyl-L-Cysteine (NAC) (1200mg), which is a superior precursor for the body's natural glutathione production, along with supporting antioxidants and liver protective compounds, offering a more comprehensive and effective detoxification strategy.
85 Performance 
Liver Refresh
NOW
4.8
★★★★★
(19787 ratings)
This product offers a broader spectrum of liver-supporting ingredients, including NAC, a higher dose of ALA, and various herbal extracts, which collectively provide a more holistic approach to liver health and detoxification than a primary glutathione supplement alone.
85 Performance 
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Offers 500mg of Glutathione (Reduced) from a highly reputable brand known for quality and research. While similar in dose to the original, Jarrow Formulas is a strong alternative for those prioritizing brand trust and a focused glutathione product.
78 Budget 
Milk Thistle Extract 175 mg
Lake Avenue Nutrition
4.7
★★★★★
(5433 ratings)
Offers targeted liver support through Milk Thistle at an exceptionally low price per serving ($0.07), providing a very cost-effective way to address the detoxification goal, though without glutathione.
82 Budget 
Silymarin Complex
California Gold Nutrition
4.8
★★★★★
(70295 ratings)
A highly affordable option at $0.08 per serving, this complex provides 300mg of Milk Thistle along with other beneficial liver-supporting herbs like Dandelion and Artichoke, delivering excellent value for broad detoxification.
75 Budget 
Milk Thistle 250 mg
Nature's Bounty
4.7
★★★★★
(6885 ratings)
Provides a good dose of Milk Thistle (250mg Silymarin) at a significantly lower price per serving ($0.08), making it a highly economical choice for liver detoxification support.
80 Value
Silymarin Complex
California Gold Nutrition
4.8
★★★★★
(70682 ratings)
This complex provides 300mg of Milk Thistle extract along with Dandelion, Artichoke, and Turmeric, offering comprehensive liver and antioxidant support at a highly competitive price per serving ($0.12), delivering excellent value for its multi-ingredient profile.
78 Value
High Potency L-Glutathione 200 mg
Swanson Ultra
4.6
★★★★★
(498 ratings)
Utilizes Setria Glutathione, a patented and highly regarded form known for better bioavailability, offering a quality glutathione option at a reasonable price per serving ($0.23), focusing on the core ingredient's efficacy.
77 Value
Double Strength Silymarin 300 mg
NOW
4.8
★★★★★
(59188 ratings)
From the same reputable brand, this provides a stronger dose of Milk Thistle (300mg) plus Artichoke and Dandelion at a very good price per serving ($0.14), offering enhanced liver and detoxification support as a primary benefit.
88 Performance
Anti-Alcohol HepatoProtection Complex
Life Extension
4.5
★★★★★
(3351 ratings)
Features a very high dose of N-Acetyl-L-Cysteine (NAC) (1200mg), which is a superior precursor for the body's natural glutathione production, along with supporting antioxidants and liver protective compounds, offering a more comprehensive and effective detoxification strategy.
85 Performance
Liver Refresh
NOW
4.8
★★★★★
(19787 ratings)
This product offers a broader spectrum of liver-supporting ingredients, including NAC, a higher dose of ALA, and various herbal extracts, which collectively provide a more holistic approach to liver health and detoxification than a primary glutathione supplement alone.
85 Performance
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Offers 500mg of Glutathione (Reduced) from a highly reputable brand known for quality and research. While similar in dose to the original, Jarrow Formulas is a strong alternative for those prioritizing brand trust and a focused glutathione product.