Sillybin Advanced
Nature's Way
Sillybin Advanced
4.4
★ ★ ★ ★ ★
(495 ratings)
Milk Thistle 120 mg
Score 85.0
A premium Milk Thistle supplement utilizing highly bioavailable Phytosome technology for superior absorption and potent liver and detoxification support.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Detoxification
Skin Health
leaderboard Score 85.0
A premium Milk Thistle supplement utilizing highly bioavailable Phytosome technology for superior absorption and potent liver and detoxification support.
Quantity: 60, Dose: 175mgQuantity: 120, Dose: 254mgQuantity: 100, Dose: 175mgQuantity: 120, Dose: 175mg
insights Analysis
Nature's Way Sillybin Advanced features 120mg of Milk Thistle fruit extract Phytosome, a specialized complex designed to dramatically improve the absorption of Silymarin, the active component of Milk Thistle. This enhanced bioavailability means that a lower dose of the phytosome form can be more effective than higher doses of standard extracts. At $0.39 per serving, it's a premium product focusing on maximum efficacy for liver detoxification and indirect skin health benefits.
- Features Milk Thistle Phytosome for significantly enhanced bioavailability and absorption.
- Ensures more effective delivery of Silymarin to the liver.
- From Nature's Way, a reputable brand known for quality herbal products.
- Higher price per serving ($0.39) compared to standard Milk Thistle extracts.
- The listed dosage (120mg) might seem lower than other products, but its enhanced absorption compensates for this.
- Consult a healthcare professional if pregnant, nursing, or taking medications, especially for liver conditions, as potent supplements may have interactions.
$23.49($0.39 per serving)
 iHerb | $ 23.49 |
bolt Effectiveness for goals
Milk Thistle, primarily through its active compound silymarin, is widely studied for its potential to support liver health. Research suggests it may offer antioxidant and anti-inflammatory benefits to liver cells. However, more comprehensive studies are ongoing to fully understand its extent of effectiveness.
Historically, Milk Thistle has been used in relation to alcoholic liver disease, and some studies suggest it may help shield liver cells from alcohol-related harm. While it shows potential, it is not considered a cure or a replacement for conventional medical treatment and abstinence. Its role is primarily supportive.
Milk Thistle is often associated with supporting the liver's natural detoxification processes due to its antioxidant properties. It may help protect liver cells from damage by harmful substances. However, the human body has its own efficient detoxification systems, and the term 'detoxification' can be broadly interpreted.
The general scientific consensus is that Milk Thistle shows promise as a supportive supplement for liver health, backed by traditional use and some research. While it's not a proven cure for severe liver diseases, it's considered a potentially beneficial agent for liver protection. More large-scale, high-quality human trials are needed to fully confirm its efficacy for various conditions.
Some preliminary studies indicate Milk Thistle may offer benefits for individuals with NAFLD, potentially by reducing inflammation and oxidative stress in the liver. Despite promising early findings, the current scientific evidence is not strong enough to recommend it as a primary treatment. Consultation with a healthcare professional is advised.
schedule Dosage, timing & forms
Typical daily dosages of Milk Thistle extract often range from 200 mg to 400 mg, standardized to 70-80% silymarin. Some research has explored higher doses for specific contexts. For general use, dosages usually fall within the 200-400 mg range, often divided into multiple smaller doses throughout the day.
Milk Thistle is generally recommended to be taken with food. This can help improve the absorption of its active compounds, particularly silymarin. Taking it with food may also help reduce the likelihood of minor digestive upset.
Many formulations of Milk Thistle recommend taking it two to three times per day. Dividing the daily dose helps maintain consistent levels of its active compounds in the body. Always refer to the specific product label for detailed instructions.
Milk Thistle is commonly available as capsules, tablets, and liquid extracts. It can also be found in tea bags or powder form. Capsules and tablets are the most prevalent, often standardized for their silymarin content.
Standardization means the extract is processed to contain a specific, guaranteed percentage of the active compound, silymarin. This process helps ensure consistency in potency between different batches and brands of the supplement. A common standardization level is 70-80% silymarin.
health_and_safety Safety & interactions
Yes, milk thistle can interact with certain prescription medications, particularly those metabolized by the cytochrome P450 enzyme system in the liver. This could potentially alter how the body processes drugs, affecting their effectiveness or increasing side effects. It is important to consult a healthcare professional before combining milk thistle with any medications.
Milk thistle is generally well-tolerated, but some individuals may experience mild gastrointestinal upset, such as nausea, diarrhea, or indigestion. Allergic reactions are also possible, especially in individuals sensitive to plants in the Asteraceae family. If severe or persistent side effects occur, discontinue use and consult a healthcare provider.
Some research suggests that milk thistle might have mild antiplatelet effects, which theoretically could increase the risk of bleeding when taken with anticoagulant or antiplatelet medications. However, the evidence for this interaction is limited and conflicting. Individuals on blood thinners should discuss milk thistle use with their healthcare provider.
Milk thistle may have a mild blood sugar-lowering effect, particularly in individuals with type 2 diabetes. Those managing diabetes or taking medications to control blood sugar should monitor their glucose levels closely if using milk thistle. Discussing this with a healthcare provider is advised to prevent potential hypoglycemia.
Due to insufficient scientific data on its safety during pregnancy and breastfeeding, milk thistle is generally not recommended for these populations. There is limited information regarding its potential effects on the fetus or infant. It is always best to consult a healthcare provider before using any supplements during these periods.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Milk Thistle fruit extract Phytosome | 120 mg |
Categories
Milk Thistle 92.0
Within the Milk Thistle category, this product is a top performer due to its use of a superior, highly bioavailable form (Phytosome), which fundamentally enhances its efficacy beyond standard extracts, positioning it as a leading choice for potent liver support.
Goals
Detoxification 95.0
The enhanced bioavailability of Milk Thistle Phytosome ensures optimal absorption and delivery of Silymarin to the liver, providing superior protection against toxins and promoting liver cell regeneration, making it exceptionally effective for detoxification processes.
Skin Health 88.0
Through its unparalleled support for liver detoxification and cellular health due to superior absorption, this product offers profound indirect benefits to skin, helping to mitigate toxin-induced skin issues and promoting overall clarity and vitality by optimizing internal cleansing processes.
Recommended Alternatives
90 Value 
Double Strength Silymarin
NOW
4.8
★★★★★
(62613 ratings)
At $0.10 per serving, this NOW product delivers 300mg of Milk Thistle extract plus Dandelion and Artichoke, offering a higher dose of Silymarin and synergistic herbs at a significantly lower price point, providing excellent value for a potent formula that, while not phytosome, offers great value.
90 Value 
Silymarin Complex
California Gold Nutrition
4.8
★★★★★
(70682 ratings)
This complex includes 300mg of Silymarin and a range of complementary herbs (Artichoke, Dandelion, Turmeric, Ginger, Black Pepper) for $0.12 per serving, presenting a superior value proposition for comprehensive liver support with a good Silymarin dose.
80 Value 
Milk Thistle
Paradise
4.7
★★★★★
(2440 ratings)
Providing 250mg of Silymarin per serving at $0.16, this Paradise product offers a substantial dose of the active ingredient at a considerably lower price, making it a strong value for those seeking effective liver support without the premium cost of advanced forms.
95 Performance 
Advanced Milk Thistle
Life Extension
4.6
★★★★★
(7146 ratings)
This product features Siliphos Phytosome, an advanced form that dramatically increases the bioavailability of Milk Thistle, ensuring more effective absorption and superior benefits for liver support, making it an equally effective and premium choice.
90 Performance 
Premium Milk Thistle 160 mg
Natural Factors
4.7
★★★★★
(1292 ratings)
Also utilizing Siliphos Milk Thistle Phytosome, this supplement provides comparable enhanced bioavailability, making its standardized Silymarin content potentially more effective than higher doses of less bioavailable forms for targeted liver support.
88 Performance 
Silymarin Plus
Futurebiotics
4.8
★★★★★
(165 ratings)
This supplement delivers a very high 552mg of standardized Silymarin combined with other potent liver-supporting ingredients, providing a more robust and multi-faceted approach to liver health through its sheer dosage and synergistic blend.
80 Budget 
Milk Thistle Extract 175 mg
Lake Avenue Nutrition
4.7
★★★★★
(5433 ratings)
At $0.07 per serving for 175mg of standardized Silymarin, this product is significantly cheaper for basic Milk Thistle benefits, though it lacks the advanced bioavailability of Phytosome.
85 Budget 
Milk Thistle 250 mg
Nature's Bounty
4.7
★★★★★
(6885 ratings)
With 250mg of Silymarin for just $0.08 per serving, this offers a high dose at an extremely low price, providing a more economical option for general liver support, albeit without the enhanced absorption.
92 Budget 
Silymarin Complex
California Gold Nutrition
4.8
★★★★★
(70295 ratings)
This complex includes 300mg of Silymarin and a comprehensive blend of synergistic herbs for only $0.08 per serving, offering a potent multi-ingredient formula at a vastly lower price point.
90 Value
Double Strength Silymarin
NOW
4.8
★★★★★
(62613 ratings)
At $0.10 per serving, this NOW product delivers 300mg of Milk Thistle extract plus Dandelion and Artichoke, offering a higher dose of Silymarin and synergistic herbs at a significantly lower price point, providing excellent value for a potent formula that, while not phytosome, offers great value.
90 Value
Silymarin Complex
California Gold Nutrition
4.8
★★★★★
(70682 ratings)
This complex includes 300mg of Silymarin and a range of complementary herbs (Artichoke, Dandelion, Turmeric, Ginger, Black Pepper) for $0.12 per serving, presenting a superior value proposition for comprehensive liver support with a good Silymarin dose.
80 Value
Milk Thistle
Paradise
4.7
★★★★★
(2440 ratings)
Providing 250mg of Silymarin per serving at $0.16, this Paradise product offers a substantial dose of the active ingredient at a considerably lower price, making it a strong value for those seeking effective liver support without the premium cost of advanced forms.
95 Performance
Advanced Milk Thistle
Life Extension
4.6
★★★★★
(7146 ratings)
This product features Siliphos Phytosome, an advanced form that dramatically increases the bioavailability of Milk Thistle, ensuring more effective absorption and superior benefits for liver support, making it an equally effective and premium choice.
90 Performance
Premium Milk Thistle 160 mg
Natural Factors
4.7
★★★★★
(1292 ratings)
Also utilizing Siliphos Milk Thistle Phytosome, this supplement provides comparable enhanced bioavailability, making its standardized Silymarin content potentially more effective than higher doses of less bioavailable forms for targeted liver support.
88 Performance
Silymarin Plus
Futurebiotics
4.8
★★★★★
(165 ratings)
This supplement delivers a very high 552mg of standardized Silymarin combined with other potent liver-supporting ingredients, providing a more robust and multi-faceted approach to liver health through its sheer dosage and synergistic blend.