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Milk Thistle Seed

4.7
★ ★ ★ ★ ★
(2436 ratings)
Milk Thistle 600 mg
Product Image
Score73
Focused liquid seed delivery is a useful feature, though unquantified silymarin and costly use remain important trade-offs.
How scoring works
Capsule
Quantity:120 Liquid(s) • (40 servings)
Goals:
Detoxification

Score 73

Focused liquid seed delivery is a useful feature, though unquantified silymarin and costly use remain important trade-offs.
How scoring works
$51.29($1.28 per serving)
iHerb
$ 51.29
Pure Formulas
$ 51.29
Amazon
$ 51.29
Vitacost
$ 51.29
Vitacost
$ 51.29
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Analysis

A 600 mg milk thistle seed extract provides a clear, single-botanical route to antioxidant and liver-cell support. Liquid-filled delivery may offer better solubility than ordinary dry seed powder.

The label does not state a silymarin percentage or active yield, so the extract amount cannot be translated into confirmed potency. The formula’s uncertainty lies in characterization rather than ingredient relevance.

The larger bottle improves supply compared with the smaller version, but regular use remains costly. It is better for format-focused users than shoppers seeking a clearly standardized active dose or strong value.

Who is it for
  • Adults who prefer liquid extracts
  • Users prioritizing seed sourcing
Best for
  • Focused botanical support
  • Liquid-filled capsule delivery

Pros

  • Seed-derived extract
  • Liquid delivery
  • Single-botanical focus

Cons

  • No active silymarin yield
  • Costly regular use
  • No standardization percentage

Warnings

  • Milk thistle can cause digestive upset in some users; stop or reduce use if symptoms persist.
  • People allergic to ragweed-family plants may also react to milk thistle.
  • Milk thistle may affect blood sugar, so people using glucose-lowering medicine should discuss it with their clinician.

Nutrient quality

84 Highest impact

The preferred seed source and liquid delivery provide useful quality signals. The extract amount is substantial, but missing active-marker standardization leaves potency uncertain.

Ingredient transparency

78 High impact

The active ingredient has a stated amount without a hidden proprietary blend. Standardization or source details, daily-use directions, and non-active ingredients remain incomplete.

Customer satisfaction

69 High impact

The supplied average rating is strong and is supported by large review count. No detailed feedback is available to assess repeated complaints or purpose-specific experiences.

Value for money

54 Moderate impact

Seed sourcing and liquid delivery support formula quality. The high qualitative serving cost is difficult to justify without a verified active yield.

Report analysis

Goals

Detoxification
Impact
High effect
B Goal FitC Strength of SupportD+ CoverageA Formula Quality
Milk Thistle · 600 mg

A concentrated seed extract directly supports liver-cell protection and antioxidant defenses. Human evidence for milk thistle is relevant, though results depend on a sufficiently characterized silymarin dose.

The liquid capsule may improve solubility, but the label does not identify a silymarin amount or standardization percentage. The formula is clean and focused, with uncertainty centered on active potency rather than ingredient relevance.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s)
Milk Thistle (Silybum marianum) seed extract
600 mg
Gluten Free Adults 18–50 Vegan Women Vegetarian
Report overview
Milk Thistle · 600 mg OverallScore24
C Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Liquid delivery may support better solubility than ordinary dry powder. Seed or fruit sourcing is appropriate, although the active-marker yield remains unclear. The very high serving cost lacks enough potency or delivery evidence to justify it.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  3. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  4. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  5. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  6. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  7. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  8. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  9. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle