Product Image

Detox & Liver Health

Reg'Activ
4.7
★ ★ ★ ★ ★
(176 ratings)
Selenium 100 mcg
Methionine
Milk Thistle 250 mg
Product Image
Score73
A coherent liver-support blend with NAC, milk thistle, selenium, methionine, and a named probiotic strain. Unstandardized milk thistle, moderate precursor amounts, and high cost limit its value.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Detoxification
General Health
Immunity

Score 73

A coherent liver-support blend with NAC, milk thistle, selenium, methionine, and a named probiotic strain. Unstandardized milk thistle, moderate precursor amounts, and high cost limit its value.
How scoring works
$39.96($1.33 per serving)
iHerb
$ 44.64
Pure Formulas
$ 39.96
Vitacost
$ 49.95
Report prices

Analysis

NAC supplies cysteine for glutathione production, while selenium and methionine support antioxidant and methylation pathways. Milk thistle adds botanical liver support, and Lactobacillus fermentum ME-3 gives the formula a distinctive probiotic component.

The selenomethionine form is well chosen and the probiotic strain is clearly named. Milk thistle lacks a stated silymarin concentration, and the NAC and methionine amounts are lower than in many focused products.

Two capsules are manageable, but the serving is expensive for the disclosed potency. It suits users who specifically want the combined probiotic and antioxidant approach rather than maximum NAC or standardized milk thistle.

Who is it for
  • Adults seeking combined antioxidant and liver support
  • Users interested in the ME-3 probiotic strain
  • People wanting NAC with milk thistle
Best for
  • Supporting glutathione production
  • General liver-support nutrition
  • Antioxidant support

Pros

  • Uses selenomethionine
  • Includes NAC
  • Names the probiotic strain
  • Combines multiple glutathione-related nutrients

Cons

  • Milk thistle is not standardized
  • NAC amount is moderate
  • Methionine amount is small
  • High serving cost

Warnings

  • NAC can intensify the blood-pressure-lowering and headache effects of nitroglycerin.
  • Milk thistle may affect how some medicines are processed.
  • Probiotic use warrants professional review in severely immunocompromised users.
  • Selenium should not be stacked freely with other high-selenium products.

Nutrient quality

80 Highest impact

Selenomethionine and N-acetyl cysteine are recognized forms, while milk thistle lacks marker standardization. Selenium and milk thistle are useful, but N-acetyl cysteine and methionine are modest for focused support.

.

Ingredient transparency

83 Highest impact

Every listed active has a specific amount. Serving count is available, but complete intake guidance is not supplied.

.

Customer satisfaction

68 High impact

The aggregate rating is strong and supported by moderate rating volume. No specific feedback was supplied to judge repeated complaints or fit with the intended use.

.

Value for money

54 Moderate impact

The formula quality does not fully justify the high asking price. Each serving is costly relative to the modest precursor and methionine amounts.

.
Report analysis

Goals

Detoxification
Detoxification
Impact
Highest effect
A Goal FitB- Strength of SupportA- CoverageA+ Formula Quality
Selenium · 100 mcgMilk Thistle · 250 mg

Milk thistle supports liver-cell protection, while N-acetyl-cysteine, selenium, and methionine contribute to glutathione production and recycling. The probiotic adds a gut-related pathway, giving the formula strong coverage across liver and antioxidant functions.

Selenomethionine is well absorbed and all ingredient amounts are visible, but the milk thistle marker is not standardized and the NAC and methionine amounts are modest. The combination is coherent and relevant, though its strongest ingredients do not all reach the depth expected from dedicated products.

Study evidence
Milk Thistle Supportive 46 studies
Selenium Supportive 10 studies
General Health
General Health
Impact
High effect
B- Goal FitC+ Strength of SupportC+ CoverageA- Formula Quality
Selenium · 100 mcg

Selenomethionine, milk thistle, N-acetyl-cysteine, methionine, and a named probiotic create a coherent antioxidant and liver-support concept. The selenium amount is useful, while several companion ingredients lack the potency details needed to confirm their contribution.

Milk thistle standardization and probiotic colony count are not given, and the N-acetyl-cysteine amount is modest for targeted use. The formula may support a focused aspect of general health but is less complete and transparent than a foundational nutrient product.

Study evidence
Selenium Supportive 70 studies
Immunity
Immunity
Impact
High effect
C Goal FitC Strength of SupportC+ CoverageB Formula Quality
Selenium · 100 mcg

Selenium, N-acetyl-cysteine, and a named probiotic strain offer plausible antioxidant and gut-immune support. Milk thistle and methionine make the formula more focused on liver metabolism than direct immune readiness.

The probiotic is reported by weight rather than viable count, and generic selenomethionine lacks isomer detail. The combination is coherent for antioxidant support but only moderately aligned with the selected immune goal.

Study evidence
Selenium Mixed 37 studies

Ingredients

IngredientAmount per serving
Selenium (Selenomethionine)
 100 mcg
Lactobacillus fermentum ME-3
60 mg
Milk Thistle fruit extract
250 mg
N-Acetyl-Cysteine
200 mg
L-Methionine
50 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Selenium (Selenomethionine) · 100 mcg OverallScore58
D+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
Generic selenomethionine suggests an organic compound, but the active L isomer and branded source are not disclosed. The maintenance-level amount leaves a broad safety buffer, though two servings are needed to reach the standard research dose. Its high standardized cost makes it weak value for someone mainly seeking selenium.
View ingredientView products
Methionine · 50 mg OverallScore55
C Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyD- Value

The biologically active L-isomer is clearly identified, but its amount sits at the low end for a combination formula. No purity grade or branded methionine source is disclosed. The expensive serving is supported by a distinctive probiotic and several substantial companion ingredients, yet value for methionine specifically remains weak.

View ingredientView products
Milk Thistle · 250 mg OverallScore16
D- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The dry format provides no stated absorption advantage. Seed or fruit sourcing is appropriate, although the active-marker yield remains unclear. The very high serving cost lacks enough potency or delivery evidence to justify it.

View ingredientView products
Loading alternative details
77 Performance

Liver Support Factors

Country Life
Ingredient quality or goal fit is stronger because the original uses unstandardized milk thistle and only modest N-acetyl cysteine and methionine amounts. A meaningful methionine amount is paired with choline, milk thistle, artichoke, and turmeric for coherent liver and bile support. Most botanical extracts lack active-marker standardization and several companion amounts are modest.
74 Performance

Glutathione Booster

Carlson
Ingredient quality or goal fit is stronger because the original uses unstandardized milk thistle and only modest N-acetyl cysteine and methionine amounts. Selenomethionine, N-acetyl cysteine, milk thistle, vitamin C, garlic, and alpha-lipoic acid provide broad antioxidant coverage. Several active amounts are modest or unstandardized, and garlic may add bleeding risk with anticoagulant or antiplatelet medicines.
71 Performance

DIM Detox

Pure Encapsulations
Ingredient quality or goal fit is stronger because the original uses unstandardized milk thistle and only modest N-acetyl cysteine and methionine amounts. DIM, calcium-D-glucarate, lignan, N-acetyl cysteine, alpha-lipoic acid, milk thistle, and methionine form a broad detoxification formula. Several supporting amino acids are modest and milk-thistle strength is unclear.
66 Budget

Advanced Liver Support

Super Nutrition
A lower serving cost improves everyday affordability. Milk thistle, reduced glutathione, N-acetyl cysteine, grape-seed polyphenols, and alpha-lipoic acid provide broad liver-oriented antioxidant coverage. A hidden enzyme blend and numerous small additions reduce focus despite the low serving cost.
65 Budget

Super Thisilyn

Nature's Way
A lower serving cost improves everyday affordability. Milk thistle is paired with artichoke, N-acetyl cysteine, methionine, turmeric, and alpha-lipoic acid in a broad liver formula. Most companion amounts are modest and a proprietary vegetable blend reduces transparency.
69 Budget

Lipotropic Complex

Integrative Therapeutics
A lower serving cost improves everyday affordability. L-methionine, active vitamin B6, methylcobalamin, choline, milk thistle, dandelion, and ox bile create a coherent lipotropic formula. Milk-thistle potency is unclear, magnesium partly uses oxide, and ox bile may be unsuitable when bile flow is obstructed.
63 Value

Liver Refresh

NOW
The balance of ingredient focus and routine cost improves practical value because the original uses unstandardized milk thistle and only modest N-acetyl cysteine and methionine amounts. Milk-thistle flavonoids are paired with glutathione, N-acetyl cysteine, grape-seed polyphenols, alpha-lipoic acid, and schisandra. A hidden enzyme blend and many modest additions limit precision.
68 Value

Extra Care Liver Support

Renew Life
The balance of ingredient focus and routine cost improves practical value because the original uses unstandardized milk thistle and only modest N-acetyl cysteine and methionine amounts. Selenomethionine, vitamin C, milk thistle, amino acids, and alpha-lipoic acid provide broad liver-oriented antioxidant coverage. Milk-thistle active yield and the composition of the amino-acid complex are not disclosed.
68 Value

LV-GB Complex

Designs for Health
The balance of ingredient focus and routine cost improves practical value because the original uses unstandardized milk thistle and only modest N-acetyl cysteine and methionine amounts. Active B vitamins, methionine, silymarin, ox bile, dandelion, and artichoke create broad liver and gallbladder support. Greater celandine has been linked to liver injury, so people with liver disease or unexplained liver symptoms should avoid unsupervised use.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  2. Selenium supplementation for the primary prevention of cardiovascular disease.
    Rees K; Hartley L; Day C; Flowers N; Clarke A; Stranges S · The Cochrane database of systematic reviews · 2013
    Meta-analysis19,715 participants12 studies pooledGeneral Health forSelenium
  3. Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials.
    Jenkins DJA; Kitts D; Giovannucci EL; Sahye-Pudaruth S; Paquette M; Blanco Mejia S; Patel D; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · The American journal of clinical nutrition · 2021
    Meta-analysis43 studies pooledGeneral Health forSelenium
  4. Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses.
    Wang P; Chen B; Huang Y; Li J; Cao D; Chen Z; Li J; Ran B; Yang J; Wang R; Wei Q; Dong Q; Liu L · Frontiers in nutrition · 2024
    Systematic reviewGeneral Health forSelenium
  5. Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial.
    Rayman MP; Winther KH; Pastor-Barriuso R; Cold F; Thvilum M; Stranges S; Guallar E; Cold S · Free radical biology & medicine · 2019
    Randomized trial491 participantsGeneral Health forSelenium
  6. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  7. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  8. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  9. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  10. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  11. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  12. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  13. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  14. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle
  15. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
    Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
    Randomized trialDetoxification forSelenium
  16. [Selenium and oxidative stress in cancer patients].
    Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
    Single-arm trial40 participantsDetoxification forSelenium
  17. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
    Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
    Other40 participantsDetoxification forSelenium
  18. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
    Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
    Cross-sectional study9,445 participantsDetoxification forSelenium
  19. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
    Randomized trial35 participantsDetoxification forSelenium
  20. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  21. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  22. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  23. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  24. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  25. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  26. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  27. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  28. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium