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Liver Support Factors

Country Life
4.7
★ ★ ★ ★ ★
(288 ratings)
Methionine
Choline 116 mg
Turmeric 25 mg
Milk Thistle 168 mg
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Score77
A coherent liver-support blend led by a solid methionine amount, with weaker evidence for its modest, unstandardized botanicals.
How scoring works
Quantity:100 Capsule(s) • (50 servings)
Goals:
Detoxification

Score 77

A coherent liver-support blend led by a solid methionine amount, with weaker evidence for its modest, unstandardized botanicals.
How scoring works
$30.44($0.60 per serving)
iHerb
$ 30.44
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Analysis

L-methionine is the best-developed component and is present at a substantial amount. Choline, milk thistle, artichoke, and turmeric add complementary liver and bile-support roles.

Every active has a stated quantity, but milk thistle lacks a silymarin percentage and turmeric lacks a curcuminoid percentage or absorption enhancer. The small turmeric amount is unlikely to provide meaningful stand-alone turmeric support.

The two-capsule serving is practical and the broad concept is coherent. Buyers seeking a high-quality standardized milk thistle or turmeric product will find the formula less compelling than those mainly interested in methionine.

Who is it for
  • Adults seeking combined liver-support ingredients
  • Users who value a substantial methionine amount
  • People comfortable with nonstandardized botanicals
Best for
  • Methionine-centered liver support
  • Combined choline and botanical use
  • Two-capsule routines

Pros

  • Substantial L-methionine amount
  • Clearly lists each active quantity
  • Coherent liver-support combination

Cons

  • Milk-thistle standardization is missing
  • Turmeric amount is small and lacks absorption support
  • Weak value for choline or botanicals alone

Nutrient quality

80 High impact

No disclosed amount is obviously excessive. L-methionine is clear, while milk thistle, artichoke, and turmeric lack full standardization details.

Ingredient transparency

84 Highest impact

All active amounts are stated individually. Inactive ingredients are not supplied.

Customer satisfaction

68 High impact

The aggregate satisfaction metric is strong. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

73 High impact

Most additions support the intended use rather than inflate the label. The serving cost is reasonable for the disclosed core actives.

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Goals

Detoxification
Detoxification
Impact
High effect
B+ Goal FitD+ Strength of SupportC+ CoverageB- Formula Quality
Milk Thistle · 168 mgCholine · 116 mg

Milk thistle, methionine, choline, artichoke, and turmeric form a plausible liver-support combination. Methionine contributes sulfur amino-acid support, while the botanicals may help protect liver cells and bile flow.

Active-marker standardization is not stated for milk thistle or most botanical extracts. Several companion botanicals are modestly dosed, which limits confidence in the formula beyond its core methionine and milk thistle.

Study evidence
Choline Supportive 6 studies
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Choline (Choline Bitartrate)
 116 mg
L-Methionine
400 mg
Milk Thistle extract
168 mg
Artichoke extract
50 mg
Turmeric extract (Curcuminoids)
 25 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
Methionine · 400 mg OverallScore83
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

The natural L-form and high dose make this a substantial Methionine option within a multi-ingredient formula. Exact quantity is clearly disclosed, though no premium grade or branded source is named. The serving cost is near the collection norm and is reasonable for the potent dose plus complementary extracts.

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Choline (Choline Bitartrate) · 116 mg OverallScore62
C+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Choline bitartrate supplies a moderate amount suited more to general liver and systemic support than focused cognitive support. The label clearly identifies the choline amount and source, while the two-capsule serving is reasonably practical. Cost efficiency is weak for the amount of elemental choline delivered.

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Turmeric (Curcuminoids) · 25 mg OverallScore28
F Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyD- Value

Only a small curcuminoid amount is supplied within a broader liver-support formula. The label clearly identifies that amount but offers no standardization percentage or absorption enhancer. Value is limited for users seeking turmeric as the main active.

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81 Performance

Milk Thistle Phytosome 150 mg

Natural Factors HerbalFactors
<p>Phytosome delivery strengthens the absorption case for milk thistle compared with the original’s unstandardized extract. The active silymarin yield is still undisclosed and supporting botanicals are modest, while methionine and choline are omitted.</p>
74 Performance

Active Liver

New Nordic
<p>Artichoke, milk thistle, and turmeric provide a coherent liver and bile-support design with strong detoxification alignment. Active-marker yields remain unclear, and the formula is less complete for methionine and choline support.</p>
69 Performance

Liver Detox & Blood Refresh

Irwin Naturals
<p>A substantial silymarin amount anchors direct liver and antioxidant support with vitamin C, selenium, burdock, and dandelion. Numerous small additions crowd the formula, while cayenne and concentrated botanicals may irritate sensitive digestion.</p>
80 Budget

Silymarin Complex

California Gold Nutrition
<p>Milk thistle, dandelion, artichoke, turmeric, ginger, and black pepper provide a coherent liver blend at substantially lower serving cost. Active silymarin yield is not disclosed, and the formula gives up the original’s meaningful methionine and choline.</p>
74 Budget

Liv-Gall Cleanse

Natural Factors HerbalFactors
<p>Artichoke, milk thistle, turmeric, and dandelion create a very low-cost liver-focused blend. Small unstandardized extracts make potency hard to verify, while methionine and choline are absent.</p>
78 Budget

Silymarin Milk Thistle Extract 150 mg

NOW
<p>Milk-thistle flavonoids and a substantial turmeric weight provide direct liver support at lower serving cost. Active silymarin and curcuminoid yields remain unclear, and the narrower formula lacks methionine and choline.</p>
65 Value

Super Thisilyn

Nature's Way
<p>Milk thistle, artichoke, NAC, methionine, turmeric, and alpha-lipoic acid broaden liver support while improving serving value. Most companion actives are small and milk-thistle potency is unclear, while a proprietary vegetable blend reduces transparency.</p>
66 Value

Advanced Liver Support

Super Nutrition
<p>Standardized milk thistle offers a useful liver-support foundation at excellent serving value. Modest companion amounts and a hidden enzyme blend reduce focus, and the original’s meaningful methionine is not matched.</p>
64 Value

Silymarin Plus

Futurebiotics
<p>Milk thistle, choline, dandelion, and inositol preserve a coherent liver-support direction at slightly better serving value. Milk-thistle standardization is missing and an undefined absorption blend adds uncertainty, while methionine is absent.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
    Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
    Cross-sectional study20,643 participantsDetoxification forCholine
  2. Relationship of Choline Intake with Biomarkers of Liver Health by Genotype-A Cross-Sectional Analysis.
    Wallace TC; Cowan-Pyle AE; Klatt KC; Bailey RL · The Journal of nutrition · 2025
    Cross-sectional study1,438 participantsDetoxification forCholine
  3. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  4. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  5. Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
    Guideline / consensusDetoxification forCholine
  6. Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
    Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
    Observational study80 participantsDetoxification forCholine
  7. Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
    Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
    Single-arm trial10 participantsDetoxification forCholine
  8. 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
    Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
    Cohort study88 participantsDetoxification forCholine
  9. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  10. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  11. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  12. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle