Joint Health title image

Joint Health

Joint & Structural Health

Joint health helps make everyday movement comfortable, controlled, and enjoyable. It involves the cartilage and other tissues within the joint, the surrounding structures that provide support, and the muscles that help guide movement. Comfort, flexibility, and stability are connected priorities, but one may matter more to you than the others. Targeted nutrition can focus on different parts of this picture. Structural ingredients are used for connective-tissue support, while other formulations center on comfort or a balanced response to physical demands. Understanding the intended role helps you choose support that fits the movement you want to maintain. Progress is often easiest to recognize through familiar activities. Walking comfortably, moving through a usual range, or feeling more confident with everyday tasks can each be meaningful. Keeping those activities in view helps bring the routine back to its practical purpose: supporting the ability to stay active and take part in the things you enjoy.

Warnings

  • Check ingredient sources: Protein powders, collagen, bee products, and other ingredients may contain relevant allergens. Check the exact source and label, especially if you have a known food or bee-product allergy.
  • Check medicine interactions: Ask a pharmacist or clinician to review your exact products alongside your medicines. The ingredient, amount, and treatment determine which combinations are suitable.
  • Tell your surgical team: Share a complete supplement list before a procedure. The team can advise which products to stop and when; a single stopping interval is not appropriate for every supplement or procedure.
  • Recognize acute joint symptoms: A hot, swollen joint, fever, significant injury, or sudden loss of function needs timely assessment. A joint supplement is not a substitute for identifying the cause.
Ingredient overview

Goal guidance

Lifestyle changes

Keep moving within a comfortable range and build strength around the joints gradually. Balance activity with recovery and choose modifications that make familiar tasks easier to maintain.

Diet changes

Include enough protein and a varied intake of plants and unsaturated fats. Support a comfortable body weight and use supplements for a clearly defined joint or connective-tissue priority.

Who this is for

Adults seeking support for joint comfort, flexibility, and staying active through daily life or exercise.

Who should be careful

Review supplements with anticoagulants, medicines for chronic conditions, or planned surgery, and check allergens. A hot or swollen joint, fever, significant injury, or sudden loss of function needs timely assessment.

Expected timeline

Track comfort and ease of movement over several weeks, using familiar activities as a reference. Changes in strength and stability develop alongside regular, appropriate movement.

Common mistakes

Avoiding all movement or increasing activity too quickly can make a routine harder to sustain. Pair supplements with suitable strengthening and review progress through everyday function.

Ingredients

Collagen Protein
Impact
Highest effect
Typical dose5000–15000 mg / day

Hydrolyzed collagen peptides are easily absorbed and have been clinically shown to accumulate in cartilage, stimulating the production of new connective tissue, reducing joint pain, and improving function.

Focuses on
Joint pain reliefKnee stiffnessRange of motionExercise-induced discomfortFunctional mobility
Most relevant for
Individuals with knee osteoarthritis or active adults who experience joint discomfort during physical activities.

Potential benefits

  • Symptom Management.Daily use of specific collagen peptides or undenatured type II collagen may reduce pain and stiffness in those with knee osteoarthritis.
  • Flexibility Support.Supplementation has been shown to improve the knee range of motion, specifically flexion and extension, in both healthy and symptomatic groups.
  • Exercise Comfort.Clinical trials in young, active adults suggest that collagen may help ease joint discomfort triggered by physical activity or exercise-related stress.

Limitations

  • Inconsistent Outcomes.Some randomized controlled trials report no significant improvement compared to placebo for joint pain or physical function.
  • No Structural Reversal.There is no consistent evidence that collagen supplementation rebuilds joint cartilage or slows the progression of osteoarthritis.
  • Preparation Specificity.Results vary significantly between different collagen forms, such as undenatured type II and hydrolyzed peptides, which are not interchangeable.
Things to consider

Mild gastrointestinal side effects such as a feeling of fullness or an unpleasant taste may occur during supplementation.

Study evidence

49 studies

Collagen supplements may modestly reduce knee pain and improve function in people with osteoarthritis or activity-related discomfort. Results vary across collagen preparations, and some trials find no advantage over placebo; symptom relief does not establish cartilage repair or prevention of joint disease.

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Omega-3 Fatty Acids
Impact
Highest effect
Typical dose1000–3000 mg / day

The fatty acids EPA and DHA from sources like fish oil are precursors to signaling molecules called resolvins and protectins, which actively resolve inflammation. A high intake of Omega-3s is strongly correlated with improved outcomes in inflammatory joint conditions.

Focuses on
Joint pain intensityMorning stiffnessTender joint countNSAID reductionInflammatory joint support
Most relevant for
Individuals with inflammatory joint conditions, such as rheumatoid arthritis, seeking to manage symptoms and reduce reliance on pain-relief medications.

Potential benefits

  • Reduce Joint Pain Intensity.Meta-analyses of clinical trials show that omega-3 supplementation for 3 to 4 months can modestly decrease patient-reported joint pain and the number of tender joints in inflammatory conditions.
  • Ease Morning Stiffness.Consistent evidence indicates that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can help reduce the duration of morning stiffness in patients with active rheumatoid arthritis.
  • Support Medication Reduction.High-dose omega-3 intake (typically >2.7 g/day) is associated with a significant reduction in the required consumption of non-steroidal anti-inflammatory drugs (NSAIDs) for pain management.

Limitations

  • Uncertain for Osteoarthritis.Large cohort studies and clinical trials have found no consistent evidence that omega-3 prevents osteoarthritis or protects knee cartilage from structural damage or volume loss.
  • Selective Symptom Relief.While pain may improve, many studies report no significant impact on overall physical function, walking speed, or clinical markers of disease activity like C-reactive protein.
  • Delayed and Dose-Dependent.Meaningful improvements in joint symptoms typically require high daily doses and a minimum duration of 3 to 6 months to reach therapeutic levels in the joints.
Things to consider

Common side effects at higher doses include mild gastrointestinal issues such as belching and flatulence. High intake of omega-3 has not been shown to reduce the risk of hip or knee replacement surgery.

Study evidence

40 studies

Omega-3 supplements may modestly ease inflammatory joint symptoms, especially in rheumatoid arthritis, and sometimes reduce pain-medicine use. Benefits are inconsistent, particularly for osteoarthritis, and the available evidence does not establish that omega-3 prevents arthritis or protects joint cartilage.

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Boswellia Botanicals
Impact
High effect
Typical dose300–1000 mg / day

Boswellia serrata extract, standardized for its active compounds like AKBA, has demonstrated strong clinical results in improving joint comfort and function, often showing noticeable benefits within a week. It works synergistically with curcumin for broader anti-inflammatory coverage.

Focuses on
Joint pain reliefStiffness reductionPhysical mobilityFaster recovery onsetCartilage biomarker support
Most relevant for
Individuals with knee osteoarthritis seeking natural relief for joint pain and improved physical mobility.

Potential benefits

  • Pain and Stiffness Relief.Standardized extracts have demonstrated significant reductions in knee pain and morning stiffness, with some clinical trials showing improvements in as little as 5 to 7 days.
  • Enhanced Mobility and Function.Consistent supplementation supports better joint function, leading to improved performance in physical tasks like walking and climbing stairs in people with degenerative knee conditions.
  • Joint Structural Support.Unconfirmed. Preliminary evidence suggests it may reduce levels of enzymes that degrade cartilage, though its ability to definitively restore joint structure or prevent long-term deterioration remains unproven.

Limitations

  • Product Inconsistency.High heterogeneity among different Boswellia preparations means results from specific patented or standardized extracts may not apply to all commercial products.
  • Limited Audience Data.Most evidence is specifically focused on knee osteoarthritis; its efficacy for other joints or for preventing issues in healthy, active individuals is less established.
  • Duration Uncertainty.While studies up to 180 days show benefits, the long-term safety and lasting clinical efficacy beyond this period are not yet fully documented.
Things to consider

Inconsistent reporting of side effects in clinical trials means long-term safety is not fully established; consult a professional if you have underlying health conditions.

Study evidence

24 studies

Boswellia extracts can help reduce pain and improve function in people with knee osteoarthritis. Results vary across products and reviews, and the evidence is stronger for symptom relief than for lasting cartilage repair or protection of otherwise healthy joints.

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Curcumin Botanicals
Impact
High effect
Typical dose500–1500 mg / day

Curcumin, the active component in Turmeric, effectively targets pathways like NF-kB and COX-2. Its efficacy is comparable to some NSAIDs for osteoarthritis pain, but standard forms have poor bioavailability; it must be combined with an absorption enhancer like piperine or formulated as a phytosome.

Focuses on
Osteoarthritis painJoint mobilityJoint stiffnessPhysical function
Most relevant for
Adults with knee osteoarthritis seeking relief from joint pain and stiffness.

Potential benefits

  • Alleviates Osteoarthritis Pain.Extensive meta-analyses indicate that curcumin significantly reduces joint pain scores, with efficacy often matching standard anti-inflammatory medications like ibuprofen and diclofenac.
  • Enhances Physical Mobility.Regular use is associated with improved physical function scores and reduced stiffness, particularly in individuals with mild-to-moderate knee osteoarthritis.
  • Better Tolerability Profile.Compared to traditional anti-inflammatory drugs, curcumin formulations are frequently associated with fewer gastrointestinal side effects while providing similar symptom relief.

Limitations

  • Unproven for Healthy Joints.Benefits are primarily proven for those with existing joint conditions; evidence does not support using curcumin to maintain normal joint function or prevent disease in healthy individuals.
  • Structural Impact Uncertainty.Evidence that curcumin preserves cartilage or protects joint structure long-term is inconsistent, as imaging studies often fail to show significant structural changes.
  • Variable Formulation Efficacy.Clinical results vary significantly between different formulations, and short-term use (less than one week) often fails to outperform a placebo.
Things to consider

Standard curcumin has poor absorption and usually requires enhancers like piperine or specialized delivery systems to be effective. Optimal results in clinical trials often require at least 4 to 12 weeks of consistent use.

Study evidence

62 studies

Curcumin can help reduce pain and improve function in knee osteoarthritis, although results differ between studies and formulations. Evidence is stronger for symptom relief than for preserving cartilage, preventing arthritis or maintaining normal joint function in people without joint disease.

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Impact
High effect
Typical dose500–1000 mg / day

Gamma Linolenic Acid (from sources like Borage or Evening Primrose oil) is converted into DGLA, a precursor to anti-inflammatory prostaglandins (PGE1). This helps to balance pro-inflammatory pathways and has shown significant benefit in reducing symptoms of rheumatoid arthritis.

Focuses on
Rheumatoid arthritis symptomsJoint pain reliefMorning stiffnessJoint tendernessInflammatory response
Most relevant for
Individuals looking to manage inflammatory symptoms and stiffness associated with rheumatoid arthritis.

Potential benefits

  • Reduces Joint Pain.Systematic reviews of clinical trials suggest GLA can effectively decrease joint pain levels in people with inflammatory arthritis.
  • Improves Morning Stiffness.Evidence indicates that GLA may help reduce the duration and severity of stiffness experienced in the morning.
  • Decreases Joint Tenderness.Multiple studies have observed significant reductions in the number of tender joints following consistent GLA supplementation.

Limitations

  • Specific to Inflammatory Arthritis.Evidence is primarily centered on rheumatoid arthritis and may not apply to general joint wear or osteoarthritis.
  • No Proven Structural Benefit.Research has not established that GLA prevents long-term structural joint damage or disease progression.
  • Preparation Variability.Results may depend on the specific plant oil source and preparation used, which varied across clinical trials.
Things to consider

Doses used in successful clinical trials for joint symptoms are often significantly higher than those found in typical over-the-counter supplements.

Study evidence

5 studies

Gamma Linolenic Acid may ease pain, stiffness and joint tenderness in people with rheumatoid arthritis. The available research is encouraging but limited by variable study quality and differing preparations, and it does not establish protection against joint damage or benefits for general joint health.

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Hyaluronic Acid Other Nutrients
Impact
High effect
Typical dose80–240 mg / day

While once thought to be poorly absorbed, studies now show that oral hyaluronic acid can reach the joints, where it helps to maintain the viscosity of synovial fluid. This can lead to reduced pain and improved mobility, particularly in the knees.

Focuses on
Joint lubricationKnee mobilityOsteoarthritis pain reliefSynovial fluid supportJoint stiffness
Most relevant for
Individuals with mild to moderate knee osteoarthritis seeking to manage pain and stiffness.

Potential benefits

  • Osteoarthritis Symptom Relief.Oral and injectable forms may help reduce joint pain and stiffness in individuals with osteoarthritis, particularly in the knees.
  • Synovial Fluid Support.Helps maintain the viscosity of the fluid that cushions and lubricates joints, which may lead to improved mobility during daily activities.
  • Non-Surgical Management Option.Unconfirmed. Provides a well-tolerated alternative for symptom management in patients who may not yet be candidates for more invasive procedures.

Limitations

  • Inconsistent Results Across Joints.While knee studies show promise, evidence for the hip, shoulder, and hands is less convincing and often shows no benefit over placebo.
  • Limited Oral Research.Most clinical data is based on direct joint injections; oral supplements have smaller, less extensive evidence and their effectiveness compared to injections is not fully established.
  • No Disease Modification.Research does not show that hyaluronic acid can reliably rebuild joint cartilage or stop the underlying progression of joint disease.
Things to consider

Oral supplements are generally well-tolerated with few side effects, while injections may cause temporary local pain or swelling. High levels of naturally occurring hyaluronic acid in the blood are often a marker of existing joint damage rather than a sign of benefit.

Study evidence

156 studies

Hyaluronic Acid may reduce joint pain and improve function in osteoarthritis, but benefits vary by joint and treatment form. Most supplied research concerns injections; oral supplements have promising but more limited evidence and are not established to rebuild cartilage.

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Studies

Explore published research for this goal.

Sources

Up to five highest-ranked published examples per ingredient. Study counts and charts include all published studies for the connection.

  1. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.
    Devasia S; Joseph JT; P S S; Koizumi S; Clarke L; V T S; Kailas AP; Madhavan S · Cartilage · 2024
    Randomized trial100 participantsCollagen
  2. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
    Lugo JP; Saiyed ZM; Lane NE · Nutrition journal · 2016
    Randomized trial191 participantsCollagen
  3. Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
    Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
    Randomized trial101 participantsCollagen
  4. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
    Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Mazurov VI; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LY · Terapevticheskii arkhiv · 2024
    Randomized trial212 participantsCollagen
  5. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial.
    Zdzieblik D; Brame J; Oesser S; Gollhofer A; König D · Nutrients · 2021
    Randomized trial180 participantsCollagen
  6. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.
    Berbert AA; Kondo CR; Almendra CL; Matsuo T; Dichi I · Nutrition (Burbank, Los Angeles County, Calif.) · 2005
    Randomized trial43 participantsOmega-3
  7. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
    Stonehouse W; Benassi-Evans B; Bednarz J; Vincent AD; Hall S; Hill CL · The American journal of clinical nutrition · 2022
    Randomized trial235 participantsOmega-3
  8. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
    Wang W; Xu Y; Zhou J; Zang Y · Clinical rheumatology · 2024
    Meta-analysis1,018 participants18 studies pooledOmega-3
  9. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis.
    Sigaux J; Mathieu S; Nguyen Y; Sanchez P; Letarouilly JG; Soubrier M; Czernichow S; Flipo RM; Sellam J; Daïen C · Arthritis research & therapy · 2022
    Meta-analysis1,420 participants30 studies pooledOmega-3
  10. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain.
    Goldberg RJ; Katz J · Pain · 2007
    Meta-analysis17 studies pooledOmega-3
  11. A standardized Boswellia serrata extract shows improvements in knee osteoarthritis within five days-a double-blind, randomized, three-arm, parallel-group, multi-center, placebo-controlled trial.
    Majeed A; Majeed S; Satish G; Manjunatha R; Rabbani SN; Patil NVP; Mundkur L · Frontiers in pharmacology · 2024
    Randomized trial105 participantsBoswellia
  12. A Standardized Boswellia serrata Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with Mild to Moderate Osteoarthritis in a Randomized Placebo-Controlled Study.
    Kumar B; Ghaytidak AB; Pandey AK; Somepalli RR; Sarda P; Raychaudhuri SP; Rokkam MP · Journal of the American Nutrition Association · 2025
    Randomized trial80 participantsBoswellia
  13. Oral herbal therapies for treating osteoarthritis.
    Cameron M; Chrubasik S · The Cochrane database of systematic reviews · 2015
    Meta-analysis5,980 participants49 studies pooledBoswellia
  14. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study.
    Haroyan A; Mukuchyan V; Mkrtchyan N; Minasyan N; Gasparyan S; Sargsyan A; Narimanyan M; Hovhannisyan A · BMC complementary and alternative medicine · 2018
    Randomized trial201 participantsBoswellia
  15. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.
    Sengupta K; Alluri KV; Satish AR; Mishra S; Golakoti T; Sarma KV; Dey D; Raychaudhuri SP · Arthritis research & therapy · 2009
    Randomized trial75 participantsBoswellia
  16. Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis.
    Zhao J; Liang G; Zhou G; Hong K; Yang W; Liu J; Zeng L · Journal of ethnopharmacology · 2024
    Meta-analysis2,175 participants23 studies pooledCurcumin
  17. Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.
    Zeng L; Yang T; Yang K; Yu G; Li J; Xiang W; Chen H · Frontiers in immunology · 2022
    Meta-analysis2,396 participants29 studies pooledCurcumin
  18. The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses.
    Bideshki MV; Jourabchi-Ghadim N; Radkhah N; Behzadi M; Asemani S; Jamilian P; Zarezadeh M · Phytotherapy research : PTR · 2024
    Meta-analysis11 studies pooledCurcumin
  19. The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis.
    Hsiao AF; Lien YC; Tzeng IS; Liu CT; Chou SH; Horng YS · Complementary therapies in medicine · 2021
    Meta-analysis1,258 participants11 studies pooledCurcumin
  20. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis.
    Zeng L; Yu G; Hao W; Yang K; Chen H · Bioscience reports · 2022
    Meta-analysis1,621 participants15 studies pooledCurcumin
  21. Effectiveness of nonpharmacological and nonsurgical interventions for patients with rheumatoid arthritis: an overview of systematic reviews.
    Christie A; Jamtvedt G; Dahm KT; Moe RH; Haavardsholm EA; Hagen KB · Physical therapy · 2008
    Systematic review28 studies pooledGamma Linolenic Acid
  22. Herbal therapy for treating rheumatoid arthritis.
    Little C; Parsons T · The Cochrane database of systematic reviews · 2001
    Systematic review11 studies pooledGamma Linolenic Acid
  23. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review.
    Soeken KL; Miller SA; Ernst E · Rheumatology (Oxford, England) · 2003
    Systematic review14 studies pooledGamma Linolenic Acid
  24. gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial.
    Zurier RB; Rossetti RG; Jacobson EW; DeMarco DM; Liu NY; Temming JE; White BM; Laposata M · Arthritis and rheumatism · 1996
    Randomized trial56 participantsGamma Linolenic Acid
  25. Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis.
    Rothman D; DeLuca P; Zurier RB · Seminars in arthritis and rheumatism · 1996
    Narrative reviewGamma Linolenic Acid
  26. Oral Hyaluronic Acid in Osteoarthritis and Low Back Pain: A Systematic Review.
    de Carvalho JF; Davidson J · Mediterranean journal of rheumatology · 2025
    Systematic review597 participants11 studies pooledHyaluronic Acid
  27. Single intra-articular injection of lightly cross-linked hyaluronic acid reduces knee pain in symptomatic knee osteoarthritis: a multicenter, double-blind, randomized, placebo-controlled trial.
    Petterson SC; Plancher KD · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019
    Randomized trial369 participantsHyaluronic Acid
  28. High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial.
    Dougados M; Nguyen M; Listrat V; Amor B · Osteoarthritis and cartilage · 1996
    Randomized trial110 participantsHyaluronic Acid
  29. Intra-articular hyaluronic acid compared with corticoid injections for the treatment of rhizarthrosis.
    Fuchs S; Mönikes R; Wohlmeiner A; Heyse T · Osteoarthritis and cartilage · 2006
    Randomized trial56 participantsHyaluronic Acid
  30. Platelet-rich plasma versus hyaluronic acid injection following arthrocentesis for temporomandibular joint disorders under sedation: a comparative clinical study.
    Mahdi MS; Abdulsattar MS · Oral and maxillofacial surgery · 2026
    Randomized trial60 participantsHyaluronic Acid
  31. Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals without symptoms of arthritis: A randomized double-blind placebo-controlled clinical study.
    Tomonaga A; Watanabe K; Fukagawa M; Suzuki A; Kurokawa M; Nagaoka I · Experimental and therapeutic medicine · 2020
    Randomized trial65 participantsN-Acetyl Glucosamine
  32. Oral polymeric N-acetyl-D-glucosamine and osteoarthritis.
    Rubin BR; Talent JM; Kongtawelert P; Pertusi RM; Forman MD; Gracy RW · The Journal of the American Osteopathic Association · 2001
    Randomized trialN-Acetyl Glucosamine
  33. Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial
    Taishi Tsuji, Jieun Yoon, Naruki Kitano, Tomohiro Okura, Kiyoji Tanaka · Aging Clinical and Experimental Research · 2016
    Randomized trial50 participantsN-Acetyl Glucosamine
  34. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495].
    Najm WI; Reinsch S; Hoehler F; Tobis JS; Harvey PW · BMC musculoskeletal disorders · 2004
    Randomized trial61 participantsSAMe
  35. Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease.
    Caruso I; Pietrogrande V · The American journal of medicine · 1988
    Clinical trial734 participantsSAMe
  36. Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis.
    Glorioso S; Todesco S; Mazzi A; Marcolongo R; Giordano M; Colombo B; Cherie-Ligniere G; Mattara L; Leardini G; Passeri M · International journal of clinical pharmacology research · 1985
    Randomized trial150 participantsSAMe
  37. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis.
    König B · The American journal of medicine · 1988
    Single-arm trial108 participantsSAMe
  38. Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis.
    Hosea Blewett HJ · Critical reviews in food science and nutrition · 2008
    Narrative reviewSAMe
  39. Effects of sulfur bath on hip osteoarthritis: a randomized, controlled, single-blind, follow-up trial: a pilot study.
    Kovács C; Bozsik Á; Pecze M; Borbély I; Fogarasi A; Kovács L; Tefner IK; Bender T · International journal of biometeorology · 2017
    Randomized trial41 participantsSulfur
  40. Biomarkers of oxidation, inflammation and cartilage degradation in osteoarthritis patients undergoing sulfur-based spa therapies.
    Benedetti S; Canino C; Tonti G; Medda V; Calcaterra P; Nappi G; Salaffi F; Canestrari F · Clinical biochemistry · 2010
    Non-randomized trialSulfur
  41. [Sulphur mineral water and SPA therapy in osteoarthritis].
    Costantino M; Filippelli A; Quenau P; Nicolas JP; Coiro V · Therapie · 2013
    Single-arm trial99 participantsSulfur
  42. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
    Lubis AMT; Siagian C; Wonggokusuma E; Marsetyo AF; Setyohadi B · Acta medica Indonesiana · 2018
    Randomized trial147 participantsSulfur
  43. Balneotherapy for osteoarthritis.
    Verhagen AP; Bierma-Zeinstra SM; Boers M; Cardoso JR; Lambeck J; de Bie RA; de Vet HC · The Cochrane database of systematic reviews · 2008
    Systematic review498 participants7 studies pooledSulfur
  44. Astaxanthin supplement improves clinical outcomes, quality of life, and inflammatory factors in patients with rheumatoid arthritis: a randomized clinical trial.
    Grigorian A; Tabatabaeyan A; Salesi M; Feizi A; Ahmadi AR; Kafeshani M · Food & function · 2025
    Randomized trial60 participantsAstaxanthin
  45. A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis.
    Hill WS; Dohnalek MH; Ha Y; Kim SJ; Jung JC; Kang SB · Nutrients · 2023
    Randomized trial100 participantsAstaxanthin
  46. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.
    Brien S; Lewith G; Walker A; Hicks SM; Middleton D · Evidence-based complementary and alternative medicine : eCAM · 2024
    Narrative reviewBromelain
  47. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.
    Kasemsuk T; Saengpetch N; Sibmooh N; Unchern S · Clinical rheumatology · 2017
    Randomized trial40 participantsBromelain
  48. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsBromelain
  49. Efficacy, tolerability, and safety of an oral enzyme combination vs diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials
    Ueberall MA, Mueller-Schwefe GH, Wigand R, Essner U · Journal of Pain Research · 2016
    Meta-analysis697 participants6 studies pooledBromelain
  50. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial
    Bolten WW, Glade MJ, Raum S, Ritz BW · Arthritis · 2015
    Randomized trial150 participantsBromelain
  51. Beneficial effect of creatine supplementation in knee osteoarthritis.
    Neves M; Gualano B; Roschel H; Fuller R; Benatti FB; Pinto AL; Lima FR; Pereira RM; Lancha AH; Bonfá E · Medicine and science in sports and exercise · 2011
    Randomized trialCreatine
  52. Beneficial effects of creatine supplementation in dystrophic patients.
    Louis M; Lebacq J; Poortmans JR; Belpaire-Dethiou MC; Devogelaer JP; Van Hecke P; Goubel F; Francaux M · Muscle & nerve · 2003
    Randomized trial15 participantsCreatine
  53. Oral creatine supplementation augments the repeated bout effect.
    Veggi K FT; Machado M; Koch AJ; Santana SC; Oliveira SS; Stec MJ · International journal of sport nutrition and exercise metabolism · 2014
    Randomized trial18 participantsCreatine
  54. Additional Benefits of Creatine Supplementation with Physical Therapy and Resistance Exercise in Knee Osteoarthritis: A Randomized Controlled Trial.
    Osama M; Afridi S; Bonnechère B · Journal of clinical medicine · 2025
    Randomized trial40 participantsCreatine
  55. Impact of creatine supplementation alone or combined with exercise on inflammatory and clinical outcomes in chronic musculoskeletal pain treated in the rheumatological field: a systematic review.
    Salazar-Méndez J; Núñez-Cortés R; Salazar-Orellana C; Suso-Martí L; Calatayud J; Cuyul-Vásquez I; Pizarro-Corbalán K; Ponce-Fuentes F · Nutrition (Burbank, Los Angeles County, Calif.) · 2026
    Systematic review189 participants8 studies pooledCreatine
  56. Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis.
    Zeng C; Li YS; Wei J; Xie DX; Xie X; Li LJ; Gao SG; Luo W; Xiong YL; Xiao WF; Lei GH · Scientific reports · 2018
    Meta-analysis16 studies pooledMagnesium
  57. Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis.
    Zeng C; Wei J; Terkeltaub R; Yang T; Choi HK; Wang YL; Xie DX; Hunter DJ; Zhang Y; Li H; Cui Y; Li LJ; Lei GH · Arthritis research & therapy · 2018
    Cross-sectional study13,947 participantsMagnesium
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    Shmagel A; Onizuka N; Langsetmo L; Vo T; Foley R; Ensrud K; Valen P · Osteoarthritis and cartilage · 2019
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    Ma R; Zhang C; Liu J; Ren J; Huang H; Wang G; Ding Y; Li X · Frontiers in immunology · 2025
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  60. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis.
    Zhang Y; Chen T; Luo P; Li S; Zhu J; Xue S; Cao P; Zhu Z; Li J; Wang X; Wluka AE; Cicuttini F; Ruan G; Ding C · Nutrients · 2022
    Cohort study392 participantsMagnesium
  61. Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes
    Naeem H, Naqvi SN, Perveen R, Ishaque F, Bano R, Abrar H, Arsalan A, Malik N · Pakistan Journal of Pharmaceutical Sciences · 2020
    Randomized trial40 participantsPapain
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    Wang X; Cicuttini F; Jin X; Wluka AE; Han W; Zhu Z; Blizzard L; Antony B; Winzenberg T; Jones G; Ding C · Osteoarthritis and cartilage · 2018
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    Vivek K; Kamal R; Perera E; Gupte CM · JBJS reviews · 2024
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    Wang T; Zheng S; Jin X; Cen H; Zhu Z; Han W; Wluka A; Cicuttini F; Cao P; Ding C · Rheumatology advances in practice · 2025
    Randomized trial413 participantsVitamin D
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    Yang W; Sun C; He SQ; Chen JY; Wang Y; Zhuo Q · Journal of general internal medicine · 2021
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    Newnham RE · Environmental health perspectives · 1995
    Randomized trial20 participantsBoron
  68. Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study
    Zbigniew Pietrzkowski, Michael J Phelan, Robert Keller, Cynthia Shu, Ruby Argumedo, Tania Reyes-Izquierdo · Clinical Interventions in Aging · 2014
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  69. A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis
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    Randomized trial60 participantsBoron
  70. Effectiveness and safety of steamed ginger extract on mild osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial.
    Baek HI; Shen L; Ha KC; Park YK; Kim CS; Kwon JE; Park SJ · Food & function · 2024
    Randomized trial100 participantsGinger
  71. Effects of a ginger extract on knee pain in patients with osteoarthritis.
    Altman RD; Marcussen KC · Arthritis and rheumatism · 2001
    Randomized trial261 participantsGinger
  72. Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain.
    Broeckel J; Estes L; Leonard M; Dickerson BL; Gonzalez DE; Purpura M; Jäger R; Sowinski RJ; Rasmussen CJ; Kreider RB · Nutrients · 2025
    Randomized trial30 participantsGinger
  73. A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.
    Mathieu S; Soubrier M; Peirs C; Monfoulet LE; Boirie Y; Tournadre A · Nutrients · 2022
    Meta-analysis1,438 participants12 studies pooledGinger
  74. Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.
    Mozaffari-Khosravi H; Naderi Z; Dehghan A; Nadjarzadeh A; Fallah Huseini H · Journal of nutrition in gerontology and geriatrics · 2017
    Randomized trial120 participantsGinger
  75. Identification for heavy metals exposure on osteoarthritis among aging people and Machine learning for prediction: A study based on NHANES 2011-2020.
    Xia F; Li Q; Luo X; Wu J · Frontiers in public health · 2022
    Cross-sectional studyManganese
  76. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis
    A. Das Jr., T. A. Hammad · Osteoarthritis and Cartilage · 2000
    Randomized trial93 participantsManganese
  77. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study
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  78. Silicon Interpositional Arthroplasty for Temporo-mandibular Joint Ankylosis.
    Agarwal P; Singh MP; Tiwari S; Sharma D · Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Single-arm trial20 participantsSilicon
  79. A 12-week randomized, double-blind, placebo-controlled multicenter study of choline-stabilized orthosilicic acid in patients with symptomatic knee osteoarthritis.
    Geusens P; Pavelka K; Rovensky J; Vanhoof J; Demeester N; Calomme M; Vanden Berghe D · BMC musculoskeletal disorders · 2017
    Randomized trial211 participantsSilicon
  80. Comparison of tendon suspension-interposition and silicon spacers in the treatment of degenerative osteoarthritis of the base of the thumb.
    Lehmann O; Herren DB; Simmen BR · Annales de chirurgie de la main et du membre superieur : organe officiel des societes de chirurgie de la main = Annals of hand and upper limb surgery · 2000
    Observational study102 participantsSilicon
  81. Ultrasonographic assessment of the quadriceps muscle and femoral cartilage in transtibial amputees using different prostheses.
    Şahin Onat Ş; Malas FÜ; Öztürk GT; Akkaya N; Kara M; Özçakar L · Prosthetics and orthotics international · 2017
    Cross-sectional study38 participantsSilicon
  82. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsVitamin C
  83. Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.
    Han G; Ye Y; Kang P · Drug design, development and therapy · 2025
    Randomized trial100 participantsVitamin C
  84. Osteoarthritis prevalence and modifiable factors: a population study.
    Plotnikoff R; Karunamuni N; Lytvyak E; Penfold C; Schopflocher D; Imayama I; Johnson ST; Raine K · BMC public health · 2016
    Cross-sectional study4,733 participantsVitamin C
  85. Anti-Inflammatory Effect of Vitamin C during the Postoperative Period in Patients Subjected to Total Knee Arthroplasty: A Randomized Controlled Trial.
    Ramón R; Holguín E; Chiriboga JD; Rubio N; Ballesteros C; Ezechieli M · Journal of personalized medicine · 2023
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    Fain O · Joint bone spine · 2005
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  87. Low vitamin K status is associated with osteoarthritis in the hand and knee.
    Neogi T; Booth SL; Zhang YQ; Jacques PF; Terkeltaub R; Aliabadi P; Felson DT · Arthritis and rheumatism · 2006
    Cohort study672 participantsVitamin K
  88. Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis.
    Liao Z; Chang J; Zhu Z; Han W; Meng T; Zheng S; Tu L; Antony B; Winzenberg T; Wluka AE; Cicuttini F; Ding C · Arthritis care & research · 2023
    Cohort study259 participantsVitamin K
  89. Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study.
    Oka H; Akune T; Muraki S; En-yo Y; Yoshida M; Saika A; Sasaki S; Nakamura K; Kawaguchi H; Yoshimura N · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2010
    Cross-sectional study719 participantsVitamin K
  90. The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence.
    Chin KY · Nutrients · 2021
    Narrative reviewVitamin K
  91. Vitamin K deficiency is associated with incident knee osteoarthritis.
    Misra D; Booth SL; Tolstykh I; Felson DT; Nevitt MC; Lewis CE; Torner J; Neogi T · The American journal of medicine · 2013
    Cohort study1,180 participantsVitamin K
  92. The influence of zinc and iron intake on osteoarthritis patients' subchondral sclerosis progression: A prospective observational study using data from the osteoarthritis Initiative.
    Zheng Z; Luo H; Sun C; Xue Q · Heliyon · 2023
    Cohort study474 participantsZinc
  93. Oral zinc sulphate in rheumatoid arthritis.
    Simkin PA · Lancet (London, England) · 1976
    Randomized trial24 participantsZinc
  94. Psoriatic arthritis treated with oral zinc sulphate.
    Clemmensen OJ; Siggaard-Andersen J; Worm AM; Stahl D; Frost F; Bloch I · The British journal of dermatology · 1981
    Randomized trial24 participantsZinc
  95. Dietary antioxidants and comorbidity of cardiovascular disease and osteoarthritis: A machine learning analysis with SHAP interpretation.
    Sheng G; Liu Y; Dou X; Zhang Y; Zhang J; Zhang D · Medicine · 2026
    Cross-sectional study7,682 participantsZinc
  96. The Daily Intake Levels of Copper, Selenium, and Zinc Are Associated with Osteoarthritis but Not with Rheumatoid Arthritis in a Cross-sectional Study.
    Yang WM; Lv JF; Wang YY; Xu YM; Lin J; Liu J; Chen JJ; Wang XZ · Biological trace element research · 2023
    Cross-sectional study4,200 participantsZinc