Highest effect
Collagen
Other
Impact
Highest effect
Typical dose:5000–15000 mg / day
Hydrolyzed collagen peptides are easily absorbed and have been clinically shown to accumulate in cartilage, stimulating the production of new connective tissue, reducing joint pain, and improving function.
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Omega-3
Fatty Acid
Impact
Highest effect
Typical dose:1000–3000 mg / day
The fatty acids EPA and DHA from sources like fish oil are precursors to signaling molecules called resolvins and protectins, which actively resolve inflammation. A high intake of Omega-3s is strongly correlated with improved outcomes in inflammatory joint conditions.
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High effect
Boswellia
Botanical
Impact
High effect
Typical dose:300–1000 mg / day
Boswellia serrata extract, standardized for its active compounds like AKBA, has demonstrated strong clinical results in improving joint comfort and function, often showing noticeable benefits within a week. It works synergistically with curcumin for broader anti-inflammatory coverage.
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Curcumin
Botanical
Impact
High effect
Typical dose:500–1500 mg / day
Curcumin, the active component in Turmeric, effectively targets pathways like NF-kB and COX-2. Its efficacy is comparable to some NSAIDs for osteoarthritis pain, but standard forms have poor bioavailability; it must be combined with an absorption enhancer like piperine or formulated as a phytosome.
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Gamma Linolenic Acid
Fatty Acid
Impact
High effect
Typical dose:500–1000 mg / day
Gamma Linolenic Acid (from sources like Borage or Evening Primrose oil) is converted into DGLA, a precursor to anti-inflammatory prostaglandins (PGE1). This helps to balance pro-inflammatory pathways and has shown significant benefit in reducing symptoms of rheumatoid arthritis.
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Hyaluronic Acid
Other
Impact
High effect
Typical dose:80–240 mg / day
While once thought to be poorly absorbed, studies now show that oral hyaluronic acid can reach the joints, where it helps to maintain the viscosity of synovial fluid. This can lead to reduced pain and improved mobility, particularly in the knees.
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N-Acetyl Glucosamine
Other
Impact
High effect
Typical dose:750–1500 mg / day
As a direct precursor to hyaluronic acid, N-Acetyl Glucosamine (NAG) is more readily incorporated into synovial fluid and cartilage than other forms of glucosamine. It supports joint lubrication and the integrity of the cartilage matrix, helping to reduce stiffness and improve comfort.
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SAMe
Other
Impact
High effect
Typical dose:400–1200 mg / day
S-Adenosyl Methionine is a naturally occurring molecule involved in methylation processes that reduce inflammation and stimulate the production of proteoglycans, a key component of cartilage. It has a dual-action benefit for both symptom relief and structural support.
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Sulfur
Mineral
Impact
High effect
Typical dose:1500–6000 mg / day
Often supplemented as MSM (Methylsulfonylmethane), sulfur is essential for the integrity of glycosaminoglycans like chondroitin and glucosamine. It helps maintain the structural framework of cartilage and has been clinically shown to reduce joint pain, stiffness, and inflammation.
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Moderate effect
Astaxanthin
Other
Impact
Moderate effect
Astaxanthin is a potent carotenoid with strong anti-inflammatory properties, capable of neutralizing multiple types of free radicals. It can help protect cartilage cells (chondrocytes) from oxidative damage and has been shown in clinical studies to reduce pain associated with conditions like rheumatoid arthritis and tennis elbow.
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Bromelain
Botanical
Impact
Moderate effect
Derived from pineapple, bromelain exerts systemic anti-inflammatory and analgesic effects when taken between meals. It has been clinically studied for its effectiveness in reducing symptoms of osteoarthritis and managing soft tissue injuries, making it a valuable tool for both chronic and acute joint discomfort.
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Creatine
Other
Impact
Moderate effect
Creatine monohydrate increases phosphocreatine stores in muscle, improving strength and power, which reduces mechanical load on joints. Emerging research also suggests it can protect chondrocytes (cartilage cells) from stress and may reduce markers of osteoarthritis progression.
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Magnesium
Mineral
Impact
Moderate effect
Magnesium is essential for proper Vitamin D and calcium metabolism, contributing to the strength of the subchondral bone that supports cartilage. It also plays a role in neuromuscular function, helping to relax muscles that can place stress on joints, and has been shown to lower systemic inflammation markers like C-reactive protein.
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Papain
Botanical
Impact
Moderate effect
Typical dose:500–1500 mg / day
Papain, derived from papaya, can exhibit systemic anti-inflammatory effects when taken on an empty stomach, allowing it to be absorbed intact. It functions by helping to clear immune complexes and reduce swelling, which can alleviate discomfort in inflammatory joint conditions.
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Vitamin D
Vitamin
Impact
Moderate effect
Typical dose:1000–5000 IU / day
Optimal Vitamin D levels are crucial for calcium metabolism, ensuring the integrity of the subchondral bone that supports cartilage. It also plays a key role in regulating inflammatory pathways, and deficiency is strongly linked to an increased risk and severity of osteoarthritis.
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Situational effect
Boron
Mineral
Impact
Situational effect
Typical dose:3–10 mg / day
Populations with low dietary boron intake tend to have higher rates of arthritis. Supplementation has been shown to reduce inflammatory markers like hs-CRP and TNF-α, and may improve the body's use of Vitamin D.
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Ginger
Botanical
Impact
Situational effect
Typical dose:500–2000 mg / day
The active compounds in ginger, known as gingerols, can inhibit the production of pro-inflammatory prostaglandins. It is particularly effective for exercise-induced muscle and joint soreness and serves as a supportive adjunct to more potent anti-inflammatories.
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Manganese
Mineral
Impact
Situational effect
Typical dose:2–10 mg / day
Manganese is required for the enzyme glycosyltransferase, which is essential for synthesizing the glycosaminoglycans that form the foundation of cartilage tissue. It is a fundamental, albeit supportive, nutrient for cartilage health.
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Silicon
Mineral
Impact
Situational effect
Silicon, often from sources like bamboo or horsetail extract, is required for the enzyme prolyl hydroxylase, which is essential for collagen formation. It cross-links collagen strands, increasing the strength and integrity of cartilage, bone, and tendons.
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Vitamin C
Vitamin
Impact
Situational effect
Typical dose:250–1000 mg / day
While not directly anti-inflammatory for joints, adequate Vitamin C is a prerequisite for tissue repair. Without it, the body cannot effectively use collagen peptides or its own amino acids to build and maintain healthy joint structures.
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Vitamin K
Vitamin
Impact
Situational effect
Typical dose:90–200 mcg / day
Vitamin K, particularly the K2 form, activates proteins responsible for bone mineralization and inhibiting vascular and cartilage calcification. Low vitamin K status is associated with a higher prevalence of osteoarthritis.
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Zinc
Mineral
Impact
Situational effect
Zinc is a critical cofactor for numerous enzymes, including matrix metalloproteinases (MMPs) involved in cartilage turnover and superoxide dismutase (SOD), which protects joints from free radical damage. Adequate zinc levels are necessary for a healthy immune response and controlling inflammation.
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