Gamma Linolenic Acid
Gamma Linolenic Acid (GLA) is a type of omega-6 fatty acid, specifically a polyunsaturated fatty acid (PUFA). Unlike many other omega-6 fatty acids that can be pro-inflammatory, GLA is metabolized in the body into compounds like dihomo-gamma-linolenic acid (DGLA) and then further into series-1 prostaglandins and leukotrienes, which generally have anti-inflammatory or neutral effects. This makes GLA unique among omega-6 fatty acids, as it can help to balance the body's inflammatory responses. GLA is not an essential fatty acid as the body can synthesize it from linoleic acid (LA), another omega-6 fatty acid. However, this conversion can be impaired by various factors such as aging, stress, certain nutrient deficiencies, and health conditions. Supplementation with preformed GLA can bypass these conversion limitations, making it readily available for the body's metabolic pathways. Its primary uses revolve around supporting healthy skin, including managing conditions like eczema and dry skin, and alleviating symptoms associated with hormonal fluctuations, such as premenstrual syndrome (PMS) and menopausal discomfort. GLA also shows promise in supporting nerve function and bone health, contributing to overall physiological well-being.
Evening Primrose OilBorage Seed OilBlack Currant Seed OilHemp Seed Oil
Cheapest Gamma Linolenic Acid supplements
Explore the cheapest Gamma Linolenic Acid (GLA) supplements to support joint health, reduce inflammation, and improve skin health.
Best Gamma Linolenic Acid supplements
Discover the best Gamma Linolenic Acid supplements for supporting joint health, reducing inflammation, and promoting radiant skin.
Value Gamma Linolenic Acid supplements
Compare top Gamma Linolenic Acid supplements known for supporting joint health, anti-inflammatory processes, and skin vitality, helping you choose the best value for your wellness goals.
Minimum240 mg
Maximum360 mg
Impact
High effect
Typical dose:240–500 mg
Unlike other omega-6s, GLA (from sources like borage or evening primrose oil) uniquely converts into anti-inflammatory prostaglandins. This makes it highly effective for conditions characterized by inflammation and immune dysregulation, such as rheumatoid arthritis and eczema. Its targeted mechanism places it in the high-impact tier.
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Impact
High effect
Typical dose:500–1000 mg
Gamma Linolenic Acid (from sources like Borage or Evening Primrose oil) is converted into DGLA, a precursor to anti-inflammatory prostaglandins (PGE1). This helps to balance pro-inflammatory pathways and has shown significant benefit in reducing symptoms of rheumatoid arthritis.
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Impact
High effect
Typical dose:240–500 mg
Gamma-Linolenic Acid (GLA), found in oils like borage and evening primrose, is converted into anti-inflammatory prostaglandins. It is highly effective for improving skin barrier integrity, increasing hydration, and reducing symptoms of inflammatory skin conditions like eczema and dermatitis.
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add_circle_outline Positive Interactions
Omega-3
GLA (an Omega-6) can work synergistically with Omega-3 fatty acids to help maintain a balanced inflammatory response in the body.
EPA (Eicosapentaenoic Acid)
GLA complements EPA in modulating inflammatory pathways, contributing to overall anti-inflammatory effects.
DHA
Similar to EPA, DHA works alongside GLA to support a healthy balance of immune and inflammatory processes.
Vitamin E
As an antioxidant, Vitamin E can help protect polyunsaturated fatty acids like GLA from oxidative damage, ensuring its stability and efficacy.
Zinc
Zinc is a cofactor for enzymes involved in fatty acid metabolism, potentially supporting the beneficial conversion pathways of GLA in the body.
Vitamin B6
Vitamin B6 is a cofactor necessary for the proper metabolism of fatty acids, including the enzymatic conversion steps involving GLA.
Magnesium
Magnesium plays a role in enzyme activities related to lipid metabolism, which may indirectly support the optimal function of GLA.
Fish Oil
Fish Oil, rich in EPA and DHA, can synergize with GLA to promote a balanced inflammatory response and overall cardiovascular health.
remove_circle_outline Negative Interactions
Turmeric
Both GLA and Turmeric (Curcumin) possess anti-inflammatory and antiplatelet properties. Combining them might theoretically enhance these effects, potentially increasing the risk of bleeding in susceptible individuals, although this interaction is generally considered mild for typical supplement doses.
Curcumin
Curcumin shares some anti-inflammatory and mild anticoagulant properties with GLA. Concurrent use could potentially heighten these effects, leading to a slightly increased risk of bruising or bleeding, particularly at high doses or in sensitive individuals.
Ginkgo
Ginkgo is known for its blood-thinning effects. When combined with GLA, which also has mild antiplatelet activity, there could be an additive effect leading to an increased risk of bleeding, especially in individuals prone to such conditions.
Ginger
Ginger possesses antiplatelet properties. Combining it with GLA might enhance these effects, potentially increasing the risk of bleeding or bruising, particularly at higher supplemental doses.
68 Best 
GLA 240 Gamma-Linolenic Acid
Designs for Health
4.7
★★★★★
(7 ratings)
Gamma Linolenic Acid: 240 mg
A simple borage seed oil softgel providing 240mg of GLA, aiming to support skin, joint, and general inflammatory balance.
78 Budget 
Spirulina Natural Tablets
Earthrise
4.8
★★★★★
(1517 ratings)
Gamma Linolenic Acid: 30 mg
A convenient spirulina tablet offering natural vitamins, minerals, and unique phytonutrients like phycocyanin and chlorophyll for general wellness support.
86 Best 
Hemp Oil
Manitoba Harvest
4.7
★★★★★
(1260 ratings)
Gamma Linolenic Acid: 420 mg
This hemp oil offers a rich and balanced blend of Omega-3 and Omega-6 fatty acids, including a notable amount of GLA, in a versatile liquid form that supports general wellness goals.
88 Best 
Organic Hemp Oil
Manitoba Harvest
4.7
★★★★★
(1355 ratings)
Gamma Linolenic Acid: 420 mg
This organic hemp oil delivers a comprehensive blend of Omega-3 and Omega-6 fatty acids, notably high in GLA, offering versatile support for joint, anti-inflammatory, and skin health.
88 Budget 
RxOmega-3
Natural Factors WS WomenSense
4.8
★★★★★
(18774 ratings)
Gamma Linolenic Acid: 50 mg
This softgel provides a balanced blend of marine-sourced omega-3s (EPA, DHA) and plant-based omega-3 (ALA) and omega-6 (GLA) for broad spectrum health support.
70 Budget 
Multi Women's Prime
Swanson
4.7
★★★★★
(815 ratings)
Gamma Linolenic Acid: 10 mg
This women's multi offers a broad mix of essential vitamins, chelated minerals, and a range of botanical extracts, providing extensive daily nutritional support with a focus on general wellness and hormonal balance.
55 Value 
Triple Omega Complex 3-6-9
21st Century
4.7
★★★★★
(5473 ratings)
Gamma Linolenic Acid: 70 mg
This omega 3-6-9 blend delivers a general mix of fatty acids from fish, flax, and borage oils, suitable for basic support of joint, skin, and inflammatory pathways.
58 Value 
Triple Omega Complex 3-6-9
21st Century
4.7
★★★★★
(5451 ratings)
Gamma Linolenic Acid: 70 mg
This 180-count bottle of Triple Omega 3-6-9 offers a broad spectrum of fatty acids from diverse sources, providing general support for skin, joints, and inflammatory balance at an economical price point.
77 Best 
Evening Primrose Oil
Barlean's
4.7
★★★★★
(549 ratings)
Gamma Linolenic Acid: 234 mg
This Evening Primrose Oil from Barlean's offers a good concentration of Gamma-Linolenic Acid (GLA), making it a focused choice for supporting skin health and inflammatory balance.
70 Best 
Total Omega 3-6-9 Lemonade Flavor
Barlean's
4.7
★★★★★
(29 ratings)
Gamma Linolenic Acid: 199 mg
This product is a convenient softgel offering a balanced mix of Omega-3, 6, and 9 fatty acids, useful for general nutritional support across several body systems.
91 Best 
Mega GLA Sesame Lignans
Life Extension
4.6
★★★★★
(817 ratings)
Gamma Linolenic Acid: 400 mg
A powerful GLA supplement offering 400mg per serving from borage oil, enhanced with sesame lignans, designed for comprehensive support for joints, inflammation balance, and skin health.
68 Budget 
PS-IQ Memory
Natural Factors PS Factor
4.6
★★★★★
(618 ratings)
Gamma Linolenic Acid: 30 mg
This product provides some Omega-3 and Omega-6 fatty acids from tuna and evening primrose oils but in lower amounts for joint, anti-inflammatory, and skin health, appearing more geared towards cognitive support.
82 Best 
Hemp Oil
Manitoba Harvest
4.7
★★★★★
(73 ratings)
Gamma Linolenic Acid: 420 mg
This hemp oil delivers a well-rounded plant-based blend of Omega-3 and Omega-6, notably including a good dose of GLA, in a convenient liquid form for daily wellness support.
81 Best 
Omega 3-6-9
Source Naturals
4.6
★★★★★
(306 ratings)
Gamma Linolenic Acid: 180 mg
A potent Omega 3-6-9 blend providing higher levels of beneficial fatty acids, offering good value for comprehensive wellness support.
89 Best 
Borage Oil
Barlean's
4.5
★★★★★
(165 ratings)
Gamma Linolenic Acid: 200 mg
Barlean's Borage Oil provides a concentrated dose of 200mg of Gamma-Linolenic Acid (GLA) per serving, making it a strong choice for targeted support of skin health and inflammatory balance.
79 Best 
Evening Primrose Oil
Barlean's
4.7
★★★★★
(554 ratings)
Gamma Linolenic Acid: 234 mg
Barlean's Evening Primrose Oil (120 count) provides a substantial 234mg of GLA per serving, offering effective support for skin health and inflammatory processes at a favorable price for consistent use.
78 Budget 
Men's Blend Iron Free
Super Nutrition
4.6
★★★★★
(2112 ratings)
Gamma Linolenic Acid: 1 mg
This is a very comprehensive, iron-free multivitamin for men, packed with essential nutrients and a broad spectrum of botanicals, suitable for daily foundational health support.
82 Budget 
Prenatal Blend
Super Nutrition
4.5
★★★★★
(1929 ratings)
Gamma Linolenic Acid: 1 mg
A comprehensive prenatal supplement packed with a broad range of vitamins, minerals, and additional supportive compounds for pregnancy.
Average$22.82
Median$21.99
Average$0.44
Median$0.39
Average$0.07
Median$0.03
Reference amount: 10 mg