Glycine
Description
Glycine is an amino acid, the smallest and simplest of the 20 amino acids commonly found in proteins. It is considered a conditionally essential amino acid, meaning the body can typically produce it, but supplemental intake may be beneficial under certain conditions, such as stress or illness. It serves as a fundamental building block for proteins and polypeptides throughout the body. Beyond its role in protein structure, glycine is integral to various physiological processes. It is a precursor to several key biomolecules, including creatine, glutathione, porphyrins (components of hemoglobin), and bile salts. Glycine also acts as an inhibitory neurotransmitter in the central nervous system, particularly in the spinal cord and brainstem, contributing to relaxation and sleep regulation. Its diverse functions extend to supporting healthy sleep patterns, promoting collagen synthesis for skin and connective tissue health, and aiding in detoxification pathways. Glycine also plays a part in glucose metabolism and has been investigated for its potential to support gut health and reduce inflammation.
Sources
Meat (beef, pork, poultry)FishDairy products (milk, cheese)Legumes (beans, lentils)SpinachKaleCabbagePumpkinBananasGelatin/Collagen
Cheapest Glycine supplements
Best Glycine Supplements
Value Glycine supplements
Optimal Dosage
Minimum1000 mg
Maximum3000 mg
Safety & Toxicity
Goals
Anti-Aging
Impact
High effect
Typical dose:1000–5000 mg
As a primary building block for collagen, glycine directly supports skin and joint integrity. Its role as a rate-limiting precursor for glutathione synthesis is critical for combating age-related oxidative stress. Furthermore, by acting as an inhibitory neurotransmitter, glycine improves sleep quality, which is essential for cellular repair, hormonal regulation, and cognitive restoration.
View goal →
Anti-Inflammatory Support
Impact
High effect
Typical dose:1–5 g
Glycine acts as an immunomodulatory agent, calming immune cells like macrophages and reducing the production of key inflammatory messengers such as TNF-alpha. It is a fundamental component for managing systemic inflammation and supporting tissue repair.
View goal →
Bone Health
Impact
High effect
Typical dose:1000–5000 mg
As the primary amino acid in the collagen that forms the bone matrix, Glycine is fundamentally important. A priority of 0 is a significant undervaluation; its priority should be high, just below whole collagen, reflecting its role as a key building block.
View goal →
Detoxification
Impact
High effect
Typical dose:1000–5000 mg
The liver uses glycine to conjugate (bind to) and neutralize specific toxins, such as salicylates and benzoate preservatives. It is a key amino acid for ensuring the body can process a wide range of common chemical exposures.
View goal →
Digestive Health
Impact
High effect
Typical dose:1–5 g
Glycine is a primary component of collagen and plays a crucial role in synthesizing new connective tissue for gut repair. It also has direct cytoprotective and anti-inflammatory effects within the gastrointestinal tract.
View goal →
Interactions
Positive Interactions
Glutathione
Glycine is a key precursor required for the body's synthesis of Glutathione, enhancing its production.
Gluthathione
Glycine is a key precursor required for the body's synthesis of Gluthathione, enhancing its production.
Creatine
Glycine is one of the amino acids that the body uses to synthesize Creatine, supporting its natural production.
Collagen
As a primary amino acid in Collagen, Glycine supports its synthesis and structural integrity.
Vitamin C
Vitamin C is essential for the enzymatic steps in collagen synthesis, complementing Glycine's role as a collagen building block.
Proline
Proline, along with Glycine, is a major amino acid component of collagen, working synergistically for connective tissue health.
Cysteine
Cysteine, alongside Glycine and Glutamic Acid, is a precursor to Glutathione, enhancing its endogenous production.
Glutamic Acid
Glutamic Acid, alongside Glycine and Cysteine, is a precursor to Glutathione, enhancing its endogenous production.
Negative Interactions
Caffeine
Glycine's calming and sleep-promoting effects may counteract the stimulant properties of Caffeine.
Theanine
Both Glycine and Theanine possess calming effects; combining them might enhance drowsiness, particularly at higher doses.
Melatonin
Both Glycine and Melatonin can promote sleep; concurrent use may lead to increased drowsiness or sedation.
Recommended products
GABA Calm Orange Flavor
Source Naturals
Glycine: 50 mg
A fast-absorbing liquid blend of GABA and calming amino acids for quick-acting stress relief.
GABA Calm Orange Flavor
Source Naturals Serene Science
Glycine: 50 mg
A fast-acting, orange-flavored sublingual liquid for quick relaxation and calm.
Glycine 500 mg
Solgar
Glycine: 500 mg
A simple and clean glycine capsule that provides flexible support for relaxation and metabolic health.
DGL Deglycyrrhizinated Licorice Root Extract
Swanson Superior Herbs
Glycine: 100 mg
A digestive support tablet combining DGL licorice and glycine to help soothe the gut and throat.
Pharmaceutical Grade AjiPure Glycine 500 mg
Swanson Ultra
Glycine: 500 mg
A premium, pharmaceutical-grade glycine supplement that offers ultra-pure support for metabolism and relaxation.
Double Strength 5-HTP 200 mg
NOW
Glycine: 100 mg
A high-dose 5-HTP capsule that provides strong support for mood and rest at a great price.
Glycine 500 mg
Country Life
Glycine: 500 mg
A metabolic-focused glycine tablet with added vitamin B6 to enhance amino acid utility and support calm.
Advanced Magnesium Complex
AOR Advanced Orthomolecular Research Advanced
Glycine: 1440 mg
A high-quality blend of four magnesium chelates and glycine designed for maximum absorption and nervous system support.
Glycine 1000 mg
Life Extension
Glycine: 1000 mg
A clinical-strength, high-dose glycine capsule that supports detoxification and a calm nervous system.
True Calm
NOW
Glycine: 200 mg
An elite, high-value calming blend designed for relaxation and emotional balance.
Sleep Nighttime Powder
youtheory
Glycine: 3000 mg
A complete nighttime powder with a full 3g dose of glycine and low melatonin for better recovery.
5-HTP 100 mg
Metabolic Maintenance
Glycine: 440 mg
A high-purity blend of 5-HTP and glycine with cofactors for mood, sleep, and appetite support.
Anxiety Control Plus
Metabolic Maintenance
Glycine: 100 mg
A clean, hypoallergenic relaxation capsule using GABA and bioavailable magnesium.
Glycine Powder
Metabolic Maintenance
Glycine: 1000 mg
A high-purity glycine powder for flexible, potent support of detoxification and relaxation.
GABA Calm
Source Naturals Serene Science
Glycine: 50 mg
A high-value bulk liquid GABA complex for rapid-acting stress and relaxation support.
5-HTP 100 mg
Metabolic Maintenance
Glycine: 300 mg
A long-term supply of mood and sleep support using a clean blend of 5-HTP, glycine, and cofactors.
Product stats
Price per product
Average$24.04
Median$17.99
Price per serving
Average$0.62
Median$0.52
Price per 100 mg
Average$0.59
Median$0.25
Price distribution
Price per serving distribution
Price per 100 mg
Reference amount: 100 mg
Forms
Paired ingredients
Ingredient forms
Magnesium Glycinate (1)92
Magnesium Glycinate is a chelated compound where magnesium is bound to two molecules of the amino acid glycine. This specific chelation enhances magnesium's absorption and bioavailability in the intestine, making it less likely to cause the digestive upset (like diarrhea) often associated with other magnesium forms. The glycine component itself contributes to the supplement's benefits, acting as an inhibitory neurotransmitter that promotes relaxation and improves sleep quality. It is widely recognized for supporting sleep, stress relief, muscle relaxation, bone health, and overall magnesium repletion.
Pros
- High bioavailability and absorption of magnesium.
- Gentle on the stomach with minimal laxative effect.
- Glycine component provides additional calming and sleep-supportive benefits.
- Supports muscle relaxation and nerve function.
- Contributes to bone health and overall well-being.
Cons
- May be more expensive than other less bioavailable forms of magnesium.
- Can cause drowsiness in some individuals, particularly at higher doses.
- Not suitable for those specifically seeking a laxative effect from magnesium.
Per product
Avg$21.96
Med$21.96
Per serving
Avg$0.24
Med$0.24
Per 1000 mg
Avg$0.17
Med$0.17
Price distribution