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Glutathione

notesDescription

Glutathione, often referred to as the 'master antioxidant', is a tripeptide molecule found in virtually every cell of the body. It is endogenously synthesized from the amino acids L-cysteine, L-glutamic acid, and glycine, and its primary function involves protecting the body from damage by reactive oxygen species, heavy metals, and various toxins. This makes it fundamental for maintaining cellular integrity and overall health. Beyond its direct antioxidant activity, glutathione is vital for numerous cellular processes including DNA synthesis and repair, protein synthesis, enzyme activation, and immune system function. It is particularly concentrated in the liver, where it assists in the detoxification of both endogenous and exogenous compounds, making it a cornerstone of the body's natural defense system against environmental pollutants and metabolic waste products. Maintaining adequate levels of glutathione is crucial for health, especially as levels can decline with age, poor nutrition, chronic stress, and exposure to toxins. Supplementation or supporting its natural production through precursors and cofactors is often pursued to bolster antioxidant defenses, support liver health, and enhance immune responses, contributing to cellular vitality and disease prevention.

ecoSources
AsparagusAvocadosSpinachBroccoliBrussels sproutsGarlicOnionsCabbageLean protein sources (for precursor amino acids)
Cheapest Glutathione supplements
Discover the most affordable Glutathione supplements designed to provide effective anti-inflammatory support, helping you find the best value for your health needs.
Best Glutathione supplements
Explore our top picks for glutathione supplements, carefully selected to help you find the best options for anti-inflammatory support.
Value Glutathione supplements
Compare top-rated Glutathione amino acid supplements to find the best value for anti-inflammatory support.
check_circleOptimal Dosage
Minimum250 mg
Maximum1000 mg
report_problemSafety & Toxicity
track_changesGoals
Anti-Inflammatory Support
local_hospitalAnti-Inflammatory Support
Impact
High effect
Typical dose:250–1000 mg
Glutathione is crucial for cellular defense against oxidative stress, a primary driver of chronic inflammation. Supplementing directly (with a bioavailable form) bolsters the body's ability to quench inflammatory fires, protecting cells from damage and supporting detoxification pathways.
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Cysteine
Cysteine is a crucial precursor amino acid for glutathione synthesis, directly enhancing the body's ability to produce glutathione.
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Glutamic Acid
Glutamic Acid is one of the three essential amino acids required for the body to synthesize glutathione.
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Glycine
Glycine is a foundational amino acid necessary for the endogenous production of glutathione.
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Vitamin C
Vitamin C helps regenerate oxidized glutathione back to its active form, extending its antioxidant capacity.
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Selenium
Selenium is a cofactor for the enzyme glutathione peroxidase, which uses glutathione to neutralize harmful peroxides.
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Milk Thistle
Milk Thistle (silymarin) is known to support liver health and may help increase hepatic glutathione levels.
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Vitamin E
Vitamin E and Glutathione work synergistically as antioxidants, where Vitamin E protects cell membranes and glutathione recycles Vitamin E, enhancing overall antioxidant defense.
inventory_2Recommended products
96 Budget Liver Refresh

Liver Refresh

NOW
4.8
★★★★★
(21304 ratings)
Glutathione: 100 mg
A premium liver support complex that provides several key antioxidants and botanical extracts for detoxification.
Buy for $27.8(from Daily Vita)
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93 Value High Potency L-Glutathione 200 mg

High Potency L-Glutathione 200 mg

Swanson Ultra
4.7
★★★★★
(1213 ratings)
Glutathione: 200 mg
A high-purity Setria glutathione supplement that supports the body's internal defense systems.
Buy for $15.99(from iHerb)
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88 Best Supplemelts Sublingual L-Glutathione Natural Orange Flavor 50 mg

Supplemelts Sublingual L-Glutathione Natural Orange Flavor 50 mg

Swanson Ultra
4.6
★★★★★
(677 ratings)
Glutathione: 50 mg
A dissolving sublingual tablet that provides a unique way to support your antioxidant levels with a pleasant orange taste.
Buy for $18.99(from iHerb)
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92 Best Brocco-Glutathione

Brocco-Glutathione

Nature's Answer
4.6
★★★★★
(2144 ratings)
Glutathione: 1000 mg
A synergistic blend of glutathione and organic broccoli designed to support long-term antioxidant status.
Buy for $32.99(from Amazon)
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93 Best L-Glutathione 100 mg

L-Glutathione 100 mg

Swanson
4.6
★★★★★
(1531 ratings)
Glutathione: 100 mg
An affordable maintenance dose of high-purity glutathione for daily antioxidant support.
Buy for $16.09(from iHerb)
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91 Best Reduced L-Glutathione 250 mg

Reduced L-Glutathione 250 mg

Solgar
4.7
★★★★★
(1136 ratings)
Glutathione: 250 mg
A 60-count supply of premium reduced glutathione for sustained antioxidant and cellular health support.
Buy for $30.74(from Amazon)
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94 Best Glutathione 250 mg

Glutathione 250 mg

NOW
4.6
★★★★★
(12267 ratings)
Glutathione: 250 mg
A reliable and widely used 250 mg glutathione supplement for foundational antioxidant support.
Buy for $15.1(from Daily Vita)
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97 Best Glutathione 500 mg

Glutathione 500 mg

NOW
4.6
★★★★★
(100027 ratings)
Glutathione: 500 mg
A high-potency antioxidant formula that supports liver health and cellular defense with glutathione and milk thistle.
Buy for $22.65(from Amazon)
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95 Best Glutathione 500 mg

Glutathione 500 mg

NOW
4.6
★★★★★
(100079 ratings)
Glutathione: 500 mg
A potent 30-day supply of glutathione and milk thistle for intensive antioxidant support.
Buy for $13.9(from Daily Vita)
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93 Best Glutathione Reduced 500 mg

Glutathione Reduced 500 mg

Jarrow Formulas
4.5
★★★★★
(21638 ratings)
Glutathione: 500 mg
A potent 500 mg reduced glutathione supplement designed for high-level antioxidant and liver support.
Buy for $28.99(from Daily Vita)
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94 Best Glutathione Reduced 500 mg

Glutathione Reduced 500 mg

Jarrow Formulas
4.5
★★★★★
(46677 ratings)
Glutathione: 500 mg
A bulk supply of high-potency 500 mg reduced glutathione for sustained cellular health and defense.
Buy for $51.99(from Pure Formulas)
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97 Best Glutathione 500 mg

Glutathione 500 mg

NOW
4.6
★★★★★
(55008 ratings)
Glutathione: 500 mg
A high-potency, bulk-sized glutathione supplement that supports liver health and cellular defense.
Buy for $37.91(from Amazon)
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sellPrice per product
Average$34.63
Median$29.87
restaurantPrice per serving
Average$0.96
Median$0.54
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