$12.83 $0.21 per serving
Product analysis
Homocysteine Defense supplies B vitamins involved in processing homocysteine, a substance in the blood. Improving that marker does not by itself establish better heart health.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality48
Vitamin B6 is clearly identified, helping you compare the type supplied. Several other forms are unspecified or lack enough quality information for a dependable comparison.
Ingredient Transparency79
Serving amounts are disclosed for the listed ingredients. Most forms remain unspecified, leaving some exact ingredient types unclear.
Value For Money56
The vitamin B6 contribution offers favorable value for the serving. Most other ingredients lack enough information for dependable price comparisons.
Customer Satisfaction86
Customer feedback is very positive across a large number of ratings. The broad review base supports confidence in the satisfaction picture, without establishing better heart or cognitive outcomes.
Product Focus68
The B vitamins have a clear role in processing homocysteine and supporting nutrition when intake is low. The many intended health uses extend beyond what a change in that blood marker can establish.
- Format
Tablet - Container
- 120 Tablet(s)
- Per serving
- $0.21
- Customer rating
- 4.6 · 3,702 ratings
Goals
Impact
Highest effect
Folate · 1360 mcg DFEVitamin B12 · 500 mcg
Folate, vitamin B12 and vitamin B6 provide nutritional availability when intake is low. Their association with one-carbon metabolism does not establish disease prevention or improved outcomes from lowering homocysteine. Larger amounts and particular chemical forms do not establish better general health beyond adequate intake.
How this product is rated for Everyday Health
Ingredient fit85
Relevant declared nutrients contribute to nutritional support. Some small nutrient amounts are present but not counted, which limits the formula's contribution.
Goal fit
The relevant declared nutrients connect with general-health nutrition; additional purposes and ingredients limit how exclusively the formula addresses this goal.
Dose adequacy
Declared nutrient amounts make varying contributions; higher amounts in the saved comparison do not establish extra benefit above adequacy.
Pathways60
The strongest association is with one-carbon metabolism and blood formation. The contribution is concentrated in a limited set of functional areas.
Depth
The strongest connection is one-carbon metabolism and blood formation, reflecting ingredient associations rather than demonstrated changes in health outcomes.
Breadth
One functional area meets the saved coverage threshold; remaining areas have less or no contribution.
Evidence82
Vitamin B9 (Folate) leads the counted contribution. The evidence supports nutritional availability without establishing improved outcomes beyond adequate intake.
Evidence strength
Vitamin B9 (Folate) provides the strongest counted contribution, with practical relevance limited to nutritional availability when intake is low.
Studied preparation
The counted preparations are accepted in the nutrient comparison; chemical form and delivery do not establish additional health benefit.
Formulation logic100
No required partner or configured conflict was found. Counted ingredients meet the saved amount inclusion threshold.
Partner coverage
No required partner is missing for the counted ingredients; this does not establish an added benefit from combining them.
Conflicts
No configured formulation conflict was found at the supplied nutrient amounts and partner declarations.
Effective doses
All counted ingredients meet the saved amount inclusion threshold, which does not prove a supplement-response dose.
Impact
High effect
Folate and B12 contribute to normal nutrient-dependent cell functions. Their amounts reach the saved comparison references, but the supplied context does not establish an independent hair-growth effect for this combination. B6 is a nutritional cofactor without standalone hair-growth support here, and the saved findings identify no coverage of the evaluated hair-specific pathways.
How this product is rated for Hair Health
Ingredient fit77
The formula includes ingredients beyond those recognized for hair health, which limits its focus on this goal. The recognized ingredient amounts reach their saved comparison references; this does not establish a proven hair-growth dose.
Goal fit
The formula includes ingredients beyond those recognized for hair health, which limits its focus on this goal.
Dose adequacy
The recognized ingredient amounts reach their saved comparison references; this does not establish a proven hair-growth dose.
Pathways0
No contribution was assigned to the evaluated androgen, hair-fibre, antioxidant or stress pathways. None of the evaluated pathways meets the saved coverage threshold.
Depth
No contribution was assigned to the evaluated androgen, hair-fibre, antioxidant or stress pathways.
Breadth
None of the evaluated pathways meets the saved coverage threshold.
Evidence78
Vitamin B12 leads the recognized evidence contribution. The counted preparations are recognized as studied, with ingredient-specific limits on hair outcomes.
Evidence strength
Vitamin B12 provides the strongest recognized evidence contribution at its declared amount; its practical limits are described with the ingredient above.
Studied preparation
The saved findings recognize the counted preparations as studied; this does not establish that the whole product improves hair growth.
Formulation logic100
No unmet partner requirement or configured conflict was found. The counted amounts meet the saved minimum comparison threshold.
Partner coverage
The recognized ingredients have no unmet partner requirement in the supplied findings.
Conflicts
No configured ingredient conflict was identified; this finding is limited to the interactions evaluated.
Effective doses
Every counted ingredient meets the saved minimum amount threshold; that threshold is not a proven effective hair-growth dose.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Calories | 5 Calorie(s) | |
Protein | 1 Gram(s) | |
Vitamin B6 (Pyridoxine Hydrochloride) | 50 mg | |
Folate | 1360 mcg DFE | |
Vitamin B12 (Cyanocobalamin) | 500 mcg | |
Calcium (Dibasic Calcium Phosphate) | 90 mg | |
Trimethylglycine | 1 Gram(s) |
Vitamin B6 (Pyridoxine Hydrochloride) · 50 mg OverallScore75
Each serving contains 50 mg of vitamin B6, exceeding the European adult daily upper limit on its own. It comes from pyridoxine hydrochloride.
How this ingredient is rated
Ingredient Form & Label Quality100
The identified vitamin B6 form is pyridoxine hydrochloride. The evaluation identifies none of the flagged colors, titanium dioxide, hydrogenated oils or talc; other additives may still be present.
Vitamin B6 Form Identification
The identified vitamin B6 form is pyridoxine hydrochloride.
Clean Label and Excipient Purity
The evaluation identifies none of the flagged colors, titanium dioxide, hydrogenated oils or talc; other additives may still be present.
Dose, Safety & Label Transparency37
The 50 mg of B6 in one serving exceeds the European adult daily upper limit before other sources are counted. The amount and B6 source, pyridoxine hydrochloride, are identified.
Vitamin B6 Dose & Safety Policy
The 50 mg of B6 in one serving exceeds the European adult daily upper limit before other sources are counted.
Label Transparency
The amount and B6 source, pyridoxine hydrochloride, are identified.
Value100
The whole-product price works out to about $0.00428 per mg of vitamin B6.
Vitamin B6 Price Efficiency
The whole-product price works out to about $0.00428 per mg of vitamin B6.
Vitamin B12 (Cyanocobalamin) · 500 mcg OverallScore44
A serving lists 500 mcg vitamin B12 as cyanocobalamin. The normalized cost is about $0.43 per 1,000 mcg, based on the whole-product serving price.
How this ingredient is rated
Active Ingredient Quality & Bioavailability10
The B12 is recorded as cyanocobalamin.
Bioactive B12 Form Selection
The saved facts identify cyanocobalamin as the B12 form.
Dose, Safety & Label Transparency79
The serving specifies both the 500 mcg B12 amount and its cyanocobalamin form.
Therapeutic Dosage Level
The recorded serving contains 500 mcg vitamin B12.
Label and Form Transparency
The saved facts identify the B12 form and its amount per serving.
Value40
The normalized price is about $0.43 per 1,000 mcg of B12, based on the whole-product serving price.
Price per 1,000 mcg B12
The recorded normalized cost is about $0.43 per 1,000 mcg B12, using the whole-product serving price.
Alternative products
Report alternatives
Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
- The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
- Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
- The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
- Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
- Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
- A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
- Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
- The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
- Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
- Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
- Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
- Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
- Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
- Factors Associated with Premature Hair Graying in a Young Indian Population.
- Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
- Hair Loss After Laparoscopic Sleeve Gastrectomy.
- Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.