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Vitamin B6

notesDescription

Vitamin B6, also known as pyridoxine, is a vital water-soluble vitamin involved in over 100 enzyme reactions, primarily related to protein, fat, and carbohydrate metabolism. It plays a crucial role in amino acid metabolism, gluconeogenesis, and glycogenolysis, helping the body convert food into energy. Beyond its metabolic functions, Vitamin B6 is essential for brain development and function, contributing to the synthesis of neurotransmitters like serotonin, dopamine, and GABA, which regulate mood and cognitive processes. It also supports immune function and the formation of hemoglobin, the protein in red blood cells that carries oxygen throughout the body. Adequate intake of Vitamin B6 is important for maintaining nervous system health, reducing homocysteine levels (a risk factor for heart disease), and may help alleviate symptoms of premenstrual syndrome (PMS) and nausea during pregnancy.

ecoSources
ChickpeasSalmonChicken breastPotatoesBananasFortified cerealsPorkTurkeyBeef liverSweet potatoesSpinachCarrots
Cheapest Vitamin B6 supplements
Find the most affordable Vitamin B6 supplements to support your various health and wellness goals, from detoxification to mood and brain health.
Best Vitamin B6 supplements
Compare the best Vitamin B6 supplements to find the ideal product for your health goals, supporting everything from mood and cognitive function to metabolism and detoxification.
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scheduleTiming & Intake
scheduleAnytimerestaurantWith foodlocal_drinkTake with Other B vitamins, Magnesium, or Zinc for synergistic benefits.
infoBest taken with food to prevent potential stomach discomfort and enhance absorption.
assignmentDaily Intake
RDA (Men)1 mg
RDA (Women)1 mg
RDI2 mg
check_circleOptimal Dosage
Minimum10 mg
Maximum25 mg
report_problemSafety & Toxicity
Upper Limit (UL)100 mg
Toxicity Threshold200 mg
Toxicity Effectsensory neuropathy
track_changesGoals
Brain Health
psychologyBrain Health
Impact
Highest effect
Vitamin B6 is required for over 100 enzyme reactions in the body, including the critical final step in synthesizing important neurotransmitters such as serotonin, dopamine, and GABA. Adequate B6 levels are essential for maintaining proper neurological function, emotional balance, and cognitive processing.
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Cognitive Support
psychology_altCognitive Support
Impact
Highest effect
Vitamin B6 is essential for converting precursor amino acids into the neurotransmitters that regulate mood, focus, and arousal. It also works with B12 and Folate to maintain healthy homocysteine levels, protecting against neurotoxicity and supporting long-term brain health.
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Detoxification
scienceDetoxification
Impact
Highest effect
Typical dose:25–100 mg
Vitamin B6 (along with Folate and B12) is required for homocysteine metabolism, a process linked to both methylation and the production of cysteine for glutathione. Adequate B6 ensures these vital liver pathways run efficiently to neutralize hormones and toxins.
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Mental Focus
center_focus_strongMental Focus
Impact
Highest effect
Vitamin B6 (as P-5-P) is required for the conversion of amino acid precursors (like L-Tyrosine) into neurotransmitters that govern alertness, motivation, and concentration. Without adequate B6, the brain cannot efficiently produce these essential chemicals, leading to impaired focus and mental fatigue.
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Metabolism Boost
local_fire_departmentMetabolism Boost
Impact
Highest effect
Vitamin B6, in its active P-5-P form, is a critical cofactor for over 100 enzyme reactions, including the breakdown of stored glycogen into glucose for energy (glycogenolysis) and the metabolism of amino acids. Ensuring adequate B6 is foundational for efficient energy conversion from stored fuels and dietary protein.
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sync_altInteractions

add_circle_outlinePositive Interactions

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Folate
Vitamin B6 works synergistically with Folate and Vitamin B12 to metabolize homocysteine, supporting cardiovascular health.
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Vitamin B12
Together with Folate and Vitamin B6, Vitamin B12 is essential for homocysteine metabolism and red blood cell formation.
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Magnesium
Magnesium is required for the activation of Vitamin B6 into its active coenzyme form (pyridoxal-5-phosphate).
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Zinc
Zinc can help improve the absorption and utilization of Vitamin B6 in the body.
inventory_2Recommended products
88 Best P-5-P 100 mg

P-5-P 100 mg

Nutricost
4.8
★★★★★
(638 ratings)
Vitamin B6: 100 mg
A high-dose 100 mg P-5-P Vitamin B6 supplement in capsule form, providing the active coenzyme for direct bodily utilization at a good value.
Buy for $21.95(from iHerb)
Other sellers
80 Best Vitamin B6 100 mg

Vitamin B6 100 mg

Solgar
4.8
★★★★★
(3136 ratings)
Vitamin B6: 100 mg
A high-potency Vitamin B6 (Pyridoxine HCl) supplement in tablet form, offering a substantial 100 mg dose and good value.
Buy for $6.29(from Vitacost)
Other sellers (2)
75 Budget 1000 mg Vitamin C Raspberry

1000 mg Vitamin C Raspberry

Emergen-C
4.5
★★★★★
(5015 ratings)
Vitamin B6: 10 mg
This effervescent drink mix combines a strong dose of Vitamin C with a full B-vitamin complex and essential electrolytes, aiming to support general well-being and energy through its comprehensive nutrient profile, though it is less cost-effective per serving than larger packs.
Buy for $5.98(from Walmart)
Other sellers
75 Value Centrum Silver Men 50+

Centrum Silver Men 50+

Centrum
4.7
★★★★★
(663 ratings)
Vitamin B6: 6 mg
A foundational multivitamin for men 50+ providing essential vitamins, minerals, and targeted nutrients like Lutein and Lycopene for general wellness and specific age-related support.
Buy for $20.12(from Walmart)
Other sellers
72 Value Daily Multi-Vitamin & Mineral

Daily Multi-Vitamin & Mineral

Swanson
4.3
★★★★★
(173 ratings)
Vitamin B6: 5 mg
This daily multi-vitamin and mineral supplement provides a broad spectrum of essential nutrients, serving as an affordable and practical option for general daily nutritional support.
Buy for $25.99(from iHerb)
Other sellers (1)
55 Best Vitamin B6 500 mg

Vitamin B6 500 mg

Vitamatic
4.8
★★★★★
(71 ratings)
Vitamin B6: 500 mg
A very high-dose 500 mg Pyridoxine HCl Vitamin B6 tablet, intended for specialized use and requiring strict professional guidance due to its potency.
Buy for $14.99(from iHerb)
Other sellers
82 Best Super Nu-Thera Powder Unflavored

Super Nu-Thera Powder Unflavored

Kirkman
4.6
★★★★★
(14 ratings)
Vitamin B6: 250 mg
This unflavored powder offers a broad spectrum of essential vitamins and minerals, aimed at comprehensive daily nutritional support, with notable doses of B vitamins and magnesium.
Buy for $65(from iHerb)
Other sellers (1)
82 Best Vitamin B6 200 mg

Vitamin B6 200 mg

Bluebonnet
4.7
★★★★★
(1011 ratings)
Vitamin B6: 200 mg
A high-potency Vitamin B6 (Pyridoxine HCl) supplement delivering a substantial 200 mg dose in a simple capsule form.
Buy for $15.16(from iHerb)
Other sellers (3)
88 Best B6 Complex

B6 Complex

Pure Encapsulations
4.8
★★★★★
(38 ratings)
Vitamin B6: 200 mg
This B-complex is an extremely high-potency formula with diverse active B vitamin forms, especially B6 and B12, tailored for specific and intensive support.
Buy for $51.5(from Vitacost)
Other sellers (1)
78 Value Vitamin B6 100 mg Sustained Release

Vitamin B6 100 mg Sustained Release

NaturesPlus
4.6
★★★★★
(37 ratings)
Vitamin B6: 100 mg
A 100 mg sustained-release pyridoxine hydrochloride B6 tablet, offering consistent daily support at a very economical price.
Buy for $5.06(from iHerb)
Other sellers (1)
No image

Extra Strength Hair Skin & Nails

Nature's Bounty Optimal Solutions
4.7
★★★★★
(69 ratings)
Vitamin B6: 5 mg
This supplement provides a comprehensive mix of high-dose biotin, essential vitamins, and minerals, plus supporting beauty ingredients like collagen and hyaluronic acid, all aimed at enhancing hair, skin, and nail health.
Buy for $5.73(from iHerb)
Other sellers
72 Value Vitamin B6 100 mg

Vitamin B6 100 mg

Vitamatic
4.9
★★★★★
(66 ratings)
Vitamin B6: 100 mg
A very economical 100 mg Pyridoxine HCl Vitamin B6 tablet, offering a large supply for general B6 needs.
Buy for $9.99(from iHerb)
Other sellers
62 Value B-Complex with Folic Acid plus Vitamin C

B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
4.7
★★★★★
(4533 ratings)
Vitamin B6: 5 mg
A very affordable B-Complex with Vitamin C, offering foundational B vitamin support primarily in common, non-active forms for general wellness.
Buy for $7.1(from Walmart)
Other sellers (2)
68 Value Folic Acid B6 & B12

Folic Acid B6 & B12

Mason Natural
4.8
★★★★★
(2704 ratings)
Vitamin B6: 50 mg
A very affordable, high-dose B6, Folate, and B12 supplement in standard, non-activated forms for general wellness and homocysteine support.
Buy for $5.78(from iHerb)
Other sellers (1)
68 Best Ketogenic Meal Shake Vanilla Cream

Ketogenic Meal Shake Vanilla Cream

Keto Science
4.5
★★★★★
(42 ratings)
Vitamin B6: 201 mg
This ketogenic meal shake provides a high-fat, low-carb macro profile with added vitamins and minerals, suitable for those following a keto diet for general nutritional support and energy.
Buy for $29.99(from iHerb)
Other sellers
72 Best Coenzymated B-6 333 mg

Coenzymated B-6 333 mg

Source Naturals
4.6
★★★★★
(198 ratings)
Vitamin B6: 200 mg
A high-dose, likely active (Coenzymated) Vitamin B6 supplement, providing 200 mg per tablet, suitable for targeted B6 support, but with some labeling ambiguity.
Buy for $12.06(from iHerb)
Other sellers
62 Budget B 50 Complex

B 50 Complex

Thompson
4.7
★★★★★
(2863 ratings)
Vitamin B6: 50 mg
An economical 'B-50' complex providing standard B vitamin forms, suitable for basic daily support, but features a proprietary blend.
Buy for $5.38(from Pure Formulas)
Other sellers (2)
88 Value B-6 100 mg

B-6 100 mg

NOW
4.8
★★★★★
(7154 ratings)
Vitamin B6: 100 mg
A high-potency Vitamin B6 (Pyridoxine HCl) supplement in a simple capsule form, offering excellent value for daily support.
Buy for $5.09(from Vitacost)
Other sellers (4)
72 Budget B-6 100 mg

B-6 100 mg

21st Century
4.7
★★★★★
(12504 ratings)
Vitamin B6: 100 mg
A budget-friendly option providing a significant dose of Vitamin B6 for metabolic and nervous system support, plus a modest addition of calcium for general health.
Buy for $5.49(from iHerb)
Other sellers (1)
85 Best Mega B-150 Balanced B-Complex

Mega B-150 Balanced B-Complex

NaturesPlus
4.7
★★★★★
(694 ratings)
Vitamin B6: 150 mg
A high-potency B-complex with methylated forms of Folate and B12, offering advanced support for energy and overall health.
Buy for $17.32(from iHerb)
Other sellers (1)
80 Value Vitamin B6 25 mg

Vitamin B6 25 mg

Solgar
4.8
★★★★★
(3682 ratings)
Vitamin B6: 25 mg
A simple and affordable Vitamin B6 (Pyridoxine HCl) tablet providing a moderate 25 mg dose for general daily support.
Buy for $5.79(from Vitacost)
Other sellers (3)
70 Budget B-50 Complex

B-50 Complex

21st Century
4.7
★★★★★
(8505 ratings)
Vitamin B6: 50 mg
<p>This B-50 Complex provides a diverse set of B vitamins at a 50mg/mcg level for daily wellness, along with added calcium for bone support, all in a very affordable tablet form.</p>
Buy for $5.37(from Pure Formulas)
Other sellers (2)
70 Value B-6 100 mg

B-6 100 mg

Source Naturals
4.7
★★★★★
(867 ratings)
Vitamin B6: 100 mg
A standard 100 mg Pyridoxine HCl Vitamin B6 tablet from Source Naturals, suitable for general B6 supplementation.
Buy for $5.87(from iHerb)
Other sellers
75 Best Vitamin B6 500 mg Sustained Release

Vitamin B6 500 mg Sustained Release

NaturesPlus
4.7
★★★★★
(78 ratings)
Vitamin B6: 500 mg
A very high-potency Vitamin B6 (Pyridoxine HCl) supplement with a sustained-release mechanism for prolonged action, requiring careful usage.
Buy for $15.05(from iHerb)
Other sellers
analyticsProduct stats
sellPrice per product
Average$30.82
Median$25.24
restaurantPrice per serving
Average$0.73
Median$0.56
sciencePrice per 10 mg
Average$0.47
Median$0.26
bar_chartPrice distribution
bar_chartPrice per serving distribution
bar_chartPrice per 10 mg
Reference amount: 10 mg
categoryForms
bar_chartPaired ingredients
water_dropIngredient forms
category Pyridoxine Hydrochloride (734) 75
Pyridoxine Hydrochloride (PN HCl) is a synthetic, water-soluble form of Vitamin B6 that is widely used in supplements. It requires enzymatic conversion in the liver to its active coenzyme form, Pyridoxal 5-Phosphate (P-5-P), before it can be utilized by the body for its metabolic functions.
thumb_upPros
  • Widely available and cost-effective
  • Stable and well-researched for general B6 deficiency
  • Effective for raising B6 levels in the body
thumb_downCons
  • Requires metabolic conversion to its active form (P-5-P)
  • High doses, particularly long-term, may lead to peripheral neuropathy
  • Potential for drug interactions
sellPer product
Avg$29.27
Med$24.13
restaurantPer serving
Avg$0.66
Med$0.51
science Per 10 mg
Avg$0.38
Med$0.22
Price distribution
category Pyridoxal 5-Phosphate (240) 90
Pyridoxal-5'-Phosphate is the complete chemical name for Pyridoxal 5-Phosphate (P-5-P), the biologically active and most important coenzyme form of Vitamin B6 in the human body. It is critical for over 100 enzymatic reactions, especially those involved in amino acid metabolism and neurotransmitter synthesis, acting directly without needing conversion.
thumb_upPros
  • Highly bioavailable and directly active form
  • Does not require liver conversion
  • Supports a wide range of critical bodily functions directly
thumb_downCons
  • Generally more expensive than pyridoxine hydrochloride
  • Less common in basic, low-cost supplements
sellPer product
Avg$40.98
Med$34.06
restaurantPer serving
Avg$0.99
Med$0.82
science Per 10 mg
Avg$0.56
Med$0.24
Price distribution
category Pyridoxal-5-Phosphate (8) 90
Pyridoxal-5'-Phosphate is the complete chemical name for Pyridoxal 5-Phosphate (P-5-P), the biologically active and most important coenzyme form of Vitamin B6 in the human body. It is critical for over 100 enzymatic reactions, especially those involved in amino acid metabolism and neurotransmitter synthesis, acting directly without needing conversion.
thumb_upPros
  • Highly bioavailable and directly active form
  • Does not require liver conversion
  • Supports a wide range of critical bodily functions directly
thumb_downCons
  • Generally more expensive than pyridoxine hydrochloride
  • Less common in basic, low-cost supplements
sellPer product
Avg$42.83
Med$42.19
restaurantPer serving
Avg$0.97
Med$0.94
science Per 1 mg
Avg$0.15
Med$0.15
Price distribution
category Pyridoxine 5-Phosphate (8) 80
Pyridoxine 5-Phosphate (PNP) is a phosphorylated derivative of pyridoxine. While closer to the active coenzyme form (P-5-P) than pyridoxine hydrochloride, it still typically requires an additional enzymatic oxidation step to be fully converted into Pyridoxal 5-Phosphate to exert its complete range of coenzyme functions in the body.
thumb_upPros
  • Potentially more efficiently converted to P-5-P than non-phosphorylated pyridoxine
  • May offer some advantages in individuals with impaired phosphorylation capacity
  • More direct than Pyridoxine HCl
thumb_downCons
  • Still requires an enzymatic conversion step to P-5-P
  • Less directly active and generally more expensive than P-5-P
  • Less commonly studied as a direct supplement form compared to PN HCl or P-5-P
sellPer product
Avg$24.23
Med$25.14
restaurantPer serving
Avg$0.80
Med$0.83
science Per 10 mg
Avg$0.49
Med$0.50
Price distribution
category Pyridoxine (7) 75
Pyridoxine Hydrochloride (PN HCl) is a synthetic, water-soluble form of Vitamin B6 that is widely used in supplements. It requires enzymatic conversion in the liver to its active coenzyme form, Pyridoxal 5-Phosphate (P-5-P), before it can be utilized by the body for its metabolic functions.
thumb_upPros
  • Widely available and cost-effective
  • Stable and well-researched for general B6 deficiency
  • Effective for raising B6 levels in the body
thumb_downCons
  • Requires metabolic conversion to its active form (P-5-P)
  • High doses, particularly long-term, may lead to peripheral neuropathy
  • Potential for drug interactions
sellPer product
Avg$13.11
Med$12.58
restaurantPer serving
Avg$0.75
Med$0.77
science Per 10 mg
Avg$0.36
Med$0.33
Price distribution
category Pyridoxine Alpha-Ketoglutarate Hydrochloride (7) 70
Pyridoxine Alpha-Ketoglutarate Hydrochloride is a salt combining pyridoxine (Vitamin B6) with alpha-ketoglutarate (AKG), an intermediate of the Krebs cycle. It is sometimes marketed for its potential roles in nitrogen metabolism, ammonia detoxification, and supporting athletic performance, alongside general B6 benefits.
thumb_upPros
  • Combines B6 benefits with potential additional advantages of AKG
  • AKG may support energy metabolism and ammonia detoxification
  • Could be beneficial in contexts requiring high protein metabolism
thumb_downCons
  • Less common and more specialized form, limited specific research compared to other B6 forms
  • Potentially more expensive
  • Still requires conversion of pyridoxine to active P-5-P
sellPer product
Avg$27.63
Med$26.24
restaurantPer serving
Avg$0.60
Med$0.57
science Per 100 mg
Avg$0.39
Med$0.38
Price distribution
category P-5-P (4) 90
P-5-P is the common abbreviation for Pyridoxal 5-Phosphate, which is the direct, biologically active coenzyme form of Vitamin B6. It plays a critical role in over 100 enzymatic reactions throughout the body, including those essential for amino acid metabolism, neurotransmitter synthesis, and glucose regulation, without requiring metabolic conversion.
thumb_upPros
  • Highly bioavailable and directly active form
  • Does not require liver conversion
  • Supports a wide range of critical bodily functions directly
thumb_downCons
  • Generally more expensive than pyridoxine hydrochloride
  • Less common in basic, low-cost supplements
sellPer product
Avg$38.66
Med$37.31
restaurantPer serving
Avg$0.97
Med$0.84
science Per 10 mg
Avg$0.15
Med$0.15
Price distribution

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