$23.99 $0.39 per serving
Product analysis
Activated Homocysteine supplies B vitamins that help the body process homocysteine and support normal nerve function when intake is low. Lowering homocysteine does not establish protection from heart problems.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality60
Vitamin B6 is clearly identified as its active form. The comparative quality of the folate, B12 and betaine preparations remains uncertain despite their named forms.
Ingredient Transparency100
All four ingredient amounts and forms are clearly identified. That makes the combination straightforward to compare with other B-vitamin supplements.
Value For Money59
The vitamin B6 content is favorably priced. Value for folate and B12 remains uncertain, limiting a firm judgment of the whole combination.
Customer Satisfaction78
Customers are very positive about their purchases. Several hundred ratings offer a useful view of satisfaction, without showing whether the supplement works.
Product Focus71
The clearest role is supporting normal B-vitamin functions, including homocysteine processing and correcting low intake. The short ingredient list is focused, although broader mood, memory and energy benefits mainly depend on nutritional need.
- Format
Capsule - Container
- 60 Capsule(s)
- Per serving
- $0.39
- Customer rating
- 4.8 · 358 ratings
Goals
Impact
Highest effect
Folate · 800 mcg DFEVitamin B12 · 500 mcg
Impact
High effect
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin B-6 (Pyridoxal 5-Phosphate) | 50 mg | |
Folate (Quatrefolic [6S]-5-Methyltetrahydrofolic Acid) | 800 mcg DFE | |
Vitamin B12 (Methylcobalamin) | 500 mcg | |
TMG (natural Betaine) | 500 mg |
Vitamin B6 (Pyridoxal 5-Phosphate) · 50 mg OverallScore74
Each serving provides 50 mg of B6, with a moderate cost per amount. The source is Pyridoxal 5-Phosphate. That serving exceeds the European adult upper limit of 12 mg per day.
How this ingredient is rated
Ingredient Form & Label Quality100
The source is Pyridoxal 5-Phosphate. No artificial colors, titanium dioxide, hydrogenated oils or talc are indicated; other excipients may still be present.
Vitamin B6 Form Identification
The source is Pyridoxal 5-Phosphate.
Clean Label and Excipient Purity
No artificial colors, titanium dioxide, hydrogenated oils or talc are indicated; other excipients may still be present.
Dose, Safety & Label Transparency37
Each serving provides 50 mg of vitamin B6. That single serving exceeds the European adult upper limit of 12 mg per day; total intake may be higher. The label names the B6 source.
Vitamin B6 Dose & Safety Policy
Each serving provides 50 mg of vitamin B6. That single serving exceeds the European adult upper limit of 12 mg per day; total intake may be higher.
Label Transparency
The label names the B6 source.
Value95
The cost per amount of B6 is moderate; the whole-product price may overstate the cost of B6 alone.
Vitamin B6 Price Efficiency
The cost per amount of B6 is moderate; the whole-product price may overstate the cost of B6 alone.
Vitamin B12 (Methylcobalamin) · 500 mcg OverallScore76
Each serving provides 500 mcg of B12 at a high cost per 1,000 mcg, based on the full product price. The B12 is Methylcobalamin, a bioactive form.
How this ingredient is rated
Active Ingredient Quality & Bioavailability100
The B12 is Methylcobalamin, a bioactive form.
Bioactive B12 Form Selection
The B12 is Methylcobalamin, a bioactive form.
Dose, Safety & Label Transparency79
Each serving provides 500 mcg of B12. The label names Methylcobalamin and gives its B12 amount.
Therapeutic Dosage Level
Each serving provides 500 mcg of B12.
Label and Form Transparency
The label names Methylcobalamin and gives its B12 amount.
Value20
The cost per 1,000 mcg of B12 is high, based on the full product price.
Price per 1,000 mcg B12
The cost per 1,000 mcg of B12 is high, based on the full product price.
Alternative products
Report alternatives
Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
- The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
- Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
- The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
- Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
- Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
- A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
- Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
- The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
- Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
- Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
- Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
- Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
- Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
- Factors Associated with Premature Hair Graying in a Young Indian Population.
- Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
- Hair Loss After Laparoscopic Sleeve Gastrectomy.
- Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.