Methyl-Guard Plus

Methyl-Guard Plus

Thorne4.9 (2,912 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 30 servings
$62.00 $2.06 per serving
iHerbLowest$62.00Vitacost$62.00Pure Formulas$62.00Vitacost$62.00

Product analysis

63 out of 100

Methyl-Guard Plus combines B vitamins and betaine, with clearly identified riboflavin and B6 forms that make comparison easier. The folate form is not disclosed.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality60

Riboflavin and B6 forms are clearly identified, with riboflavin showing a favorable quality profile. The missing folate form and less certain comparisons for B12 and betaine limit a judgment of the full mix.

Ingredient Transparency93

All ingredient amounts and most forms are stated, making the formula fairly easy to compare. The folate form is the main missing detail.

Value For Money33

The cost per serving looks high when considered for riboflavin, and the B6 amount offers limited value. Value from folate and betaine remains uncertain.

Customer Satisfaction91

Customer ratings are very favorable across a large body of feedback. That provides a broad view of satisfaction without establishing a specific health benefit.

Product Focus40

The short nutrient-and-betaine mix is easy to identify. A specific health benefit cannot be judged confidently from the ingredient list alone.

Format
Capsule
Container
90 Capsule(s)
Per serving
$2.06
Customer rating
4.9 · 2,912 ratings
Report analysis

Ingredients

IngredientAmount per servingScore
Riboflavin (Riboflavin 5'-Phosphate Sodium)
 90 mg 82
Vitamin B6 (Pyridoxal 5-Phosphate)
 45 mg 65
Folate
5 mcg DFE
Vitamin B12 (Methylcobalamin)
 3 mg
Betaine Anhydrous (Trimethylglycine)
 1.8 Gram(s)
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate) · 45 mg OverallScore65
A+ Ingredient Form & Label QualityD- Dose, Safety & Label TransparencyD- Value
Each serving provides 45 mg of B6 at a fairly high cost per mg. That amount exceeds the 12 mg daily adult upper limit set by EFSA. It uses Pyridoxal 5-Phosphate.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 source is Pyridoxal 5-Phosphate. The listed Other Ingredients show no dyes, titanium dioxide or talc.
Vitamin B6 Form Identification
The B6 source is Pyridoxal 5-Phosphate.
Clean Label and Excipient Purity
The listed Other Ingredients show no dyes, titanium dioxide or talc.

Dose, Safety & Label Transparency42

45 mg per serving exceeds the 12 mg daily adult upper limit set by EFSA. The chemical source is named.
Vitamin B6 Dose & Safety Policy
45 mg per serving exceeds the 12 mg daily adult upper limit set by EFSA.
Label Transparency
The chemical source of B6 is named.

Value41

The cost per mg of B6 is fairly high.
Vitamin B6 Price Efficiency
The cost per mg of B6 is fairly high.
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Riboflavin (Riboflavin 5'-Phosphate Sodium) · 90 mg OverallScore82
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving provides 90 mg of riboflavin, and the cost per serving is high. It uses Riboflavin 5-Phosphate Sodium. No artificial colors, flavors or synthetic sweeteners are listed.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses Riboflavin 5-Phosphate Sodium.
Riboflavin Form Quality
It uses Riboflavin 5-Phosphate Sodium.

Dose, Safety & Label Transparency100

Each serving provides 90 mg of riboflavin. No artificial colors, flavors or synthetic sweeteners are listed.
Dosage for Energy & Metabolism
Each serving provides 90 mg of riboflavin.
R5P Elemental Yield Transparency
The riboflavin amount is stated.
Additive Purity
No artificial colors, flavors or synthetic sweeteners are listed.

Value10

The cost per serving is high.
Price per Serving Value
The cost per serving is high.
View ingredientView products
89 Performance

P-5-P 50 mg

Country Life
Active pyridoxal phosphate provides a clean, directly usable vitamin B6 form without the original’s poorly contributing folate entry. It is a focused B6 product rather than a complete methylation formula, and the amount remains above ordinary maintenance needs.
83 Performance

R-5-P Coenzymated Vitamin B-2 50 mg

Swanson Ultra
Active riboflavin phosphate provides clear form quality and a meaningful amount. The narrower capsule omits methylfolate, methylcobalamin, betaine, and vitamin B6, so it fits only isolated riboflavin needs.
81 Performance

Tri-B

Carlson
Vitamin B6, folate, and vitamin B12 create a simple combination relevant to homocysteine metabolism. Conventional forms, high folate, and elevated pyridoxine are less refined than the original’s active forms, but the formula avoids a questionable low folate declaration.
78 Budget

B-50 Complex

21st Century
A clearly disclosed B-complex with a long supply costs far less than the original methylation formula. Conventional forms and high vitamin B6 limit long-term routine use, while betaine and the original’s targeted methylation emphasis are absent.
83 Budget

B-2 100 mg

NOW
A focused riboflavin capsule provides a substantial amount at a very low serving cost. Standard riboflavin requires conversion and does not replace the original’s methylfolate, methylcobalamin, vitamin B6, or betaine.
89 Budget

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
Active pyridoxal phosphate offers direct vitamin B6 support at a small fraction of the original’s cost. The single-nutrient formula cannot replace broader methylation support, and its amount is still high for indefinite daily use.
83 Value

BioCoenzymated Riboflavin 5'-Phosphate 50 mg

Natural Factors
Active riboflavin phosphate delivers strong form quality at a much lower serving cost. It is only a riboflavin supplement, so broader methylation ingredients would need to come from diet or another carefully selected formula.
79 Value

P-5-P 50 mg

NOW
A P-5-P-positioned formula with magnesium bisglycinate provides active-form value at a low serving cost. The ingredient entry does not fully confirm the vitamin B6 form, and users should avoid combining it with other high-dose B6 products.
87 Value

Vitamin B-6 50 mg

Nature's Way
A mixed active and precursor vitamin B6 blend offers a focused, low-cost way to obtain some ready-to-use P-5-P. It does not supply the original’s riboflavin, folate, vitamin B12, or betaine and remains a high-potency B6 option.
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