SAMe with Vitamins B-6 B-12 and 5-MTHF
Goals
$60.49 $2.01 per serving
Product analysis
SAMe with Vitamins B-6 B-12 and 5-MTHF combines SAMe with B vitamins involved in normal nutrient processing. Its SAMe content is relatively costly for the amount provided.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality40
SAMe and the B vitamin forms are identified. Their names alone do not establish better absorption or stronger benefits.
Ingredient Transparency80
The ingredient amounts and forms are disclosed, helping you check the serving. Applicable composition details are incomplete, limiting a fuller comparison.
Value For Money33
SAMe is expensive for the amount supplied. The value contributed by the accompanying B vitamins cannot be judged confidently.
Customer Satisfaction75
Customer ratings are favorable, but the review base is small. The limited feedback does not establish effectiveness or safety.
Product Focus75
The ingredients participate in related nutrient-processing functions. Those roles do not establish routine toxin clearance or a general detox benefit.
- Format
Capsule - Container
- 30 Capsule(s)
- Per serving
- $2.01
- Customer rating
- 5.0 · 11 ratings
Goals
Impact
High effect
Folate · 100 mcgVitamin B12 · 50 mcgVitamin B6 · 5 mgSAMe · 200 mg
Vitamin B6 Not classified
No linked studies yet.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin B-6 (Pyridoxal 5-Phosphate) | 5 mg | |
Folate ([6s]-5-Methyltetrahydrofolate, Glucosamine Salt) | 100 mcg | |
Vitamin B12 (Methylcobalamin) | 50 mcg | |
SAMe (S-Adenosyl-L-Methionine Disulfate P-Toluensulfate) | 200 mg |
The serving provides 200 mg of SAMe at a high cost per 400 mg. Blister packaging is not documented. The active yield is not clearly separated from the salt weight. It also includes vitamins B-6, B-12 and 5-MTHF.
How this ingredient is rated
Active Ingredient Quality & Bioavailability17
The SAMe salt form is not specified, leaving its stability unclear. Protective blister packaging is not documented, so moisture protection is unclear.
Stabilized Salt Form
The SAMe salt form is not specified, leaving its stability unclear.
Packaging Integrity
Protective blister packaging is not documented, so moisture protection is unclear.
Dose, Safety & Label Transparency60
A serving lists 200 mg of SAMe. The amount is not clearly distinguished as active SAMe versus salt weight.
Active Dosage Strength
A serving lists 200 mg of SAMe.
Net SAMe Yield Transparency
The amount is not clearly distinguished as active SAMe versus salt weight.
Value20
The cost per 400 mg of SAMe is high. Enteric coating or delayed release is not documented, leaving protection from stomach acid uncertain.
Price Per 400mg Active Dose
The cost per 400 mg of SAMe is high. Enteric coating or delayed release is not documented, leaving protection from stomach acid uncertain.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: a randomized clinical trial.
- Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
- Serum folate levels and urinary arsenic methylation profiles in the US population: NHANES, 2003-2012.
- Association between serum folate levels and blood concentrations of cadmium and lead in US adults.
- Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
- Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
- Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
- S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
- Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
- S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
- Antidotes for acute cyanide poisoning.
- Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation.
- Comment on "Rapid visual detection of blood cyanide" by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4, 2632.
- [Acute intoxication in adults - what you should know].
- Investigating vitamin B12 levels in children with obesity: the role of metformin.